Type of skin eruption is an independent prognostic indicator for adult T-cell leukemia/lymphoma.


:Cutaneous involvement is seen in ~ 50% of adult T-cell leukemia/lymphoma (ATLL) patients. We investigated the association between skin eruption type and prognosis in 119 ATLL patients. ATLL eruptions were categorized into patch (6.7%), plaque (26.9%), multipapular (19.3%), nodulotumoral (38.7%), erythrodermic (4.2%), and purpuric (4.2%) types. When the T stage of the tumor-node-metastasis-blood (TNMB) classification of mycosis fungoides/Sézary syndrome was applied to ATLL staging, 16.0% were T1, 17.7% T2, 38.7% T3, and 4.2% T4, and the remaining 23.5% were of the multipapular and purpuric types. For the patch type, the mean survival time (median survival time could not be estimated) was 188.4 months. The median survival times (in months) for the remaining types were as follows: plaque, 114.9; multipapular, 17.3; nodulotumoral, 17.3; erythrodermic, 3.0; and purpuric, 4.4. Kaplan-Meier curves of overall survival showed that the erythrodermic type had the poorest prognosis, followed by the nodulotumoral and multipapular types. The patch and plaque types were associated with better survival rates. Multivariate analysis demonstrated that the hazard ratios of the erythrodermic and nodulotumoral types were significantly higher than that of the patch type, and that the eruption type is an independent prognostic factor for ATLL. The overall survival was worse as the T stage became more advanced: the multipapular type and T2 were comparable, and the purpuric type had a significantly poorer prognosis than T1.






Sawada Y,Hino R,Hama K,Ohmori S,Fueki H,Yamada S,Fukamachi S,Tajiri M,Kubo R,Yoshioka M,Nakashima D,Sugita K,Yoshiki R,Shimauchi T,Mori T,Izu K,Kobayashi M,Nakamura M,Tokura Y




Has Abstract


2011-04-14 00:00:00
















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    abstract::Previous studies suggested a role for prostaglandins or thromboxane A2, or both in the exposure of fibrinogen receptors on normal platelets in response to several aggregating agents. Platelets from diabetics are known to be more sensitive to aggregating agents and to produce more prostaglandins and thromboxane than pl...


    pub_type: 杂志文章


    authors: DiMinno G,Silver MJ,Cerbone AM,Riccardi G,Rivellese A,Mancini M,Thiagarajan P

    更新日期:1985-01-01 00:00:00

  • Favorable outcome of B-cell acute lymphoblastic leukemia in childhood: a report of three consecutive studies of the BFM group.

    abstract::In 1981 the BFM group introduced a new treatment strategy for B-cell acute lymphoblastic leukemia (B-ALL). A cytoreductive prephase (prednisone/cyclophosphamide) was followed by eight 5-day courses of chemotherapy. Fractionated cyclophosphamide, methotrexate (MTX) 0.5 g/m2 (24-hour infusion), and MTX intrathecally wer...


    pub_type: 杂志文章


    authors: Reiter A,Schrappe M,Ludwig WD,Lampert F,Harbott J,Henze G,Niemeyer CM,Gadner H,Müller-Weihrich S,Ritter J

    更新日期:1992-11-15 00:00:00

  • Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.

    abstract::The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance or homing of MM cells into new sites of the BM. Hypoxia in solid tumors was shown to promote metastasis through activation of proteins involved in the epithelial-mesenchymal transition (EMT) process. We hypothesized...


    pub_type: 杂志文章


    authors: Azab AK,Hu J,Quang P,Azab F,Pitsillides C,Awwad R,Thompson B,Maiso P,Sun JD,Hart CP,Roccaro AM,Sacco A,Ngo HT,Lin CP,Kung AL,Carrasco RD,Vanderkerken K,Ghobrial IM

    更新日期:2012-06-14 00:00:00

  • Antigen--antibody complexes related to the baboon endogenous virus in humans with acute lymphoblastic leukemia--hand mirror variant (ALL-HMC).

    abstract::Hand mirror cells are a morphological configuration that are seen in immunologically stimulated lymphocytes and can be induced by antigen--antibody complexes. Therefore, the bone marrow and peripheral blood plasma of two patients with acute lymphoblastic leukemia--hand mirror variant were evaluated for the presence of...


    pub_type: 杂志文章


    authors: Stass SA,Phillips TM,Weislow OS,Perlin E,Schumacher HR

    更新日期:1980-10-01 00:00:00

  • How I treat postthrombotic syndrome.

    abstract::Postthrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) that reduces quality of life and has important socioeconomic consequences. More than one-third of patients with DVT will develop PTS, and 5% to 10% of patients will develop severe PTS, which may manifest as venous ulceration. The p...


    pub_type: 杂志文章,评审


    authors: Kahn SR

    更新日期:2009-11-19 00:00:00

  • Notch1 as a potential therapeutic target in cutaneous T-cell lymphoma.

    abstract::Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signaling is involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the most common subtypes of cutaneous T-cell lymphoma. By immunohistochemistry of 4...


    pub_type: 杂志文章


    authors: Kamstrup MR,Gjerdrum LM,Biskup E,Lauenborg BT,Ralfkiaer E,Woetmann A,Ødum N,Gniadecki R

    更新日期:2010-10-07 00:00:00

  • Follicular helper T-cell-related lymphomas.

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    pub_type: 评论,杂志文章


    authors: Pileri SA

    更新日期:2015-10-08 00:00:00

  • A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice.

    abstract::In vivo lentiviral vector (LV)-mediated gene delivery would represent a great step forward in the field of gene therapy. Therefore, we have engineered a novel LV displaying SCF and a mutant cat endogenous retroviral glycoprotein, RDTR. These RDTR/SCF-LVs outperformed RDTR-LVs for transduction of human CD34(+) cells (h...


    pub_type: 杂志文章


    authors: Frecha C,Costa C,Nègre D,Amirache F,Trono D,Rio P,Bueren J,Cosset FL,Verhoeyen E

    更新日期:2012-02-02 00:00:00

  • In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

    abstract::Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...


    pub_type: 杂志文章


    authors: Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

    更新日期:2008-11-01 00:00:00

  • CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection.

    abstract::It has been suggested that human cytomegalovirus (HCMV) evades the immune system by infecting and paralyzing antigen-presenting cells. This view is based mainly on studies of dendritic cells (DCs) obtained after culture of monocytes (moDCs). It is contradicted by the asymptomatic course of HCMV infection in healthy pe...


    pub_type: 杂志文章


    authors: Kvale EØ,Dalgaard J,Lund-Johansen F,Rollag H,Farkas L,Midtvedt K,Jahnsen FL,Brinchmann JE,Olweus J

    更新日期:2006-03-01 00:00:00

  • Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission.

    abstract::To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph(-) ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph(-) ALL patients using the registry data, particula...


    pub_type: 杂志文章


    authors: Nishiwaki S,Inamoto Y,Sakamaki H,Kurokawa M,Iida H,Ogawa H,Fukuda T,Ozawa Y,Kobayashi N,Kasai M,Mori T,Iwato K,Yoshida T,Onizuka M,Kawa K,Morishima Y,Suzuki R,Atsuta Y,Miyamura K

    更新日期:2010-11-18 00:00:00

  • Identification and characterization of a differentiation antigen in human neutrophils and monocytes.

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    pub_type: 杂志文章


    authors: Nozawa R,Kato H,Ito T,Yokota T

    更新日期:1988-05-01 00:00:00

  • Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

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    pub_type: 杂志文章


    authors: Maillard I,Chen YX,Friedman A,Yang Y,Tubbs AT,Shestova O,Pear WS,Hua X

    更新日期:2009-02-19 00:00:00

  • Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium.

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    pub_type: 杂志文章


    authors: von Hundelshausen P,Koenen RR,Sack M,Mause SF,Adriaens W,Proudfoot AE,Hackeng TM,Weber C

    更新日期:2005-02-01 00:00:00

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    更新日期:2007-06-15 00:00:00

  • Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation.

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    authors: Zhong JF,Zhan Y,Anderson WF,Zhao Y

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  • Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells.

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    authors: Leimig T,Mann L,Martin Mdel P,Bonten E,Persons D,Knowles J,Allay JA,Cunningham J,Nienhuis AW,Smeyne R,d'Azzo A

    更新日期:2002-05-01 00:00:00

  • Development of pluripotent hematopoietic progenitor cells in the human fetus.

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    authors: Hann IM,Bodger MP,Hoffbrand AV

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  • Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients.

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    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Tassara M,Döhner K,Brossart P,Held G,Götze K,Horst HA,Ringhoffer M,Köhne CH,Kremers S,Raghavachar A,Wulf G,Kirchen H,Nachbaur D,Derigs HG,Wattad M,Koller E,Brugger W,Matzdorff A,Greil R,Heil G,Paschka P,Gaidzik

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  • Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients.

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    authors: André M,Mounier N,Leleu X,Sonet A,Brice P,Henry-Amar M,Tilly H,Coiffier B,Bosly A,Morel P,Haioun C,Gaulard P,Reyes F,Gisselbrecht C,Groupe D'Etude Des Lymphomes De L'Adulte.

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    pub_type: 杂志文章


    authors: Melki JR,Vincent PC,Brown RD,Clark SJ

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  • Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor.

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    authors: Hogge DE,Lansdorp PM,Reid D,Gerhard B,Eaves CJ

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    pub_type: 杂志文章


    authors: Hernandez Mir G,Helin J,Skarp KP,Cummings RD,Mäkitie A,Renkonen R,Leppänen A

    更新日期:2009-07-16 00:00:00

  • Persistent macrocytosis assessed by erythrocyte subpopulation analysis following erythrocyte regeneration in cats.

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    pub_type: 杂志文章


    authors: Weiser MG,Kociba GJ

    更新日期:1982-08-01 00:00:00

  • JAK2 inhibitors for myeloproliferative neoplasms: what is next?

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    pub_type: 杂志文章,评审


    authors: Bose P,Verstovsek S

    更新日期:2017-07-13 00:00:00

  • A role for transforming growth factor-beta1 in the increased pneumonitis in murine allogeneic bone marrow transplant recipients with graft-versus-host disease after pulmonary herpes simplex virus type 1 infection.

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    pub_type: 杂志文章


    authors: Adler H,Beland JL,Kozlow W,Del-Pan NC,Kobzik L,Rimm IJ

    更新日期:1998-10-01 00:00:00

  • AC133, a novel marker for human hematopoietic stem and progenitor cells.

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    pub_type: 杂志文章


    authors: Yin AH,Miraglia S,Zanjani ED,Almeida-Porada G,Ogawa M,Leary AG,Olweus J,Kearney J,Buck DW

    更新日期:1997-12-15 00:00:00

  • Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience.

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    pub_type: 杂志文章


    authors: Hebraud B,Magrangeas F,Cleynen A,Lauwers-Cances V,Chretien ML,Hulin C,Leleu X,Yon E,Marit G,Karlin L,Roussel M,Stoppa AM,Belhadj K,Voillat L,Garderet L,Macro M,Caillot D,Mohty M,Facon T,Moreau P,Attal M,Munshi N

    更新日期:2015-03-26 00:00:00

  • Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.

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    pub_type: 杂志文章,评审


    authors: Sadler JE

    更新日期:2008-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Chen R,Palmer JM,Thomas SH,Tsai NC,Farol L,Nademanee A,Forman SJ,Gopal AK

    更新日期:2012-06-28 00:00:00