Abstract:
:Neutrophils play a crucial early role during the innate response, but little is known about their possible contribution when an adaptive immune response is installed. A robust neutrophilia and a T helper 1 (Th1) immune response are present after immunization with Complete Freund Adjuvant (CFA). We show that when FITC-labeled OVA was injected into the footpad of OVA/CFA immunized mice, the main OVA-FITC+ cells recruited in draining popliteal lymph nodes (LNs) were neutrophils, with most of them arriving at the LN by means of lymphatic vessels. The development of this OVA-FITC+ neutrophil influx requires an immune response against OVA. The OVA-FITC+ neutrophils present in LNs displayed mainly intracellular TNF-alpha, and their depletion resulted in an increase in the specific IL-5 levels. These data provide new evidence about the role played by neutrophils in vivo in adaptive immunity.
journal_name
Bloodjournal_title
Bloodauthors
Maletto BA,Ropolo AS,Alignani DO,Liscovsky MV,Ranocchia RP,Moron VG,Pistoresi-Palencia MCdoi
10.1182/blood-2006-04-016659subject
Has Abstractpub_date
2006-11-01 00:00:00pages
3094-102issue
9eissn
0006-4971issn
1528-0020pii
blood-2006-04-016659journal_volume
108pub_type
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