alpha-Actinin and vinculin in normal and thrombasthenic platelets.

abstract：:Systemic inflammation perturbs the bone marrow environment by evicting resident B cells and favoring granulopoiesis over lymphopoiesis. Despite these conditions, a subset of marrow B cell remains to become activated and produce potent acute immunoglobulin M (IgM) responses. This discrepancy is currently unresolved and...

journal_title：Blood

authors： Moreau JM,Berger A,Nelles ME,Mielnik M,Furlonger C,Cen SY,Besla R,Robbins CS,Paige CJ

更新日期：2015-09-03 00:00:00

abstract：:Surrogate light chain expression during B lineage differentiation was examined by using indicator fluorochrome-filled liposomes in an enhanced immunofluorescence assay. Pro-B cells bearing surrogate light chain components were found in mice, but not in humans. A limited subpopulation of relatively large pre-B cells in...

journal_title：Blood

authors： Wang YH,Stephan RP,Scheffold A,Kunkel D,Karasuyama H,Radbruch A,Cooper MD

更新日期：2002-04-01 00:00:00

abstract：:The mechanism leading to the formation of antiphospholipid antibodies (aPL) is still unknown. Because an in vitro study suggested that aPL may derive from pro-oxidant conditions, we sought a relationship between aPL and isoprostanes, indices of lipid peroxidation in vivo. Thirty patients with systemic lupus erythemato...

journal_title：Blood

authors： Iuliano L,Praticò D,Ferro D,Pittoni V,Valesini G,Lawson J,FitzGerald GA,Violi F

更新日期：1997-11-15 00:00:00

abstract：:A rapid sensitive spectrophotometric assay for the measurement of methylmalonic and propionic acids in urine is described. The assay is based upon the quantitation of propionic acid using acetyl coenzyme A synthetase isolated from baker's yeast. This enzyme is highly specific for acetate and propionate, and acetate in...

journal_title：Blood

authors： Frenkel EP,Kitchens RL

更新日期：1977-01-01 00:00:00

abstract：:The t(11;14)(q13;q32) translocation and its molecular counterpart, BCL-1 rearrangement, are consistent features of intermediate lymphocytic lymphoma (ILL). Rearrangement is thought to deregulate the nearby PRAD-1/BCL-1 proto-oncogene that is a newly identified member of the cyclin family. To characterize further the a...

journal_title：Blood

authors： Rimokh R,Berger F,Delsol G,Charrin C,Berthéas MF,Ffrench M,Garoscio M,Felman P,Coiffier B,Bryon PA

更新日期：1993-06-01 00:00:00

abstract：:Because of their potent immunoregulatory capacity, dendritic cells (DCs) have been exploited as therapeutic tools to boost immune responses against tumors or pathogens, or dampen autoimmune or allergic responses. Murine bone marrow-derived DCs (BM-DCs) are the closest known equivalent of the blood monocyte-derived DCs...

journal_title：Blood

authors： Creusot RJ,Yaghoubi SS,Chang P,Chia J,Contag CH,Gambhir SS,Fathman CG

更新日期：2009-06-25 00:00:00

abstract：:The inclusion of exon 16 in the mature protein 4.1R messenger RNA (mRNA) is a critical event in red blood cell membrane biogenesis. It occurs during late erythroid development and results in inclusion of the 10-kd domain needed for stabilization of the spectrin/actin lattice. In this study, an experimental model was e...

journal_title：Blood

authors： Deguillien M,Huang SC,Morinière M,Dreumont N,Benz EJ Jr,Baklouti F

更新日期：2001-12-15 00:00:00

abstract：:Clinical results after T-cell-depleted allografts might be improved by modifying the graft content of progenitor and accessory cells. Although the association of the number of donor T cells with the clinical outcome has been studied extensively, the optimum number of progenitor cells that should be administered to pat...

journal_title：Blood

authors： Urbano-Ispizua A,Carreras E,Marín P,Rovira M,Martínez C,Fernández-Avilés F,Xicoy B,Hernández-Boluda JC,Montserrat E

更新日期：2001-10-15 00:00:00

abstract：:Dendritic cells (DC) are the main stimulators of primary T-cell responses and, thus, probably play a role in the immune reactions after stem cell transplantation. Very little is known about DC in cord blood (CB) and about their potential involvement in the low incidence and severity of acute graft-versus-host disease ...

journal_title：Blood

authors： Sorg RV,Kögler G,Wernet P

更新日期：1999-04-01 00:00:00

abstract：:During thrombopoiesis, maturing megakaryocytes (MKs) migrate within the complex bone marrow stromal microenvironment from the proliferative osteoblastic niche to the capillary-rich vascular niche where proplatelet formation and platelet release occurs. This physiologic process involves proliferation, differentiation, ...

journal_title：Blood

authors： Dhanjal TS,Pendaries C,Ross EA,Larson MK,Protty MB,Buckley CD,Watson SP

更新日期：2007-05-15 00:00:00

abstract：:BMS-354825 (dasatinib) and AMN107 (nilotinib) are potent alternate Abl inhibitors with activity against many imatinib mesylate-resistant BCR-ABL kinase domain (KD) mutants, except T315I. We used N-ethyl-N-nitrosourea (ENU)-exposed Ba/F3-p210(BCR-ABL) cells to compare incidence and types of KD mutants emerging in the p...

journal_title：Blood

authors： Bradeen HA,Eide CA,O'Hare T,Johnson KJ,Willis SG,Lee FY,Druker BJ,Deininger MW

更新日期：2006-10-01 00:00:00

abstract：:Activation of plasminogen, the zymogen of the primary thrombolytic enzyme, plasmin, is markedly promoted when plasminogen is bound to cell surfaces, arming cells with the broad spectrum proteolytic activity of plasmin. In addition to its role in thrombolysis, cell surface plasmin facilitates a wide array of physiologi...

journal_title：Blood

authors： Andronicos NM,Chen EI,Baik N,Bai H,Parmer CM,Kiosses WB,Kamps MP,Yates JR 3rd,Parmer RJ,Miles LA

更新日期：2010-02-18 00:00:00

abstract：:The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic oxidative DNA damage resulting in double-strand breaks (DSBs) in S and G(2)/M cell cycle phases. These lesions are rep...

journal_title：Blood

authors： Nowicki MO,Falinski R,Koptyra M,Slupianek A,Stoklosa T,Gloc E,Nieborowska-Skorska M,Blasiak J,Skorski T

更新日期：2004-12-01 00:00:00

abstract：:Accumulating evidence has designated B cells as central players in the pathogenesis of immune diseases. In the late 1990s, anti-CD20 monoclonal antibodies were developed for the treatment of B-cell non-Hodgkin lymphomas, offering the opportunity to efficiently deplete the B-cell compartment for therapeutic immunointer...

journal_title：Blood

authors： Thaunat O,Morelon E,Defrance T

更新日期：2010-07-29 00:00:00

abstract：:The von Willebrand factor propeptide, vW AgII, has been shown to be required for the formation of vWF multimers and sorting of vWF to storage granules; whether these 2 processes are independent events has been unclear. Chimeric constructs of human and canine vWF were developed to further define these processes and to ...

journal_title：Blood

authors： Haberichter SL,Fahs SA,Montgomery RR

更新日期：2000-09-01 00:00:00

abstract：:Peripheral blood cells are increasingly used in place of bone marrow as a source of hematopoietic stem cells for allogeneic transplantation. The relative efficacy of these 2 approaches is unknown. This retrospective multivariate analysis compared results of 288 HLA-identical sibling blood stem cell transplantations wi...

journal_title：Blood

authors： Champlin RE,Schmitz N,Horowitz MM,Chapuis B,Chopra R,Cornelissen JJ,Gale RP,Goldman JM,Loberiza FR Jr,Hertenstein B,Klein JP,Montserrat E,Zhang MJ,Ringdén O,Tomany SC,Rowlings PA,Van Hoef ME,Gratwohl A

更新日期：2000-06-15 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a rare pediatric myeloid neoplasm characterized by excessive proliferation of myelomonocytic cells. Somatic mutations in genes involved in GM-CSF signal transduction, such as NRAS, KRAS, PTPN11, NF1, and CBL, have been identified in more than 70% of children with JMML. In the...

journal_title：Blood

authors： Doisaki S,Muramatsu H,Shimada A,Takahashi Y,Mori-Ezaki M,Sato M,Kawaguchi H,Kinoshita A,Sotomatsu M,Hayashi Y,Furukawa-Hibi Y,Yamada K,Hoshino H,Kiyoi H,Yoshida N,Sakaguchi H,Narita A,Wang X,Ismael O,Xu Y,Nishio N

更新日期：2012-08-16 00:00:00

abstract：:Chronic myeloid leukemia is effectively treated with imatinib, but reactivation of BCR-ABL frequently occurs through acquisition of kinase domain mutations. The additional approved ABL tyrosine kinase inhibitors (TKIs) nilotinib and dasatinib, along with investigational TKIs such as ponatinib (AP24534) and DCC-2036, s...

journal_title：Blood

authors： O'Hare T,Zabriskie MS,Eide CA,Agarwal A,Adrian LT,You H,Corbin AS,Yang F,Press RD,Rivera VM,Toplin J,Wong S,Deininger MW,Druker BJ

更新日期：2011-11-10 00:00:00

abstract：:Marginal zone B-cell lymphoma (MZL) is a recently individualized lymphoma that encompasses mucosa-associated lymphoid tissue (MALT) lymphoma, splenic lymphoma with or without villous lymphocytes, and nodal lymphoma with or without monocytoid B-cells. If the clinical description and outcome of MALT lymphoma is well kno...

journal_title：Blood

authors： Berger F,Felman P,Thieblemont C,Pradier T,Baseggio L,Bryon PA,Salles G,Callet-Bauchu E,Coiffier B

更新日期：2000-03-15 00:00:00

abstract：:Despite major improvements in outcome over the past decades, acute myeloid leukemia (AML) remains a life-threatening malignancy in children, with current survival rates of ∼70%. State-of-the-art recommendations in adult AML have recently been published in this journal by Döhner et al. The primary goal of an internatio...

journal_title：Blood

authors： Creutzig U,van den Heuvel-Eibrink MM,Gibson B,Dworzak MN,Adachi S,de Bont E,Harbott J,Hasle H,Johnston D,Kinoshita A,Lehrnbecher T,Leverger G,Mejstrikova E,Meshinchi S,Pession A,Raimondi SC,Sung L,Stary J,Zwaan CM,K

更新日期：2012-10-18 00:00:00

abstract：:We have recently shown that proteasome inhibitor PS-341 induces apoptosis in drug-resistant multiple myeloma (MM) cells, inhibits binding of MM cells in the bone marrow microenvironment, and inhibits cytokines mediating MM cell growth, survival, drug resistance, and migration in vitro. PS-341 also inhibits human MM ce...

journal_title：Blood

authors： Hideshima T,Mitsiades C,Akiyama M,Hayashi T,Chauhan D,Richardson P,Schlossman R,Podar K,Munshi NC,Mitsiades N,Anderson KC

更新日期：2003-02-15 00:00:00

abstract：:A 7-yr-old girl with self-limited pulmonary aspergillosis was found to have a defect in granulocyte superoxide production. Her cells produced superoxide at 3% of control rates in response to phorbol myristate acetate (PMA) and opsonized zymosan. Lag times for O-2 production were normal with PMA, opsonized zymosan, and...

journal_title：Blood

authors： Shurin SB,Cohen HJ,Whitin JC,Newburger PE

更新日期：1983-09-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome characterized by progressive bone marrow failure and cancer predisposition. Eight FA complementation groups have been identified. The FANCA, FANCC, FANCE, FANCF, and FANCG proteins form a nuclear complex required for the monoubiquination of the FANCD2 protein. To ...

journal_title：Blood

authors： Gordon SM,Buchwald M

更新日期：2003-07-01 00:00:00

abstract：:Hypereosinophilic syndromes (HESs) are a heterogeneous group of uncommon disorders characterized by marked peripheral eosinophilia and end organ manifestations attributable to the eosinophilia or unexplained in the clinical setting. Whereas corticosteroids remain the mainstay of treatment for most patients, recent dia...

journal_title：Blood

authors： Klion AD

更新日期：2009-10-29 00:00:00

abstract：:The regulatory function of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) on granulocyte production in vivo was evaluated in an autologous bone marrow transplantation model using rhesus monkeys. Monkeys were exposed to 9.0 Gy total body irradiation and then transplanted with 5.0 x 10(7) ...

journal_title：Blood

authors： Monroy RL,Skelly RR,MacVittie TJ,Davis TA,Sauber JJ,Clark SC,Donahue RE

更新日期：1987-11-01 00:00:00

abstract：:We performed a pilot study to test the effectiveness of allogeneic bone marrow transplantation in the treatment of chronic myelogenous leukemia. Five patients in the advanced stages of chronic myelogenous leukemia (four in blast crisis, one in accelerated phase) with abnormal chromosomes underwent matched-sibling allo...

journal_title：Blood

authors： McGlave PB,Miller WJ,Hurd DD,Arthur DC,Kim T

更新日期：1981-11-01 00:00:00

abstract：:Hydroxyurea, interferon, and HLA-identical sibling bone marrow transplantation are common therapies for chronic myelogenous leukemia (CML) in chronic phase. Which is best is controversial. The purpose of this study was to compare survival of patients with CML receiving HLA-identical sibling transplants versus hydroxyu...

journal_title：Blood

authors： Gale RP,Hehlmann R,Zhang MJ,Hasford J,Goldman JM,Heimpel H,Hochhaus A,Klein JP,Kolb HJ,McGlave PB,Passweg JR,Rowlings PA,Sobocinski KA,Horowitz MM

更新日期：1998-03-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a systemic inflammatory response due to the recognition of major histocompatibility complex disparity between donor and recipient after hematopoietic stem cell transplantation (HSCT). T-cell activation is critical to the induction of GVHD, and data from our group and others have sho...

journal_title：Blood

authors： Lin KL,Fulton LM,Berginski M,West ML,Taylor NA,Moran TP,Coghill JM,Blazar BR,Bear JE,Serody JS

更新日期：2014-03-06 00:00:00

abstract：:We investigated whether the stem cell that reconstitutes total erythropoiesis of a WBB6F1-W/Wv mouse differentiates into lymphoid lineage. The electrophoretic pattern of hemoglobin was used as a marker of the reconstitution; 3-phosphoglycerate kinase (PGK), an X chromosome-linked enzyme was used as a tool for estimati...

journal_title：Blood

authors： Nakano T,Waki N,Asai H,Kitamura Y

更新日期：1989-04-01 00:00:00

abstract：:Under normal conditions, platelets do not adhere to endothelium. However, when platelets or endothelial cells are stimulated by thrombin or cytokines, respectively, platelets bind avidly to endothelium. Because there is accumulating evidence that endothelial cells may become apoptotic under certain proinflammatory or ...

journal_title：Blood

authors： Bombeli T,Schwartz BR,Harlan JM

更新日期：1999-06-01 00:00:00