The future of anti-CD20 monoclonal antibodies: are we making progress?

abstract：:Internal tandem duplication of the Fms-like tyrosine kinase-3 receptor (FLT3) internal tandem duplication (ITD) is found in 30% of acute myeloid leukemia (AML) and is associated with a poor outcome. In addition to tyrosine kinase inhibitors, therapeutic strategies that modulate the expression of FLT3-ITD are also prom...

journal_title：Blood

authors： Larrue C,Saland E,Boutzen H,Vergez F,David M,Joffre C,Hospital MA,Tamburini J,Delabesse E,Manenti S,Sarry JE,Récher C

更新日期：2016-02-18 00:00:00

abstract：:Whether platelet volume increases during the morphological changes preceding aggregation has been investigated. Previous research is controversial; resistive-counting techniques reveal an increase, centrifugal methods do not. Platelets were sized with a computerized, resistive-particle counter before and after incubat...

journal_title：Blood

authors： Gear AR

更新日期：1981-09-01 00:00:00

abstract：:The Scianna blood group encompasses the high-frequency antigens Sc1 and Sc3 and the low-frequency antigen Sc2. Another low-frequency antigen Rd (Radin) was suggested to belong to the Scianna blood group. The molecular basis of the Scianna blood group was unknown. The erythrocyte membrane-associated protein (ERMAP) sha...

journal_title：Blood

authors： Wagner FF,Poole J,Flegel WA

更新日期：2003-01-15 00:00:00

abstract：:Cytotoxic lymphocytes clear infected and transformed cells by releasing the content of lytic granules at cytolytic synapses, and the ability of cytolytic effectors to kill in an iterative manner has been documented previously. Although bidirectional trafficking of cytolytic machinery components along the endosomal pat...

journal_title：Blood

authors： Capuano C,Paolini R,Molfetta R,Frati L,Santoni A,Galandrini R

更新日期：2012-03-08 00:00:00

abstract：:The ultrastructure of the lymphocytes from three children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53%, 41%, and 13%) in three SCID patients when compared to age-matched controls. The size of these incl...

journal_title：Blood

authors： Payne CM,Jones JF,Sieber OF Jr,Fulginiti VA

更新日期：1977-07-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cells have emerged as a novel form of treatment of patients with B-cell malignancies. In particular, anti-CD19 CAR T-cell therapy has effected impressive clinical responses in B-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma. However, not all patients respond, and...

journal_title：Blood

authors： Scarfò I,Ormhøj M,Frigault MJ,Castano AP,Lorrey S,Bouffard AA,van Scoyk A,Rodig SJ,Shay AJ,Aster JC,Preffer FI,Weinstock DM,Maus MV

更新日期：2018-10-04 00:00:00

abstract：:Phagocytes from X-linked chronic granulomatous disease (X-CGD) patients are deficient in their ability to generate superoxide because of a defective gene that encodes a heavy chain of cytochrome b, a critical component in the superoxide-generating pathway. Previously we have shown that a single in vivo treatment of se...

journal_title：Blood

authors： Ezekowitz RA,Sieff CA,Dinauer MC,Nathan DG,Orkin SH,Newburger PE

更新日期：1990-12-15 00:00:00

abstract：:Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses the common gamma chain for signaling but also have their private high-affinity receptors. Since it is well known that IL-4 modulates differentiation and activation of dendritic cells (DCs), ...

journal_title：Blood

authors： Brandt K,Bulfone-Paus S,Foster DC,Rückert R

更新日期：2003-12-01 00:00:00

abstract：:Humans and grey collie dogs with cyclic neutropenia are known to suffer from an increased rate of bacterial infection. Because of the previously described microanatomic abnormalities of lysosome formation found in the polymorphonuclear leukocytes (PMNs) of dogs with canine cyclic neutropenia, studies of these cells we...

journal_title：Blood

authors： Chusid MJ,Bujak JS,Dale DC

更新日期：1975-12-01 00:00:00

abstract：:In this study, we show that microRNA-150 (miR-150) is significantly downregulated in advanced cutaneous T-cell lymphoma (CTCL), and that this downregulation is strongly associated with tumor invasion/metastasis. Inoculation of CTCL cell lines into nonobese diabetic/Shi-scid interleukin 2γ (IL-2γ) null mice led to CTCL...

journal_title：Blood

authors： Ito M,Teshima K,Ikeda S,Kitadate A,Watanabe A,Nara M,Yamashita J,Ohshima K,Sawada K,Tagawa H

更新日期：2014-03-06 00:00:00

abstract：:Adenovirus-transduced CD34+ cells expressing membrane-bound tumor necrosis factor-related apoptosis-inducing ligand (CD34-TRAIL+ cells) exert potent antitumor activity. To further investigate the mechanism(s) of action of CD34-TRAIL+ cells, we analyzed their homing properties as well as antitumor and antivascular effe...

journal_title：Blood

authors： Lavazza C,Carlo-Stella C,Giacomini A,Cleris L,Righi M,Sia D,Di Nicola M,Magni M,Longoni P,Milanesi M,Francolini M,Gloghini A,Carbone A,Formelli F,Gianni AM

更新日期：2010-03-18 00:00:00

abstract：:C-abl oncogene 1, nonreceptor tyrosine kinase (ABL1) kinase inhibitors such as imatinib mesylate (imatinib) are effective in managing chronic myeloid leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), suggesting that kinase-independent pathways support LSC survival. Given that the bone marrow (BM)...

journal_title：Blood

authors： Ng KP,Manjeri A,Lee KL,Huang W,Tan SY,Chuah CT,Poellinger L,Ong ST

更新日期：2014-05-22 00:00:00

abstract：:The response to intravenous challenge with sheep erythrocytes was determined in Sprague-Dawley rats following autotransplantation of splenic tissue into the subcutaneous tissue, peritoneal cavity, or a surgically created omental pouch. There was a marked rise in heterophil antibody titer following intravenous challeng...

journal_title：Blood

authors： Schwartz AD,Dadash-Zadeh M,Goldstein R,Luck S,Conway JJ

更新日期：1977-05-01 00:00:00

abstract：:Most bone marrow (BM) malignancies develop in association with an angiogenic phenotype and increased numbers of endothelial cells. The molecular mechanisms involved in the modulation and recruitment of BM endothelium are largely unknown and may provide novel therapeutic targets for neoplastic diseases. We observed tha...

journal_title：Blood

authors： Costa LF,Balcells M,Edelman ER,Nadler LM,Cardoso AA

更新日期：2006-01-01 00:00:00

abstract：:Growing evidence indicates antibody-dependent cellular cytotoxicity (ADCC) contributes to the clinical response to monoclonal antibody (mAb) therapy of lymphoma. Recent in vitro analysis suggests C3b can inhibit mAb-induced natural killer (NK)-cell activation and ADCC. Further studies were conducted to assess the effe...

journal_title：Blood

authors： Wang SY,Veeramani S,Racila E,Cagley J,Fritzinger DC,Vogel CW,St John W,Weiner GJ

更新日期：2009-12-17 00:00:00

abstract：:Interleukin-8 (IL-8) is a neutrophil chemotactic and activating cytokine that is produced in response to several stimuli. Because monocytic cells are important producers of IL-8, we investigated whether interferon-gamma (IFN-gamma), a potent inducer of activation and differentiation of mononuclear phagocytes, affected...

journal_title：Blood

authors： Bosco MC,Gusella GL,Espinoza-Delgado I,Longo DL,Varesio L

更新日期：1994-01-15 00:00:00

abstract：:The syndrome of episodic angioedema and eosinophilia is characterized by cyclic edema, marked peripheral blood eosinophilia, and eosinophil degranulation in the dermis. Using a sensitive immunoenzymetric method, we measured serum interleukin (IL)-5 levels in four patients with this syndrome. We also determined the per...

journal_title：Blood

authors： Butterfield JH,Leiferman KM,Abrams J,Silver JE,Bower J,Gonchoroff N,Gleich GJ

更新日期：1992-02-01 00:00:00

abstract：:Chemokine stromal derived factor 1 (SDF-1) is involved in trafficking of hematopoietic stem cells (HSCs) from the bone marrow (BM) to peripheral blood (PB) and has been found to enhance postischemia angiogenesis. This study was aimed at investigating whether SDF-1 plays a role in differentiation of BM-derived c-kit(+)...

journal_title：Blood

authors： De Falco E,Porcelli D,Torella AR,Straino S,Iachininoto MG,Orlandi A,Truffa S,Biglioli P,Napolitano M,Capogrossi MC,Pesce M

更新日期：2004-12-01 00:00:00

abstract：:Familial pseudohyperkalemia is a "leaky red blood cell" condition in which the cells show a temperature-dependent loss of potassium (K) from red blood cells when stored at room temperature, manifesting as apparent hyperkalemia. The red blood cells show a reduced lifespan in vivo but there is no frank hemolysis. Studie...

journal_title：Blood

authors： Iolascon A,Stewart GW,Ajetunmobi JF,Perrotta S,Delaunay J,Carella M,Zelante L,Gasparini P

更新日期：1999-05-01 00:00:00

abstract：:Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have alre...

journal_title：Blood

authors： Holtan SG,Pasquini M,Weisdorf DJ

更新日期：2014-07-17 00:00:00

abstract：:The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures and is currently treated empirically. We transplanted human first-trimester fetal blood mesenchymal stem cells (MSCs) into homozygous oim mice in utero. This resulted in a two-thirds reduction in long bone fractures (P < .01), ...

journal_title：Blood

authors： Guillot PV,Abass O,Bassett JH,Shefelbine SJ,Bou-Gharios G,Chan J,Kurata H,Williams GR,Polak J,Fisk NM

更新日期：2008-02-01 00:00:00

abstract：:To assess the influence of graft-versus-host disease (GVHD) on recurrent leukemia and survival after allogeneic marrow transplantation, we studied 1,202 patients with acute nonlymphocytic leukemia (ANL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML) given unmodified marrow grafts from HLA-id...

journal_title：Blood

authors： Sullivan KM,Weiden PL,Storb R,Witherspoon RP,Fefer A,Fisher L,Buckner CD,Anasetti C,Appelbaum FR,Badger C

更新日期：1989-05-01 00:00:00

abstract：:Adoptive transfer of allogeneic T cells has unmatched efficacy to eradicate leukemic cells. We therefore sought to evaluate in kinetic terms interactions between T cells and allogeneic leukemic cells. T cells primed against the model B6(dom1) minor histocompatibility antigen were adoptively transferred in irradiated B...

journal_title：Blood

authors： Meunier MC,Roy-Proulx G,Labrecque N,Perreault C

更新日期：2003-01-15 00:00:00

abstract：:The purpose of this report was to evaluate scintigraphy analysis of Southern blot hybridization as a method to quantify the breakpoint cluster region (BCR) rearrangement of Philadelphia chromosome (Ph)+ chronic myelogenous leukemia (CML). Cytogenetic and molecular studies performed simultaneously on 474 bone marrow an...

journal_title：Blood

authors： Verschraegen CF,Talpaz M,Hirsch-Ginsberg CF,Pherwani R,Rios MB,Stass SA,Kantarjian HM

更新日期：1995-05-15 00:00:00

abstract：:The von Willebrand factor propeptide, vW AgII, has been shown to be required for the formation of vWF multimers and sorting of vWF to storage granules; whether these 2 processes are independent events has been unclear. Chimeric constructs of human and canine vWF were developed to further define these processes and to ...

journal_title：Blood

authors： Haberichter SL,Fahs SA,Montgomery RR

更新日期：2000-09-01 00:00:00

abstract：:Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here, we isolated 4 distinct populations at successive erythropoietin-dependent stages of erythropoiesis, including the terminal, pyknotic stage. The transcriptome was determined using Affy...

journal_title：Blood

authors： Merryweather-Clarke AT,Atzberger A,Soneji S,Gray N,Clark K,Waugh C,McGowan SJ,Taylor S,Nandi AK,Wood WG,Roberts DJ,Higgs DR,Buckle VJ,Robson KJ

更新日期：2011-03-31 00:00:00

abstract：:In chronic lymphocytic leukemia (CLL) patients with mutated IGHV, 3 recent studies have demonstrated prolonged progression-free survival (PFS) after treatment with fludarabine-cyclophosphamide-rituximab (FCR) chemoimmunotherapy. We performed a systematic review to assess the benefit of FCR for patients with CLL and id...

journal_title：Blood

authors： Chai-Adisaksopha C,Brown JR

更新日期：2017-11-23 00:00:00

abstract：:This study investigated the immunogenicity of Wilms tumor gene product 1 (WT1)-peptide vaccination in WT1-expressing acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients without curative treatment option. Vaccination consisted of granulocyte-macrophage colony-stimulating factor subcutaneously days ...

journal_title：Blood

authors： Keilholz U,Letsch A,Busse A,Asemissen AM,Bauer S,Blau IW,Hofmann WK,Uharek L,Thiel E,Scheibenbogen C

更新日期：2009-06-25 00:00:00

abstract：:DNA amplification combined with hybridization with 32P-labeled synthetic oligonucleotide probes has been used to identify base substitutions in the 5' promoter region of the A gamma globin gene in members of eleven families from China, Sardinia, Canada, and the United States who had a heterozygosity for the A gamma-be...

journal_title：Blood

authors： Yang KG,Stoming TA,Fei YJ,Liang S,Wong SC,Masala B,Huang RB,Wei ZP,Huisman TH

更新日期：1988-05-01 00:00:00

abstract：:Because interleukin-10 (IL-10) is a potent differentiation factor of human B cells into mature plasma cells, we investigated its effect on human malignant plasma cells. IL-10 did not induce any differentiation and increase in Ig synthesis in four human IL-6-dependent malignant plasma cell lines. However, it stimulated...

journal_title：Blood

authors： Lu ZY,Zhang XG,Rodriguez C,Wijdenes J,Gu ZJ,Morel-Fournier B,Harousseau JL,Bataille R,Rossi JF,Klein B

更新日期：1995-05-01 00:00:00