Prognostic value of baseline metabolic tumor volume in early-stage Hodgkin lymphoma in the standard arm of the H10 trial.

abstract：:To elucidate the role of retinoic acid (RA) in anti-CD40 + interleukin-4 (IL-4)-mediated B-cell activation, the effect of 10(-12) to 10(-6) mol/L RA was studied in anti-CD40 (1 microgram/mL) + IL-4 (5 ng/mL)-mediated proliferation and Ig synthesis by human peripheral blood mononuclear cells (PBMC) and B cells in healt...

journal_title：Blood

authors： Worm M,Krah JM,Manz RA,Henz BM

更新日期：1998-09-01 00:00:00

abstract：:Human neutrophil elastase (NE), a 29-Kd potent serine protease stored in azurophilic granules of mature neutrophils, is coded for by the NE gene, a single copy gene with 5 exons spanning a 6-kb segment of chromosome 11 at q14. With the knowledge that the NE gene expression is limited to early myeloid cell differentiat...

journal_title：Blood

authors： Yoshimura K,Crystal RG

更新日期：1992-05-15 00:00:00

abstract：:In this issue of Blood, Bartel and colleagues report the independent predictive value of the PET/CT and of the FDG suppression before transplantation in newly diagnosed myeloma patients who were treated using the TT3 regimen. ...

journal_title：Blood

authors： Dimopoulos MA,Moulopoulos LA,Terpos E

更新日期：2009-09-03 00:00:00

abstract：:We have investigated the clonality of Ph1-negative hemopoietic progenitor cells appearing in long-term marrow cultures established with cells from a mosaic Turner syndrome patient (46,XX/45,X) with Ph1-positive chronic myeloid leukemia (CML). The Ph1-positive clone had been shown previously to have arisen from a cell ...

journal_title：Blood

authors： Dubé ID,Arlin ZA,Kalousek DK,Eaves CJ,Eaves AC

更新日期：1984-12-01 00:00:00

abstract：:The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML). We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a. Here, we confirm miR-30c as a novel...

journal_title：Blood

authors： Katzerke C,Madan V,Gerloff D,Bräuer-Hartmann D,Hartmann JU,Wurm AA,Müller-Tidow C,Schnittger S,Tenen DG,Niederwieser D,Behre G

更新日期：2013-10-03 00:00:00

abstract：:An immunologic and virologic work-up was undertaken in 425 symptom-free multitransfused patients with hemophilias or hemoglobinopathies living in France. Patients were entered into five groups according to the type of blood product they received: local factor VIII, a mixture of local and imported factor VIII, imported...

journal_title：Blood

authors：

更新日期：1985-10-01 00:00:00

abstract：:Genetic variation in the PEAR1 locus is linked to platelet reactivity and cardiovascular disease. The major G allele of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG-SNP), is associated with higher PEAR1 expression in platelets and endothelial cells than the minor A allele. ...

journal_title：Blood

authors： Izzi B,Pistoni M,Cludts K,Akkor P,Lambrechts D,Verfaillie C,Verhamme P,Freson K,Hoylaerts MF

更新日期：2016-08-18 00:00:00

abstract：:Erythropoietin (EPO) and its receptor (EPOR) are critical for definitive erythropoiesis, as mice lacking either gene product die during embryogenesis with severe anemia. Here we demonstrate that mice expressing just one functional allele of the EpoR have lower hematocrits and die more frequently than do wild-type litt...

journal_title：Blood

authors： Jegalian AG,Acurio A,Dranoff G,Wu H

更新日期：2002-04-01 00:00:00

abstract：:Acute myeloid leukemia (AML) may follow a JAK2-positive myeloproliferative neoplasm (MPN), although the mechanisms of disease evolution, often involving loss of mutant JAK2, remain obscure. We studied 16 patients with JAK2-mutant (7 of 16) or JAK2 wild-type (9 of 16) AML after a JAK2-mutant MPN. Primary myelofibrosis ...

journal_title：Blood

authors： Beer PA,Delhommeau F,LeCouédic JP,Dawson MA,Chen E,Bareford D,Kusec R,McMullin MF,Harrison CN,Vannucchi AM,Vainchenker W,Green AR

更新日期：2010-04-08 00:00:00

abstract：:To assess the relationship between venous thrombosis and plasma glucosylceramide (GlcCer) or phosphatidylethanolamine (PE), plasma levels of GlcCer and PE were determined for 70 venous thrombosis patients referred for evaluation and 70 healthy blood donors. The mean GlcCer level, but not the PE level, was lower in pat...

journal_title：Blood

authors： Deguchi H,Fernández JA,Pabinger I,Heit JA,Griffin JH

更新日期：2001-04-01 00:00:00

abstract：:Scott syndrome, a bleeding disorder caused by defective phospholipid scrambling, has been associated with mutations in the TMEM16F gene. The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects. Whereas stimulation...

journal_title：Blood

authors： van Kruchten R,Mattheij NJ,Saunders C,Feijge MA,Swieringa F,Wolfs JL,Collins PW,Heemskerk JW,Bevers EM

更新日期：2013-03-07 00:00:00

abstract：:CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10-MUM1+ with 119 typical CD10+MUM1- FLs. All CD10-MUM1+ FL patients exhibited follicular structure with fol...

journal_title：Blood

authors： Karube K,Guo Y,Suzumiya J,Sugita Y,Nomura Y,Yamamoto K,Shimizu K,Yoshida S,Komatani H,Takeshita M,Kikuchi M,Nakamura N,Takasu O,Arakawa F,Tagawa H,Seto M,Ohshima K

更新日期：2007-04-01 00:00:00

abstract：:In this issue of Blood, Tebas et al report antiviral effects in a clinical trial of multiple infusions of lentiviral vector–modified autologous CD4T lymphocytes in 17 HIV-infected patients aviremic on antiretroviral therapy (ART). ...

journal_title：Blood

authors： Jacobson JM

更新日期：2013-02-28 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction. At the same time, ongoing consumption of platelets and coagulation proteins results in ...

journal_title：Blood

authors： Levi M,Scully M

更新日期：2018-02-22 00:00:00

abstract：:Hemoglobin Great Lakes, beta 68 (E12) Leu replaced by His is a new high oxygen affinity hemoglobin variant discovered in a 29-yr-old female having numerous hospitalizations for thrombophlebitis associated with mild erythrocytosis. The mutant hemoglobin has normal stability and normal electrophoretic mobility, but incr...

journal_title：Blood

authors： Rahbar S,Winkler K,Louis J,Rea C,Blume K,Beutler E

更新日期：1981-10-01 00:00:00

abstract：:Human plasma fibrinogen is produced by liver parenchymal cells. Such molecules contain two classes of gamma-chains (gamma A, gamma'), which differ with respect to their COOH-terminal sequences. When fibrin is crosslinked in the presence of factor XIIIa and Ca2+, three types of gamma-dimer are formed (gamma A-gamma A; ...

journal_title：Blood

authors： Mosesson MW,Homandberg GA,Amrani DL

更新日期：1984-05-01 00:00:00

abstract：:IL-17 and its receptor are founding members of a novel family of inflammatory cytokines. IL-17 plays a pathogenic role in rheumatoid arthritis (RA)-associated bone destruction. However, IL-17 is also an important regulator of host defense through granulopoiesis and neutrophil trafficking. Therefore, the role of IL-17 ...

journal_title：Blood

authors： Yu JJ,Ruddy MJ,Wong GC,Sfintescu C,Baker PJ,Smith JB,Evans RT,Gaffen SL

更新日期：2007-05-01 00:00:00

abstract：:Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct consequence of delayed T-cell recovery. Thymic output can be imp...

journal_title：Blood

authors： Meek B,Cloosen S,Borsotti C,Van Elssen CH,Vanderlocht J,Schnijderberg MC,van der Poel MW,Leewis B,Hesselink R,Manz MG,Katsura Y,Kawamoto H,Germeraad WT,Bos GM

更新日期：2010-01-14 00:00:00

abstract：:Three populations of erythrocytes have been shown by flow cytometric analysis on complement regulatory proteins: CD59 and decay-accelerating factor (DAF) on erythrocytes in paroxysmal nocturnal hemoglobinuria (PNH). CD59 and DAF in PNH may be completely deficient in CD59- and DAF-negative erythrocytes, they may be dec...

journal_title：Blood

authors： Fujioka S,Yamada T

更新日期：1992-04-01 00:00:00

abstract：:We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibr...

journal_title：Blood

authors： Barbui T,Thiele J,Passamonti F,Rumi E,Boveri E,Randi ML,Bertozzi I,Marino F,Vannucchi AM,Pieri L,Rotunno G,Gisslinger H,Gisslinger B,Müllauer L,Finazzi G,Carobbio A,Gianatti A,Ruggeri M,Nichele I,D'Amore E,Rambald

更新日期：2012-03-08 00:00:00

abstract：:Besides regulating leukocyte trafficking in normal and injured tissues, several chemokines may positively or negatively regulate angiogenesis. Here we report that CCL16 activates an angiogenic program in vascular endothelial cells by activating CCR1. CCL16 induces dose-dependent random and directional migration of end...

journal_title：Blood

authors： Strasly M,Doronzo G,Cappello P,Valdembri D,Arese M,Mitola S,Moore P,Alessandri G,Giovarelli M,Bussolino F

更新日期：2004-01-01 00:00:00

abstract：:A study in 121 infants with severe combined immunodeficiency (SCID) was performed to determine the prevalence of an engraftment by transplacentally acquired maternal T cells and to explore clinical and immunological findings related to this abnormality. Each newly diagnosed patient with SCID presenting with circulatin...

journal_title：Blood

authors： Müller SM,Ege M,Pottharst A,Schulz AS,Schwarz K,Friedrich W

更新日期：2001-09-15 00:00:00

abstract：:In patients with common variable immunodeficiency (CVI), we have previously defined a subgroup of patients (CVIHyper) characterized by decreased numbers of CD4+ lymphocytes in peripheral blood, splenomegaly, and persistent immune activation in vivo, particularly of monocytes/macrophages. To further characterize this h...

journal_title：Blood

authors： Aukrust P,Lien E,Kristoffersen AK,Müller F,Haug CJ,Espevik T,Frøland SS

更新日期：1996-01-15 00:00:00

abstract：:To examine the role of the fibrinogen gamma chain in the assembly and secretion of this multichain protein, we synthesized a series of fibrinogen variants with truncated gamma chains, terminating between residues gamma379 and the C-terminus, gamma411. The variant fibrinogens were synthesized from altered gamma-chain c...

journal_title：Blood

authors： Okumura N,Terasawa F,Tanaka H,Hirota M,Ota H,Kitano K,Kiyosawa K,Lord ST

更新日期：2002-05-15 00:00:00

abstract：:CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-...

journal_title：Blood

authors： Wei S,Kryczek I,Zou W

更新日期：2006-07-15 00:00:00

abstract：:Overexpression of BAALC is an adverse prognostic factor in adults with cytogenetically normal acute myeloid leukemia and T-cell acute lymphoblastic leukemia (ALL). Here, we analyzed the prognostic significance of BAALC in B-precursor ALL. BAALC MRNA expression was determined in 368 primary adult B-precursor ALL patien...

journal_title：Blood

authors： Kühnl A,Gökbuget N,Stroux A,Burmeister T,Neumann M,Heesch S,Haferlach T,Hoelzer D,Hofmann WK,Thiel E,Baldus CD

更新日期：2010-05-06 00:00:00

abstract：:Identification of receptor activator of nuclear factor-kappaB (RANK) and RANK-ligand (RANKL) has provided new insights into the osteoclast differentiation pathway. Osteoclast precursor cells were isolated using monoclonal antibodies against c-Fms and RANK, and the effect of adherence on the in vitro differentiation an...

journal_title：Blood

authors： Miyamoto T,Arai F,Ohneda O,Takagi K,Anderson DM,Suda T

更新日期：2000-12-15 00:00:00

abstract：:The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/p...

journal_title：Blood

authors： Dos Santos C,McDonald T,Ho YW,Liu H,Lin A,Forman SJ,Kuo YH,Bhatia R

更新日期：2013-09-12 00:00:00

abstract：:The calcium, sodium, and magnesium permeability of erythrocytes from blood stored at 4 degrees C in various anticoagulant media has been studied and compared to that of fresh erythrocytes. Passive influx of CA2+ was measured at 37 degrees C in cells pretreated to abolish Ca2+ pumping and was up to fivefold greater for...

journal_title：Blood

authors： Wiley JS,McCulloch KE,Bowden DS

更新日期：1982-07-01 00:00:00

abstract：:GATA family proteins play essential roles in development of many cell types, including hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3, are essential for normal hematopoiesis, and their mutations are responsible for a variety of blood disorders. Acquired and inherited GATA1 ...

journal_title：Blood

authors： Crispino JD,Horwitz MS

更新日期：2017-04-13 00:00:00