Human monocytes and neutrophils store transforming growth factor-alpha in a subpopulation of cytoplasmic granules.

abstract：:Sardinian beta-thalassemia patients all are homozygotes for the same null allele in the beta-globin gene, but the clinical manifestations are extremely variable in severity. Previous studies have shown that the coinheritance of alpha-thalassemia or the presence of genetic variants that sustain fetal hemoglobin product...

journal_title：Blood

authors： Galanello R,Sanna S,Perseu L,Sollaino MC,Satta S,Lai ME,Barella S,Uda M,Usala G,Abecasis GR,Cao A

更新日期：2009-10-29 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a severe renal disease that is associated with defective complement regulation caused by multiple factors. We previously described the deficiency of factor H-related proteins CFHR1 and CFHR3 as predisposing factor for aHUS. Here we identify in an extended cohort of 147 aHUS...

journal_title：Blood

authors： Józsi M,Licht C,Strobel S,Zipfel SL,Richter H,Heinen S,Zipfel PF,Skerka C

更新日期：2008-02-01 00:00:00

abstract：:The high frequency of allogeneic reactive CD8(+) T cells in human and their resistance to immunosuppression might be one of the reasons why successful tolerance-inducing strategies in rodents have failed in primates. Studies on the requirement for T-helper cells in priming CD8(+) T-cell responses have led to disparate...

journal_title：Blood

authors： Lemoine R,Velge-Roussel F,Herr F,Felix R,Nivet H,Lebranchu Y,Baron C

更新日期：2010-10-21 00:00:00

abstract：:A patient, CAL, with gamma heavy chain disease is presented who has had a complete remission lasting over 2 yr with combination chemotherapy consisting of pulsatile cyclophosphamide and prednisone. The patient exhibited many features of an atuoimmune process including a vasculitis, low serum complement levels, a posit...

journal_title：Blood

authors： Lyons RM,Chaplin H,Tillack TW,Majerus PW

更新日期：1975-07-01 00:00:00

abstract：:The Kindlin family of intracellular proteins has recently emerged as key regulators of cellular functions and cell-matrix interactions. The 3 members of this family, Kindlin-1, -2, and -3, perform an essential role in activation of integrin adhesion receptors, and expression of at least 1 Kindlin paralog is required t...

journal_title：Blood

authors： Malinin NL,Plow EF,Byzova TV

更新日期：2010-05-20 00:00:00

abstract：:Postthrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) that reduces quality of life and has important socioeconomic consequences. More than one-third of patients with DVT will develop PTS, and 5% to 10% of patients will develop severe PTS, which may manifest as venous ulceration. The p...

journal_title：Blood

authors： Kahn SR

更新日期：2009-11-19 00:00:00

abstract：:The phosphatidylcholine specific transfer protein (PCTP) from bovine liver was used to retailor the molecular species composition of phosphatidylcholine (PC) in the membrane of normal (AA) and sickleable (SS) human erythrocytes. Changes in molecular species composition of PC altered morphology as well as cellular defo...

journal_title：Blood

authors： Kuypers FA,Chiu D,Mohandas N,Roelofsen B,Op den Kamp JA,Lubin B

更新日期：1987-10-01 00:00:00

abstract：:Acquired factor XIII (FXIII) deficiency due to autoantibody against FXIII is a very rare severe hemorrhagic diathesis. Antibodies directed against the A subunit of FXIII, which interfere with different functions of FXIII, have been described. Here, for the first time, we report an autoantibody against the B subunit of...

journal_title：Blood

authors： Ajzner E,Schlammadinger A,Kerényi A,Bereczky Z,Katona E,Haramura G,Boda Z,Muszbek L

更新日期：2009-01-15 00:00:00

abstract：:Endotoxin is a component of gram-negative bacteria that causes hematologic and immunologic changes through its induction of cytokines. Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of IL-1 that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity....

journal_title：Blood

authors： Granowitz EV,Porat R,Mier JW,Orencole SF,Callahan MV,Cannon JG,Lynch EA,Ye K,Poutsiaka DD,Vannier E

更新日期：1993-11-15 00:00:00

abstract：:Protein Z is a vitamin K-dependent glycoprotein that plays a role in the regulation of coagulation. A nucleotide substitution of G by C in exon II of the protein Z gene, resulting in the replacement of Glu-30 with Gln (E30Q), and a G to A transition at the 79th nucleotide in intron F (IntF79G/A) were heterozygously id...

journal_title：Blood

authors： Souri M,Koseki-Kuno S,Iwata H,Kemkes-Matthes B,Ichinose A

更新日期：2005-04-15 00:00:00

abstract：:We have conducted a pilot study to investigate the role of high-dose therapy and autologous bone marrow/stem cell transplantation (ASCT) during first complete or partial remission in 52 patients with poor-risk aggressive lymphoma. There were 42 patients with intermediate-grade or immunoblastic lymphoma who were consid...

journal_title：Blood

authors： Nademanee A,Molina A,O'Donnell MR,Dagis A,Snyder DS,Parker P,Stein A,Smith E,Planás I,Kashyap A,Spielberger R,Fung H,Wong KK,Somlo G,Margolin K,Chow W,Sniecinski I,Vora N,Blume KG,Niland J,Forman SJ

更新日期：1997-11-15 00:00:00

abstract：:Thirty-eight children between the ages of 0.8 and 17 years with acute nonlymphoblastic leukemia in first remission induced by chemotherapy were given cyclophosphamide, total body irradiation, and bone marrow transplants from HLA-matched donors. Six patients died of pneumonia, one died of metabolic problems, and one di...

journal_title：Blood

authors： Sanders JE,Thomas ED,Buckner CD,Flournoy N,Stewart PS,Clift RA,Lum L,Bensinger WI,Storb R,Appelbaum FR

更新日期：1985-08-01 00:00:00

abstract：:Highly purified natural killer (NK) cell suspensions were tested for their capacity to release colony-stimulating activity (CSA) in vitro. NK cell suspensions comprised primarily CD16+ cells and were devoid of CD3+ T cells, CD15+ monocytes, and of B cells. CSA was detected in the NK cell supernatants and sustained the...

journal_title：Blood

authors： Pistoia V,Zupo S,Corcione A,Roncella S,Matera L,Ghio R,Ferrarini M

更新日期：1989-07-01 00:00:00

abstract：:Coagulation factor XIII (FXIII) is the main stabilizer of the fibrin clot. It circulates in plasma as a tetramer of two A-subunits and two B-subunits. Under physiological conditions, FXIII-A exists as a dimer (FXIII-A2). The interactions between the FXIII-A-subunits that stabilize the FXIII-A2 dimer are not fully unde...

journal_title：Blood

authors： Li B,Kohler HP,Schroeder V

更新日期：2020-01-09 00:00:00

abstract：:We report 2 new mutations identified in 3 patients and characterized by the markedly decreased affinity of von Willebrand factor (vWF) for factor VIII (FVIII). Patients 2 and 3, who have a typical type 2N phenotype, were found to be compound heterozygous for Arg91Gln and Cys25Tyr or Cys95Phe, respectively. Patient 1, ...

journal_title：Blood

authors： Jorieux S,Fressinaud E,Goudemand J,Gaucher C,Meyer D,Mazurier C

更新日期：2000-05-15 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular pathophysiology. To systematically characterize AML's genetic dependencies, we conducted genome-scale short hairpin RNA screens in 17 AML cell lines and analyzed dependencies relative to parallel screens in 199 cell lines of other cancer ty...

journal_title：Blood

authors： Li H,Mar BG,Zhang H,Puram RV,Vazquez F,Weir BA,Hahn WC,Ebert B,Pellman D

更新日期：2017-01-26 00:00:00

abstract：:Immune thrombocytopenia (ITP) is a bleeding disorder in which antibodies and/or T cells lead to enhanced peripheral platelet destruction and reduced bone marrow platelet production. Several reports have observed that ITP is associated with a peripheral deficiency of tolerance-inducing CD4+CD25+FoxP3+ T regulatory cell...

journal_title：Blood

authors： Aslam R,Hu Y,Gebremeskel S,Segel GB,Speck ER,Guo L,Kim M,Ni H,Freedman J,Semple JW

更新日期：2012-09-06 00:00:00

abstract：:In this study, we show that microRNA-150 (miR-150) is significantly downregulated in advanced cutaneous T-cell lymphoma (CTCL), and that this downregulation is strongly associated with tumor invasion/metastasis. Inoculation of CTCL cell lines into nonobese diabetic/Shi-scid interleukin 2γ (IL-2γ) null mice led to CTCL...

journal_title：Blood

authors： Ito M,Teshima K,Ikeda S,Kitadate A,Watanabe A,Nara M,Yamashita J,Ohshima K,Sawada K,Tagawa H

更新日期：2014-03-06 00:00:00

abstract：:The 5-lipoxygenase (5-LO) pathway in human CD34(+) hematopoietic progenitor cells, which were induced to differentiate into dendritic cells (DCs) by cytokines in vitro and in DCs of lymphoid tissues in situ, was examined. Extracts prepared from HPCs contained low levels of 5-LO or 5-LO-activating protein. Granulocyte-...

journal_title：Blood

authors： Spanbroek R,Hildner M,Steinhilber D,Fusenig N,Yoneda K,Rådmark O,Samuelsson B,Habenicht AJ

更新日期：2000-12-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced both cytotoxic (apoptosis) and cytostatic (cell cycle perturbation) effects on the human myeloid K562 cell line. TRAIL stimulated caspase 3 and nitric oxide synthase (NOS) activities, and both pathways cooperate in mediating inhibition of K5...

journal_title：Blood

authors： Secchiero P,Gonelli A,Celeghini C,Mirandola P,Guidotti L,Visani G,Capitani S,Zauli G

更新日期：2001-10-01 00:00:00

abstract：:AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD. AC133 antigen is selectively expressed on CD34(bright) hematopoietic stem and progenitor cells (progenitors) derived from human fetal liver and b...

journal_title：Blood

authors： Yin AH,Miraglia S,Zanjani ED,Almeida-Porada G,Ogawa M,Leary AG,Olweus J,Kearney J,Buck DW

更新日期：1997-12-15 00:00:00

abstract：:Alas2 encodes the erythroid-specific delta-aminolevulinate synthase (ALAS2 or ALAS-E), the first enzyme in heme biosynthesis in erythroid cells. Mice with the Alas2-null phenotype showed massive cytoplasmic, but not mitochondrial, iron accumulation in their primitive erythroblasts. Because these animals died by day 11...

journal_title：Blood

authors： Harigae H,Nakajima O,Suwabe N,Yokoyama H,Furuyama K,Sasaki T,Kaku M,Yamamoto M,Sassa S

更新日期：2003-02-01 00:00:00

abstract：:The lymphocytosis manifested in infectious mononucleosis (IM) during acute phase is ascribed to a reactive expansion of CD8+ T lymphocytes caused by Epstein-Barr virus (EBV)-infected B lymphocytes. Expression of HLA-DR antigen on IM lymphocytes suggests that these T lymphocytes are somehow activated in vivo. In the pr...

journal_title：Blood

authors： Kamio M,Uchiyama T,Hori T,Kodaka T,Ishikawa T,Onishi R,Uchino H,Yoneda N,Tatsumi E,Yamaguchi N

更新日期：1990-01-15 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) is an important modulator of platelet responses to agonists. Cyclic nucleotide phosphodiesterase (PDE) controls intracellular cAMP concentrations by hydrolyzing it to AMP. The major PDE activity in platelets is PDE3A (cyclic guanosine monophosphate [cGMP]-inhibited PDE). To obtain...

journal_title：Blood

authors： Cheung PP,Xu H,McLaughlin MM,Ghazaleh FA,Livi GP,Colman RW

更新日期：1996-08-15 00:00:00

abstract：:The administration of interleukin-2 (IL-2) may induce complete remissions in acute myelogenous leukemia (AML) patients with a low proportion of residual bone marrow (BM) blasts. To confirm this preliminary observation, we treated 14 AML patients with advanced disease and with a residual BM blastosis that ranged betwee...

journal_title：Blood

authors： Meloni G,Foa R,Vignetti M,Guarini A,Fenu S,Tosti S,Tos AG,Mandelli F

更新日期：1994-10-01 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of defective immune cells through an unknown mechanism. A likely candid...

journal_title：Blood

authors： Annunziata CM,Safiran YJ,Irving SG,Kasid UN,Cossman J

更新日期：2000-10-15 00:00:00

abstract：:We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1 (HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 pr...

journal_title：Blood

authors： Gibbons J,Cory JM,Hewlett IK,Epstein JS,Eyster ME

更新日期：1990-11-15 00:00:00

abstract：:During the course of multiple myeloma (MM), new monoclonal proteins of an isotype distinct from the original clone, referred to as secondary monoclonal gammopathy of undetermined significance (MGUS), have been described. We report on the frequency, characteristics, and outcome of secondary MGUS. Of the 1942 patients w...

journal_title：Blood

authors： Wadhera RK,Kyle RA,Larson DR,Dispenzieri A,Kumar S,Lazarus HM,Rajkumar SV

更新日期：2011-09-15 00:00:00

abstract：:Fetal hemoglobin (HbF, α2γ2) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that UNC0638, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces γ-globin expression. EHMT1/2 catalyze mono- and dimethylation of lysine 9 on hi...

journal_title：Blood

authors： Renneville A,Van Galen P,Canver MC,McConkey M,Krill-Burger JM,Dorfman DM,Holson EB,Bernstein BE,Orkin SH,Bauer DE,Ebert BL

更新日期：2015-10-15 00:00:00