Intermediate-dose versus high-dose prophylaxis for severe hemophilia: comparing outcome and costs since the 1970s.

abstract：:Patients with severe aplastic anemia (SAA) and a neutrophil (PMN) count of less than 0.5 x 10(9)/L are exposed to a high risk of early mortality when treated with antilymphocyte globulin (ALG) and steroids, with the major problem being infectious complications. The addition of human recombinant granulocyte colony-stim...

journal_title：Blood

authors： Bacigalupo A,Broccia G,Corda G,Arcese W,Carotenuto M,Gallamini A,Locatelli F,Mori PG,Saracco P,Todeschini G

更新日期：1995-03-01 00:00:00

abstract：:Von Willebrand factor (VWF) is a key hemostatic protein synthesized in both endothelial cells and megakaryocytes. Megakaryocyte-derived VWF is stored in α-granules of platelets and is enriched in hyperactive "ultra-large" VWF multimers. To elucidate the specific contribution of platelet VWF in hemostasis and thrombosi...

journal_title：Blood

authors： Verhenne S,Denorme F,Libbrecht S,Vandenbulcke A,Pareyn I,Deckmyn H,Lambrecht A,Nieswandt B,Kleinschnitz C,Vanhoorelbeke K,De Meyer SF

更新日期：2015-10-01 00:00:00

abstract：:The clinical hallmark of paroxysmal nocturnal hemoglobinuria (PNH) is chronic intravascular hemolysis that is a consequence of unregulated activation of the alternative pathway of complement (APC). Intravascular hemolysis can be inhibited in patients by treatment with eculizumab, a monoclonal antibody that binds compl...

journal_title：Blood

authors： Lindorfer MA,Pawluczkowycz AW,Peek EM,Hickman K,Taylor RP,Parker CJ

更新日期：2010-03-18 00:00:00

abstract：:Pseudomonas aeruginosa pneumonia was produced in dogs with radiation-induced leukopenia to study the comparative efficacy of several different therapies. In a randomized control trial, five treatment regimens were compared: no antibiotics or granulocytes (controls), gentamicin (5 mg/kg/day), carbenicillin (500 mg/kg/d...

journal_title：Blood

authors： Dale DC,Reynolds HY,Pennington JE,Elin RJ,Herzig GP

更新日期：1976-05-01 00:00:00

abstract：:In this issue of Blood, Stepensky et al provide an astute description of immunosenescence arising from deficiency in tripeptidyl peptidase II (TPPII). Senescence of T and B lymphocytes is a striking finding, which has recently come into the limelight because it can be linked to primary immunodeficiency syndromes with ...

journal_title：Blood

authors： Seidel MG

更新日期：2015-01-29 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) is the most important cytokine involved in the promotion of myelofibrosis. Mechanisms leading to its local activation in the bone marrow environment remain unclear. As a recent study has highlighted the role of thrombospondin-1 (TSP-1) in platelet-derived TGF-β1 activation, we in...

journal_title：Blood

authors： Evrard S,Bluteau O,Tulliez M,Rameau P,Gonin P,Zetterberg E,Palmblad J,Bonnefoy A,Villeval JL,Vainchenker W,Giraudier S,Wagner-Ballon O

更新日期：2011-01-06 00:00:00

abstract：:Mast cells may be cultured from human peripheral blood in the presence of recombinant human stem cell factor (rhSCF). The characteristics of the cells in peripheral blood that give rise to mast cells are unknown. Because mast cell precursors in human marrow are CD34+, human peripheral blood mononuclear cells from pati...

journal_title：Blood

authors： Rottem M,Okada T,Goff JP,Metcalfe DD

更新日期：1994-10-15 00:00:00

abstract：:Red cell concentrates (RCC) are stored for 35 to 42 days in plastic containers manufactured with the liquid plasticizer di(2-ethylhexyl)phthalate (DEHP). DEHP leaches from the polyvinylchloride (PVC) plastic bag, then binds to and stabilizes the RC membrane. This study was undertaken to determine the deformability of ...

journal_title：Blood

authors： Labow RS,Card RT,Rock G

更新日期：1987-07-01 00:00:00

abstract：:We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 patients, a significa...

journal_title：Blood

authors： Gutman JA,Turtle CJ,Manley TJ,Heimfeld S,Bernstein ID,Riddell SR,Delaney C

更新日期：2010-01-28 00:00:00

abstract：:A 2-yr-old black girl presented with a thalassemic clinical picture and was found to have nearly 100% fetal hemoglobin in her red cells. Pedigree analysis indicated that she was a heterozygote for the hereditary persistence of fetal hemoglobin gene and for a beta O-thalassemia gene. A brother, who also had nearly 100%...

journal_title：Blood

authors： Beutler E,Turner E,Kuhl W

更新日期：1981-06-01 00:00:00

abstract：:D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides to form ultralong VWF concatemers. D'D3 forms the binding site fo...

journal_title：Blood

authors： Dong X,Leksa NC,Chhabra ES,Arndt JW,Lu Q,Knockenhauer KE,Peters RT,Springer TA

更新日期：2019-04-04 00:00:00

abstract：:People with hemophilia were formerly at very high risk of infection with hepatitis C virus (HCV). Approximately 20% of HCV-infected patients spontaneously clear the virus. To identify correlates of spontaneous clearance of HCV, we studied a cohort of HCV-infected hemophilic subjects without human immunodeficiency viru...

journal_title：Blood

authors： Zhang M,Rosenberg PS,Brown DL,Preiss L,Konkle BA,Eyster ME,Goedert JJ,Second Multicenter Hemophilia Cohort Study.

更新日期：2006-02-01 00:00:00

abstract：:The extravasation of leukocytes from the lumen of the vessel to a site of inflammation requires specific binding events. The interaction of leukocytes with endothelium, via specific receptors, may provide intracellular signals that activate extravasating cells. In the present study, we have investigated the production...

journal_title：Blood

authors： Lukacs NW,Strieter RM,Elner V,Evanoff HL,Burdick MD,Kunkel SL

更新日期：1995-10-01 00:00:00

abstract：:In this issue of Blood, Martin et al report poor outcomes for ibrutinib-refractory patients with mantle cell lymphoma (MCL). MCL, an uncommon B-cell lymphoma driven by dysregulated cyclin D1, responds well to initial therapy but is destined to relapse. Subsequent single-agent treatments had modest response rates and d...

journal_title：Blood

authors： Smith MR

更新日期：2016-03-24 00:00:00

abstract：:We have identified an intergenic transcriptional activity that is located between the human HOXA1 and HOXA2 genes, shows myeloid-specific expression, and is up-regulated during granulocytic differentiation. The novel gene, termed HOTAIRM1 (HOX antisense intergenic RNA myeloid 1), is transcribed antisense to the HOXA g...

journal_title：Blood

authors： Zhang X,Lian Z,Padden C,Gerstein MB,Rozowsky J,Snyder M,Gingeras TR,Kapranov P,Weissman SM,Newburger PE

更新日期：2009-03-12 00:00:00

abstract：:Lym-1 is a murine IgG2a monoclonal antibody that recognizes a polymorphic variant of HLA-DR antigens on malignant B cells, with minimal cross-reactivity with normal tissues. Because it can be safely administered in vivo, a detailed knowledge of its ability to recruit and trigger the antitumor immune effector systems i...

journal_title：Blood

authors： Ottonello L,Morone P,Dapino P,Dallegri F

更新日期：1996-06-15 00:00:00

abstract：:To evaluate the association between fetal hemoglobin (HbF) levels and morbidity in β-thalassemia intermedia (TI), we analyzed data from 63 untransfused patients who had also never received HbF induction therapy. Patient records were reviewed for any history of 10 predefined morbidities. Laboratory measurements for mar...

journal_title：Blood

authors： Musallam KM,Sankaran VG,Cappellini MD,Duca L,Nathan DG,Taher AT

更新日期：2012-01-12 00:00:00

abstract：:Hemoglobin and ferritin iron content have been followed during differentiation in tissue cultures of murine erythroleukemia cells (MELC) using the techniques of Mössbauer spectroscopy and electron microscopy. In undifferentiated cells grown without DMSO, only iron stored in ferritin was detected. The amount of iron in...

journal_title：Blood

authors： Ofer S,Fibach E,Kessel M,Bauminger ER,Cohen SG,Eikelboom J,Rachmilewitz EA

更新日期：1981-08-01 00:00:00

abstract：:Identification of human hematopoietic stem cells and analysis of molecular mechanisms regulating their function require biological assays that permit differentiation in all hematopoietic lineages simultaneously. In this study, we established conditions that permit the joint expression of the B-lymphoid and myeloid pot...

journal_title：Blood

authors： Berardi AC,Meffre E,Pflumio F,Katz A,Vainchenker W,Schiff C,Coulombel L

更新日期：1997-05-15 00:00:00

abstract：:We have shown that human B-cell non-Hodgkin lymphomas (B-NHLs) express heat shock protein (HSP)H1/105 in function of their aggressiveness. Here, we now clarify its role as a functional B-NHL target by testing the hypothesis that it promotes the stabilization of key lymphoma oncoproteins. HSPH1 silencing in 4 models of...

journal_title：Blood

authors： Zappasodi R,Ruggiero G,Guarnotta C,Tortoreto M,Tringali C,Cavanè A,Cabras AD,Castagnoli L,Venerando B,Zaffaroni N,Gianni AM,De Braud F,Tripodo C,Pupa SM,Di Nicola M

更新日期：2015-03-12 00:00:00

abstract：:Cord plasma contains colony-stimulating activity (CSA) which stimulates the in vitro clonal growth of neutrophils, eosinophils, macrophages, erythrocytes, and persisting mast cells in semisolid cultures. Analysis of day 35 colonies in agar cultures was found to be a suitable means of demonstrating this activity and di...

journal_title：Blood

authors： Brown RD,Yuen E,Kronenberg H,Rickard KA

更新日期：1986-07-01 00:00:00

abstract：:The purpose of this report was to evaluate scintigraphy analysis of Southern blot hybridization as a method to quantify the breakpoint cluster region (BCR) rearrangement of Philadelphia chromosome (Ph)+ chronic myelogenous leukemia (CML). Cytogenetic and molecular studies performed simultaneously on 474 bone marrow an...

journal_title：Blood

authors： Verschraegen CF,Talpaz M,Hirsch-Ginsberg CF,Pherwani R,Rios MB,Stass SA,Kantarjian HM

更新日期：1995-05-15 00:00:00

abstract：:The present study focuses on a large family with an X-linked immunodeficiency in which there are variable clinical and laboratory phenotypes, including recurrent viral and bacterial infections, hypogammaglobulinemia, Epstein-Barr virus-driven lymphoproliferation, splenomegaly, colitis, and liver disease. Molecular and...

journal_title：Blood

authors： Rigaud S,Lopez-Granados E,Sibéril S,Gloire G,Lambert N,Lenoir C,Synaeve C,Stacey M,Fugger L,Stephan JL,Fischer A,Picard C,Durandy A,Chapel H,Latour S

更新日期：2011-07-14 00:00:00

abstract：:Immune thrombocytopenias are usually associated with normal or increased numbers of megakaryocytes in the marrow. Therefore, the mechanism(s) responsible for the destruction of circulating platelets may not affect megakaryocytes in the same way. One of the possibilities which could account for the differential effect ...

journal_title：Blood

authors： Stahl CP,Zucker-Franklin D,McDonald TP

更新日期：1986-02-01 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi sarcoma (KS) and multicentric Castleman disease (MCD), a life-threatening, virally induced B-cell lymphoproliferative disorder. HHV-8 is a B-lymphotropic γ-herpesvirus closely related to the Epstein-Barr virus (EBV). Invariant natural killer T (iNKT) cells a...

journal_title：Blood

authors： Sbihi Z,Dossier A,Boutboul D,Galicier L,Parizot C,Emarre A,Hoareau B,Dupin N,Marcelin AG,Oudin A,Fieschi C,Agbalika F,Autran B,Oksenhendler E,Carcelain G

更新日期：2017-02-16 00:00:00

abstract：:FLT3 is constitutively activated by internal tandem duplications (ITDs) in the juxtamembrane domain or by activation loop mutations in acute myeloid leukemia (AML). We tested the sensitivity of 8 activation loop mutations to the small molecule FLT3 inhibitor, MLN518. Each FLT3 activation loop mutant, including D835Y, ...

journal_title：Blood

authors： Clark JJ,Cools J,Curley DP,Yu JC,Lokker NA,Giese NA,Gilliland DG

更新日期：2004-11-01 00:00:00

abstract：:Induction of red blood cell (RBC) fetal hemoglobin (HbF; α2γ2) ameliorates the pathophysiology of sickle cell disease (SCD) by reducing the concentration of sickle hemoglobin (HbS; α2βS2) to inhibit its polymerization. Hydroxyurea (HU), the only US Food and Drug Administration (FDA)-approved drug for SCD, acts in part...

journal_title：Blood

authors： Zhang Y,Paikari A,Sumazin P,Ginter Summarell CC,Crosby JR,Boerwinkle E,Weiss MJ,Sheehan VA

更新日期：2018-07-19 00:00:00

abstract：:Dendritic cells (DCs) are considered critical for the induction of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In addition to their priming function, dendritic cells have been shown to induce organ-tropism through induction of specific homing molecules on T cells. Using adoptive transfer ...

journal_title：Blood

authors： Kim TD,Terwey TH,Zakrzewski JL,Suh D,Kochman AA,Chen ME,King CG,Borsotti C,Grubin J,Smith OM,Heller G,Liu C,Murphy GF,Alpdogan O,van den Brink MR

更新日期：2008-03-01 00:00:00

abstract：:An abnormality of platelet aggregation has been detected in six family members with mild bleeding tendencies. In citrated platelet-rich plasma, primary aggregation induced by ADP or epinephrine and agglutination in response to ristocetin were present but second wave aggregation and aggregation in response to collagen ...

journal_title：Blood

authors： Ingerman CM,Smith JB,Shapiro S,Sedar A,Silver MJ

更新日期：1978-08-01 00:00:00

abstract：:Arsenic trioxide, as a single agent, has proven efficacy in inducing molecular remission in patients with acute promyelocytic leukemia (APL). There is limited long-term outcome data with single-agent As2O3 in the management of newly diagnosed cases of APL. Between January 1998 to December 2004, 72 newly diagnosed case...

journal_title：Blood

authors： Mathews V,George B,Lakshmi KM,Viswabandya A,Bajel A,Balasubramanian P,Shaji RV,Srivastava VM,Srivastava A,Chandy M

更新日期：2006-04-01 00:00:00