Abstract:
:In this issue of Blood, Goussetis et al identify autophagy as a new pathway for the degradation of the oncoprotein BCR-ABL. They show that the therapeutic drug arsenic trioxide (AS(2)O(3)) targets BCR-ABL for autophagic degradation via a p62/SQSTM1-dependent mechanism that is critical for the antileukemic effect of the drug.
journal_name
Bloodjournal_title
Bloodauthors
Auberger Pdoi
10.1182/blood-2012-08-451492subject
Has Abstractpub_date
2012-10-25 00:00:00pages
3389-90issue
17eissn
0006-4971issn
1528-0020pii
120/17/3389journal_volume
120pub_type
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