Rearrangement and overexpression of the BCL-1/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11q13)-bearing leukemias.

abstract：:Aberrant regulation of endogenous survival pathways plays a major role in progression of chronic lymphocytic leukemia (CLL). Signaling via conjugation of surface receptors within the tumor environmental niche activates survival and proliferation pathways in CLL. Of these, the phosphoinositide 3-kinase (PI3K)/protein k...

journal_title：Blood

authors： Liu TM,Ling Y,Woyach JA,Beckwith K,Yeh YY,Hertlein E,Zhang X,Lehman A,Awan F,Jones JA,Andritsos LA,Maddocks K,MacMurray J,Salunke SB,Chen CS,Phelps MA,Byrd JC,Johnson AJ

更新日期：2015-01-08 00:00:00

abstract：:The development of erythroid colonies of fetal liver hemopoietic cell origin in adult irradiated polycythemic mice was studied. It was found that orchidectomy sharply reduced the number of erythroid colonies developed in the spleen of these polycythemic male recipients. Estrogen injection to the orchidectomized polycy...

journal_title：Blood

authors： Bleiberg I,Perah G

更新日期：1975-04-01 00:00:00

abstract：:Eighty patients with chronic myeloid leukemia (CML) underwent T cell-depleted stem cell transplantation from an HLA-identical sibling, with add-back of donor T cells on days 30 to 45 and days 60 to 100 in patients in whom grade 2 or greater acute graft-versus-host disease (GVHD) developed. The outcomes for 54 patients...

journal_title：Blood

authors： Savani BN,Rezvani K,Mielke S,Montero A,Kurlander R,Carter CS,Leitman S,Read EJ,Childs R,Barrett AJ

更新日期：2006-02-15 00:00:00

abstract：:The t(1;19)(q23;p13) chromosomal translocation is observed cytogenetically in 25% of children with pre-B-cell acute lymphoblastic leukemia (ALL) and is associated with an adverse treatment outcome. The t(1;19) juxtaposes the E2A gene from chromosome 19 with the PBX1 gene on chromosome 1, leading to the production of f...

journal_title：Blood

authors： Hunger SP,Galili N,Carroll AJ,Crist WM,Link MP,Cleary ML

更新日期：1991-02-15 00:00:00

abstract：:Doxorubicin, bleomycin, vinblastine sulfate, and dacarbazine (ABVD) is associated with severe toxicity in older patients, particularly from bleomycin-induced lung toxicity (BLT). Therefore, using bleomycin has been questioned in older Hodgkin lymphoma (HL) patients, especially in early-stage HL. We therefore analyzed ...

journal_title：Blood

authors： Böll B,Goergen H,Behringer K,Bröckelmann PJ,Hitz F,Kerkhoff A,Greil R,von Tresckow B,Eichenauer DA,Bürkle C,Borchmann S,Fuchs M,Diehl V,Engert A,Borchmann P

更新日期：2016-05-05 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective tumor immunotherapy available. Although allo-HSCT provides beneficial graft-versus-tumor effects, acute GVHD (aGVHD) is the primary source of morbidity and mortality after HSCT. Diagnosis of aGVHD is typically based on clinical sympto...

journal_title：Blood

authors： Paczesny S

更新日期：2013-01-24 00:00:00

abstract：:Although thrombin is a key enzyme in the coagulation cascade and is required for both normal hemostasis and pathologic thrombogenesis, it also participates in its own negative feedback via activation of protein C, which downregulates thrombin generation by enzymatically inactivating factors Va and VIIIa. Our group and...

journal_title：Blood

authors： Tucker EI,Verbout NG,Markway BD,Wallisch M,Lorentz CU,Hinds MT,Shatzel JJ,Pelc LA,Wood DC,McCarty OJT,Di Cera E,Gruber A

更新日期：2020-02-27 00:00:00

abstract：:All-trans retinoic acid (ATRA) is an essential component of the treatment of acute promyelocytic leukemia (APL), but the optimal timing and duration remain to be determined. Molecular characterization of this disease can refine the diagnosis and could be potentially useful in monitoring response to treatment. Patients...

journal_title：Blood

authors： Burnett AK,Grimwade D,Solomon E,Wheatley K,Goldstone AH

更新日期：1999-06-15 00:00:00

abstract：:Terminal erythroid differentiation starts from morphologically recognizable proerythroblasts that proliferate and differentiate to generate red cells. Although this process has been extensively studied in mice, its characterization in humans is limited. By examining the dynamic changes of expression of membrane protei...

journal_title：Blood

authors： Hu J,Liu J,Xue F,Halverson G,Reid M,Guo A,Chen L,Raza A,Galili N,Jaffray J,Lane J,Chasis JA,Taylor N,Mohandas N,An X

更新日期：2013-04-18 00:00:00

abstract：:The mechanisms of resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) often remain obscure. Analysis of patient samples during disease progression revealed the up-regulation of the oncogene TWIST-1, also measured in primary samples from TKI-resistant patients. Moreover, we found that TWIS...

journal_title：Blood

authors： Cosset E,Hamdan G,Jeanpierre S,Voeltzel T,Sagorny K,Hayette S,Mahon FX,Dumontet C,Puisieux A,Nicolini FE,Maguer-Satta V

更新日期：2011-02-03 00:00:00

abstract：:Studying human antigen-specific memory B cells has been challenging because of low frequencies in peripheral blood, slow proliferation, and lack of antibody secretion. Therefore, most studies have relied on conversion of memory B cells into antibody-secreting cells by in vitro culture. To facilitate direct ex vivo iso...

journal_title：Blood

authors： Franz B,May KF Jr,Dranoff G,Wucherpfennig K

更新日期：2011-07-14 00:00:00

abstract：:The choice of either induction or postremission therapy for adults with acute myeloid leukemia is still largely based on the "one size fits all" principle. Moreover, pretreatment prognostic parameters, especially chromosome and gene abnormalities, may fail in predicting individual patient outcome. Measurement of minim...

journal_title：Blood

authors： Buccisano F,Maurillo L,Del Principe MI,Del Poeta G,Sconocchia G,Lo-Coco F,Arcese W,Amadori S,Venditti A

更新日期：2012-01-12 00:00:00

abstract：:Coagulation factor XIII (FXIII) is the main stabilizer of the fibrin clot. It circulates in plasma as a tetramer of two A-subunits and two B-subunits. Under physiological conditions, FXIII-A exists as a dimer (FXIII-A2). The interactions between the FXIII-A-subunits that stabilize the FXIII-A2 dimer are not fully unde...

journal_title：Blood

authors： Li B,Kohler HP,Schroeder V

更新日期：2020-01-09 00:00:00

abstract：:The human pluripotent UT-7 cell line is growth factor-dependent for proliferation and differentiation. We have previously shown that (1) granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Epo) induce a myeloid and erythroid pattern of differentiation, respectively; (2) GM-CSF acts predominan...

journal_title：Blood

authors： Hermine O,Dubart A,Porteux F,Mayeux P,Titeux M,Dumenil D,Vainchenker W

更新日期：1996-03-01 00:00:00

abstract：:Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in ...

journal_title：Blood

authors： Lindemann A,Ludwig WD,Oster W,Mertelsmann R,Herrmann F

更新日期：1989-03-01 00:00:00

abstract：:Blood cells of an adult vertebrate are continuously generated by hematopoietic stem cells (HSCs) that originate during embryonic life within the aorta-gonad-mesonephros region. There is now compelling in vivo evidence that HSCs are generated from aortic endothelial cells and that this process is critically regulated b...

journal_title：Blood

authors： Lam EY,Hall CJ,Crosier PS,Crosier KE,Flores MV

更新日期：2010-08-12 00:00:00

abstract：:The median age of chronic myeloid leukemia (CML) patients is ~60 years, and age is still considered an important prognostic factor, included in Sokal and EURO risk scores. However, few data are available about the long-term outcome of older patients treated with imatinib (IM) frontline. We analyzed the relationship be...

journal_title：Blood

authors： Gugliotta G,Castagnetti F,Palandri F,Breccia M,Intermesoli T,Capucci A,Martino B,Pregno P,Rupoli S,Ferrero D,Gherlinzoni F,Montefusco E,Bocchia M,Tiribelli M,Pierri I,Grifoni F,Marzocchi G,Amabile M,Testoni N,Martin

更新日期：2011-05-26 00:00:00

abstract：:Non-Hodgkin lymphoma (NHL) incidence is greatly increased after kidney transplantation. NHL risk was investigated in a nationwide cohort of 8164 kidney transplant recipients registered on the Australia and New Zealand Dialysis and Transplant Registry. NHL diagnoses were ascertained using linkage with national cancer r...

journal_title：Blood

authors： van Leeuwen MT,Grulich AE,Webster AC,McCredie MR,Stewart JH,McDonald SP,Amin J,Kaldor JM,Chapman JR,Vajdic CM

更新日期：2009-07-16 00:00:00

abstract：:Autologous membrane-bound IgG was isolated from a subpopulation of human red blood cells (RBC) with specific density greater than 1.110, by affinity chromatography of purified RBC membrane glycoprotein preparations using immobilized wheat germ agglutinin and immobilized anti-human immunoglobulin (Ig) as immunoabsorben...

journal_title：Blood

authors： Alderman EM,Fudenberg HH,Lovins RE

更新日期：1981-08-01 00:00:00

abstract：:Monocytes from patients with sickle cell disease (SCD) are in an activated state. However, the mechanism of activation of monocytes in SCD is not known. Our studies showed that placenta growth factor (PlGF) activated monocytes and increased mRNA levels of cytokines (tumor necrosis factor-alpha [TNF-alpha] and interleu...

journal_title：Blood

authors： Selvaraj SK,Giri RK,Perelman N,Johnson C,Malik P,Kalra VK

更新日期：2003-08-15 00:00:00

abstract：:Hematopoietic stem cell (HSC) transplantation is a lifesaving therapy for malignant and nonmalignant hematologic diseases and metabolic disorders. Although successful, hematopoietic transplantation can be hindered by inadequate stem cell number or poor engrafting efficiency. To overcome these deficits, we and others h...

journal_title：Blood

authors： Hoggatt J,Mohammad KS,Singh P,Pelus LM

更新日期：2013-10-24 00:00:00

abstract：:The activation of polymorphonuclear leukocytes (PMN) is an important step in the development of tissue damage associated with inflammatory and ischemic conditions. Catecholamines have been reported to inhibit PMN functions, but the high concentrations required cast doubt on their actual relevance as a defense mechanis...

journal_title：Blood

authors： Bazzoni G,Dejana E,Del Maschio A

更新日期：1991-05-01 00:00:00

abstract：:For many years, human hemoglobin (Hb) isolated from erythrocytes has been investigated as a potential oxygen delivery therapeutic. Advantages with respect to the need for blood typing were balanced with various undesirable properties of cell-free Hb, including cost, overall oxygen affinity, alterations in cooperativit...

journal_title：Blood

authors： Sanders KE,Lo J,Sligar SG

更新日期：2002-07-01 00:00:00

abstract：:Acute promyelocytic leukemias (APLs) are characterized by a translocation that involves chromosomes 15 and 17. The translocation breakpoints have recently been identified and shown to involve the RAR-alpha gene on 17 and myl on 15. Here we report Southern blotting analysis of 26 APLs, including cases with normal karyo...

journal_title：Blood

authors： Biondi A,Rambaldi A,Alcalay M,Pandolfi PP,Lo Coco F,Diverio D,Rossi V,Mencarelli A,Longo L,Zangrilli D

更新日期：1991-04-01 00:00:00

abstract：:T-cell production depends on the recruitment of hematopoietic progenitors into the thymus. T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT), but the reasons for this delay are not well understood. Under normal physiologic conditions, thymic settling is selecti...

journal_title：Blood

authors： Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A

更新日期：2011-08-18 00:00:00

abstract：:The Leukemia and Lymphoma Molecular Profiling Project recently published results from DNA microarray analyses of 240 diffuse large B-cell lymphomas (DLBCLs). Four gene expression "signatures" were identified as correlated with patient outcome, including the major histocompatibility complex (MHC) class II genes (eg, HL...

journal_title：Blood

authors： Rimsza LM,Roberts RA,Miller TP,Unger JM,LeBlanc M,Braziel RM,Weisenberger DD,Chan WC,Muller-Hermelink HK,Jaffe ES,Gascoyne RD,Campo E,Fuchs DA,Spier CM,Fisher RI,Delabie J,Rosenwald A,Staudt LM,Grogan TM

更新日期：2004-06-01 00:00:00

abstract：:The human interleukin-3 receptor (IL-3R) is expressed on myeloid, lymphoid, and vascular endothelial cells, where it transduces IL-3-dependent signals leading to cell activation. Although IL-3R activation may play a role in hematopoiesis and immunity, its aberrant expression or excessive stimulation may contribute to ...

journal_title：Blood

authors： Sun Q,Woodcock JM,Rapoport A,Stomski FC,Korpelainen EI,Bagley CJ,Goodall GJ,Smith WB,Gamble JR,Vadas MA,Lopez AF

更新日期：1996-01-01 00:00:00

abstract：:To obtain insight into the mechanism(s) of posttransplantation humoral immunodeficiency, we evaluated factors affecting serum antibody levels against polio, tetanus, Haemophilus influenzae, and Streptococcus pneumoniae in 87 patients. Patients with hematologic malignancies were randomized to receive marrow versus bloo...

journal_title：Blood

authors： Storek J,Viganego F,Dawson MA,Herremans MM,Boeckh M,Flowers ME,Storer B,Bensinger WI,Witherspoon RP,Maloney DG

更新日期：2003-04-15 00:00:00

abstract：:Through its Src homology 3 (SH3) and SH2 domains, the Src kinase Lyn interacts with a small number of phosphoproteins, such as Shc, Cbl, and Vav, which regulate cell cycle and the cytoskeleton. Using Lyn's Unique, SH3, and SH2 domains as bait in a yeast 2-hybrid screen, we isolated a novel gene product with features o...

journal_title：Blood

authors： Dombrosky-Ferlan P,Grishin A,Botelho RJ,Sampson M,Wang L,Rudert WA,Grinstein S,Corey SJ

更新日期：2003-04-01 00:00:00

abstract：:In this issue of Blood, Bagnara et al describe the development of a reliable and convincing xenograft model of CLL that recapitulates aspects of the leukemic microenvironment and gives intriguing insights into disease biology. ...

journal_title：Blood

authors： Devereux S

更新日期：2011-05-19 00:00:00