Ibrutinib: a force with a dark side?

abstract：:Recently, a novel gene of the major histocompatibility complex (MHC) class I family, HFE (HLA-H), has been found to be mutated in a large proportion of hereditary hemochromatosis (HH) patients. Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (bet...

journal_title：Blood

authors： Santos M,Clevers H,de Sousa M,Marx JJ

更新日期：1998-04-15 00:00:00

abstract：:Protein tyrosine phosphorylation plays a crucial role in signaling from the receptor for erythropoietin (Epo), although the Epo receptor (EpoR) lacks the tyrosine kinase domain. We have previously shown that the Jak2 tyrosine kinase couples with the EpoR to transduce a growth signal. In the present study, we demonstra...

journal_title：Blood

authors： Chin H,Arai A,Wakao H,Kamiyama R,Miyasaka N,Miura O

更新日期：1998-05-15 00:00:00

abstract：:It has been shown that histamine induces early changes on endothelial cells (EC), such as a transient expression of P-selectin and secretion and/or surface expression of early mediators (eg, prostacyclin [PG1(2)], platelet-activating factor [PAF], and leukotriene B4 [LTB4]). However, delayed effects of histamine on EC...

journal_title：Blood

authors： Jeannin P,Delneste Y,Gosset P,Molet S,Lassalle P,Hamid Q,Tsicopoulos A,Tonnel AB

更新日期：1994-10-01 00:00:00

abstract：:BCL3 encodes a protein with close homology to IkappaB proteins and interacts with p50 NF-kappaB homodimers. However, the regulation and transcriptional activity of BCL3 remain ill-defined. We observed here that interleukin-9 (IL-9) and IL-4, but not IL-2 or IL-3, transcriptionally upregulated BCL3 expression in T cell...

journal_title：Blood

authors： Richard M,Louahed J,Demoulin JB,Renauld JC

更新日期：1999-06-15 00:00:00

abstract：:Families with 3 different syndromes characterized by autosomal dominant inheritance of low platelet count and giant platelets were studied. Fechtner syndrome is an autosomal-dominant variant of Alport syndrome manifested by nephritis, sensorineural hearing loss, and cataract formation in addition to macrothrombocytope...

journal_title：Blood

authors： Toren A,Rozenfeld-Granot G,Rocca B,Epstein CJ,Amariglio N,Laghi F,Landolfi R,Brok-Simoni F,Carlsson LE,Rechavi G,Greinacher A

更新日期：2000-11-15 00:00:00

abstract：:Molecular diagnostics has generated substantial dividends in dissecting the genetic basis of myeloid neoplasms with eosinophilia. The family of diseases generated by dysregulated fusion tyrosine kinase (TK) genes is recognized by the World Health Organization (WHO) category, "Myeloid/lymphoid neoplasms with eosinophil...

journal_title：Blood

authors： Reiter A,Gotlib J

更新日期：2017-02-09 00:00:00

abstract：:Antibodies play a fundamental role in diagnostic immunophenotyping of leukemias and in cell-targeting therapy. However, this versatility is not reflected in imaging diagnostics. In the present study, we labeled anti–human mAbs monochromatically against selected human myeloid markers expressed on acute myeloid leukemia...

journal_title：Blood

authors： McCormack E,Mujić M,Osdal T,Bruserud Ø,Gjertsen BT

更新日期：2013-02-14 00:00:00

abstract：:The purpose of this study was to determine the relative merits of idarubicin and daunorubicin in acute myeloid leukemia (AML) therapy. Thirty-two sites provided 214 previously untreated adults with AML aged 15 years or more who were randomized to receive for induction therapy cytarabine 100 mg/m2/d as a continuous 7-d...

journal_title：Blood

authors： Wiernik PH,Banks PL,Case DC Jr,Arlin ZA,Periman PO,Todd MB,Ritch PS,Enck RE,Weitberg AB

更新日期：1992-01-15 00:00:00

abstract：:The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) is the most problematic and costly complication of FVIII replacement therapy that affects up to 30% of previously untreated patients with severe hemophilia A. The development of inhibitors is a multifactorial complication i...

journal_title：Blood

authors： Gorski MM,Blighe K,Lotta LA,Pappalardo E,Garagiola I,Mancini I,Mancuso ME,Fasulo MR,Santagostino E,Peyvandi F

更新日期：2016-06-09 00:00:00

abstract：:A large number of alterations in genes encoding receptor tyrosine kinase (RTK), namely FLT3, c-KIT, platelet-derived growth factor (PDGF) receptors, fibroblast growth factor (FGF) receptors, and the anaplastic large cell lymphoma kinase (ALK), have been found in hematopoietic malignancies. They have drawn much attenti...

journal_title：Blood

authors： Toffalini F,Demoulin JB

更新日期：2010-10-07 00:00:00

abstract：:Translation of small interfering RNA (siRNA)-based approaches into practical therapeutics is limited because of lack of an effective and cell-specific delivery system. Herein, we present a new method of selectively delivering siRNA to dendritic cells (DCs) in vivo using CD40 siRNA-containing immunoliposomes (siILs) th...

journal_title：Blood

authors： Zheng X,Vladau C,Zhang X,Suzuki M,Ichim TE,Zhang ZX,Li M,Carrier E,Garcia B,Jevnikar AM,Min WP

更新日期：2009-03-19 00:00:00

abstract：:Hydroxyurea treatment of sickle cell mice improved their survival from pneumococcal pneumonia, counteracting the abnormally elevated inflammatory response and reducing invasion of bacteria into the bloodstream, through down regulation of E-selectin. ...

journal_title：Blood

authors： Hsu LL

更新日期：2012-02-23 00:00:00

abstract：:The timely clearance of apoptotic neutrophils from inflammation sites is an important function of macrophages; however, the role of macrophages in maintaining neutrophil homeostasis under steady-state conditions is less well understood. By conditionally deleting the antiapoptotic gene cellular FLICE-like inhibitory pr...

journal_title：Blood

authors： Gordy C,Pua H,Sempowski GD,He YW

更新日期：2011-01-13 00:00:00

abstract：:Adenosine deaminase (ADA) deficiency is a disorder of the purine metabolism leading to combined immunodeficiency and systemic alterations, including skeletal abnormalities. We report that ADA deficiency in mice causes a specific bone phenotype characterized by alterations of structural properties and impaired mechanic...

journal_title：Blood

authors： Sauer AV,Mrak E,Hernandez RJ,Zacchi E,Cavani F,Casiraghi M,Grunebaum E,Roifman CM,Cervi MC,Ambrosi A,Carlucci F,Roncarolo MG,Villa A,Rubinacci A,Aiuti A

更新日期：2009-10-08 00:00:00

abstract：:Recombinant human interleukin-6 (IL-6) has previously been shown to increase platelet counts in normal and sublethally irradiated mice, dogs, and primates. To assess its tolerance and efficacy in clinical use, we performed a randomized phase Ib study in patients with ovarian carcinoma. IL-6 was administered during an ...

journal_title：Blood

authors： D'Hondt V,Humblet Y,Guillaume T,Baatout S,Chatelain C,Berlière M,Longueville J,Feyens AM,de Greve J,Van Oosterom A

更新日期：1995-05-01 00:00:00

abstract：:We describe a patient with the so-called "prolymphocytic variant" form of hairy cell leukemia (HCL) resistant to treatment with interferon-alpha (IFN-alpha). Analysis of immunoglobulin (Ig) and T-cell receptor-beta (TCR beta) gene rearrangements from serial peripheral blood mononuclear cell specimens (MNCs) confirmed ...

journal_title：Blood

authors： Giardina SL,Young HA,Faltynek CR,Jaffe ES,Clark JW,Steis RG,Urba WJ,Mathieson BJ,Gralnick H,Lawrence J

更新日期：1988-11-01 00:00:00

abstract：:Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARalpha fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, but recurrent, APL has been described that does not respond to ATRA treatment and is associated with a variant chromosomal translocati...

journal_title：Blood

authors： Guidez F,Ivins S,Zhu J,Söderström M,Waxman S,Zelent A

更新日期：1998-04-15 00:00:00

abstract：:CCAAT displacement protein (cux/CDP) is an atypical homeodomain protein that represses expression of several developmentally regulated lymphoid and myeloid genes in vitro, including gp91-phox, immunoglobulin heavy chain, the T-cell receptor beta and gamma chains, and CD8. To determine how this activity affects cell de...

journal_title：Blood

authors： Sinclair AM,Lee JA,Goldstein A,Xing D,Liu S,Ju R,Tucker PW,Neufeld EJ,Scheuermann RH

更新日期：2001-12-15 00:00:00

abstract：:Monoclonally-derived neoplastic T-cells from a patient with cutaneous T-cell lymphoma respond to multiple human HLA-D antigens in mixed lymphocyte culture. The implications of this phenomenon relevant to normal T-cell function and to malignancy are discussed. ...

journal_title：Blood

authors： Rubenfeld MR,Edelson RL,Löfström LM,Berger CL,Warburton D

更新日期：1980-03-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that accounts for ∼20% of ALL cases. Intensive chemotherapy regimens result in cure rates >85% in children and <50% in adults, warranting a search of novel therapeutic strategies. Although immune-based therapies have tremendously improved the trea...

journal_title：Blood

authors： Tran Quang C,Zaniboni B,Humeau R,Lengliné E,Dourthe ME,Ganesan R,Singh S,Scheer JM,Asnafi V,Ghysdael J

更新日期：2020-09-10 00:00:00

abstract：:Light chain deposition disease (LCDD) results from a propensity of some human monoclonal L chains to form tissue deposits. We designed an experimental model for in vivo expression of human kappa L chain sequences in mice and compared a somatically mutated LCDD chain with a closely related control kappa chain, both enc...

journal_title：Blood

authors： Khamlichi AA,Rocca A,Touchard G,Aucouturier P,Preud'homme JL,Cogné M

更新日期：1995-11-15 00:00:00

abstract：:Potassium tellurite (K2TeO3) was found to be a potent antisickling agent that inhibited red cell sickling at concentrations less than 10 mumol/L. The inhibitory effect depended on the incubation time, with the effect increasing with longer incubation periods. Because tellurite causes swelling of red cells, and because...

journal_title：Blood

authors： Asakura T,Shibutani Y,Reilly MP,DeMeio RH

更新日期：1984-07-01 00:00:00

abstract：:Recently various genetic defects in immunity mediated by interferon gamma (IFN-gamma) have been described, including mutations in the IFN-gamma receptor 1 (IFN-gammaR1) and receptor 2 (IFN-gammaR2), signal transducer and activator of transcription 1 (STAT 1), and interleukin 12 receptor beta 1 (IL-12Rbeta1), and IL-12...

journal_title：Blood

authors： Höflich C,Sabat R,Rosseau S,Temmesfeld B,Slevogt H,Döcke WD,Grütz G,Meisel C,Halle E,Göbel UB,Volk HD,Suttorp N

更新日期：2004-01-15 00:00:00

abstract：:Combined deficiency of ankyrin and spectrin represents the most common biochemical abnormality in hereditary spherocytosis (HS). To examine whether a decrease in ankyrin mRNA represents a frequent cause of this type of HS, we took advantage of the reported (AC)n microsatellite polymorphism in the 3' untranslated regio...

journal_title：Blood

authors： Jarolim P,Rubin HL,Brabec V,Palek J

更新日期：1995-06-01 00:00:00

abstract：:Early B-cell factor 1 (Ebf1) is a transcription factor with documented dose-dependent functions in normal and malignant B-lymphocyte development. To understand more about the roles of Ebf1 in malignant transformation, we investigated the impact of reduced functional Ebf1 dosage on mouse B-cell progenitors. Gene expres...

journal_title：Blood

authors： Prasad MA,Ungerbäck J,Åhsberg J,Somasundaram R,Strid T,Larsson M,Månsson R,De Paepe A,Lilljebjörn H,Fioretos T,Hagman J,Sigvardsson M

更新日期：2015-06-25 00:00:00

abstract：:Seven of 21 patients with sickle cell anemia developed neurologic complications 5 to 243 days (median, 33 days) after allogeneic marrow transplantation. Among these 7 patients, indications for transplantation included either a past history of stroke (4 patients) or recurrent severe vaso-occlusive events (3 patients). ...

journal_title：Blood

authors： Walters MC,Sullivan KM,Bernaudin F,Souillet G,Vannier JP,Johnson FL,Lenarsky C,Powars D,Bunin N,Ohene-Frempong K

更新日期：1995-02-15 00:00:00

abstract：:Ly6G is a glycosylphosphatidylinositol (GPI)-anchored protein of unknown function that is commonly targeted to induce experimental neutrophil depletion in mice. In the present study, we found that doses of anti-Ly6G Abs too low to produce sustained neutropenia remained capable of inhibiting experimental arthritis, lea...

journal_title：Blood

authors： Wang JX,Bair AM,King SL,Shnayder R,Huang YF,Shieh CC,Soberman RJ,Fuhlbrigge RC,Nigrovic PA

更新日期：2012-08-16 00:00:00

abstract：:The role of T-cell subsets in the induction of tissue factor (TF) production by human monocytes in vitro was investigated. Mitogen stimulation enabled both unfractionated T cells and their CD4+ or CD8+ subsets to promote procoagulant activity (PCA). After mitogen or antigen activation, all seven T-cell clones with Th1...

journal_title：Blood

authors： Del Prete G,De Carli M,Lammel RM,D'Elios MM,Daniel KC,Giusti B,Abbate R,Romagnani S

更新日期：1995-07-01 00:00:00

abstract：:Both SDF-1 and CXCR4 disruption are lethal to mice at the embryonic stage and cause abnormalities in B lymphopoiesis, myelopoiesis, cardiogenesis, vasculogenesis, and cerebellar development. To investigate the role of SDF-1 and CXCR4 in hematopoiesis during the adult stage, mice reconstituted with bone marrow-derived ...

journal_title：Blood

authors： Onai N,Zhang Yy,Yoneyama H,Kitamura T,Ishikawa S,Matsushima K

更新日期：2000-09-15 00:00:00

abstract：:Pharmacologic infusion of activated protein C (APC) improves survival in severe sepsis, and platelet factor 4 (PF4) accelerates APC generation in a primate thrombin-infusion model. We now tested whether endogenous platelet PF4 content affects APC generation. Mice completely deficient in PF4 (mPF4(-/-)) had impaired AP...

journal_title：Blood

authors： Kowalska MA,Mahmud SA,Lambert MP,Poncz M,Slungaard A

更新日期：2007-09-15 00:00:00