当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity.

Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity.

Abstract：

:Arsenic trioxide, as a single agent, has proven efficacy in inducing molecular remission in patients with acute promyelocytic leukemia (APL). There is limited long-term outcome data with single-agent As2O3 in the management of newly diagnosed cases of APL. Between January 1998 to December 2004, 72 newly diagnosed cases of APL were treated with a regimen of single-agent As2O3 at our center. Complete hematologic remission was achieved in 86.1%. At a median follow-up of 25 months (range: 8-92 months), the 3-year Kaplan-Meier estimate of EFS, DFS, and OS was 74.87% +/- 5.6%, 87.21% +/- 4.93%, and 86.11% +/- 4.08%, respectively. Patients presenting with a white blood cell (WBC) count lower than 5 x 10(9)/L and a platelet count higher than 20 x 10(9)/L at diagnosis (n = 22 [30.6%]) have an excellent prognosis with this regimen (EFS, OS, and DFS of 100%). The toxicity profile, in the majority, was mild and reversible. After remission induction, this regimen was administered on an outpatient basis. Single-agent As2O3, as used in this series, in the management of newly diagnosed cases of APL, is associated with responses comparable with conventional chemotherapy regimens. Additionally, this regimen has minimal toxicity and can be administered on an outpatient basis after remission induction.

journal_name

Blood

journal_title

Blood

authors

Mathews V,George B,Lakshmi KM,Viswabandya A,Bajel A,Balasubramanian P,Shaji RV,Srivastava VM,Srivastava A,Chandy M

doi

10.1182/blood-2005-08-3532

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

2627-32

issue

7

eissn

0006-4971

issn

1528-0020

pii

2005-08-3532

journal_volume

107

pub_type

临床试验,杂志文章

相关文献

BLOOD文献大全
  • Second to none.

    abstract：:In this issue of Blood, Usmani et al provide important information on second primary malignancies in patients treated with thalidomide and lenalidomide in the Arkansas total therapy trials. ...

    journal_title：Blood

    pub_type： 评论,杂志文章

    doi：10.1182/blood-2012-07-439158

    authors： Rajkumar SV

    更新日期：2012-08-23 00:00:00

  • Contribution of distinct adhesive interactions to platelet aggregation in flowing blood.

    abstract：:Aggregation of blood platelets contributes to the arrest of bleeding at sites of vascular injury, but it can occlude atherosclerotic arteries and precipitate diseases such as myocardial infarction. The bonds that link platelets under flow conditions were identified using confocal videomicroscopy in real time. Glycopro...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ruggeri ZM,Dent JA,Saldívar E

    更新日期：1999-07-01 00:00:00

  • Quantitation, selection, and functional characterization of Epstein-Barr virus-specific and alloreactive T cells detected by intracellular interferon-gamma production and growth of cytotoxic precursors.

    abstract：:Techniques for the quantitation of virus-specific and alloantigen-reactive T cells vary in their measurement of clinically relevant T-cell effector populations, their sensitivity and quantitative accuracy, and the time required to obtain measurable results. We compared frequencies of Epstein-Barr virus (EBV)-specific ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.5.1730

    authors： Koehne G,Smith KM,Ferguson TL,Williams RY,Heller G,Pamer EG,Dupont B,O'Reilly RJ

    更新日期：2002-03-01 00:00:00

  • Involvement of CD36 on erythrocytes as a rosetting receptor for Plasmodium falciparum-infected erythrocytes.

    abstract：:Plasmodium falciparum-infected erythrocytes (parasitized red blood cells [PRBCs]) can adhere to uninfected erythrocytes (RBCs) to form rosettes, and adhere to the endothelial cell (EC) surface antigen CD36. These adherence phenomena have previously been considered quite different. We show that anti-CD36 monoclonal ant...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Handunnetti SM,van Schravendijk MR,Hasler T,Barnwell JW,Greenwalt DE,Howard RJ

    更新日期：1992-10-15 00:00:00

  • Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage.

    abstract：:Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, but few genetic risk factors have been associated with its development. Recently, it has been reported that some polymorphisms that affect clotting factors increase the risk for thrombosis. However, reports have analyzed the effect of...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v97.10.2979

    authors： Corral J,Iniesta JA,González-Conejero R,Villalón M,Vicente V

    更新日期：2001-05-15 00:00:00

  • Effect of platelet calpain on normal T-lymphocyte CD43: hypothesis of events in the Wiskott-Aldrich syndrome.

    abstract：:The Wiskott-Aldrich syndrome (WAS) is an inherited disease involving defects of platelets (small size, severe thrombocytopenia due to accelerated destruction) and T lymphocytes (progressive immunodeficiency, lymphopenia). The best-characterized molecular defect is the deficiency and, in some cases, abnormal forms of t...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Remold-O'Donnell E,Van Brocklyn J,Kenney DM

    更新日期：1992-04-01 00:00:00

  • Negative regulation of erythroblast maturation by Fas-L(+)/TRAIL(+) highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma.

    abstract：:Multiple myeloma (MM) is associated with severe normochromic/normocytic anemia. This study demonstrates that the abnormal up-regulation of apoptogenic receptors, including both Fas ligand (L) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), by highly malignant myeloma cells is involved in the patho...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.4.1305

    authors： Silvestris F,Cafforio P,Tucci M,Dammacco F

    更新日期：2002-02-15 00:00:00

  • Activation of the erythropoietin receptor is not required for internalization of bound erythropoietin.

    abstract：:Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding to its cognate receptor, EPO promotes receptor homodimerization, activation of receptor-associated JAK2, subs...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Beckman DL,Lin LL,Quinones ME,Longmore GD

    更新日期：1999-10-15 00:00:00

  • A monoclonal antibody that recognizes a neo-antigen exposed in the E domain of fibrin monomer complexed with fibrinogen or its derivatives: its application to the measurement of soluble fibrin in plasma.

    abstract：:Using urea-solubilized human fibrin monomer as an immunogen, we raised in mice a battery of monoclonal antibodies that reacted with the immunogen but not with urea-treated or native fibrinogen. Although they all failed to react with acid-solubilized fibrin monomer (acid-FM) alone, an antibody designated as IF-43 was f...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Soe G,Kohno I,Inuzuka K,Itoh Y,Matsuda M

    更新日期：1996-09-15 00:00:00

  • Late failure of autologous marrow grafts in lethally irradiated dogs given anti-class II monoclonal antibody.

    abstract：:We established a model of canine marrow autografts after 9.2 Gy total body irradiation (TBI) to study the role of class II antigens in hematopoietic stem cell growth and differentiation. Twenty dogs were given 9.2 Gy TBI, marrow, and intravenous (IV) murine anti-class II monoclonal antibody (MoAb). Infusion of 0.6 mg/...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Greinix HT,Ladiges WC,Graham TC,Maslan S,Raff RF,Sandmaier BM,Appelbaum FR,Schuening FG,Deeg HJ,Storb R

    更新日期：1991-10-15 00:00:00

  • Inhibition of BCR-ABL expression with antisense oligodeoxynucleotides restores beta1 integrin-mediated adhesion and proliferation inhibition in chronic myelogenous leukemia hematopoietic progenitors.

    abstract：:Chronic myelogenous leukemia (CML) is characterized by the continuous proliferation and abnormal circulation of malignant hematopoietic progenitors. This may be related to the unresponsiveness of CML progenitors to beta1 integrin adhesion receptor-mediated inhibition of progenitor proliferation by the marrow microenvi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bhatia R,Verfaillie CM

    更新日期：1998-05-01 00:00:00

  • The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.

    abstract：:The transcription factor c-Maf is extensively involved in the pathophysiology of multiple myeloma (MM), a fatal malignancy of plasma cells. In the present study, affinity chromatography and mass spectrometry were used to identify c-Maf ubiquitination-associated proteins, from which the E3 ligase HERC4 was found to int...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2015-07-658203

    authors： Zhang Z,Tong J,Tang X,Juan J,Cao B,Hurren R,Chen G,Taylor P,Xu X,Shi CX,Du J,Hou J,Wang G,Wu D,Stewart AK,Schimmer AD,Moran MF,Mao X

    更新日期：2016-03-31 00:00:00

  • Progressive dysfunction of monocytes associated with iron overload and age in patients with thalassemia major.

    abstract：:We evaluated phagocytic and lytic activities of peripheral blood monocytes (PBMo) from patients with thalassemia major (ThP) using C pseudotropicalis as the target. PBMo from ThP showed decreased lytic activity (P less than .001), whereas the phagocytic activity did not differ from that of the controls. Significant in...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ballart IJ,Estevez ME,Sen L,Diez RA,Giuntoli J,de Miani SA,Peñalver J

    更新日期：1986-01-01 00:00:00

  • Vitamin D receptor-mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis.

    abstract：:Myelofibrosis in myeloproliferative neoplasms (MPNs) with mutations such as JAK2V617F is an unfavorable sign for uncontrollable disease progression in the clinic and is complicated with osteosclerosis whose pathogenesis is largely unknown. Because several studies have revealed that macrophages are an indispensable sup...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2018-09-876615

    authors： Wakahashi K,Minagawa K,Kawano Y,Kawano H,Suzuki T,Ishii S,Sada A,Asada N,Sato M,Kato S,Shide K,Shimoda K,Matsui T,Katayama Y

    更新日期：2019-04-11 00:00:00

  • Plasmids in bacteria exposed to activated neutrophils mediate mutagenesis when transferred to new hosts.

    abstract：:The plasmid pUC18 contains a lacZ alpha-complementation gene that codes for a small peptide that can complement the delta M15 mutation of the Escherichia coli lacZ (beta-galactosidase) gene, converting bacteria carrying that mutated gene from the lacZ- to the lacZ+ phenotype. This plasmid was used in experiments desig...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： De Togni P,Fox HB,Morrissey S,Tansey LR,Levy SB,Babior BM

    更新日期：1988-02-01 00:00:00

  • Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of interleukin-4.

    abstract：:The stress-activated protein/c-Jun N-terminal kinases (SAPK/JNK) have been shown to be activated by pro-inflammatory cytokines, as well as physical and chemical stresses. We now show that a variety of hematopoietic growth factors, including Steel locus factor (SLF), granulocyte-macrophage colony-stimulating factor (GM...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Foltz IN,Schrader JW

    更新日期：1997-05-01 00:00:00

  • A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo.

    abstract：:Previous in vitro findings suggest a critical role for the polymorphonuclear leukocyte (PMN) membrane glycoprotein complex CD18 in PMN adherence and chemotaxis. We examined the effect of the murine monoclonal antibody (MoAb) 60.3, recognizing CD18, on induced PMN accumulation in vivo. Rabbits were pretreated with MoAb...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Arfors KE,Lundberg C,Lindbom L,Lundberg K,Beatty PG,Harlan JM

    更新日期：1987-01-01 00:00:00

  • Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils.

    abstract：:In vitro studies as well as clinical trials indicate that the cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) enhance the ability of neutrophils (polymorphonuclear leukocytes) to eliminate microbial organisms. Toll-like receptor (TLR) proteins, homo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Kurt-Jones EA,Mandell L,Whitney C,Padgett A,Gosselin K,Newburger PE,Finberg RW

    更新日期：2002-09-01 00:00:00

  • High risk of severe bleeding in aged patients with chronic idiopathic thrombocytopenic purpura.

    abstract：:The purpose of this study was to estimate the incidence and to establish which factors were associated with an increased risk of hemorrhagic complications in an historic cohort of 117 consecutive and unselected patients with chronic idiopathic thrombocytopenic purpura (ITP). Sixty-eight patients (58%) underwent medica...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Cortelazzo S,Finazzi G,Buelli M,Molteni A,Viero P,Barbui T

    更新日期：1991-01-01 00:00:00

  • Association of tissue factor pathway inhibitor with human umbilical vein endothelial cells.

    abstract：:Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation system, synthesized in endothelial cells, which has recently been shown to play an important role in the regulation of activated coagulation factors at the endothelial cell surface. In the present study we investigated t...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Hansen JB,Olsen R,Webster P

    更新日期：1997-11-01 00:00:00

  • Neoplastic human T-cells capable of responding to multiple human alloantigens.

    abstract：:Monoclonally-derived neoplastic T-cells from a patient with cutaneous T-cell lymphoma respond to multiple human HLA-D antigens in mixed lymphocyte culture. The implications of this phenomenon relevant to normal T-cell function and to malignancy are discussed. ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Rubenfeld MR,Edelson RL,Löfström LM,Berger CL,Warburton D

    更新日期：1980-03-01 00:00:00

  • Elevated serum levels of interleukin-5 in patients with the syndrome of episodic angioedema and eosinophilia.

    abstract：:The syndrome of episodic angioedema and eosinophilia is characterized by cyclic edema, marked peripheral blood eosinophilia, and eosinophil degranulation in the dermis. Using a sensitive immunoenzymetric method, we measured serum interleukin (IL)-5 levels in four patients with this syndrome. We also determined the per...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Butterfield JH,Leiferman KM,Abrams J,Silver JE,Bower J,Gonchoroff N,Gleich GJ

    更新日期：1992-02-01 00:00:00

  • Bone marrow contains virus-specific cytotoxic T lymphocytes.

    abstract：:Immunizing bone marrow donors prior to bone marrow transplant (BMT) has the potential for adoptively transferring specific immunity against opportunistic pathogens. Studies have shown that long-term antibody production occurs in the bone marrow and that specific humoral immunity may be transferred from donor to recipi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Slifka MK,Whitmire JK,Ahmed R

    更新日期：1997-09-01 00:00:00

  • Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6.

    abstract：:NF-IL6 was originally identified as a DNA binding protein regulating interleukin-1 (IL-1)-stimulated IL-6 expression. Direct cloning of NF-IL6 showed its homology with C/EBP, a hepatocyte- and adipocyte-specific transcription factor. This study showed that the expression of NF-IL6 messenger RNA (mRNA) increased marked...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Natsuka S,Akira S,Nishio Y,Hashimoto S,Sugita T,Isshiki H,Kishimoto T

    更新日期：1992-01-15 00:00:00

  • The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients.

    abstract：:Staining with CD14 and CD16 monoclonal antibodies will identify two monocyte subpopulations in human blood: a major population of regular monocytes, which strongly expresses the CD14 antigen (CD14++), and a minor population with weak expression of CD14 and expression of the CD16 antigen (CD14+/CD16+ cells). As shown h...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Fingerle G,Pforte A,Passlick B,Blumenstein M,Ströbel M,Ziegler-Heitbrock HW

    更新日期：1993-11-15 00:00:00

  • Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.

    abstract：:Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection. However, its role in adaptive immune responses has not been well defined. In this study, we report that the lack of SRA/CD204 promotes Toll-like...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-11-190033

    authors： Yi H,Yu X,Gao P,Wang Y,Baek SH,Chen X,Kim HL,Subjeck JR,Wang XY

    更新日期：2009-06-04 00:00:00

  • A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster.

    abstract：:We have identified an intergenic transcriptional activity that is located between the human HOXA1 and HOXA2 genes, shows myeloid-specific expression, and is up-regulated during granulocytic differentiation. The novel gene, termed HOTAIRM1 (HOX antisense intergenic RNA myeloid 1), is transcribed antisense to the HOXA g...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-06-162164

    authors： Zhang X,Lian Z,Padden C,Gerstein MB,Rozowsky J,Snyder M,Gingeras TR,Kapranov P,Weissman SM,Newburger PE

    更新日期：2009-03-12 00:00:00

  • Erratum: Airoldi I, Bertaina A, Prigione I, et al. γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes. Blood. 2015;125(15):2349-2358.

    abstract：:[This corrects the article DOI: 10.1182/blood-2014-09-599423.]. ...

    journal_title：Blood

    pub_type： 杂志文章,已发布勘误

    doi：10.1182/blood-2016-02-700625

    authors：

    更新日期：2016-03-24 00:00:00

  • Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum.

    abstract：:Intracellular protein transport in endothelial cells is selectively inhibited by homocysteine, a thiol amino acid associated with both thrombosis and atherosclerosis. In a previous study, homocysteine decreased cell surface expression of the surface transmembrane glycoprotein thrombomodulin without decreasing secretio...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Lentz SR,Sadler JE

    更新日期：1993-02-01 00:00:00

  • Changes in activities and isozyme patterns of glycolytic enzymes during erythroid differentiation in vitro.

    abstract：:Late committed progenitor cells of erythropoiesis, CFU-E (colony-forming unit--erythroid), were isolated from mouse spleens to near homogeneity by a three-step enrichment procedure. The procedure included a four-day pretreatment of bled mice with the antibiotic thiamphenicol, a recovery period of 3 1/2 days, followed ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Nijhof W,Wierenga PK,Staal GE,Jansen G

    更新日期：1984-09-01 00:00:00