Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene.

abstract：:Reduced lymphopoiesis during aging contributes to declines in immunity, but little consideration has been given to its effect on the development of hematologic disease. This report demonstrates that age-related defects in lymphopoiesis underlie the myeloid dominance of adult leukemia. Using a murine model of chronic m...

journal_title：Blood

authors： Signer RA,Montecino-Rodriguez E,Witte ON,McLaughlin J,Dorshkind K

更新日期：2007-09-15 00:00:00

abstract：:To determine whether the erythropoietin receptor (Epo-R) plays a role in the course of malignant erythropoietic disorders, this gene was studied in murine and human erythroleukemia cells. An altered Epo-R gene was found in a murine Friend erythroleukemia cell line, FCL1, due to a spleen focus-forming virus (SFFV) long...

journal_title：Blood

authors： Chretien S,Moreau-Gachelin F,Apiou F,Courtois G,Mayeux P,Dutrillaux B,Cartron JP,Gisselbrecht S,Lacombe C

更新日期：1994-04-01 00:00:00

abstract：:Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit information bidirectionally across the plasma membrane, and plays a critical role in hemostasis and thrombosis. Upon platelet activation, inside-out signaling pathways increase the affinity of αIIbβ3 for fibrinogen and other ligands...

journal_title：Blood

authors： Durrant TN,van den Bosch MT,Hers I

更新日期：2017-10-05 00:00:00

abstract：:Recombinant rat stem cell factor (rrSCF) administered to rats as a single intravenous injection causes a dose-dependent neutrophilia and lymphocytosis as well as the appearance of immature myeloid cells and occasional blast cells in the circulation. Neutrophilia begins at 2 hours, peaks at 4 to 6 hours, and subsides b...

journal_title：Blood

authors： Ulich TR,del Castillo J,Yi ES,Yin S,McNiece I,Yung YP,Zsebo KM

更新日期：1991-08-01 00:00:00

abstract：:C3H mice have higher average ploidy megakaryocytes than all other mouse strains tested, but the mode of inheritance of this anomaly is unknown. Therefore, to clarify the genetics of high ploidy megakaryocytes in C3H mice, we measured megakaryocyte DNA content from both male and female offspring from F1, as well as bac...

journal_title：Blood

authors： McDonald TP,Jackson CW

更新日期：1994-03-15 00:00:00

abstract：:Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. However, only a limited number of target genes have been identified. We have studied 10 MCL cell lines and 28 primary tumors with a combination of a high-density single...

journal_title：Blood

authors： Beà S,Salaverria I,Armengol L,Pinyol M,Fernández V,Hartmann EM,Jares P,Amador V,Hernández L,Navarro A,Ott G,Rosenwald A,Estivill X,Campo E

更新日期：2009-03-26 00:00:00

abstract：:Neurexin I α (NRXN1α) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the neuronal system. Neurexophilins (NXPHs) bind NRXN1α. NRXN1α was expressed in primitive populations in human CB (huCB) and murine BM (muBM). DAG1 is ubiquitously expressed in hematopoietic tissue; however, osteobla...

journal_title：Blood

authors： Kinzfogl J,Hangoc G,Broxmeyer HE

更新日期：2011-07-21 00:00:00

abstract：:Fanconi anemia (FA) is a genetic disorder associated with bone marrow (BM) failure and leukemia. Recent studies demonstrate variable immune defects in FA. However, the cause for FA immunodeficiency is unknown. Here we report that deletion of Fanca or Fancd2 dysregulates the suppressive activity of regulatory T cells (...

journal_title：Blood

authors： Du W,Erden O,Wilson A,Sipple JM,Schick J,Mehta P,Myers KC,Steinbrecher KA,Davies SM,Pang Q

更新日期：2014-03-20 00:00:00

abstract：:Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. In a murine retrovir...

journal_title：Blood

authors： Million RP,Aster J,Gilliland DG,Van Etten RA

更新日期：2002-06-15 00:00:00

abstract：:A 14-year-old boy with hemoglobin SC disease and alpha-thalassemia-2 experienced five episodes of acute splenic sequestration crisis (ASSC), while two of his siblings with identical globin genotypes (SC and -alpha/alpha alpha) had no such experience. To determine if an additional red blood cell (RBC) defect was respon...

journal_title：Blood

authors： Warkentin TE,Barr RD,Ali MA,Mohandas N

更新日期：1990-01-01 00:00:00

abstract：:CC chemokine receptor (CCR) 9, the receptor for the CC-chemokine CCL25/thymus-expressed chemokine (TECK), is mainly expressed by thymocytes and by intraepithelial (IEL) and lamina propria lymphocytes of the small intestine. To study the biologic role of CCR9, a mouse strain was generated in which the CCR9 gene was del...

journal_title：Blood

authors： Wurbel MA,Malissen M,Guy-Grand D,Meffre E,Nussenzweig MC,Richelme M,Carrier A,Malissen B

更新日期：2001-11-01 00:00:00

abstract：:To evaluate internal tandem duplication (ITD) insertion sites and length as well as their clinical impact in younger adult patients with FLT3-ITD-positive acute myeloid leukemia (AML), sequencing after DNA-based amplification was performed in diagnostic samples from 241 FLT3-ITD-mutated patients. All patients were tre...

journal_title：Blood

authors： Kayser S,Schlenk RF,Londono MC,Breitenbuecher F,Wittke K,Du J,Groner S,Späth D,Krauter J,Ganser A,Döhner H,Fischer T,Döhner K,German-Austrian AML Study Group (AMLSG).

更新日期：2009-09-17 00:00:00

abstract：:We have studied the effect of prostaglandin I2 on platelet turnover, attachment to the subendothelium, and secretion following balloon deendothelialization of the rabbit aorta. Survival of 51Cr-labeled platelets in the balloon-injured animals remained normal. Thirty minutes after injury, there were 4.52 X 10(6) platel...

journal_title：Blood

authors： Adelman B,Stemerman MB,Mennell D,Handin RI

更新日期：1981-08-01 00:00:00

abstract：:Vaccination of patients with cancer using dendritic cells (DCs) was shown to be effective for B-cell lymphoma and malignant melanoma. Here we provide evidence that patients with advanced breast and ovarian cancer can be efficiently vaccinated with autologous DCs pulsed with HER-2/neu- or MUC1-derived peptides. Ten pat...

journal_title：Blood

authors： Brossart P,Wirths S,Stuhler G,Reichardt VL,Kanz L,Brugger W

更新日期：2000-11-01 00:00:00

abstract：:Genetic alteration is considered a probable cause of malignant lymphoma. Folate and methionine metabolism play essential roles in DNA synthesis and DNA methylation, and their metabolic pathways might thus affect disease susceptibility. In the present study, 2 polymorphisms were evaluated for a folate metabolic enzyme,...

journal_title：Blood

authors： Matsuo K,Suzuki R,Hamajima N,Ogura M,Kagami Y,Taji H,Kondoh E,Maeda S,Asakura S,Kaba S,Nakamura S,Seto M,Morishima Y,Tajima K

更新日期：2001-05-15 00:00:00

abstract：:Hepatitis B virus (HBV)-infected individuals are occasionally used as donors for bone marrow transplantation (BMT). We studied the rate of HBV infection and the clinical expression of the associated liver disease in patients receiving marrow from HBsAg+ donors. We performed a retrospective survey in 14 BMT units in It...

journal_title：Blood

authors： Locasciulli A,Alberti A,Bandini G,Polchi P,Arcese W,Alessandrino P,Bosi A,Testa M,Bacigalupo A

更新日期：1995-10-15 00:00:00

abstract：:An estimated 22 350 patients had multiple myeloma diagnosed in 2013, representing 1.3% of all new cancers; 10 710 deaths are projected, representing 1.8% of cancer deaths. Approximately 0.7% of US men and women will have a myeloma diagnosis in their lifetime, and with advances in therapy, 77 600 US patients are living...

journal_title：Blood

authors： Gertz MA,Dingli D

更新日期：2014-08-07 00:00:00

abstract：:We have verified the hypothesis that multiple myeloma (MM) may be disseminated by circulating clonogenic cells that selectively home to the bone marrow (BM) to receive the signal(s) leading to proliferation, terminal differentiation, and production of the osteoclast activating factors. Long-term cultures of stromal ce...

journal_title：Blood

authors： Caligaris-Cappio F,Bergui L,Gregoretti MG,Gaidano G,Gaboli M,Schena M,Zallone AZ,Marchisio PC

更新日期：1991-06-15 00:00:00

abstract：:Leukemic B cells from a majority of patients with chronic lymphocytic leukemia (CLL) enter the cell cycle upon stimulation in vitro with loxoribine, a potent 7,8-disubstituted guanine ribonucleoside immunostimulant. In the absence of added costimulants, a proportion of these cells become activated and undergo DNA synt...

journal_title：Blood

authors： Goodman MG,Wormsley SB,Spinosa JC,Piro LD

更新日期：1994-11-15 00:00:00

abstract：:Interleukin (IL)-23 is a proinflammatory cytokine belonging to the IL-12 superfamily. The antitumor activity of IL-23 is controversial, and it is unknown whether or not the cytokine can act directly on tumor cells. The aim of this study was to investigate the potential direct antitumor activity of IL-23 in pediatric B...

journal_title：Blood

authors： Cocco C,Canale S,Frasson C,Di Carlo E,Ognio E,Ribatti D,Prigione I,Basso G,Airoldi I

更新日期：2010-11-11 00:00:00

abstract：:During development, mice with mutations of stem cell factor (SCF) or its receptor c-kit exhibit defects in melanogenesis, as well as hematopoiesis and gonadogenesis. Because melanocytes derive from neural crest cells, the role of SCF and c-kit was investigated in the neural crest-derived childhood tumor neuroblastoma....

journal_title：Blood

authors： Cohen PS,Chan JP,Lipkunskaya M,Biedler JL,Seeger RC

更新日期：1994-11-15 00:00:00

abstract：:Expression of B7 family costimulatory molecules on B cells defines their capacity to function as antigen presenting cells (APCs). B cells that do not express B7 costimulatory molecules induce T-cell tolerance. Therefore, the expression of B7 costimulatory molecules on malignant B cells might be critical for their reco...

journal_title：Blood

authors： Dorfman DM,Schultze JL,Shahsafaei A,Michalak S,Gribben JG,Freeman GJ,Pinkus GS,Nadler LM

更新日期：1997-12-01 00:00:00

abstract：:Cytokine gene-modified tumor cells have increased immunogenicity and retain the antigenic repertoire of a particular neoplasia. However, practical concerns have led to an increased interest in allogeneic gene-transduced bystander cells as a broader source of cytokines for autologous tumor cell-based vaccines. Here, we...

journal_title：Blood

authors： Curti A,Parenza M,Colombo MP

更新日期：2003-01-15 00:00:00

abstract：:Endothelial progenitor cells are critically involved in essential biologic processes, such as vascular homeostasis, regeneration, and tumor angiogenesis. Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells with robust proliferative potential. Their profound vessel-forming capacity makes them a pr...

journal_title：Blood

authors： Reinisch A,Hofmann NA,Obenauf AC,Kashofer K,Rohde E,Schallmoser K,Flicker K,Lanzer G,Linkesch W,Speicher MR,Strunk D

更新日期：2009-06-25 00:00:00

abstract：:Although much is now known about the biological properties of the c-kit receptor and its ligand, stem cell factor (SCF), little is known of the structural basis for the binding and function of this hematopoietic cytokine. By analyzing the activities of chimeric interspecies and homologue muteins and epitope mapping of...

journal_title：Blood

authors： Matous JV,Langley K,Kaushansky K

更新日期：1996-07-15 00:00:00

abstract：:Homing of blood-borne lymphocytes to peripheral lymph nodes (PLNs) is a multistep process dependent on the sequential engagement of L-selectin, which mediates lymphocyte rolling along the luminal surface of high endothelial venules (HEVs), followed by activation of lymphocyte integrins and transmigration through HEVs....

journal_title：Blood

authors： Stein JV,Soriano SF,M'rini C,Nombela-Arrieta C,de Buitrago GG,Rodríguez-Frade JM,Mellado M,Girard JP,Martínez-A C

更新日期：2003-01-01 00:00:00

abstract：:In vivo lentiviral vector (LV)-mediated gene delivery would represent a great step forward in the field of gene therapy. Therefore, we have engineered a novel LV displaying SCF and a mutant cat endogenous retroviral glycoprotein, RDTR. These RDTR/SCF-LVs outperformed RDTR-LVs for transduction of human CD34(+) cells (h...

journal_title：Blood

authors： Frecha C,Costa C,Nègre D,Amirache F,Trono D,Rio P,Bueren J,Cosset FL,Verhoeyen E

更新日期：2012-02-02 00:00:00

abstract：:Activated ras genes are often associated with human myeloid leukemias with a monocytic differentiated phenotype. To investigate the role of the activated ras gene in leukemogenesis, a myeloid nontumorigenic cell line (FDC-P1) was infected with a selectable retroviral vector carrying the v-Ha-ras gene (H1neo). Infected...

journal_title：Blood

authors： Hibi S,Löhler J,Friel J,Stocking C,Ostertag W

更新日期：1993-04-01 00:00:00

abstract：:Lymphocyte kinetic studies employing 51-chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the nonrecirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recircula...

journal_title：Blood

authors： Fauci AS,Dale DC

更新日期：1975-08-01 00:00:00

abstract：:This report describes the clinical and immunoglobulin features of a patient with gamma heavy chain disease (HCD), who presented with a clinical picture suggestive of an underlying malignancy rather than the usual picture of lymphoma or granulomatous disease. A unique clinical feature was the nearly total replacement o...

journal_title：Blood

authors： Faguet GB,Barton BP,Smith LL,Garver FA

更新日期：1977-04-01 00:00:00