Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency--possible immunologic and clinical consequences.

abstract：:Human subjects maintain long-term immunologic memory against infective organisms but the mechanism is unclear. CD4+ T-helper memory (Thmem) cells are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of protective immunity. To prob...

journal_title：Blood

authors： Di Genova G,Roddick J,McNicholl F,Stevenson FK

更新日期：2006-04-01 00:00:00

abstract：:Although infants with acute lymphoblastic leukemia (ALL) and a germline MLL gene have a better prognosis than comparable infants with a rearranged MLL gene, their optimal therapy is controversial. In 2 consecutive studies, conducted between 1996 and 2002, we treated 22 cases of infant ALL with germline MLL using chemo...

journal_title：Blood

authors： Nagayama J,Tomizawa D,Koh K,Nagatoshi Y,Hotta N,Kishimoto T,Takahashi Y,Kuno T,Sugita K,Sato T,Kato K,Ogawa A,Nakahata T,Mizutani S,Horibe K,Ishii E,Japan Infant Leukemia Study Group.

更新日期：2006-06-15 00:00:00

abstract：:Recent studies have shown a discrepancy between the level of tissue factor (TF) expression and the level of TF procoagulant activity on the apical and basolateral surface domains of polarized epithelial cells. The present investigation was performed to elucidate possible reasons for the discordant expression of TF and...

journal_title：Blood

authors： Hansen CB,van Deurs B,Petersen LC,Rao LV

更新日期：1999-09-01 00:00:00

abstract：:The proapoptotic function of p53 is thought to underlie most anticancer modalities and is also activated in response to oncogenic insults, such as overexpression of the Myc oncoprotein. Here we generated tractable B lymphomas using retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in al...

journal_title：Blood

authors： Yu D,Carroll M,Thomas-Tikhonenko A

更新日期：2007-06-01 00:00:00

abstract：:Incubation of human mononuclear leukocytes (MNL) with human stroma-free hemolysate (SFH), purified adult hemoglobin Ao (HbAo), and oxidized HbAo (METHb) caused MNL to release compounds into the supernate that mediated neutrophil (polymorphonuclear leukocytes, PMN) chemotaxis and PMN adherence to human umbilical vein e...

journal_title：Blood

authors： McFaul SJ,Bowman PD,Villa VM,Gutierrez-Ibanez MJ,Johnson M,Smith D

更新日期：1994-11-01 00:00:00

abstract：:The association of fibrinogen with washed human platelets was examined by immunocytochemistry during aggregation induced by adenosine diphosphate (ADP) and during deaggregation. The platelets were suspended either in a medium containing 2 mmol/L Ca2+ or in a medium containing no added Ca2+ (20 mumol/L Ca2+). Platelets...

journal_title：Blood

authors： Suzuki H,Kinlough-Rathbone RL,Packham MA,Tanoue K,Yamazaki H,Mustard JF

更新日期：1988-04-01 00:00:00

abstract：:Approximately 60% of patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL) are curable with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemoimmunotherapy. Epratuzumab (E) is an unlabeled anti-CD22 monoclonal antibody with efficacy in relapsed DLBCL. This phase 2 trial te...

journal_title：Blood

authors： Micallef IN,Maurer MJ,Wiseman GA,Nikcevich DA,Kurtin PJ,Cannon MW,Perez DG,Soori GS,Link BK,Habermann TM,Witzig TE

更新日期：2011-10-13 00:00:00

abstract：:The number of cells transplanted and their capacity to induce graft-versus-host reactivity (GvHR) are two factors that are suspected to influence the engraftment of allogeneic bone marrow. We have investigated their impact on graft rejection rates in busulfan-treated LEW rats. In a series of experiments, we varied (1)...

journal_title：Blood

authors： Uharek L,Gassmann W,Glass B,Steinmann J,Loeffler H,Mueller-Ruchholtz W

更新日期：1992-03-15 00:00:00

abstract：:For this study, 118 children with standard-risk acute lymphoblastic leukemia (ALL) were given randomized assignments to receive native or pegylated Escherichia coli asparaginase as part of induction and 2 delayed intensification phases. Patients treated with pegaspargase had more rapid clearance of lymphoblasts from d...

journal_title：Blood

authors： Avramis VI,Sencer S,Periclou AP,Sather H,Bostrom BC,Cohen LJ,Ettinger AG,Ettinger LJ,Franklin J,Gaynon PS,Hilden JM,Lange B,Majlessipour F,Mathew P,Needle M,Neglia J,Reaman G,Holcenberg JS,Stork L

更新日期：2002-03-15 00:00:00

abstract：:Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose p...

journal_title：Blood

authors： Bachireddy P,Hainz U,Rooney M,Pozdnyakova O,Aldridge J,Zhang W,Liao X,Hodi FS,O'Connell K,Haining WN,Goldstein NR,Canning CM,Soiffer RJ,Ritz J,Hacohen N,Alyea EP 3rd,Kim HT,Wu CJ

更新日期：2014-02-27 00:00:00

abstract：:The biochemical basis for complement acting directly on antigen-presenting cells to enhance their function in T-cell stimulation has been unclear. Here we present evidence that engagement of C3a receptor (C3aR) on the surface of dendritic cells (DCs) leads to alterations in the level of intracellular cyclic adenosine ...

journal_title：Blood

authors： Li K,Anderson KJ,Peng Q,Noble A,Lu B,Kelly AP,Wang N,Sacks SH,Zhou W

更新日期：2008-12-15 00:00:00

abstract：:We have studied adenovirus-mediated cytotoxicity after infection of malignant cells obtained from patients with chronic lymphocytic leukemia (CLL). Our studies indicate that adenoviruses can infect primary CLL cells and that infection of CLL cells with a replication-competent strain of human adenovirus 5 (Ad5dl309) re...

journal_title：Blood

authors： Medina DJ,Sheay W,Goodell L,Kidd P,White E,Rabson AB,Strair RK

更新日期：1999-11-15 00:00:00

abstract：:Quantitative studies of bone marrow neutrophil pool sizes and production rates and of blood neutrophil kinetics were performed in 16 patients with chronic neutropenia without splenomegaly. Marrow netrophil cellularity was determined from a ferrokinetic estimate of marrow normoblasts and from neutrophil-erythroid ratio...

journal_title：Blood

authors： Price TH,Lee MY,Dale DC,Finch CA

更新日期：1979-09-01 00:00:00

abstract：:In this issue of Blood, Finn et al have taken a factor IX variant with increased specific activity associated with thrombophilia and used it to improve gene therapy of hemophilia B in dogs, and Cantore et al have shown similar results in mice. ...

journal_title：Blood

authors： Lozier JN

更新日期：2012-11-29 00:00:00

abstract：:Maintaining a steady pool of self-renewing hematopoietic stem cells (HSCs) is critical for sustained production of multiple blood lineages. Many transcription factors and molecules involved in chromatin and epigenetic modifications have been found to be critical for HSC self-renewal and differentiation; however, their...

journal_title：Blood

authors： Yu S,Cui K,Jothi R,Zhao DM,Jing X,Zhao K,Xue HH

更新日期：2011-02-17 00:00:00

abstract：:The white-spotting (Ws) locus of rats represents a 12-base deletion of the c-kit receptor tyrosine kinase. Homozygous Ws/Ws rats are deficient in melanocytes, mast cells, and erythrocytes. Although mice possessing two mutant alleles at the c-kit (W) locus, such as mice of W/Wv genotype, show severe anemia even in adul...

journal_title：Blood

authors： Morimoto M,Kasugai T,Tei H,Jippo-Kanemoto T,Kanakura Y,Kitamura Y

更新日期：1993-12-01 00:00:00

abstract：:The anti-CD20 monoclonal antibody (mAb) rituximab has revolutionized the treatment of B-cell malignancies. This unprecedented success has not only substantially changed the mindset of the clinical community about the ability of mAb to improve outcomes but has catalyzed the interest in the pharmaceutical industry to de...

journal_title：Blood

authors： Alduaij W,Illidge TM

更新日期：2011-03-17 00:00:00

abstract：:The bcr-abl chimeric messenger RNA is frequently detected in chronic myeloid leukemia (CML) patients after bone marrow transplantation. It was previously reported that the relapse risk of bcr-abl detection 6 to 12 months after transplantation was greater than 40%. This risk decreased as the time between transplantatio...

journal_title：Blood

authors： Radich JP,Gooley T,Bryant E,Chauncey T,Clift R,Beppu L,Edmands S,Flowers ME,Kerkof K,Nelson R,Appelbaum FR

更新日期：2001-09-15 00:00:00

abstract：:In this issue of Blood, Bachanova et al describe how modulation of the inhibitory tumor environment may enhance natural killer (NK) cell clinical activity and produce encouraging results in the treatment of refractory acute myeloid leukemia (AML). NK cells are highly proliferative, early responders of the innate immun...

journal_title：Blood

authors： Rooney CM

更新日期：2014-06-19 00:00:00

abstract：:Bleeding problems are associated with defects in platelet alpha-granules, yet little is known about how these granules are formed and released. Mutations affecting VPS33B, a novel Sec1/Munc18 protein, have recently been linked to arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome. We have characterized ...

journal_title：Blood

authors： Lo B,Li L,Gissen P,Christensen H,McKiernan PJ,Ye C,Abdelhaleem M,Hayes JA,Williams MD,Chitayat D,Kahr WH

更新日期：2005-12-15 00:00:00

abstract：:Twenty-four adults with ALL were treated with AMSA alone or in combination. Twenty-two were treated at time of relapse and two patients after failing primary induction therapy. All had been treated with anthracyclines prior to receiving AMSA. Of the 22 patients with ALL in relapse, 4 achieved a complete remission. Two...

journal_title：Blood

authors： Arlin ZA,Fanucchi MP,Gee TS,Kempin SJ,Mertelsmann R,Young CW,Clarkson BD

更新日期：1982-11-01 00:00:00

abstract：:The relative requirements of colonies derived from erythroid (BFU-E) and myeloid (CFU-c) progenitors for transferrin were examined using monoclonal antibodies directed against the transferrin molecule (TF-6) or its cell surface receptor (TFR-A12, TFR1-2B). Growth of erythroid bursts was profoundly reduced at concentra...

journal_title：Blood

authors： Shannon KM,Larrick JW,Fulcher SA,Burck KB,Pacely J,Davis JC,Ring DB

更新日期：1986-06-01 00:00:00

abstract：:A variant subline (KG-1a) of the human acute myelogenous leukemia (AML) cell line (KG-1) has been isolated. The cells retain the same constitutive markers as the parent line, including HLA antigens, isoenzymes, and karyotype. The cells from the subline are morphologically and histochemically undifferentiated blast cel...

journal_title：Blood

authors： Koeffler HP,Billing R,Lusis AJ,Sparkes R,Golde DW

更新日期：1980-08-01 00:00:00

abstract：:The mechanisms responsible for the low factor VIII (fVIII) activity in the plasma of patients with mild/moderate hemophilia A are poorly understood. In such patients, we have identified a series of fVIII mutations (Ile2098Ser, Ser2119Tyr, Asn2129Ser, Arg2150His, and Pro2153Gln) clustered in the C1 domain and associate...

journal_title：Blood

authors： Jacquemin M,Lavend'homme R,Benhida A,Vanzieleghem B,d'Oiron R,Lavergne JM,Brackmann HH,Schwaab R,VandenDriessche T,Chuah MK,Hoylaerts M,Gilles JG,Peerlinck K,Vermylen J,Saint-Remy JM

更新日期：2000-08-01 00:00:00

abstract：:A postulated role of the contact system in anaphylactic reactions to insect stings was investigated. During prospective, in-hospital sting challenge, we collected serial blood samples from five normal volunteers and 16 patients with a history of insect-sting anaphylaxis. Activation of the contact system was assessed b...

journal_title：Blood

authors： van der Linden PW,Hack CE,Eerenberg AJ,Struyvenberg A,van der Zwan JK

更新日期：1993-09-15 00:00:00

abstract：:We have previously observed an increased frequency of liver failure in human immunodeficiency virus (HIV)-infected hemophiliacs. The purpose of this study was to quantitate hepatitis C virus (HCV) RNA levels in serial samples from HIV-seropositive (HIV+) and HIV-seronegative (HIV-) hemophiliacs before and after HIV se...

journal_title：Blood

authors： Eyster ME,Fried MW,Di Bisceglie AM,Goedert JJ

更新日期：1994-08-15 00:00:00

abstract：:Lymphomas afflict all age groups of people, with certain types demonstrating a female predilection in adolescents and young adults. A proportion of lymphomas that are diagnosed in this population demographic occur in the setting of pregnancy. Most of these behave aggressively at presentation and require immediate or u...

journal_title：Blood

authors： Dunleavy K,McLintock C

更新日期：2020-11-05 00:00:00

abstract：:Interleukin-13 (IL-13) induced a potent mitogenic response in IL-3-dependent TF-1 cells and DNA synthesis to a lesser extent in MO7E and FDC-P1 cells. IL-13 stimulation of these lines, like IL-4 and insulin-like growth factor-1 (IGF-1), resulted in tyrosine phosphorylation of a 170-kD substrate. The tyrosine-phosphory...

journal_title：Blood

authors： Wang LM,Michieli P,Lie WR,Liu F,Lee CC,Minty A,Sun XJ,Levine A,White MF,Pierce JH

更新日期：1995-12-01 00:00:00

abstract：:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a...

journal_title：Blood

authors： Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJ

更新日期：1988-09-01 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells with the capacity to prime naive T cells for efficient cellular responses against pathogens such as HIV-1. DCs are also susceptible to HIV-1 infection, which may impair their ability to induce immunity. Here, we examined the ability of HIV-1-infected, in vitro-derived...

journal_title：Blood

authors： Smed-Sörensen A,Loré K,Walther-Jallow L,Andersson J,Spetz AL

更新日期：2004-11-01 00:00:00