Longer in vivo survival of CD59- and decay-accelerating factor-almost normal positive and partly positive erythrocytes in paroxysmal nocturnal hemoglobinuria as compared with negative erythrocytes: a demonstration by differential centrifugation and flow c

abstract：:Malignant cells from 52 children with acute lymphocytic leukemia (ALL) were investigated for inactivation of the p15ink4B and p16ink4 genes and other genetic alterations on chromosome 9p21. Homozygous deletions of the p15ink4B and/or the p16ink4 genes were detected in 16 cases and a further 9 cases showed evidence of ...

journal_title：Blood

authors： Rasool O,Heyman M,Brandter LB,Liu Y,Grandér D,Söderhäll S,Einhorn S

更新日期：1995-06-15 00:00:00

abstract：:Combined deficiency of ankyrin and spectrin represents the most common biochemical abnormality in hereditary spherocytosis (HS). To examine whether a decrease in ankyrin mRNA represents a frequent cause of this type of HS, we took advantage of the reported (AC)n microsatellite polymorphism in the 3' untranslated regio...

journal_title：Blood

authors： Jarolim P,Rubin HL,Brabec V,Palek J

更新日期：1995-06-01 00:00:00

abstract：:The current study presents evidence that all human serum contains a class of high-affinity folate binders (KA=2.8 X10(10 liters/mole), which migrate as a single peak on gel filtration. Failure of previous studies to detect this characteristic in all but a minority of subjects is attributable to its variable, often tot...

journal_title：Blood

authors： Colman N,Herbert V

更新日期：1976-12-01 00:00:00

abstract：:Although CD4(+)CD25(+) T cells (T regulatory cells [Tregs]) and natural killer T cells (NKT cells) each protect against graft-versus-host disease (GVHD), interactions between these 2 regulatory cell populations after allogeneic bone marrow transplantation (BMT) have not been studied. We show that host NKT cells can in...

journal_title：Blood

authors： Pillai AB,George TI,Dutt S,Strober S

更新日期：2009-04-30 00:00:00

abstract：:Custom-made monoclonal anti-idiotype antibodies (anti-Id MoAbs) have been tested as a treatment modality in 34 non-Hodgkin's lymphoma (NHL) patients. Partial or complete tumor remissions have been induced with this treatment in 68% of these patients. One mechanism by which anti-idiotype antibodies may have induced the...

journal_title：Blood

authors： Vuist WM,Levy R,Maloney DG

更新日期：1994-02-15 00:00:00

abstract：:The level of expression of the enzyme thiopurine methyltransferase (TPMT) is an important determinant of the metabolism of thiopurines used in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Studies in red blood cells (RBC) have shown that TPMT expression displays genetic polymorp...

journal_title：Blood

authors： Coulthard SA,Howell C,Robson J,Hall AG

更新日期：1998-10-15 00:00:00

abstract：:Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in intracellular glutamine catabolism involves its conversion to glutamate by glutaminase (GA). Different GA isoforms are encoded by the genes GLS1 and GLS2 in humans. Herein, we show that glutamine levels control mitochondri...

journal_title：Blood

authors： Jacque N,Ronchetti AM,Larrue C,Meunier G,Birsen R,Willems L,Saland E,Decroocq J,Maciel TT,Lambert M,Poulain L,Hospital MA,Sujobert P,Joseph L,Chapuis N,Lacombe C,Moura IC,Demo S,Sarry JE,Recher C,Mayeux P,Tambur

更新日期：2015-09-10 00:00:00

abstract：:A large English pedigree in which heterocellular hereditary persistence of fetal hemoglobin (HPFH) segregates is described. beta-globin cluster deletions and gamma gene promoter mutations associated with HPFH have been excluded. Of particular importance in this pedigree is the absence of any cosegregating hemoglobinop...

journal_title：Blood

authors： Craig JE,Rochette J,Sampietro M,Wilkie AO,Barnetson R,Hatton CS,Demenais F,Thein SL

更新日期：1997-07-01 00:00:00

abstract：:Serum response factor (SRF) is a ubiquitously expressed transcription factor and master regulator of the actin cytoskeleton. We have previously shown that SRF is essential for megakaryocyte maturation and platelet formation and function. Here we elucidate the role of SRF in neutrophils, the primary defense against inf...

journal_title：Blood

authors： Taylor A,Tang W,Bruscia EM,Zhang PX,Lin A,Gaines P,Wu D,Halene S

更新日期：2014-05-08 00:00:00

abstract：:It has previously been shown that human granulocyte-macrophage colony-stimulating factor (GM-CSF) can be fused to a truncated diphtheria toxin (DT) to produce a recombinant fusion toxin that kills GM-CSF receptor-bearing cells. We now report that DT388-GM-CSF induces apoptosis and inhibition of colony formation in sem...

journal_title：Blood

authors： Frankel AE,Hall PD,Burbage C,Vesely J,Willingham M,Bhalla K,Kreitman RJ

更新日期：1997-11-01 00:00:00

abstract：:We tested the hypothesis that the antibody response to human factor IX in mice is controlled by genetic factors, especially histocompatibility antigens. Seven inbred mouse strains were immunized against human factor IX by adenoviral gene transfer or serial injections of human factor IX protein. A/J mice had the highes...

journal_title：Blood

authors： Lozier JN,Tayebi N,Zhang P

更新日期：2005-02-01 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong p...

journal_title：Blood

authors： Stoppa-Lyonnet D,Soulier J,Laugé A,Dastot H,Garand R,Sigaux F,Stern MH

更新日期：1998-05-15 00:00:00

abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...

journal_title：Blood

authors： Marr KA,Crippa F,Leisenring W,Hoyle M,Boeckh M,Balajee SA,Nichols WG,Musher B,Corey L

更新日期：2004-02-15 00:00:00

abstract：:Erythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes. After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression. Although erythroid progenitors appear to be the princ...

journal_title：Blood

authors： Gaffen SL,Lai SY,Longmore GD,Liu KD,Goldsmith MA

更新日期：1999-07-01 00:00:00

abstract：:Endogenous cytokines are thought to mediate numerous biologic processes and may account for some adverse effects experienced following the administration of recombinant proteins. This study describes the pattern of endogenous cytokine exposure following high-dose chemotherapy. Blood concentrations of interleukin-6 (IL...

journal_title：Blood

authors： Rabinowitz J,Petros WP,Stuart AR,Peters WP

更新日期：1993-05-01 00:00:00

abstract：:Platelets originate from megakaryocytes (MKs) by cytoplasmic elongation into proplatelets. Direct platelet release is not seen in bone marrow hematopoietic islands. It was suggested that proplatelet fragmentation into platelets can occur intravascularly, yet evidence of its dependence on hydrodynamic forces is missing...

journal_title：Blood

authors： Dunois-Lardé C,Capron C,Fichelson S,Bauer T,Cramer-Bordé E,Baruch D

更新日期：2009-08-27 00:00:00

abstract：:The paradoxical correlation between thrombosis and the lupus anticoagulant (LAC) effect is an enigmatic feature of the antiphospholipid (aPL) syndrome. The Dutch authors previously reported that thrombosis-related anti-beta2-glycoprotein I (beta2GPI) antibodies recognize domain I and cause LAC. The American authors re...

journal_title：Blood

authors： de Laat B,Wu XX,van Lummel M,Derksen RH,de Groot PG,Rand JH

更新日期：2007-02-15 00:00:00

abstract：:We previously showed the presence of receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) on tumor tissues and tumor cell lines that are derived from the neural crest. To determine whether normal neural cells express functional GM-CSF receptors, we isolated and analyzed primary rat brain cells, incl...

journal_title：Blood

authors： Baldwin GC,Benveniste EN,Chung GY,Gasson JC,Golde DW

更新日期：1993-12-01 00:00:00

abstract：:Fetal hemoglobin (HbF) induction can ameliorate the clinical severity of sickle cell disease and β-thalassemia. We previously reported that activation of the eukaryotic initiation factor 2α (eIF2α) stress pathway increased HbF through a posttranscriptional mechanism. In this study, we explored the underlying means by ...

journal_title：Blood

authors： Hahn CK,Lowrey CH

更新日期：2014-10-23 00:00:00

abstract：:It has been reported that the intracellular antiapoptotic factor myeloid cell leukemia sequence 1 (Mcl-1) is required for mast cell survival in vitro, and that genetic manipulation of Mcl-1 can be used to delete individual hematopoietic cell populations in vivo. In the present study, we report the generation of C57BL/...

journal_title：Blood

authors： Lilla JN,Chen CC,Mukai K,BenBarak MJ,Franco CB,Kalesnikoff J,Yu M,Tsai M,Piliponsky AM,Galli SJ

更新日期：2011-12-22 00:00:00

abstract：:Although infants with acute lymphoblastic leukemia (ALL) and a germline MLL gene have a better prognosis than comparable infants with a rearranged MLL gene, their optimal therapy is controversial. In 2 consecutive studies, conducted between 1996 and 2002, we treated 22 cases of infant ALL with germline MLL using chemo...

journal_title：Blood

authors： Nagayama J,Tomizawa D,Koh K,Nagatoshi Y,Hotta N,Kishimoto T,Takahashi Y,Kuno T,Sugita K,Sato T,Kato K,Ogawa A,Nakahata T,Mizutani S,Horibe K,Ishii E,Japan Infant Leukemia Study Group.

更新日期：2006-06-15 00:00:00

abstract：:Imatinib has revolutionized drug therapy of chronic myeloid leukemia (CML). Preclinical studies were promising but the results of clinical trials by far exceeded expectations. Responses in chronic phase are unprecedented, with rates of complete cytogenetic response (CCR) of more than 40% in patients after failure of i...

journal_title：Blood

authors： Deininger M,Buchdunger E,Druker BJ

更新日期：2005-04-01 00:00:00

abstract：:The genes for the hemopoietic growth factors, GM colony-stimulating factor (CSF) and G-CSF have been cloned, and recombinant material is available for both. We tested these recombinant factors for their effects on the blast cells of acute myeloblastic leukemia (AML). Culture methods are available that support both col...

journal_title：Blood

authors： Kelleher C,Miyauchi J,Wong G,Clark S,Minden MD,McCulloch EA

更新日期：1987-05-01 00:00:00

abstract：:We have shown that human B-cell non-Hodgkin lymphomas (B-NHLs) express heat shock protein (HSP)H1/105 in function of their aggressiveness. Here, we now clarify its role as a functional B-NHL target by testing the hypothesis that it promotes the stabilization of key lymphoma oncoproteins. HSPH1 silencing in 4 models of...

journal_title：Blood

authors： Zappasodi R,Ruggiero G,Guarnotta C,Tortoreto M,Tringali C,Cavanè A,Cabras AD,Castagnoli L,Venerando B,Zaffaroni N,Gianni AM,De Braud F,Tripodo C,Pupa SM,Di Nicola M

更新日期：2015-03-12 00:00:00

abstract：:The molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome is the presence of a mutation in the iron-responsive element (IRE) of the L ferritin gene, located on chromosome 19q13.3-13.4. Two mutations have been reported so far, altering adjacent nucleotides in the IRE loop, in a regio...

journal_title：Blood

authors： Martin ME,Fargion S,Brissot P,Pellat B,Beaumont C

更新日期：1998-01-01 00:00:00

abstract：:We studied the efficiency of indirect tumor cell purging via enrichment of CD34+ hematopoietic progenitor cells from leukapheresis products (LP) in breast cancer patients based on immunomagnetic selection of CD34+ cells. Detection of tumor cells was made by immunocytochemical staining. In addition, we evaluated the ca...

journal_title：Blood

authors： Mapara MY,Körner IJ,Hildebrandt M,Bargou R,Krahl D,Reichardt P,Dörken B

更新日期：1997-01-01 00:00:00

abstract：:Interleukin-2 (IL-2) and IL-15 exert similar biological actions, which largely reflect the fact that their receptors share common beta and gamma subunits; in contrast, distinct subunits are required for high-affinity binding of either cytokine to a heterotrimeric receptor complex. Human neutrophils are known to expres...

journal_title：Blood

authors： McDonald PP,Russo MP,Ferrini S,Cassatella MA

更新日期：1998-12-15 00:00:00

abstract：:In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial ...

journal_title：Blood

authors： Ertault-Daneshpouy M,Leboeuf C,Lemann M,Bouhidel F,Ades L,Gluckman E,Socié G,Janin A

更新日期：2004-06-15 00:00:00

abstract：:The JAK2 V617F mutation is present in the majority of patients with a myeloproliferative neoplasm (MPN) and is sufficient to recapitulate an MPN in murine models. However, the consequences of JAK2 mutations for myeloid differentiation are poorly understood. After systematic analyses of a large cohort of JAK2-mutated M...

journal_title：Blood

authors： Anand S,Stedham F,Beer P,Gudgin E,Ortmann CA,Bench A,Erber W,Green AR,Huntly BJ

更新日期：2011-07-07 00:00:00

abstract：:We have developed an in vitro clonal assay of murine hematopoietic precursor cells that form spleen colonies (CFU-S day 12) or produce in vitro clonable progenitors in the marrow (MRA cells) of lethally irradiated mice. The assay is essentially a long-term bone marrow culture in microtiter wells containing marrow-deri...

journal_title：Blood

authors： Ploemacher RE,van der Sluijs JP,van Beurden CA,Baert MR,Chan PL

更新日期：1991-11-15 00:00:00