Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis.

abstract：:Expression of inhibitory killer cell immunoglobulin-like receptors (KIRs) specific for self-major histocompatibility complex (MHC) class I molecules provides an educational signal that generates functional natural killer (NK) cells. However, the effects of activating KIRs specific for self-MHC class I on NK-cell educa...

journal_title：Blood

authors： Fauriat C,Ivarsson MA,Ljunggren HG,Malmberg KJ,Michaëlsson J

更新日期：2010-02-11 00:00:00

abstract：:Caspases play a critical role in regulation of apoptosis, cell differentiation, inflammation, and innate immunity, and several are mutated or have altered expression in non-Hodgkin lymphoma (NHL). To study the impact of genetic variation in caspases on NHL risk, we analyzed tag single nucleotide polymorphisms (SNPs) i...

journal_title：Blood

authors： Lan Q,Morton LM,Armstrong B,Hartge P,Menashe I,Zheng T,Purdue MP,Cerhan JR,Zhang Y,Grulich A,Cozen W,Yeager M,Holford TR,Vajdic CM,Davis S,Leaderer B,Kricker A,Schenk M,Zahm SH,Chatterjee N,Chanock SJ,Rothman N

更新日期：2009-07-09 00:00:00

abstract：:Primary effusion lymphoma (PEL) constitutes a subset of non-Hodgkin lymphoma whose incidence is highly increased in the context of HIV infection. Kaposi sarcoma-associated herpesvirus is the causative agent of PEL. The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a critical role in cell proliferation a...

journal_title：Blood

authors： Bhatt AP,Bhende PM,Sin SH,Roy D,Dittmer DP,Damania B

更新日期：2010-06-03 00:00:00

abstract：:The International Lymphoma Radiation Oncology Group (ILROG) guidelines for using radiation therapy (RT) in hematological malignancies are widely used in many countries. The emergency situation created by the COVID-19 pandemic may result in limitations of treatment resources. Furthermore, in recognition of the need to ...

journal_title：Blood

authors： Yahalom J,Dabaja BS,Ricardi U,Ng A,Mikhaeel NG,Vogelius IR,Illidge T,Qi S,Wirth A,Specht L

更新日期：2020-05-21 00:00:00

abstract：:The principal aim of our study was to investigate whether patients transplanted more than 20 years ago for β-thalassemia major had a different health-related quality of life (HRQoL) compared with the general population. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Functional Assessment o...

journal_title：Blood

authors： La Nasa G,Caocci G,Efficace F,Dessì C,Vacca A,Piras E,Sanna M,Marcias M,Littera R,Carcassi C,Lucarelli G

更新日期：2013-09-26 00:00:00

abstract：:A male neonate with Down's syndrome and congenital myeloproliferative disorder was studied. His blood picture showed the unique coexistence of leukocytosis with matured cells and a large number of blast cells. The in vitro proliferation and differentiation of blast cells into various lineages in the presence of phytoh...

journal_title：Blood

authors： Suda J,Eguchi M,Akiyama Y,Iwama Y,Furukawa T,Sato Y,Miura Y,Suda T,Saito M

更新日期：1987-02-01 00:00:00

abstract：:Mammalian erythrocytes undergo a unique maturation process in which they discard their nuclei and organelles and assume a flexible biconcave shape. We found that altered plasma lipoprotein metabolism can profoundly influence these events. Abnormal erythrocyte morphology was observed in hypercholesterolemic mice lackin...

journal_title：Blood

authors： Holm TM,Braun A,Trigatti BL,Brugnara C,Sakamoto M,Krieger M,Andrews NC

更新日期：2002-03-01 00:00:00

abstract：:Recent studies of retroviral-mediated gene transfer have shown that retroviral integrations themselves may trigger nonmalignant clonal expansion of hematopoietic stem cells (HSCs) in transplant recipients. These observations suggested that previous conclusions of HSC dynamics based on gamma-retroviral gene marking sho...

journal_title：Blood

authors： Gonzalez-Murillo A,Lozano ML,Montini E,Bueren JA,Guenechea G

更新日期：2008-10-15 00:00:00

abstract：:In this issue of Blood, Smith and colleagues report on the functional role of the interaction between these 2 proteins by studying the involved binding sites responsible for clot stabilization.(1) ...

journal_title：Blood

authors： Kohler HP

更新日期：2013-03-14 00:00:00

abstract：:We previously reported the characterization of human osteoclast-associated receptor (hOSCAR), a novel Fc receptor gamma-chain (FcRgamma)-associated receptor expressed by myeloid cells. Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell (DC) survival by an extracellular signal-regulated...

journal_title：Blood

authors： Merck E,de Saint-Vis B,Scuiller M,Gaillard C,Caux C,Trinchieri G,Bates EE

更新日期：2005-05-01 00:00:00

abstract：:Glycoprotein (GP) Ibalpha, a member of the leucine-rich repeat (LRR) protein family, mediates platelet adhesion to immobilized von Willebrand factor (VWF). We investigated the role in VWF binding of charged residues in the LRR region of GP Ibalpha that are conserved in human, canine, and murine proteins. Substitution ...

journal_title：Blood

authors： Peng Y,Shrimpton CN,Dong JF,López JA

更新日期：2005-09-15 00:00:00

abstract：:Administration of cyclosporine A (CsA) after autologous stem cell transplantation elicits an autoimmune syndrome with pathology similar to graft-versus-host disease (GVHD). This syndrome, termed autologous GVHD, is associated with the appearance of autoreactive T cells directed at major histocompatibility class (MHC) ...

journal_title：Blood

authors： Miura Y,Thoburn CJ,Bright EC,Sommer M,Lefell S,Ueda M,Nakao S,Hess AD

更新日期：2001-08-01 00:00:00

abstract：:The c-myb proto-oncogene has been implicated in leukemogenesis, but possible mechanisms remain ill defined. To gain further insight to this process, we used transcript profiling in K562 cells expressing a dominant-negative Myb (MERT) protein. A total of 105 potential Myb gene targets were identified. Neuromedin U (NmU...

journal_title：Blood

authors： Shetzline SE,Rallapalli R,Dowd KJ,Zou S,Nakata Y,Swider CR,Kalota A,Choi JK,Gewirtz AM

更新日期：2004-09-15 00:00:00

abstract：:To evaluate the importance of the thymus for the reconstitution of immunity in recipients of a T-cell-depleted bone marrow, we measured the appearance of CD4(+)CD45RA(+)RO(-) naive T cells (thymic rebound), restoration of the diversity of the T-cell-receptor (TCR) repertoire and the response to vaccinations with tetan...

journal_title：Blood

authors： Roux E,Dumont-Girard F,Starobinski M,Siegrist CA,Helg C,Chapuis B,Roosnek E

更新日期：2000-09-15 00:00:00

abstract：:Inhibition of the tissue factor pathway has been shown to attenuate the activation of coagulation and to prevent death in a gram-negative bacteremia primate model of sepsis. It has been suggested that tissue factor influences inflammatory cascades other than the coagulation system. The authors sought to determine the ...

journal_title：Blood

authors： de Jonge E,Dekkers PE,Creasey AA,Hack CE,Paulson SK,Karim A,Kesecioglu J,Levi M,van Deventer SJ,van Der Poll T

更新日期：2000-02-15 00:00:00

abstract：:The spatial distribution of subpopulations of hemopoietic progenitor cells following syngeneic transplantation was investigated at the single-cell level. The location of infused hemopoietic progenitor cells within the femoral bone marrow of nonablated recipients was determined by 5-(and-6)-carboxyfluorescein diacetate...

journal_title：Blood

authors： Nilsson SK,Johnston HM,Coverdale JA

更新日期：2001-04-15 00:00:00

abstract：:Allogeneic stem cell transplantation (SCT) is now a commonplace procedure. Clinicians who care for patients with hematologic malignancies and aplastic anemia are almost certain to follow up patients after SCT. This review is intended to help clinicians observe patients for probably the most important late complication...

journal_title：Blood

authors： Vogelsang GB

更新日期：2001-03-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpes virus (KSHV)/human herpes virus 8 (HHV8) DNA sequences have been demonstrated in Kaposi's sarcoma (KS), as well as in some acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin's lymphomas (NHL) and in multicentric Castleman's disease. Although KSHV DNA generally is abundant ...

journal_title：Blood

authors： Reed JA,Nador RG,Spaulding D,Tani Y,Cesarman E,Knowles DM

更新日期：1998-05-15 00:00:00

abstract：:A significant proportion of hemophilia A patients receiving transfusions of factor VIII (FVIII) develop a specific antibody response towards FVIII. These antibodies are usually detected by assays in which they inhibit the function of the molecule, such as the Bethesda clotting test. We have prepared anti-FVIII antibod...

journal_title：Blood

authors： Gilles JG,Arnout J,Vermylen J,Saint-Remy JM

更新日期：1993-10-15 00:00:00

abstract：:Autologous hematopoietic cell transplant (AHCT) for HIV-infected patients is largely limited to centers with HIV-specific expertise. The Blood and Marrow Transplant Clinical Trials Network 0803/AIDS Malignancy Consortium 071 trial is a multicenter phase 2 study of AHCT for patients with HIV-related lymphoma (HRL). Eli...

journal_title：Blood

authors： Alvarnas JC,Le Rademacher J,Wang Y,Little RF,Akpek G,Ayala E,Devine S,Baiocchi R,Lozanski G,Kaplan L,Noy A,Popat U,Hsu J,Morris LE Jr,Thompson J,Horowitz MM,Mendizabal A,Levine A,Krishnan A,Forman SJ,Navarro WH,

更新日期：2016-08-25 00:00:00

abstract：:Receptors for the Fc portion of IgG (FcγRs) are mandatory for the induction of various IgG-dependent models of autoimmunity, inflammation, anaphylaxis, and cancer immunotherapy. A few FcγRs have the ability to bind monomeric IgG: high-affinity mouse mFcγRI, mFcγRIV, and human hFcγRI. All others bind IgG only when aggr...

journal_title：Blood

authors： Mancardi DA,Albanesi M,Jönsson F,Iannascoli B,Van Rooijen N,Kang X,England P,Daëron M,Bruhns P

更新日期：2013-02-28 00:00:00

abstract：:p38 MAP kinase in human platelets is activated by platelet agonists including thrombin, thromboxane A2 (TxA2), ADP, and others. However, both upstream mechanisms of p38 MAP kinase activation, and their downstream sequelae, are presently controversial and essentially unclear. Certain studies report sequential activatio...

journal_title：Blood

authors： Begonja AJ,Geiger J,Rukoyatkina N,Rauchfuss S,Gambaryan S,Walter U

更新日期：2007-01-15 00:00:00

abstract：:Although the critical requirement for the transcription factor RUNX1/AML1 at the onset of hematopoietic development is well established, little is known about its transcriptional targets at this pivotal stage of blood development. Using microarrays, we identified the uncharacterized gene AI467606 as a gene whose expre...

journal_title：Blood

authors： Ferreras C,Lancrin C,Lie-A-Ling M,Kouskoff V,Lacaud G

更新日期：2011-07-21 00:00:00

abstract：:The stress-activated protein/c-Jun N-terminal kinases (SAPK/JNK) have been shown to be activated by pro-inflammatory cytokines, as well as physical and chemical stresses. We now show that a variety of hematopoietic growth factors, including Steel locus factor (SLF), granulocyte-macrophage colony-stimulating factor (GM...

journal_title：Blood

authors： Foltz IN,Schrader JW

更新日期：1997-05-01 00:00:00

abstract：:Acquired chromosomal anomalies (most commonly translocations) in lymphoma and leukemia usually result in either activation of a quiescent gene (by means of immunoglobulin or T-cell-receptor promotors) and expression of an intact protein product, or creation of a fusion gene encoding a chimeric protein. This review sum...

journal_title：Blood

authors： Falini B,Mason DY

更新日期：2002-01-15 00:00:00

abstract：:In this issue of Blood, Leonhardt et al report that neovascularization during graft-versus-host disease (GVHD) is regulated by av integrins and the micro RNA miR-100. ...

journal_title：Blood

authors： Komanduri KV

更新日期：2013-04-25 00:00:00

abstract：:Platelet-associated C3 (PA-C3) was measured with a quantitative immunofluorescence assay. With this assay, PA-C3 levels were determined for 78 normal volunteers, 30 patients with immune thrombocytopenic purpura (ITP), and 20 patients with nonimmune thrombocytopenias. Platelet-associated IgG (PA-IgG) levels were also m...

journal_title：Blood

authors： Myers TJ,Kim BK,Steiner M,Baldini MG

更新日期：1982-05-01 00:00:00

abstract：:Neutrophils play a crucial early role during the innate response, but little is known about their possible contribution when an adaptive immune response is installed. A robust neutrophilia and a T helper 1 (Th1) immune response are present after immunization with Complete Freund Adjuvant (CFA). We show that when FITC-...

journal_title：Blood

authors： Maletto BA,Ropolo AS,Alignani DO,Liscovsky MV,Ranocchia RP,Moron VG,Pistoresi-Palencia MC

更新日期：2006-11-01 00:00:00

abstract：:In this issue of Blood, Martin et al report poor outcomes for ibrutinib-refractory patients with mantle cell lymphoma (MCL). MCL, an uncommon B-cell lymphoma driven by dysregulated cyclin D1, responds well to initial therapy but is destined to relapse. Subsequent single-agent treatments had modest response rates and d...

journal_title：Blood

authors： Smith MR

更新日期：2016-03-24 00:00:00

abstract：:Epo-induced endocytosis of EpoR plays important roles in the down-regulation of EpoR signaling and is the primary means that regulates circulating Epo concentrations. Here we show that cell-surface EpoR is internalized via clathrin-mediated endocytosis. Both JAK2 kinase activity and EpoR cytoplasmic tyrosines are impo...

journal_title：Blood

authors： Sulahian R,Cleaver O,Huang LJ

更新日期：2009-05-21 00:00:00