Abstract：
:The median age of chronic myeloid leukemia (CML) patients is ~60 years, and age is still considered an important prognostic factor, included in Sokal and EURO risk scores. However, few data are available about the long-term outcome of older patients treated with imatinib (IM) frontline. We analyzed the relationship between age and outcome in 559 early chronic-phase CML patients enrolled in 3 prospective clinical trials of Gruppo Italiano Malattie Ematologiche dell'Adulto CML Working Party, treated frontline with IM, with a median follow-up of 60 months. There were 115 older patients (≥ 65 years; 21%). The complete cytogenetic and major molecular response rates were similar in the 2 age groups. In older patients, event-free survival (55% vs 67%), failure-free survival (78% vs 92%), progression-free survival (62% vs 78%), and overall survival (75% vs 89%) were significantly inferior (all P < .01) because of a higher proportion of deaths that occurred in complete hematologic response, therefore unrelated to CML progression (15% vs 3%, P < .0001). The outcome was similar once those deaths were censored. These data show that response to IM was not affected by age and that the mortality rate linked to CML is similar in both age groups. This trial was registered at www.clinicaltrials.gov as #NCT00514488 and #NCT00510926.
journal_name
Bloodjournal_title
Bloodauthors
Gugliotta G,Castagnetti F,Palandri F,Breccia M,Intermesoli T,Capucci A,Martino B,Pregno P,Rupoli S,Ferrero D,Gherlinzoni F,Montefusco E,Bocchia M,Tiribelli M,Pierri I,Grifoni F,Marzocchi G,Amabile M,Testoni N,Martindoi
10.1182/blood-2010-12-324228subject
Has Abstractpub_date
2011-05-26 00:00:00pages
5591-9issue
21eissn
0006-4971issn
1528-0020pii
blood-2010-12-324228journal_volume
117pub_type
杂志文章相关文献
BLOOD文献大全abstract：:Fourteen patients with cytogenetic relapse of chronic myeloid leukemia (CML) after transplantation with unmanipulated bone marrow were treated with alpha-2a-interferon. There were eight men and six women, median age, 33 years. Twelve patients received marrow from a related allogeneic donor and two received marrow from...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Proteasome inhibition is an effective treatment strategy for multiple myeloma. With improving survival, attention is increasingly focusing on ease of administration and toxicity profile. Ixazomib is an investigational, orally bioavailable 20S proteasome inhibitor. Sixty patients with relapsed and/or refractory multipl...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2014-01-548941
更新日期：2014-08-14 00:00:00
abstract：:In this issue of Blood, Goussetis et al identify autophagy as a new pathway for the degradation of the oncoprotein BCR-ABL. They show that the therapeutic drug arsenic trioxide (AS(2)O(3)) targets BCR-ABL for autophagic degradation via a p62/SQSTM1-dependent mechanism that is critical for the antileukemic effect of th...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2012-08-451492
更新日期：2012-10-25 00:00:00
abstract：:Little is known about the molecular mechanisms controlling primitive hematopoietic stem cells, especially during embryogenesis. Homeobox genes encode a family of transcription factors that have gained increasing attention as master regulators of developmental processes and recently have been implicated in the differen...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Immune thrombocytopenia (ITP) is a bleeding disorder in which antibodies and/or T cells lead to enhanced peripheral platelet destruction and reduced bone marrow platelet production. Several reports have observed that ITP is associated with a peripheral deficiency of tolerance-inducing CD4+CD25+FoxP3+ T regulatory cell...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2012-02-413526
更新日期：2012-09-06 00:00:00
abstract：:Val34Leu polymorphism of the A subunit of coagulation factor XIII (FXIII-A) is located in the activation peptide (AP) just 3 amino acids away from the thrombin cleavage site. This mutation has been associated with a protective effect against occlusive arterial diseases and venous thrombosis; however, its biochemical c...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:Bruton tyrosine kinase (Btk) has a well-defined role in B-cell development, whereas its expression in osteoclasts (OCs) further suggests a role in osteoclastogenesis. Here we investigated effects of PCI-32765, an oral and selective Btk inhibitor, on osteoclastogenesis as well as on multiple myeloma (MM) growth within ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-12-396853
更新日期：2012-08-30 00:00:00
abstract：:Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v99.6.2262
更新日期：2002-03-15 00:00:00
abstract：:Peripheral blood mononuclear cells (PBMC) from 17 patients receiving HLA-identical sibling bone marrow grafts were stimulated with host pretransplant PBMC. Cytotoxic T-cell lines (TCL) with specificity for host pretransplant PBMC were obtained from 9 of these patients, all presenting with severe graft-versus-host dise...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1993-04-15 00:00:00
abstract：:Hematopoietic fate maps in the developing mouse embryo remain imprecise. Definitive, adult-type hematopoiesis first appears in the fetal liver, then progresses to the spleen and bone marrow. Clonogenic common lymphoid progenitors and clonogenic common myeloid progenitors (CMPs) in adult mouse bone marrow that give ris...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v98.3.627
更新日期：2001-08-01 00:00:00
abstract：:The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) is the most problematic and costly complication of FVIII replacement therapy that affects up to 30% of previously untreated patients with severe hemophilia A. The development of inhibitors is a multifactorial complication i...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2015-12-685735
更新日期：2016-06-09 00:00:00
abstract：:The phagocyte nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) oxidase was functionally reconstituted in monkey kidney COS-7 cells by transfection of essential subunits, gp91(phox), p22(phox), p47(phox), and p67(phox). COS-7 cells express the essential small guanosine 5'-triphosphatase, Rac1. Transge...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v99.8.2653
更新日期：2002-04-15 00:00:00
abstract：:Sequencing the complete factor IX gene of 2 sisters with hemophilia B with different phenotypes and no family history of hemorrhagic diathesis revealed a common 5' splice site mutation in intron 3 (T6704C) in both and an additional missense mutation (I344T) in one. The presence of dysfunctional antigen in the latter s...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-08-15 00:00:00
abstract：:We have re-evaluated the previously reported ability of TLCK-thrombin (N alpha-tosyl-L-lysine chloromethyl ketone-treated alpha-thrombin) and PPACK-thrombin (D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-treated alpha-thrombin) to inhibit alpha-thrombin-induced platelet activation (Harmon JT, Jamieson GA: J B...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1990-05-15 00:00:00
abstract：:Despite increasing use of targeted therapies to treat cancer, anemia remains a common complication of cancer therapy. Physician concerns about the safety of intravenous (IV) iron products and erythropoiesis-stimulating agents (ESAs) have resulted in many patients with cancer receiving no or suboptimal anemia therapy. ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.2019004017
更新日期：2020-08-13 00:00:00
abstract：:Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population that shares certain characteristics including an aberrant myeloid phenotype and the ability to suppress T cells. MDSCs have been predominantly studied in malignant diseases and findings suggest involvement in tumor-associated immune suppress...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：10.1182/blood-2013-12-546416
更新日期：2014-07-31 00:00:00
abstract：:Recombinant gibbon interleukin-3 (IL-3) is a multilineage hematopoietic colony-stimulating factor (CSF) that recently was cloned and found to be highly homologous with human IL-3. Gibbon IL-3, as well as human granulocyte-CSF (G-CSF) and human granulocyte-macrophage CSF (GM-CSF), stimulated normal human bone marrow ce...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:The subcellular localization of the platelet membrane receptors glycoproteins (GP) Ib and IIb/IIIa [corrected] has been studied within resting platelets by a combination of biochemical and cytochemical techniques. While both GPIb and GPIIb/IIIa are localized within the plasma membrane and surface-connected canalicular...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-02-15 00:00:00
abstract：:Approximately 4% to 5% of all bone marrow (BM) cells and 8% to 9% of low density BM cells from FVB/N and BALB/c mice (Ly-6a haplotype) show high to intermediate expression of Ly-6E.1 antigen, recognized by the Sca-1 antibody. Functional properties of enriched cells expressing Ly-6E.1-allelic form of Sca-1 antigen were...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:Recently, the contractile protein alpha-actinin was identified in normal human platelets by its antigenic cross-reaction with a monospecific antibody to purified muscle alpha-actinin. In this study, we extend that preliminary identification of platelet alpha-actinin. Amino acid analysis, one-dimensional peptide maps, ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:In this issue of Blood, Stepensky et al provide an astute description of immunosenescence arising from deficiency in tripeptidyl peptidase II (TPPII). Senescence of T and B lymphocytes is a striking finding, which has recently come into the limelight because it can be linked to primary immunodeficiency syndromes with ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2014-12-614149
更新日期：2015-01-29 00:00:00
abstract：:Chronic myelogenous leukemia (CML) is characterized by the continuous proliferation and abnormal circulation of malignant hematopoietic progenitors. This may be related to the unresponsiveness of CML progenitors to beta1 integrin adhesion receptor-mediated inhibition of progenitor proliferation by the marrow microenvi...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：:Endogenous cytokines are thought to mediate numerous biologic processes and may account for some adverse effects experienced following the administration of recombinant proteins. This study describes the pattern of endogenous cytokine exposure following high-dose chemotherapy. Blood concentrations of interleukin-6 (IL...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-type (WT) or Mll-AF9 ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-04-281428
更新日期：2012-05-10 00:00:00
abstract：:In haploidentical transplantation, the mismatched haplotype of the donor can originate from either of the parents. We refer to such mismatched haplotypes as noninherited maternal antigens (NIMA haplotype) or noninherited paternal antigens (NIPA haplotype). To determine whether exposure to maternal HLA antigens benefit...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v99.5.1572
更新日期：2002-03-01 00:00:00
abstract：:The aim of this study was to investigate whether interleukin (IL)-6 induces the production of IL-1 and tumor necrosis factor (TNF) antagonists. Serial plasma samples were obtained from cancer patients participating in phase I and II trials of recombinant IL-6 administered as a 120-hour continuous intravenous (IV) infu...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Ubiquitin is suggested to play a key role in essential intracellular functions, such as heat shock response, protein breakdown, and regulation of immune responses. Ubiquitin has also been detected in the extracellular space, but the function and biologic significance is unclear. We describe a new function of extracell...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-03-0918
更新日期：2003-03-01 00:00:00
abstract：:The primate erythrocyte (E) complement receptor, CR1, is a transmembrane glycoprotein located in clusters on the surface of E. In vivo studies have demonstrated that during processing and clearance of complement-opsonized immune complexes, large amounts of immunoglobulin G (IgG) can be bound to primate E via CR1 with ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:Joint bleeding after (sports) trauma, after major joint surgery, or as seen in hemophilia in general leads to arthropathy. Joint degeneration is considered to result from the direct effects of blood components on cartilage and indirectly from synovial inflammation. Blood-provided proinflammatory cytokines trigger chon...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2015-03-635524
更新日期：2015-11-05 00:00:00
abstract：:During mouse cytomegalovirus (CMV) infection, a population of Ly49H(+) natural killer (NK) cells expands and is responsible for disease clearance through the induction of a "memory NK-cell response." Whether similar events occur in human CMV infection is unknown. In the present study, we characterized the kinetics of ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-10-386995
更新日期：2012-03-15 00:00:00
