Type of skin eruption is an independent prognostic indicator for adult T-cell leukemia/lymphoma.

Abstract:

:Cutaneous involvement is seen in ~ 50% of adult T-cell leukemia/lymphoma (ATLL) patients. We investigated the association between skin eruption type and prognosis in 119 ATLL patients. ATLL eruptions were categorized into patch (6.7%), plaque (26.9%), multipapular (19.3%), nodulotumoral (38.7%), erythrodermic (4.2%), and purpuric (4.2%) types. When the T stage of the tumor-node-metastasis-blood (TNMB) classification of mycosis fungoides/Sézary syndrome was applied to ATLL staging, 16.0% were T1, 17.7% T2, 38.7% T3, and 4.2% T4, and the remaining 23.5% were of the multipapular and purpuric types. For the patch type, the mean survival time (median survival time could not be estimated) was 188.4 months. The median survival times (in months) for the remaining types were as follows: plaque, 114.9; multipapular, 17.3; nodulotumoral, 17.3; erythrodermic, 3.0; and purpuric, 4.4. Kaplan-Meier curves of overall survival showed that the erythrodermic type had the poorest prognosis, followed by the nodulotumoral and multipapular types. The patch and plaque types were associated with better survival rates. Multivariate analysis demonstrated that the hazard ratios of the erythrodermic and nodulotumoral types were significantly higher than that of the patch type, and that the eruption type is an independent prognostic factor for ATLL. The overall survival was worse as the T stage became more advanced: the multipapular type and T2 were comparable, and the purpuric type had a significantly poorer prognosis than T1.

journal_name

Blood

journal_title

Blood

authors

Sawada Y,Hino R,Hama K,Ohmori S,Fueki H,Yamada S,Fukamachi S,Tajiri M,Kubo R,Yoshioka M,Nakashima D,Sugita K,Yoshiki R,Shimauchi T,Mori T,Izu K,Kobayashi M,Nakamura M,Tokura Y

doi

10.1182/blood-2010-11-316794

subject

Has Abstract

pub_date

2011-04-14 00:00:00

pages

3961-7

issue

15

eissn

0006-4971

issn

1528-0020

pii

blood-2010-11-316794

journal_volume

117

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Increased binding of fibrinogen to platelets in diabetes: the role of prostaglandins and thromboxane.

    abstract::Previous studies suggested a role for prostaglandins or thromboxane A2, or both in the exposure of fibrinogen receptors on normal platelets in response to several aggregating agents. Platelets from diabetics are known to be more sensitive to aggregating agents and to produce more prostaglandins and thromboxane than pl...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: DiMinno G,Silver MJ,Cerbone AM,Riccardi G,Rivellese A,Mancini M,Thiagarajan P

    更新日期:1985-01-01 00:00:00

  • Favorable outcome of B-cell acute lymphoblastic leukemia in childhood: a report of three consecutive studies of the BFM group.

    abstract::In 1981 the BFM group introduced a new treatment strategy for B-cell acute lymphoblastic leukemia (B-ALL). A cytoreductive prephase (prednisone/cyclophosphamide) was followed by eight 5-day courses of chemotherapy. Fractionated cyclophosphamide, methotrexate (MTX) 0.5 g/m2 (24-hour infusion), and MTX intrathecally wer...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Reiter A,Schrappe M,Ludwig WD,Lampert F,Harbott J,Henze G,Niemeyer CM,Gadner H,Müller-Weihrich S,Ritter J

    更新日期:1992-11-15 00:00:00

  • Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.

    abstract::The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance or homing of MM cells into new sites of the BM. Hypoxia in solid tumors was shown to promote metastasis through activation of proteins involved in the epithelial-mesenchymal transition (EMT) process. We hypothesized...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-09-380410

    authors: Azab AK,Hu J,Quang P,Azab F,Pitsillides C,Awwad R,Thompson B,Maiso P,Sun JD,Hart CP,Roccaro AM,Sacco A,Ngo HT,Lin CP,Kung AL,Carrasco RD,Vanderkerken K,Ghobrial IM

    更新日期:2012-06-14 00:00:00

  • Antigen--antibody complexes related to the baboon endogenous virus in humans with acute lymphoblastic leukemia--hand mirror variant (ALL-HMC).

    abstract::Hand mirror cells are a morphological configuration that are seen in immunologically stimulated lymphocytes and can be induced by antigen--antibody complexes. Therefore, the bone marrow and peripheral blood plasma of two patients with acute lymphoblastic leukemia--hand mirror variant were evaluated for the presence of...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Stass SA,Phillips TM,Weislow OS,Perlin E,Schumacher HR

    更新日期:1980-10-01 00:00:00

  • How I treat postthrombotic syndrome.

    abstract::Postthrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) that reduces quality of life and has important socioeconomic consequences. More than one-third of patients with DVT will develop PTS, and 5% to 10% of patients will develop severe PTS, which may manifest as venous ulceration. The p...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2009-07-199174

    authors: Kahn SR

    更新日期:2009-11-19 00:00:00

  • Notch1 as a potential therapeutic target in cutaneous T-cell lymphoma.

    abstract::Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signaling is involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the most common subtypes of cutaneous T-cell lymphoma. By immunohistochemistry of 4...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-12-260216

    authors: Kamstrup MR,Gjerdrum LM,Biskup E,Lauenborg BT,Ralfkiaer E,Woetmann A,Ødum N,Gniadecki R

    更新日期:2010-10-07 00:00:00

  • Follicular helper T-cell-related lymphomas.

    abstract::In this issue of Blood, Wang et al describe the occurrence and pathogenetic relevance of IDH2R172 mutations in angioimmunoblastic T-cell lymphoma (AITL). ...

    journal_title:Blood

    pub_type: 评论,杂志文章

    doi:10.1182/blood-2015-08-665075

    authors: Pileri SA

    更新日期:2015-10-08 00:00:00

  • A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice.

    abstract::In vivo lentiviral vector (LV)-mediated gene delivery would represent a great step forward in the field of gene therapy. Therefore, we have engineered a novel LV displaying SCF and a mutant cat endogenous retroviral glycoprotein, RDTR. These RDTR/SCF-LVs outperformed RDTR-LVs for transduction of human CD34(+) cells (h...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-04-346619

    authors: Frecha C,Costa C,Nègre D,Amirache F,Trono D,Rio P,Bueren J,Cosset FL,Verhoeyen E

    更新日期:2012-02-02 00:00:00

  • In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

    abstract::Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-04-151753

    authors: Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

    更新日期:2008-11-01 00:00:00

  • CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection.

    abstract::It has been suggested that human cytomegalovirus (HCMV) evades the immune system by infecting and paralyzing antigen-presenting cells. This view is based mainly on studies of dendritic cells (DCs) obtained after culture of monocytes (moDCs). It is contradicted by the asymptomatic course of HCMV infection in healthy pe...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-05-2016

    authors: Kvale EØ,Dalgaard J,Lund-Johansen F,Rollag H,Farkas L,Midtvedt K,Jahnsen FL,Brinchmann JE,Olweus J

    更新日期:2006-03-01 00:00:00

  • Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission.

    abstract::To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph(-) ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph(-) ALL patients using the registry data, particula...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-02-269571

    authors: Nishiwaki S,Inamoto Y,Sakamaki H,Kurokawa M,Iida H,Ogawa H,Fukuda T,Ozawa Y,Kobayashi N,Kasai M,Mori T,Iwato K,Yoshida T,Onizuka M,Kawa K,Morishima Y,Suzuki R,Atsuta Y,Miyamura K

    更新日期:2010-11-18 00:00:00

  • Identification and characterization of a differentiation antigen in human neutrophils and monocytes.

    abstract::Human promyelocytic leukemia (HL-60) cells were induced to differentiate into macrophage-like cells by treatment with 10(-7) mol/L 1,25-dihydroxyvitamin D3 (VD3). A monoclonal antibody (MoAb, 60B8), reactive with the particulate of the differentiated cells but not of the untreated cells, was isolated. The antigen reco...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Nozawa R,Kato H,Ito T,Yokota T

    更新日期:1988-05-01 00:00:00

  • Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

    abstract::Men1 is a tumor suppressor gene mutated in endocrine neoplasms. Besides its endocrine role, the Men1 gene product menin interacts with the mixed lineage leukemia (MLL) protein, a histone H3 lysine 4 methyltransferase. Although menin and MLL fusion proteins cooperate to activate Homeobox (Hox) gene expression during tr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-01-135012

    authors: Maillard I,Chen YX,Friedman A,Yang Y,Tubbs AT,Shestova O,Pear WS,Hua X

    更新日期:2009-02-19 00:00:00

  • Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium.

    abstract::The chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell expressed and secreted) are secreted by activated platelets and influence multiple cell types and biologic processes. For instance, PF4 inhibits progenitor cell proliferation and angiogenesis, while platelet-derived RANTES is invo...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-06-2475

    authors: von Hundelshausen P,Koenen RR,Sack M,Mause SF,Adriaens W,Proudfoot AE,Hackeng TM,Weber C

    更新日期:2005-02-01 00:00:00

  • Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets.

    abstract::Human blood contains 2 populations of dendritic cells (DCs): plasmacytoid and myeloid (mDC). mDCs are subdivided into 3 subsets using the surface markers CD16, CD1c, and BDCA-3. Their role as pathogen sentinels and adjuvant targets was tested by phenotypic and functional analysis. We show that mDC subsets are immature...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2006-08-038422

    authors: Piccioli D,Tavarini S,Borgogni E,Steri V,Nuti S,Sammicheli C,Bardelli M,Montagna D,Locatelli F,Wack A

    更新日期:2007-06-15 00:00:00

  • Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation.

    abstract::The engraftment of donor bone marrow (BM) cells in nonablated mice is inefficient. Niche availability has been thought to be the reason, and cytoablation with irradiation or cytotoxic agents is routinely used with the belief that this frees the preoccupied niches in recipients. In this study, donor cell redistribution...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-04-1256

    authors: Zhong JF,Zhan Y,Anderson WF,Zhao Y

    更新日期:2002-11-15 00:00:00

  • Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells.

    abstract::Protective protein/cathepsin A (PPCA), a lysosomal carboxypeptidase, is deficient in the neurodegenerative lysosomal disorder galactosialidosis (GS). PPCA(-/-) mice display a disease course similar to that of severe human GS, resulting in nephropathy, ataxia, and premature death. Bone marrow transplantation (BMT) in m...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v99.9.3169

    authors: Leimig T,Mann L,Martin Mdel P,Bonten E,Persons D,Knowles J,Allay JA,Cunningham J,Nienhuis AW,Smeyne R,d'Azzo A

    更新日期:2002-05-01 00:00:00

  • Development of pluripotent hematopoietic progenitor cells in the human fetus.

    abstract::Pluripotent hematopoietic progenitor cells (CFU-GEMM), myeloid progenitor cells (CFU-GM), and erythroid progenitors (BFU-E) were studied in midtrimester human fetuses using the mixed colony assay. All three progenitor cell populations were detected at high levels in the fetal liver from 12 to 23 wk of gestation. Stem ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Hann IM,Bodger MP,Hoffbrand AV

    更新日期:1983-07-01 00:00:00

  • Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients.

    abstract::The outcome of patients with acute myeloid leukemia who are older than 60 years has remained poor because of unfavorable disease characteristics and patient-related factors. The randomized German-Austrian AML Study Group 06-04 protocol was designed on the basis of in vitro synergistic effects of valproic acid (VPA) an...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1182/blood-2013-12-546283

    authors: Tassara M,Döhner K,Brossart P,Held G,Götze K,Horst HA,Ringhoffer M,Köhne CH,Kremers S,Raghavachar A,Wulf G,Kirchen H,Nachbaur D,Derigs HG,Wattad M,Koller E,Brugger W,Matzdorff A,Greil R,Heil G,Paschka P,Gaidzik

    更新日期:2014-06-26 00:00:00

  • Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients.

    abstract::The survival of patients with aggressive non-Hodgkin lymphoma (NHL) is increasing, but the incidence of secondary cancer and late toxicity is poorly defined for those treated with cyclophosphamide-hydroxydaunomycin/doxorubicin-Oncovin-prednisone (CHOP)-like chemotherapy. From February 1984 to January 1998, 2837 patien...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-04-1124

    authors: André M,Mounier N,Leleu X,Sonet A,Brice P,Henry-Amar M,Tilly H,Coiffier B,Bosly A,Morel P,Haioun C,Gaulard P,Reyes F,Gisselbrecht C,Groupe D'Etude Des Lymphomes De L'Adulte.

    更新日期:2004-02-15 00:00:00

  • Hypermethylation of E-cadherin in leukemia.

    abstract::E-cadherin gene is often termed a "metastasis suppressor" gene because the E-cadherin protein can suppress tumor cell invasion and metastasis. Inactivation of the E-cadherin gene occurs in undifferentiated solid tumors by both genetic and epigenetic mechanisms; however, the role of E-cadherin in hematologic malignanci...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Melki JR,Vincent PC,Brown RD,Clark SJ

    更新日期:2000-05-15 00:00:00

  • Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor.

    abstract::To determine whether the sensitivity of the human long-term culture-initiating cell (LTC-IC) assay could be increased, we have evaluated a spectrum of different fibroblast cell lines for their abilities to influence the number of cells detectable as LTC-IC, to influence LTC-IC maintenance, and/or to influence LTC-IC d...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Hogge DE,Lansdorp PM,Reid D,Gerhard B,Eaves CJ

    更新日期:1996-11-15 00:00:00

  • Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans.

    abstract::Endothelial sialomucin CD34 functions as an L-selectin ligand mediating lymphocyte extravasation only when properly glycosylated to express a sulfated carbohydrate epitope, 6-sulfo sialyl Lewis x (6-sulfo SLe(x)). It is thought that multivalent 6-sulfo SLe(x) expression promotes high-affinity binding to L-selectin by ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-03-210237

    authors: Hernandez Mir G,Helin J,Skarp KP,Cummings RD,Mäkitie A,Renkonen R,Leppänen A

    更新日期:2009-07-16 00:00:00

  • Persistent macrocytosis assessed by erythrocyte subpopulation analysis following erythrocyte regeneration in cats.

    abstract::Serial erythrocyte volume distribution curves were used to characterize changes in erythrocyte subpopulations following the induction of Heinz body hemolytic anemia in cats. Macrocytes produced in response to hemolysis were observed after loss of reticulum. After recovery from hemolysis, a gradual reduction in mean ce...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Weiser MG,Kociba GJ

    更新日期:1982-08-01 00:00:00

  • JAK2 inhibitors for myeloproliferative neoplasms: what is next?

    abstract::Since its approval in 2011, the Janus kinase 1/2 (JAK1/2) inhibitor ruxolitinib has evolved to become the centerpiece of therapy for myelofibrosis (MF), and its use in patients with hydroxyurea resistant or intolerant polycythemia vera (PV) is steadily increasing. Several other JAK2 inhibitors have entered clinical te...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2017-04-742288

    authors: Bose P,Verstovsek S

    更新日期:2017-07-13 00:00:00

  • A role for transforming growth factor-beta1 in the increased pneumonitis in murine allogeneic bone marrow transplant recipients with graft-versus-host disease after pulmonary herpes simplex virus type 1 infection.

    abstract::To gain further insights in the pathogenesis of herpesvirus pneumonia in allogeneic bone marrow transplant recipients, transplanted mice (B10.BR --> CBA) with graft-versus-host disease (GVHD) and control mice (transplanted mice without GVHD and normal CBA mice) were infected intranasally with herpes simplex virus type...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Adler H,Beland JL,Kozlow W,Del-Pan NC,Kobzik L,Rimm IJ

    更新日期:1998-10-01 00:00:00

  • AC133, a novel marker for human hematopoietic stem and progenitor cells.

    abstract::AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD. AC133 antigen is selectively expressed on CD34(bright) hematopoietic stem and progenitor cells (progenitors) derived from human fetal liver and b...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Yin AH,Miraglia S,Zanjani ED,Almeida-Porada G,Ogawa M,Leary AG,Olweus J,Kearney J,Buck DW

    更新日期:1997-12-15 00:00:00

  • Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience.

    abstract::In multiple myeloma, cytogenetic changes are important predictors of patient outcome. In this setting, the most important changes are deletion 17p, del(17p), and translocation of chromosomes 4 and 14, t(4;14), conferring a poor outcome. However, a certain degree of heterogeneity is observed in the survival of these hi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2014-07-587964

    authors: Hebraud B,Magrangeas F,Cleynen A,Lauwers-Cances V,Chretien ML,Hulin C,Leleu X,Yon E,Marit G,Karlin L,Roussel M,Stoppa AM,Belhadj K,Voillat L,Garderet L,Macro M,Caillot D,Mohty M,Facon T,Moreau P,Attal M,Munshi N

    更新日期:2015-03-26 00:00:00

  • Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.

    abstract::Discoveries during the past decade have revolutionized our understanding of idiopathic thrombotic thrombocytopenic purpura (TTP). Most cases in adults are caused by acquired autoantibodies that inhibit ADAMTS13, a metalloprotease that cleaves von Willebrand factor within nascent platelet-rich thrombi to prevent hemoly...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2008-02-078170

    authors: Sadler JE

    更新日期:2008-07-01 00:00:00

  • Brentuximab vedotin enables successful reduced-intensity allogeneic hematopoietic cell transplantation in patients with relapsed or refractory Hodgkin lymphoma.

    abstract::Brentuximab vedotin induces an overall response rate of 75% in patients with relapsed/refractory Hodgkin lymphoma, but its impact on future allogeneic transplantation (allo-HCT) is not known. We retrospectively examined the records of 18 patients with relapsed/refractory Hodgkin lymphoma who were treated on brentuxima...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-03-418673

    authors: Chen R,Palmer JM,Thomas SH,Tsai NC,Farol L,Nademanee A,Forman SJ,Gopal AK

    更新日期:2012-06-28 00:00:00