Transplacentally acquired maternal T lymphocytes in severe combined immunodeficiency: a study of 121 patients.

abstract：:CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally active adenovirus ve...

journal_title：Blood

authors： Tatsis N,Fitzgerald JC,Reyes-Sandoval A,Harris-McCoy KC,Hensley SE,Zhou D,Lin SW,Bian A,Xiang ZQ,Iparraguirre A,Lopez-Camacho C,Wherry EJ,Ertl HC

更新日期：2007-09-15 00:00:00

abstract：:Approximately 20% of childhood B-precursor acute lymphoblastic leukemia (ALL) has a TEL-AML1 fusion gene, often in association with deletions of the nonrearranged TEL allele. TEL-AML1 gene fusion appears to be an initiating event and usually occurs before birth, in utero. This subgroup of ALL generally presents with l...

journal_title：Blood

authors： Ford AM,Fasching K,Panzer-Grümayer ER,Koenig M,Haas OA,Greaves MF

更新日期：2001-08-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, intercellular adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration. An important unanswered question is whether ICAM-1-activated signal...

journal_title：Blood

authors： Liu G,Place AT,Chen Z,Brovkovych VM,Vogel SM,Muller WA,Skidgel RA,Malik AB,Minshall RD

更新日期：2012-08-30 00:00:00

abstract：:We have previously shown that G-CSF-deficient (G-CSF(-/-)) mice are markedly protected from collagen-induced arthritis (CIA), which is the major murine model of rheumatoid arthritis, and now investigate the mechanisms by which G-CSF can promote inflammatory disease. Serum G-CSF levels were significantly elevated durin...

journal_title：Blood

authors： Eyles JL,Hickey MJ,Norman MU,Croker BA,Roberts AW,Drake SF,James WG,Metcalf D,Campbell IK,Wicks IP

更新日期：2008-12-15 00:00:00

abstract：:To characterize juvenile chronic myelogenous leukemia (JCML), the proliferative properties of bone marrow (BM) and peripheral blood (PB) cells from nine patients were studied using assays for CFU-C and CFU-GEMM and liquid cultures. All specimens showed two reproducible abnormalities: impaired growth of normal hematopo...

journal_title：Blood

authors： Estrov Z,Grunberger T,Chan HS,Freedman MH

更新日期：1986-05-01 00:00:00

abstract：:Type 3 von Willebrand disease (VWD) is a severe hemorrhagic defect in humans. We now identify the homozygous mutation in the Chapel Hill strain of canine type 3 VWD that results in premature termination of von Willebrand factor (VWF) protein synthesis. We cultured endothelium from VWD and normal dogs to study intracel...

journal_title：Blood

authors： Haberichter SL,Merricks EP,Fahs SA,Christopherson PA,Nichols TC,Montgomery RR

更新日期：2005-01-01 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong p...

journal_title：Blood

authors： Stoppa-Lyonnet D,Soulier J,Laugé A,Dastot H,Garand R,Sigaux F,Stern MH

更新日期：1998-05-15 00:00:00

abstract：:In vitro models of granulopoiesis involving the inducible expression of either CCAAT enhancer binding protein alpha (C/EBP alpha) or C/EBP epsilon in myeloid cells have been shown to lead to the induction of a granulocytic maturation program accompanied by the expression of myeloid-specific genes. Since members of the...

journal_title：Blood

authors： Khanna-Gupta A,Zibello T,Sun H,Gaines P,Berliner N

更新日期：2003-05-01 00:00:00

abstract：:The mechanisms underlying granulocyte-colony stimulating factor (G-CSF)-induced mobilization of granulocytic lineage cells from the bone marrow to the peripheral blood remain elusive. We provide evidence that the transcriptional repressor growth factor independence-1 (Gfi-1) is involved in G-CSF-induced mobilization o...

journal_title：Blood

authors： De La Luz Sierra M,Gasperini P,McCormick PJ,Zhu J,Tosato G

更新日期：2007-10-01 00:00:00

abstract：:Chronic myelomonocytic leukemia (CMML) is a hematological malignancy characterized by uncontrolled proliferation of dysplastic myelomonocytes and frequent progression to acute myeloid leukemia (AML). We identified mutations in the Cbl gene, which encodes a negative regulator of cytokine signaling, in a subset of CMML ...

journal_title：Blood

authors： Nakata Y,Ueda T,Nagamachi A,Yamasaki N,Ikeda KI,Sera Y,Takubo K,Kanai A,Oda H,Sanada M,Ogawa S,Tsuji K,Ebihara Y,Wolff L,Honda ZI,Suda T,Inaba T,Honda H

更新日期：2017-04-13 00:00:00

abstract：:Hypoxia is a strong stimulus for the transcription of a set of genes, including erythropoietin and vascular endothelial growth factor. Here we report on the cloning, functional significance, and expression of a complementary DNA (cDNA) that is involved in hypoxia-mediated expression of these 2 genes. The full-length c...

journal_title：Blood

authors： Gupta M,Mungai PT,Goldwasser E

更新日期：2000-07-15 00:00:00

abstract：:In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve mixed hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning or immunosuppression. The primary limitation to the clinical application of IUHSCTx has been minimal donor cell engraftment, well below therapeutic levels...

journal_title：Blood

authors： Hayashi S,Peranteau WH,Shaaban AF,Flake AW

更新日期：2002-08-01 00:00:00

abstract：:In this issue of Blood, Finn et al have taken a factor IX variant with increased specific activity associated with thrombophilia and used it to improve gene therapy of hemophilia B in dogs, and Cantore et al have shown similar results in mice. ...

journal_title：Blood

authors： Lozier JN

更新日期：2012-11-29 00:00:00

abstract：:Twenty four samples of DNA from 23 unrelated individuals were analyzed for the presence of a novel restriction fragment length polymorphism (RFLP) involving the proto-oncogene ETS-1 at an Xba I site. Four samples from unrelated individuals lacked an Xba I site, giving rise to a longer restriction fragment detectable b...

journal_title：Blood

authors： Savage PD,Hanson CA,Kersey JH

更新日期：1987-07-01 00:00:00

abstract：:BCL3 encodes a protein with close homology to IkappaB proteins and interacts with p50 NF-kappaB homodimers. However, the regulation and transcriptional activity of BCL3 remain ill-defined. We observed here that interleukin-9 (IL-9) and IL-4, but not IL-2 or IL-3, transcriptionally upregulated BCL3 expression in T cell...

journal_title：Blood

authors： Richard M,Louahed J,Demoulin JB,Renauld JC

更新日期：1999-06-15 00:00:00

abstract：:The production of interleukin-1beta (IL-1beta), a powerful mediator of inflammation, is tightly regulated at several levels. However, in some pathologic conditions, a pharmacologic treatment is required to control the toxicity of excessive extracellular IL-1beta. Because of the heavy side effects of most therapies use...

journal_title：Blood

authors： Hamon Y,Luciani MF,Becq F,Verrier B,Rubartelli A,Chimini G

更新日期：1997-10-15 00:00:00

abstract：:The malaria parasite Plasmodium falciparum releases the ring-infected erythrocyte surface antigen (RESA) inside the red cell on entry. The protein migrates to the host cell membrane, where it binds to spectrin, but neither the nature of the interaction nor its functional consequences have previously been defined. Here...

journal_title：Blood

authors： Pei X,Guo X,Coppel R,Bhattacharjee S,Haldar K,Gratzer W,Mohandas N,An X

更新日期：2007-08-01 00:00:00

abstract：:Skewed X-chromosome inactivation in peripheral blood granulocytes becomes more frequent with increasing age, affecting up to half of those over 75 years old. To investigate the mechanisms underlying this phenomenon, X-inactivation profiles in 33 monozygotic and 22 dizygotic elderly twin pairs were studied. Differentia...

journal_title：Blood

authors： Vickers MA,McLeod E,Spector TD,Wilson IJ

更新日期：2001-03-01 00:00:00

abstract：:Several signaling cascades are engaged by expression of the p210 bcr-abl tyrosine kinase, and evidence suggests that these signals drive leukemogenesis. In this report, signaling pathways were examined and compared between cells derived from leukemic patients and cells expressing a bcr-abl construct (MBA). The effects...

journal_title：Blood

authors： Donato NJ,Wu JY,Zhang L,Kantarjian H,Talpaz M

更新日期：2001-05-01 00:00:00

abstract：:Dexamethasone (DM) is a synthetic member of the glucocorticoid (GC) class of hormones that possesses anti-inflammatory and immunosuppressant activity and is commonly used to treat chronic inflammatory disorders, severe allergies, and other disease states. Although GCs are known to mediate well-defined transcriptional ...

journal_title：Blood

authors： Ghosh MC,Baatar D,Collins G,Carter A,Indig F,Biragyn A,Taub DD

更新日期：2009-01-15 00:00:00

abstract：:The ob gene product, leptin, has been shown in several studies to be involved in weight control and recombinant leptin recently has entered clinical trials to treat obesity. The leptin receptor (OB-R/B219) is expressed in a variety of protein isoforms not only in the central nervous system, but also in reproductive, a...

journal_title：Blood

authors： Mikhail AA,Beck EX,Shafer A,Barut B,Gbur JS,Zupancic TJ,Schweitzer AC,Cioffi JA,Lacaud G,Ouyang B,Keller G,Snodgrass HR

更新日期：1997-03-01 00:00:00

abstract：:We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet generation were recor...

journal_title：Blood

authors： Di Buduo CA,Wray LS,Tozzi L,Malara A,Chen Y,Ghezzi CE,Smoot D,Sfara C,Antonelli A,Spedden E,Bruni G,Staii C,De Marco L,Magnani M,Kaplan DL,Balduini A

更新日期：2015-04-02 00:00:00

abstract：:Recently, the term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney disease from those that are benign. By definition, patients with MGRS have B-cell clones that do not meet the definition of multiple myeloma or lymphoma. ...

journal_title：Blood

authors： Fermand JP,Bridoux F,Kyle RA,Kastritis E,Weiss BM,Cook MA,Drayson MT,Dispenzieri A,Leung N,International Kidney and Monoclonal Gammopathy Research Group.

更新日期：2013-11-21 00:00:00

abstract：:Fluid shear stress in arteries and arterioles partially obstructed by atherosclerosis or spasm may exceed the normal time-average level of 20 dyne/cm2. In vitro, at fluid shear stresses of 30 to 60 dyne/cm2 applied for 30 seconds, platelet aggregation occurs. At these shear stresses, either large or unusually large vo...

journal_title：Blood

authors： Moake JL,Turner NA,Stathopoulos NA,Nolasco L,Hellums JD

更新日期：1988-05-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor. We hypothesized that having a higher mtDNA copy number in peripheral white blood ce...

journal_title：Blood

authors： Lan Q,Lim U,Liu CS,Weinstein SJ,Chanock S,Bonner MR,Virtamo J,Albanes D,Rothman N

更新日期：2008-11-15 00:00:00

abstract：:Human subjects maintain long-term immunologic memory against infective organisms but the mechanism is unclear. CD4+ T-helper memory (Thmem) cells are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of protective immunity. To prob...

journal_title：Blood

authors： Di Genova G,Roddick J,McNicholl F,Stevenson FK

更新日期：2006-04-01 00:00:00

abstract：:Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding to its cognate receptor, EPO promotes receptor homodimerization, activation of receptor-associated JAK2, subs...

journal_title：Blood

authors： Beckman DL,Lin LL,Quinones ME,Longmore GD

更新日期：1999-10-15 00:00:00

abstract：:Although double umbilical cord blood transplantation (dUCBT) in adult patients may be associated with less graft failure compared with single UCBT, hematopoietic recovery generally originates from a single cord blood unit (CBU). CBU predominance is still incompletely understood. We recently showed that blood CD4+ T-ce...

journal_title：Blood

authors： Lamers CH,Wijers R,van Bergen CA,Somers JA,Braakman E,Gratama JW,Debets R,Falkenburg JH,Cornelissen JJ

更新日期：2016-10-27 00:00:00

abstract：:Identification of the 25 known human blood group molecules is of fundamental importance for the fields of erythroid cell biology and transfusion medicine. Here we provide the first molecular description of the "Dombrock" blood group system. A candidate gene was identified by in silico analyses of approximately 5000 ex...

journal_title：Blood

authors： Gubin AN,Njoroge JM,Wojda U,Pack SD,Rios M,Reid ME,Miller JL

更新日期：2000-10-01 00:00:00

abstract：:Calreticulin mutations (CALR(MUT)) are found in a significant proportion of patients with essential thrombocythemia (ET) lacking JAK2(V617F) or MPL mutations. They are associated with substantially different hematological and clinical features and define a distinct subtype of ET. We show here that their presence is si...

journal_title：Blood

authors： Allen C,Lambert JR,Linch DC,Gale RE

更新日期：2014-09-25 00:00:00