Abstract:
:In chronic lymphocytic leukemia (CLL) patients with mutated IGHV, 3 recent studies have demonstrated prolonged progression-free survival (PFS) after treatment with fludarabine-cyclophosphamide-rituximab (FCR) chemoimmunotherapy. We performed a systematic review to assess the benefit of FCR for patients with CLL and identified 5 randomized trials that met our inclusion criteria. FCR improved complete remission, PFS and overall survival vs the comparator; median PFS was not reached in the subgroup of CLL patients with mutated IGHV.
journal_name
Bloodjournal_title
Bloodauthors
Chai-Adisaksopha C,Brown JRdoi
10.1182/blood-2017-07-731588subject
Has Abstractpub_date
2017-11-23 00:00:00pages
2278-2282issue
21eissn
0006-4971issn
1528-0020pii
blood-2017-07-731588journal_volume
130pub_type
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