How I treat chronic graft-versus-host disease.

abstract：:The influence of intestinal bacterial decontamination on the occurrence of grades II to IV acute graft-versus-host disease (GVHD) was retrospectively analyzed in 194 predominantly adult patients treated by genotypically identical sibling marrow transplantation under conditions of strict protective isolation and intest...

journal_title：Blood

authors： Beelen DW,Haralambie E,Brandt H,Linzenmeier G,Müller KD,Quabeck K,Sayer HG,Graeven U,Mahmoud HK,Schaefer UW

更新日期：1992-11-15 00:00:00

abstract：:Nitric oxide (NO) exerts vasodilatatory, antiplatelet, antioxidant, and antiproliferative effects. Endothelium-derived NO has been shown to be of crucial importance in cardiovascular protection, whereas evidence that NO is synthesized by platelets and regulates platelet function is still controversial. By using a sens...

journal_title：Blood

authors： Cozzi MR,Guglielmini G,Battiston M,Momi S,Lombardi E,Miller EC,De Zanet D,Mazzucato M,Gresele P,De Marco L

更新日期：2015-01-22 00:00:00

abstract：:Signaling mediated by various Notch receptors and their ligands regulates diverse biological processes, including lymphoid cell fate decisions. Notch1 is required during T-cell development, while Notch2 and the Notch ligand Delta-like1 control marginal zone B (MZB) cell development. We previously determined that Maste...

journal_title：Blood

authors： Wu L,Maillard I,Nakamura M,Pear WS,Griffin JD

更新日期：2007-11-15 00:00:00

abstract：:Cervical internal carotid artery (cICA) occlusion is a recognized cause of acute ischemic stroke (AIS) in sickle cell disease (SCD), but the associated clinical and radiologic features are not well described. We reviewed data on cervical magnetic resonance angiography (cMRA) performed prospectively in 67 patients (55 ...

journal_title：Blood

authors： Telfer PT,Evanson J,Butler P,Hemmaway C,Abdulla C,Gadong N,Whitmarsh S,Kaya B,Kirkham FJ

更新日期：2011-12-01 00:00:00

abstract：:The platelet collagen receptor glycoprotein (GP) VI-Fc receptor gamma-chain (FcRgamma) complex transduces signals in an immunoreceptorlike manner. We examined a role for the Triton X-100-insoluble membrane rafts in GPVI-FcRgamma complex signaling. Methyl-beta-cyclodextrin (MbetaCD)-induced disruption of the membrane r...

journal_title：Blood

authors： Ezumi Y,Kodama K,Uchiyama T,Takayama H

更新日期：2002-05-01 00:00:00

abstract：:In this report the role played by human immunodeficiency virus type-1 (HIV-1) in the pathogenesis of HIV-1-related thrombocytopenia was investigated. CD34+ hematopoietic stem/progenitor cells were purified from the bone marrow (BM) of HIV-1(+) thrombocytopenic patients, HIV-1(+) nonthrombocytopenic individuals, HIV-1(...

journal_title：Blood

authors： Zauli G,Re MC,Davis B,Sen L,Visani G,Gugliotta L,Furlini G,La Placa M

更新日期：1992-05-15 00:00:00

abstract：:The short-term beneficial effect of hydroxyurea (HU) in sickle cell disease (SCD) has been proven by randomized studies in children and adults. The Belgian registry of HU-treated SCD patients was created to evaluate its long-term efficacy and toxicity. The median follow-up of the 93 patients registered is 3.5 years; c...

journal_title：Blood

authors： Ferster A,Tahriri P,Vermylen C,Sturbois G,Corazza F,Fondu P,Devalck C,Dresse MF,Feremans W,Hunninck K,Toppet M,Philippet P,Van Geet C,Sariban E

更新日期：2001-06-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. The absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontrolled complement activation that accounts for hemol...

journal_title：Blood

authors： Brodsky RA

更新日期：2014-10-30 00:00:00

abstract：:Both extrinsic and intrinsic mechanisms tightly govern hematopoietic stem cell (HSC) decisions of self-renewal and differentiation. However, transcription factors that can selectively regulate HSC self-renewal division after stress remain to be identified. Slug is an evolutionarily conserved zinc-finger transcription ...

journal_title：Blood

authors： Sun Y,Shao L,Bai H,Wang ZZ,Wu WS

更新日期：2010-03-04 00:00:00

abstract：:In childhood acute lymphoblastic leukemia (ALL), early response to treatment is a powerful prognostic indicator. To identify genes associated with this response, we analyzed gene expression of diagnostic lymphoblasts from 189 children with ALL and compared the findings with minimal residual disease (MRD) levels on day...

journal_title：Blood

authors： Flotho C,Coustan-Smith E,Pei D,Iwamoto S,Song G,Cheng C,Pui CH,Downing JR,Campana D

更新日期：2006-08-01 00:00:00

abstract：:Natural killer (NK) activity against K-562 tumor cells was evaluated in peripheral blood leukocytes (PBL) obtained from untreated patients affected by hairy cell leukemia (HCL). NK activity present in PBL from 10 HCL patients was at least six-fold lower (p less than 0.01) than that present in PBL from 15 healthy donor...

journal_title：Blood

authors： Ruco LP,Procopio A,Maccallini V,Calogero A,Uccini S,Annino L,Mandelli F,Baroni CD

更新日期：1983-06-01 00:00:00

abstract：:The tumorigenicity of most cases of ALK-positive anaplastic large-cell lymphoma (ALK+ ALCL) is driven by the oncogenic fusion protein NPM-ALK in a STAT3-dependent manner. Because it has been shown that STAT3 can be inhibited by STAT1 in some experimental models, we hypothesized that the STAT1 signaling pathway is defe...

journal_title：Blood

authors： Wu C,Molavi O,Zhang H,Gupta N,Alshareef A,Bone KM,Gopal K,Wu F,Lewis JT,Douglas DN,Kneteman NM,Lai R

更新日期：2015-07-16 00:00:00

abstract：:Primary infection with the human herpesvirus, Epstein-Barr virus (EBV), may result in subclinical seroconversion or may appear as infectious mononucleosis (IM), a lymphoproliferative disease of variable severity. Why primary infection manifests differently between patients is unknown, and, given the difficulties in id...

journal_title：Blood

authors： Silins SL,Sherritt MA,Silleri JM,Cross SM,Elliott SL,Bharadwaj M,Le TT,Morrison LE,Khanna R,Moss DJ,Suhrbier A,Misko IS

更新日期：2001-12-15 00:00:00

abstract：:One hundred thirty-eight patients with hairy cell leukemia were randomized to receive either a dose of 2.0 megaunits (MU)/m2 or a 10-fold lower dose of 0.2 MU/m2 of a highly purified natural alpha-interferon, administered daily for 28 days followed by a three times a week schedule. Ninety-seven of these patients had p...

journal_title：Blood

authors： Smalley RV,Anderson SA,Tuttle RL,Connors J,Thurmond LM,Huang A,Castle K,Magers C,Whisnant JK

更新日期：1991-12-15 00:00:00

abstract：:Initial molecular events leading to natural killer lymphocyte (NK) and dendritic cell (DC) interactions are largely unknown. Here, the role of CX3CL1 (fractalkine), a chemokine expressed on mature dendritic cells (mDCs) has been investigated. We show that CX3CL1 promotes NK activation by mDCs. After blocking of CX3CL1...

journal_title：Blood

authors： Pallandre JR,Krzewski K,Bedel R,Ryffel B,Caignard A,Rohrlich PS,Pivot X,Tiberghien P,Zitvogel L,Strominger JL,Borg C

更新日期：2008-12-01 00:00:00

abstract：:BCR-ABL antisense oligodeoxynucleotides (ODN) have provided evidence of antileukemia effect when tested in vitro against Philadelphia-positive (Ph-pos) cells and in vivo when injected into leukemic mice. On the basis of the results obtained in vitro at diagnosis, eight patients with chronic myelogenous leukemia (CML) ...

journal_title：Blood

authors： de Fabritiis P,Petti MC,Montefusco E,De Propris MS,Sala R,Bellucci R,Mancini M,Lisci A,Bonetto F,Geiser T,Calabretta B,Mandelli F

更新日期：1998-05-01 00:00:00

abstract：:We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8- [double-negative, DN], T-cell receptor [TCR] alpha beta+). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no differ...

journal_title：Blood

authors： Suzushima H,Asou N,Nishimura S,Nishikawa K,Wang JX,Okubo T,Naito M,Hattori T,Takatsuki K

更新日期：1993-02-15 00:00:00

abstract：:The platelet-specific alloantigen, Siba, located within the alpha-subunit of the glycoprotein (GP) Ib-IX membrane receptor, has been found to be involved in the pathogenesis of platelet transfusion refractoriness. We have identified the existence of a naturally occurring threonine/methionine dimorphism at position 145...

journal_title：Blood

authors： Murata M,Furihata K,Ishida F,Russell SR,Ware J,Ruggeri ZM

更新日期：1992-06-01 00:00:00

abstract：:The Sox4 transcription factor mediates early B-cell differentiation. Compared with normal pre-B cells, SOX4 promoter regions in Ph(+) ALL cells are significantly hypomethylated. Loss and gain-of-function experiments identified Sox4 as a critical activator of PI3K/AKT and MAPK signaling in ALL cells. ChIP experiments c...

journal_title：Blood

authors： Ramezani-Rad P,Geng H,Hurtz C,Chan LN,Chen Z,Jumaa H,Melnick A,Paietta E,Carroll WL,Willman CL,Lefebvre V,Müschen M

更新日期：2013-01-03 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry. It was recently demonstrated that HIV-1 glycoprotein 120 (gp120) elevated calcium and activated several ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo...

journal_title：Blood

authors： Del Corno M,Liu QH,Schols D,de Clercq E,Gessani S,Freedman BD,Collman RG

更新日期：2001-11-15 00:00:00

abstract：:Rauscher murine erythroleukemia cells, grown continuously in vitro, undergo erythroid differentiation in response to the hormone erythropoietin. Therefore, they serve as an important model system with which to examine critical biochemical aspects of this developmental process. Intact, uninduced Rauscher cells possess ...

journal_title：Blood

authors： Sytkowski AJ,Kessler CJ

更新日期：1984-07-01 00:00:00

abstract：:The CCAAT/enhancer binding protein-alpha (C/EBPalpha) is a transcription factor required for differentiation of myeloid progenitors. In addition to specific DNA binding, C/EBPalpha is also involved in protein-protein interactions, some of which (p21, Cdk2/Cdk4, E2F) appear to be required for inhibition of proliferatio...

journal_title：Blood

authors： Keeshan K,Santilli G,Corradini F,Perrotti D,Calabretta B

更新日期：2003-08-15 00:00:00

abstract：:Insights into immune-mediated thrombotic thrombocytopenic purpura (iTTP) pathophysiology have led to novel targeted therapies. Immunomodulatory strategies target anti-ADAMTS13 antibodies: rituximab is effective in inducing responses in refractory/relapsed TTP and increasing relapse-free survival; caplacizumab targets ...

journal_title：Blood

authors： Mazepa MA,Masias C,Chaturvedi S

更新日期：2019-08-01 00:00:00

abstract：:We have previously observed an increased frequency of liver failure in human immunodeficiency virus (HIV)-infected hemophiliacs. The purpose of this study was to quantitate hepatitis C virus (HCV) RNA levels in serial samples from HIV-seropositive (HIV+) and HIV-seronegative (HIV-) hemophiliacs before and after HIV se...

journal_title：Blood

authors： Eyster ME,Fried MW,Di Bisceglie AM,Goedert JJ

更新日期：1994-08-15 00:00:00

abstract：:Fibronectin is a major component of the extracellular matrix of adherent layers of human long-term marrow cultures where it may stabilize the extracellular matrix network and provide adhesion sites for primitive hemopoietic cells. This study was devised to analyze the role of adherent cell populations in fibronectin s...

journal_title：Blood

authors： Lerat H,Lissitzky JC,Singer JW,Keating A,Herve P,Charbord P

更新日期：1993-09-01 00:00:00

abstract：:A novel Hodgkin's disease (HD) derived cell line, L1236, was established from the peripheral blood of a patient with advanced Hodgkin's disease. Analysis of immunoglobulin (Ig) gene rearrangements revealed a biallelic Ig heavy chain and a monoallelic Ig kappa light chain gene rearrangement, pointing to a B-lymphoid or...

journal_title：Blood

authors： Wolf J,Kapp U,Bohlen H,Kornacker M,Schoch C,Stahl B,Mücke S,von Kalle C,Fonatsch C,Schaefer HE,Hansmann ML,Diehl V

更新日期：1996-04-15 00:00:00

abstract：:The effects of arachidonic acid on human granulocytes (polymorphonuclear neutrophil leukocytes, PMN) were examined with respect to early events associated with activation of the superoxide (O2-)-generating system and its reactivation with other stimuli after the addition of fatty acid-free bovine serum albumin. As wit...

journal_title：Blood

authors： Cohen HJ,Chovaniec ME,Takahashi K,Whitin JC

更新日期：1986-04-01 00:00:00

abstract：:Tumor necrosis factor (TNF) and lymphotoxin (LT; TNF-beta) are major cytokines produced by B lymphocytes. Stimulation by okadaic acid, a phosphatase 1 and 2A inhibitor, markedly increased TNF mRNA accumulation and cytokine production. On the other hand, the accumulation of LT mRNA was not affected by okadaic acid desp...

journal_title：Blood

authors： Xia HZ,Kannapell CC,Fu SM,Sung SS

更新日期：1993-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Novel therapeutic targets against preleukemic stem cells need to be identified for potentially curative strategies. We conducted parallel transcriptional...

journal_title：Blood

authors： Schinke C,Giricz O,Li W,Shastri A,Gordon S,Barreyro L,Bhagat T,Bhattacharyya S,Ramachandra N,Bartenstein M,Pellagatti A,Boultwood J,Wickrema A,Yu Y,Will B,Wei S,Steidl U,Verma A

更新日期：2015-05-14 00:00:00

abstract：:Loss or mutation of the TP53 tumor suppressor gene is not commonly observed in acute myeloid leukemia (AML), suggesting that there is an alternate route for cell transformation. We investigated the hypothesis that previously observed Bcl-2 family member overexpression suppresses wild-type p53 activity in AML. We demon...

journal_title：Blood

authors： Irish JM,Anensen N,Hovland R,Skavland J,Børresen-Dale AL,Bruserud O,Nolan GP,Gjertsen BT

更新日期：2007-03-15 00:00:00