Defensin promotes the binding of lipoprotein(a) to vascular matrix.

abstract：:Using urea-solubilized human fibrin monomer as an immunogen, we raised in mice a battery of monoclonal antibodies that reacted with the immunogen but not with urea-treated or native fibrinogen. Although they all failed to react with acid-solubilized fibrin monomer (acid-FM) alone, an antibody designated as IF-43 was f...

journal_title：Blood

authors： Soe G,Kohno I,Inuzuka K,Itoh Y,Matsuda M

更新日期：1996-09-15 00:00:00

abstract：:In this issue of Blood, Martin et al report poor outcomes for ibrutinib-refractory patients with mantle cell lymphoma (MCL). MCL, an uncommon B-cell lymphoma driven by dysregulated cyclin D1, responds well to initial therapy but is destined to relapse. Subsequent single-agent treatments had modest response rates and d...

journal_title：Blood

authors： Smith MR

更新日期：2016-03-24 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha) exerts several effects on target cells, such as neovascularization promotion and mitogenic signalling. Using immunoelectron microscopy, we show that monocytes and neutrophils, store TGF-alpha in cytoplasmic granules. In monocytes, TGF-alpha did not colocalize with component...

journal_title：Blood

authors： Calafat J,Janssen H,Ståhle-Bäckdahl M,Zuurbier AE,Knol EF,Egesten A

更新日期：1997-08-01 00:00:00

abstract：:Regulatory T (Tr) cells have the potential to treat immune-mediated disease, but cloning such cells for study from patients with autoimmune disease has proven difficult. Here, we describe autoantigen-specific, interleukin-10 (IL-10)-secreting Tr cell clones recovered ex vivo from a patient with autoimmune hemolytic an...

journal_title：Blood

authors： Ward FJ,Hall AM,Cairns LS,Leggat AS,Urbaniak SJ,Vickers MA,Barker RN

更新日期：2008-01-15 00:00:00

abstract：:Mucopolysaccharidosis type I-Hurler syndrome (MPS-IH) is a lysosomal storage disease characterized by multisystem morbidity and death in early childhood. Although hematopoietic cell transplantation (HCT) has been performed in these patients for more than 30 years, large studies on the long-term outcome of patients wit...

journal_title：Blood

authors： Aldenhoven M,Wynn RF,Orchard PJ,O'Meara A,Veys P,Fischer A,Valayannopoulos V,Neven B,Rovelli A,Prasad VK,Tolar J,Allewelt H,Jones SA,Parini R,Renard M,Bordon V,Wulffraat NM,de Koning TJ,Shapiro EG,Kurtzberg J,Boel

更新日期：2015-03-26 00:00:00

abstract：:During thrombopoiesis, maturing megakaryocytes (MKs) migrate within the complex bone marrow stromal microenvironment from the proliferative osteoblastic niche to the capillary-rich vascular niche where proplatelet formation and platelet release occurs. This physiologic process involves proliferation, differentiation, ...

journal_title：Blood

authors： Dhanjal TS,Pendaries C,Ross EA,Larson MK,Protty MB,Buckley CD,Watson SP

更新日期：2007-05-15 00:00:00

abstract：:Severe congenital neutropenia (CN) (Kostmann syndrome) is a hematologic disorder characterized by a maturation arrest of myelopoiesis at the promyelocyte/myelocyte stage of development. This arrest results in severe neutropenia leading to absolute neutrophil counts (ANC) below 0.2 x 10(9)/L associated with severe bact...

journal_title：Blood

authors： Zeidler C,Welte K,Barak Y,Barriga F,Bolyard AA,Boxer L,Cornu G,Cowan MJ,Dale DC,Flood T,Freedman M,Gadner H,Mandel H,O'Reilly RJ,Ramenghi U,Reiter A,Skinner R,Vermylen C,Levine JE

更新日期：2000-02-15 00:00:00

abstract：:The transmembrane 4 superfamily (TM4SF) has come into prominence for its association with a wide range of cell surface molecules, especially integrins. We report that TM4SF molecules CD9, CD63, and CD81 are physically associated with c-kit receptor tyrosine kinase in the human factor-dependent myeloid cell line, MO7e....

journal_title：Blood

authors： Anzai N,Lee Y,Youn BS,Fukuda S,Kim YJ,Mantel C,Akashi M,Broxmeyer HE

更新日期：2002-06-15 00:00:00

abstract：:Thrombopoietin (TPO) is a hematopoietic growth factor that regulates megakaryocytopoiesis and platelet production through binding to its receptor, Mpl, encoded by the c-mpl proto-oncogene. Circulating levels of TPO are regulated by receptor-mediated uptake and degradation. To better understand this mode of TPO regulat...

journal_title：Blood

authors： Cohen-Solal K,Vitrat N,Titeux M,Vainchenker W,Wendling F

更新日期：1999-05-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) can kill target cells by the granule/exocytosis pathway or the Fas-mediated apoptosis pathway. The sensitivity of chronic lymphocytic leukemia (CLL) B cells to CTL-mediated apoptosis before and after CD40 activation was examined. Resting or CD40-activated CLL cells were found to be equal...

journal_title：Blood

authors： Chu P,Wierda WG,Kipps TJ

更新日期：2000-06-15 00:00:00

abstract：:Childhood acute myeloid leukemia (AML) has a poor prognosis with standard chemotherapy. Allogeneic bone marrow transplantation (BMT) in remission improves the outlook only for the one third of patients with sibling donors. Autologous BMT with a lower morbidity and mortality is available to all. In this study, maximum ...

journal_title：Blood

authors： Tiedemann K,Waters KD,Tauro GP,Tucker D,Ekert H

更新日期：1993-12-15 00:00:00

abstract：:Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid lineages. The expression of short isoforms lacking DNA-binding motifs alters the differentiation capacities of hematopoietic progenitors, arresting lineage commitment. We sought to determine whether molecular abnormaliti...

journal_title：Blood

authors： Iacobucci I,Lonetti A,Messa F,Cilloni D,Arruga F,Ottaviani E,Paolini S,Papayannidis C,Piccaluga PP,Giannoulia P,Soverini S,Amabile M,Poerio A,Saglio G,Pane F,Berton G,Baruzzi A,Vitale A,Chiaretti S,Perini G,Foà R

更新日期：2008-11-01 00:00:00

abstract：:In this issue of Blood, Usmani et al provide important information on second primary malignancies in patients treated with thalidomide and lenalidomide in the Arkansas total therapy trials. ...

journal_title：Blood

authors： Rajkumar SV

更新日期：2012-08-23 00:00:00

abstract：:Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals. The duration of the thrombolytic effect of infused t-PA is unknown. We compared the duration of the thrombolytic effect of t-PA with streptokinase by measuring the lysis of 125I-fibrin-labeled thrombi in rabbit jugular...

journal_title：Blood

authors： Agnelli G,Buchanan MR,Fernandez F,Van Ryn J,Hirsh J

更新日期：1985-08-01 00:00:00

abstract：:In this issue of Blood, den Exter et al highlight the importance of subsegmental pulmonary emboli. ...

journal_title：Blood

authors： Raskob GE

更新日期：2013-08-15 00:00:00

abstract：:In a previous study, we described a form of nondeletion alpha-thalassemia (alpha T Saudi alpha) found in subjects of Saudi Arabian origin. In the current study, using synthetic oligoprobe hybridization and restriction enzyme analysis, we have demonstrated that the molecular basis of alpha T Saudi alpha is due solely t...

journal_title：Blood

authors： Thein SL,Wallace RB,Pressley L,Clegg JB,Weatherall DJ,Higgs DR

更新日期：1988-02-01 00:00:00

abstract：:Peripheral blood B cells in patients with paroxysmal nocturnal hemoglobinuria (PNH) comprise variable mixtures of normal B cells produced before the onset of disease and glycosylphosphatidylinositol (GPI)-deficient B cells derived from the PNH hematopoietic stem cell. In a detailed phenotypic analysis of 29 patients w...

journal_title：Blood

authors： Richards SJ,Morgan GJ,Hillmen P

更新日期：2000-11-15 00:00:00

abstract：:Combretastatin A-4-phosphate (CA-4-P) is a tubulin-binding compound currently in clinical trial as a tumor vascular-targeting agent. In endothelial cells, CA-4-P is known to cause microtubule depolymerization, but little is known about its subsequent effects on cell morphology and function. Here, we demonstrate that w...

journal_title：Blood

authors： Kanthou C,Tozer GM

更新日期：2002-03-15 00:00:00

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00

abstract：:The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pe...

journal_title：Blood

authors： Paugh SW,Paugh BS,Rahmani M,Kapitonov D,Almenara JA,Kordula T,Milstien S,Adams JK,Zipkin RE,Grant S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:Protein S, an inhibitor of coagulation, interacts reversibly with C4b binding protein (C4bBP). The physiologic role of this complex formation remains unknown. In this study we examined the possibility that protein S would facilitate C4bBP binding to the surface of neutrophils where, in turn, this complex could help pr...

journal_title：Blood

authors： Furmaniak-Kazmierczak E,Hu CY,Esmon CT

更新日期：1993-01-15 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) have previously been reported to mediate phagocytosis of anti-CD20-opsonized B cells from patients with chronic lymphocytic leukemia (CLL). However, recent data have suggested that PMNs, like macrophages, can also mediate trogocytosis. We have performed experiments to more precisel...

journal_title：Blood

authors： Valgardsdottir R,Cattaneo I,Klein C,Introna M,Figliuzzi M,Golay J

更新日期：2017-05-11 00:00:00

abstract：:The presence of a serum factor in chronic renal failure (CRF) which inhibits erythropoietin-stimulated erythropoiesis was studied, using a technique in which dog marrow cells were stimulated to produce heme in the presence of human serum. In the total series comparing 27 normal sera with 52 CRF sera, less heme was syn...

journal_title：Blood

authors： Wallner SF,Kurnick JE,Ward HP,Vautrin R,Alfrey AC

更新日期：1976-04-01 00:00:00

abstract：:Previous studies indicate that human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells. Cells of this nature can initiate and maintain leukemic cell growth in both long-term cultures and nonobese diabetic/severe combined immune-deficient mice. To characterize the biology of primitiv...

journal_title：Blood

authors： Guzman ML,Upchurch D,Grimes B,Howard DS,Rizzieri DA,Luger SM,Phillips GL,Jordan CT

更新日期：2001-04-01 00:00:00

abstract：:Exposed subendothelial collagen acts as a substrate for platelet adhesion and thrombus formation after vascular injury. Synthetic collagen-derived triple-helical peptides, designated collagen-related peptide (CRP), GFOGER, and VWF-III, can specifically engage the platelet collagen receptors, glycoprotein VI and integr...

journal_title：Blood

authors： Pugh N,Simpson AM,Smethurst PA,de Groot PG,Raynal N,Farndale RW

更新日期：2010-06-17 00:00:00

abstract：:Anaplastic large cell lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma kinase (ALK) to dimerization partners. The constitutive activation of ALK fusion proteins leads to cellular transformation through a complex signaling network. To elucidate the ALK pathways s...

journal_title：Blood

authors： Boccalatte FE,Voena C,Riganti C,Bosia A,D'Amico L,Riera L,Cheng M,Ruggeri B,Jensen ON,Goss VL,Lee K,Nardone J,Rush J,Polakiewicz RD,Comb MJ,Chiarle R,Inghirami G

更新日期：2009-03-19 00:00:00

abstract：:Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer-associated genes is highly prevalent in the normal population. Its etiology, biological impact on hematopoiesis, and oncogenic risk is poorly defined at this time. To gain insight into this phenomenon, we analyzed a cohort of 2530 relat...

journal_title：Blood

authors： Buscarlet M,Provost S,Zada YF,Barhdadi A,Bourgoin V,Lépine G,Mollica L,Szuber N,Dubé MP,Busque L

更新日期：2017-08-10 00:00:00

abstract：:Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers. All 50 household contac...

journal_title：Blood

authors： Lawrence DN,Jason JM,Bouhasin JD,McDougal JS,Knutsen AP,Evatt BL,Joist JH

更新日期：1985-09-01 00:00:00

abstract：:Granzyme H (GzmH) belongs to a family of 5 human serine proteases that are expressed by cytotoxic immune effector cells. Although GzmH is most closely related to the caspase-activating granzyme B (GzmB), neither a natural substrate nor a role in immune defense reactions has been demonstrated for this orphan granzyme. ...

journal_title：Blood

authors： Fellows E,Gil-Parrado S,Jenne DE,Kurschus FC

更新日期：2007-07-15 00:00:00

abstract：:Leukocytes are classified as myelocytic or lymphocytic, and each class of leukocytes consists of several types of cells that have different phenotypes and different roles. To define the gene expression in these cells, we have performed serial analysis of gene expression (SAGE) using human leukocytes and have provided ...

journal_title：Blood

authors： Hashimoto S,Nagai S,Sese J,Suzuki T,Obata A,Sato T,Toyoda N,Dong HY,Kurachi M,Nagahata T,Shizuno K,Morishita S,Matsushima K

更新日期：2003-05-01 00:00:00