Kindlins in FERM adhesion.

abstract：:Although CD4(+)CD25(+) T cells (T regulatory cells [Tregs]) and natural killer T cells (NKT cells) each protect against graft-versus-host disease (GVHD), interactions between these 2 regulatory cell populations after allogeneic bone marrow transplantation (BMT) have not been studied. We show that host NKT cells can in...

journal_title：Blood

authors： Pillai AB,George TI,Dutt S,Strober S

更新日期：2009-04-30 00:00:00

abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

journal_title：Blood

authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

更新日期：1997-02-15 00:00:00

abstract：:Retrospective studies of patients with thrombotic microangiopathies (TMAs) have shown that a deficient activity of von Willebrand factor (vWF)-cleaving protease is involved in thrombotic thrombocytopenic purpura (TTP) but not in the hemolytic-uremic syndrome (HUS). To further analyze the relevance of this enzymatic ac...

journal_title：Blood

authors： Veyradier A,Obert B,Houllier A,Meyer D,Girma JP

更新日期：2001-09-15 00:00:00

abstract：:Most anticancer chemotherapies are immunosuppressive and induce nonimmunogenic tumor cell death. Bortezomib, a specific inhibitor of 26S proteasome, has shown clinical activity in several human tumors, including myeloma. Here we show that the uptake of human myeloma cells by dendritic cells (DCs) after tumor cell deat...

journal_title：Blood

authors： Spisek R,Charalambous A,Mazumder A,Vesole DH,Jagannath S,Dhodapkar MV

更新日期：2007-06-01 00:00:00

abstract：:In vitro agar culture patterns of bone marrow cells in acute myeloid leukemia may show several growth patterns, including cultures where no colonies or clusters develop, cultures with varying numbers of clusters and no colonies, or colony and cluster formation with an extremely high ratio of clusters to colonies. Twel...

journal_title：Blood

authors： McCarthy JH,Sullivan JR,Ungar B,Metcalf D

更新日期：1979-08-01 00:00:00

abstract：:Fetal/neonatal immune responses generally are considered to be immature and weaker than that of adults. We have studied the cord-blood T cells of newborns congenitally infected with Trypanosoma cruzi, the protozoan agent of Chagas disease. Our data demonstrate a predominant activation of CD8 T cells expressing activat...

journal_title：Blood

authors： Hermann E,Truyens C,Alonso-Vega C,Even J,Rodriguez P,Berthe A,Gonzalez-Merino E,Torrico F,Carlier Y

更新日期：2002-09-15 00:00:00

abstract：:Chronic granulomatous disease (CGD) is an inherited immunodeficiency resulting from the inability of an individual's phagocytes to produce superoxide anions because of defective NADPH oxidase. The disease may be treated by bone marrow transplantation and as such is a candidate for somatic gene therapy. Two thirds of p...

journal_title：Blood

authors： Porter CD,Parkar MH,Levinsky RJ,Collins MK,Kinnon C

更新日期：1993-10-01 00:00:00

abstract：:The presence of lysosomal enzymes in human platelets is well documented; the identity of the "lysosome," however, has been the subject of some disagreement. In order to determine the time of appearance and subcellular localization of two lysosomal enzymes in megakaryocytes (MK) and platelets, we examined normal human ...

journal_title：Blood

authors： Bentfeld-Barker ME,Bainton DF

更新日期：1982-03-01 00:00:00

abstract：:Peripheral T-cell lymphomas (PTCLs) are aggressive tumors in which the current therapy based on multiagent chemotherapy is not successful. Since cytochrome P450 3A subfamily (CYP3A) enzymes are involved in the inactivation of chemotherapy drugs, we hypothesized that CYP3A and P-glycoprotein (MDR1) expression in these ...

journal_title：Blood

authors： Rodríguez-Antona C,Leskelä S,Zajac M,Cuadros M,Alvés J,Moneo MV,Martín C,Cigudosa JC,Carnero A,Robledo M,Benitez J,Martínez-Delgado B

更新日期：2007-11-01 00:00:00

abstract：:We found an unusual fc gamma receptor IIIa (CD16) phenotype on the natural killer (NK) cells of a 3-year-old boy, who suffered from recurrent viral respiratory tract infections since birth. He also had severe clinical problems after Bacille Calmette-Geérin (BCG) vaccination and following Epstein-Barr virus and Varicel...

journal_title：Blood

authors： de Vries E,Koene HR,Vossen JM,Gratama JW,von dem Borne AE,Waaijer JL,Haraldsson A,de Haas M,van Tol MJ

更新日期：1996-10-15 00:00:00

abstract：:Accumulating evidence has designated B cells as central players in the pathogenesis of immune diseases. In the late 1990s, anti-CD20 monoclonal antibodies were developed for the treatment of B-cell non-Hodgkin lymphomas, offering the opportunity to efficiently deplete the B-cell compartment for therapeutic immunointer...

journal_title：Blood

authors： Thaunat O,Morelon E,Defrance T

更新日期：2010-07-29 00:00:00

abstract：:Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular target...

journal_title：Blood

authors： Valent P,Akin C,Metcalfe DD

更新日期：2017-03-16 00:00:00

abstract：:Angiogenesis, the formation of new capillaries from preexisting blood vessels, is a multistep, highly orchestrated process involving vessel sprouting, endothelial cell migration, proliferation, tube differentiation, and survival. Eicosanoids, arachidonic acid (AA)-derived metabolites, have potent biologic activities o...

journal_title：Blood

authors： Nie D,Tang K,Diglio C,Honn KV

更新日期：2000-04-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has a specific genetic rearrangement between the retinoic acid receptor (RAR)-alpha gene and the pml nuclear protein gene. All-trans retinoic acid (ATRA) induces granulocytic differentiation of APL-derived cells and is used to treat APL patients. However, ATRA interacts with normal c...

journal_title：Blood

authors： Makishima M,Umesono K,Shudo K,Naoe T,Kishi K,Honma Y

更新日期：1998-06-15 00:00:00

abstract：:The syndrome of episodic angioedema and eosinophilia is characterized by cyclic edema, marked peripheral blood eosinophilia, and eosinophil degranulation in the dermis. Using a sensitive immunoenzymetric method, we measured serum interleukin (IL)-5 levels in four patients with this syndrome. We also determined the per...

journal_title：Blood

authors： Butterfield JH,Leiferman KM,Abrams J,Silver JE,Bower J,Gonchoroff N,Gleich GJ

更新日期：1992-02-01 00:00:00

abstract：:Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2. However, the role o...

journal_title：Blood

authors： Shi X,He BL,Ma AC,Guo Y,Chi Y,Man CH,Zhang W,Zhang Y,Wen Z,Cheng T,Leung AY

更新日期：2015-05-07 00:00:00

abstract：:Alternatively activated macrophages (AAMs), triggered by interleukin-4 (IL-4) and IL-13, play a modulating role during Th2 cytokine-driven pathologies, but their molecular armament remains poorly characterized. Here, we established E-cadherin (Cdh1) as a selective marker for IL-4/IL-13-exposed mouse and human macropha...

journal_title：Blood

authors： Van den Bossche J,Bogaert P,van Hengel J,Guérin CJ,Berx G,Movahedi K,Van den Bergh R,Pereira-Fernandes A,Geuns JM,Pircher H,Dorny P,Grooten J,De Baetselier P,Van Ginderachter JA

更新日期：2009-11-19 00:00:00

abstract：:Dendritic cells (DCs) express many endocytic receptors that deliver antigens for major histocompatibility class (MHC) I and II presentation to CD8(+) and CD4(+) T cells, respectively. Here, we show that targeting Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) to one of them, the human multilectin DEC-205 receptor,...

journal_title：Blood

authors： Gurer C,Strowig T,Brilot F,Pack M,Trumpfheller C,Arrey F,Park CG,Steinman RM,Münz C

更新日期：2008-08-15 00:00:00

abstract：:Recently, the contractile protein alpha-actinin was identified in normal human platelets by its antigenic cross-reaction with a monospecific antibody to purified muscle alpha-actinin. In this study, we extend that preliminary identification of platelet alpha-actinin. Amino acid analysis, one-dimensional peptide maps, ...

journal_title：Blood

authors： Langer BG,Gonnella PA,Nachmias VT

更新日期：1984-03-01 00:00:00

abstract：:In this issue of Blood, Sun and colleagues from the Bone Marrow Transplant Survivors Study report the chronic health outcomes of more than 1000 survivors of stem cell transplantation. Their results demonstrate a significant burden of chronic conditions among survivors. ...

journal_title：Blood

authors： Cutler C

更新日期：2010-10-28 00:00:00

abstract：:In vitro studies suggest that Ras activation is necessary for erythroid cell development. However, genetic inactivation of the Ras isoforms H-Ras, N-Ras, and K-Ras in mice reportedly did not affect adult or fetal erythropoiesis, though K-Ras(-/-) embryos were anemic. Given these discrepancies, we performed a more deta...

journal_title：Blood

authors： Khalaf WF,White H,Wenning MJ,Orazi A,Kapur R,Ingram DA

更新日期：2005-05-01 00:00:00

abstract：:Exposure of endothelial cells to recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced a modest (2-fold) increase of HL-60 cell adhesion as compared to TNF-alpha (40-fold) or interleukin 1beta (IL-1beta; 20-fold). However, pretreatment of endothelial cultures with TRAIL determined a...

journal_title：Blood

authors： Secchiero P,Corallini F,di Iasio MG,Gonelli A,Barbarotto E,Zauli G

更新日期：2005-05-01 00:00:00

abstract：:Uncontrolled activation of the complement system against endothelial and blood cells is central to the pathogenesis of atypical hemolytic uremic syndrome (aHUS). aHUS patients frequently carry mutations in the inhibitory complement regulator factor H (FH). Mutations cluster in domains 19 and 20 (FH19-20), which are cr...

journal_title：Blood

authors： Hyvärinen S,Meri S,Jokiranta TS

更新日期：2016-06-02 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder, characterized by the presence of BCR/ABL fusion gene. It is unclear which cellular events drive BCR/ABL gene translocation or initiate leukemogenesis in CML. Bcl-2 promotes survival of hematopoietic stem cells. Accordingly, apoptosis-related pathw...

journal_title：Blood

authors： Kim DH,Xu W,Ma C,Liu X,Siminovitch K,Messner HA,Lipton JH

更新日期：2009-03-12 00:00:00

abstract：:In this issue of Blood, Buchlis and colleagues describe the long-term persistence (up to 10 years) of factor IX (FIX) expression in adeno-associated virus serotype 2 (AAV-2)–injected muscles of a patient with hemophilia B. ...

journal_title：Blood

authors： Benveniste O

更新日期：2012-03-29 00:00:00

abstract：:About 80% of all cases of Fanconi anemia (FA) can be accounted for by complementation groups A and C. To understand the relationship between these groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca) during embryogenesis and compared it with the known pattern of the group-C gene (Fancc). Nor...

journal_title：Blood

authors： Abu-Issa R,Eichele G,Youssoufian H

更新日期：1999-07-15 00:00:00

abstract：:We report results from a study exploring the combination of romidepsin, bortezomib, and dexamethasone for the treatment of patients with multiple myeloma (MM) previously treated with > 1 prior therapy. The primary objective was to determine the maximum tolerated dose (MTD) of the combination using a novel accelerated ...

journal_title：Blood

authors： Harrison SJ,Quach H,Link E,Seymour JF,Ritchie DS,Ruell S,Dean J,Januszewicz H,Johnstone R,Neeson P,Dickinson M,Nichols J,Prince HM

更新日期：2011-12-08 00:00:00

abstract：:Hodgkin- and Reed-Sternberg (HRS) cells microdissected from 41 classical Hodgkin lymphomas (cHL) of 40 patients comprising 8 lymphocyte-rich (cHL-LR), 16 nodular sclerosis (cHL-NS), 15 mixed-cellularity (cHL-MC), and 2 lymphocyte-depletion (cHL-LD) subtypes were analyzed by comparative genomic hybridization for recurr...

journal_title：Blood

authors： Joos S,Menz CK,Wrobel G,Siebert R,Gesk S,Ohl S,Mechtersheimer G,Trümper L,Möller P,Lichter P,Barth TF

更新日期：2002-02-15 00:00:00

abstract：:Emerging evidence indicates that tumors can follow several evolutionary paths over a patient's disease course. With the use of serial genomic analysis of samples collected at different points during the disease course of 28 patients with multiple myeloma, we found that the genomes of standard-risk patients show few ch...

journal_title：Blood

authors： Keats JJ,Chesi M,Egan JB,Garbitt VM,Palmer SE,Braggio E,Van Wier S,Blackburn PR,Baker AS,Dispenzieri A,Kumar S,Rajkumar SV,Carpten JD,Barrett M,Fonseca R,Stewart AK,Bergsagel PL

更新日期：2012-08-02 00:00:00

abstract：:Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose p...

journal_title：Blood

authors： Bachireddy P,Hainz U,Rooney M,Pozdnyakova O,Aldridge J,Zhang W,Liao X,Hodi FS,O'Connell K,Haining WN,Goldstein NR,Canning CM,Soiffer RJ,Ritz J,Hacohen N,Alyea EP 3rd,Kim HT,Wu CJ

更新日期：2014-02-27 00:00:00