Stimulation of persisting colonies in agar cultures by sera from patients with CML and AML.

abstract：:In a chromosome study in childhood T-cell leukemia/lymphoma, we found t(7;11)(q35;p13) in 2 patients, t(7;14) (q35;q11) in one patient, and t(7;14)(p15;q32) in 1 patient. Southern blotting and in situ chromosomal hybridization studies in one patient with the t(7;11) demonstrated that both alleles of the T-cell antigen...

journal_title：Blood

authors： Kaneko Y,Maseki N,Homma C,Sakurai M,Mizutani S,Takeda T,Shikano T,Fujimoto T,Yaoi K,Shimokawa T

更新日期：1988-08-01 00:00:00

abstract：:Emerging evidence indicates that tumors can follow several evolutionary paths over a patient's disease course. With the use of serial genomic analysis of samples collected at different points during the disease course of 28 patients with multiple myeloma, we found that the genomes of standard-risk patients show few ch...

journal_title：Blood

authors： Keats JJ,Chesi M,Egan JB,Garbitt VM,Palmer SE,Braggio E,Van Wier S,Blackburn PR,Baker AS,Dispenzieri A,Kumar S,Rajkumar SV,Carpten JD,Barrett M,Fonseca R,Stewart AK,Bergsagel PL

更新日期：2012-08-02 00:00:00

abstract：:Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (e.g., p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins is a novel therap...

journal_title：Blood

authors： Ranganathan P,Yu X,Na C,Santhanam R,Shacham S,Kauffman M,Walker A,Klisovic R,Blum W,Caligiuri M,Croce CM,Marcucci G,Garzon R

更新日期：2012-08-30 00:00:00

abstract：:The W locus of mice encodes the c-kit receptor tyrosine kinase. Heterozygous WJic/+ and Wn/+ mice and homozygous Wf/Wf mice were similar in appearance; all of them have large depigmented areas lacking any well-defined pattern. The WJic, Wn, and Wf mutant alleles were characterized and their molecular nature was correl...

journal_title：Blood

authors： Tsujimura T,Koshimizu U,Katoh H,Isozaki K,Kanakura Y,Tono T,Adachi S,Kasugai T,Tei H,Nishimune Y

更新日期：1993-05-15 00:00:00

abstract：:The prevalence of anti-hepatitis C virus (HCV) enzyme immunoassay (EIA)-positive in 167,511 Australian volunteer blood donors from Adelaide, Melbourne, Perth, and Sydney was 0.78%. One thousand two-hundred and eighteen EIA-positive serum samples were assessed by supplemental tests including a blocking EIA and two pept...

journal_title：Blood

authors： Allain JP,Coghlan PJ,Kenrick KG,Whitson K,Keller A,Cooper GJ,Vallari DS,Delaney SR,Kuhns MC

更新日期：1991-11-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) caused by impaired FAS-mediated apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased risk of invasive bacterial infection, notably following splenectomy. We surveyed a cohort of 100 ALPS patients (including 33 splenectomize...

journal_title：Blood

authors： Neven B,Bruneau J,Stolzenberg MC,Meyts I,Magerus-Chatinet A,Moens L,Lanzarotti N,Weller S,Amiranoff D,Florkin B,Bader-Meunier B,Leverger G,Ferster A,Chantrain C,Blanche S,Picard C,Molina TJ,Brousse N,Durandy A,Rizzi

更新日期：2014-09-04 00:00:00

abstract：:An acquired gain-of-function mutation in the Janus kinase 2 (JAK2-V617F) is frequently found in patients with myeloproliferative disorders (MPDs). To test the hypothesis that JAK2-V617F is the disease-initiating mutation, we examined whether all cells of clonal origin carry the JAK2-V617F mutation. Using allele-specif...

journal_title：Blood

authors： Kralovics R,Teo SS,Li S,Theocharides A,Buser AS,Tichelli A,Skoda RC

更新日期：2006-08-15 00:00:00

abstract：:Viral infections are common and are potentially life-threatening in patients with moderate to severe primary immunodeficiency disorders. Because T-cell immunity contributes to the control of many viral pathogens, adoptive immunotherapy with virus-specific T cells (VSTs) has been a logical and effective way of combatin...

journal_title：Blood

authors： Keller MD,Bollard CM

更新日期：2020-02-27 00:00:00

abstract：:Loss or mutation of the TP53 tumor suppressor gene is not commonly observed in acute myeloid leukemia (AML), suggesting that there is an alternate route for cell transformation. We investigated the hypothesis that previously observed Bcl-2 family member overexpression suppresses wild-type p53 activity in AML. We demon...

journal_title：Blood

authors： Irish JM,Anensen N,Hovland R,Skavland J,Børresen-Dale AL,Bruserud O,Nolan GP,Gjertsen BT

更新日期：2007-03-15 00:00:00

abstract：:Human cord blood progenitor-derived erythroblasts have recently been shown to respond to erythropoietin (Epo) or granulocyte-macrophage colony-stimulating factor (GM-CSF) with a transient increase in intracellular free calcium concentration [Cac]. However, the importance of [Cac] changes in mediating cell proliferatio...

journal_title：Blood

authors： Miller BA,Cheung JY,Tillotson DL,Hope SM,Scaduto RC Jr

更新日期：1989-04-01 00:00:00

abstract：:In common variable immunodeficiency (CVID) defects in early stages of B-cell development, bone marrow (BM) plasma cells and T lymphocytes have not been studied systematically. Here we report the first morphologic and flow cytometric study of B- and T-cell populations in CVID BM biopsies and aspirates. Whereas the hema...

journal_title：Blood

authors： Ochtrop ML,Goldacker S,May AM,Rizzi M,Draeger R,Hauschke D,Stehfest C,Warnatz K,Goebel H,Technau-Ihling K,Werner M,Salzer U,Eibel H,Schlesier M,Peter HH

更新日期：2011-07-14 00:00:00

abstract：:Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-t...

journal_title：Blood

authors： Pendino F,Nguyen E,Jonassen I,Dysvik B,Azouz A,Lanotte M,Ségal-Bendirdjian E,Lillehaug JR

更新日期：2009-04-02 00:00:00

abstract：:Through its Src homology 3 (SH3) and SH2 domains, the Src kinase Lyn interacts with a small number of phosphoproteins, such as Shc, Cbl, and Vav, which regulate cell cycle and the cytoskeleton. Using Lyn's Unique, SH3, and SH2 domains as bait in a yeast 2-hybrid screen, we isolated a novel gene product with features o...

journal_title：Blood

authors： Dombrosky-Ferlan P,Grishin A,Botelho RJ,Sampson M,Wang L,Rudert WA,Grinstein S,Corey SJ

更新日期：2003-04-01 00:00:00

abstract：:Human recombinant interleukin-4 (IL-4) was studied for its effects on myeloid progenitor cells from normal and leukemic bone marrow cells in the presence and absence of additional growth factors. IL-4 itself did not support myeloid cluster or colony formation (CFU-GM). However, cultures supplied with IL-4 (300 U/mL) a...

journal_title：Blood

authors： Vellenga E,de Wolf JT,Beentjes JA,Esselink MT,Smit JW,Halie MR

更新日期：1990-02-01 00:00:00

abstract：:The survival of patients with Waldenstrom macroglobulinemia (WM) varies enormously. The development of prognostic models in WM has been fraught by limited follow-up in current studies. Here, we update the outcome of a prospective WM trial with a median follow-up of 10 years for live patients. Of the 59 previously untr...

journal_title：Blood

authors： Dhodapkar MV,Hoering A,Gertz MA,Rivkin S,Szymonifka J,Crowley J,Barlogie B

更新日期：2009-01-22 00:00:00

abstract：:One hundred eight consecutive patients with indolent lymphoproliferative diseases were stratified into chronic lymphocytic leukemia (CLL), stage III and IV well-differentiated lymphocytic lymphoma (WDLL), and stage III and IV follicular lymphoma (FL). Within each stratum, patients were prospectively and randomly assig...

journal_title：Blood

authors： Jacobs P,King HS

更新日期：1987-06-01 00:00:00

abstract：:The role of platelets in hemostasis and thrombosis is clearly established; however, the mechanisms by which platelets mediate inflammatory and immune pathways are less well understood. Platelets interact and modulate the function of blood and vascular cells by releasing bioactive molecules. Although the platelet is an...

journal_title：Blood

authors： Risitano A,Beaulieu LM,Vitseva O,Freedman JE

更新日期：2012-06-28 00:00:00

abstract：:The metalloprotease ADAMTS13 is assumed to regulate the functional levels of von Willebrand factor (VWF) appropriate for normal hemostasis in vivo by reducing VWF multimer size, which directly represents the thrombogenic activity of this factor. Using an in vitro perfusion chamber system, we studied the mechanisms of ...

journal_title：Blood

authors： Shida Y,Nishio K,Sugimoto M,Mizuno T,Hamada M,Kato S,Matsumoto M,Okuchi K,Fujimura Y,Yoshioka A

更新日期：2008-02-01 00:00:00

abstract：:The ability of platelets to provide a highly reactive surface for the recruitment of other platelets and leukocytes to sites of vascular injury is critical for hemostasis, atherothrombosis, and a variety of inflammatory diseases. The mechanisms coordinating platelet-platelet and platelet-leukocyte interactions have be...

journal_title：Blood

authors： Kulkarni S,Woollard KJ,Thomas S,Oxley D,Jackson SP

更新日期：2007-09-15 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is composed of large, frequently bizarre, cells of T- or null-cell phenotype that show a preferential sinusoidal growth pattern and consistent CD30 positivity. Whether these tumors represent a single entity or several, and what the exact cell origin, is controversial. Recently, gr...

journal_title：Blood

authors： Krenacs L,Wellmann A,Sorbara L,Himmelmann AW,Bagdi E,Jaffe ES,Raffeld M

更新日期：1997-02-01 00:00:00

abstract：:The TEL/PDGFbetaR fusion protein is expressed as the consequence of a recurring t(5;12) translocation associated with chronic myelomonocytic leukemia (CMML). Unlike other activated protein tyrosine kinases associated with hematopoietic malignancies, TEL/PDGFbetaR is invariably associated with a myeloid leukemia phenot...

journal_title：Blood

authors： Tomasson MH,Williams IR,Hasserjian R,Udomsakdi C,McGrath SM,Schwaller J,Druker B,Gilliland DG

更新日期：1999-03-01 00:00:00

abstract：:Drug-induced immune thrombocytopenia (DITP) is caused by drug-dependent antibodies (DDAbs) that are nonreactive in themselves but bind tightly to specific platelet membrane glycoproteins (GP) when soluble drug is present at pharmacologic concentrations. This reaction takes place without covalent linkage of drug to the...

journal_title：Blood

authors： Bougie DW,Birenbaum J,Rasmussen M,Poncz M,Aster RH

更新日期：2009-01-29 00:00:00

abstract：:A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive im...

journal_title：Blood

authors： Shimazu T,Iida R,Zhang Q,Welner RS,Medina KL,Alberola-Lla J,Kincade PW

更新日期：2012-05-24 00:00:00

abstract：:Multidrug resistance (MDR) is often characterized by the expression of P-glycoprotein (P-gp), a 170-kd ATP-dependent drug efflux protein. As well as effluxing xenotoxins, functional P-gp can confer resistance to caspase-dependent apoptosis induced by a range of different stimuli, including Fas ligand, tumor necrosis f...

journal_title：Blood

authors： Ruefli AA,Smyth MJ,Johnstone RW

更新日期：2000-04-01 00:00:00

abstract：:CCR5 is a receptor for several beta chemokines and the entry coreceptor used by macrophage-tropic (R5) strains of HIV-1. In addition to supporting viral entry, CCR5 ligation by the HIV-1 envelope glycoprotein 120 (gp120) can activate intracellular signals in macrophages and trigger inflammatory mediator release. Using...

journal_title：Blood

authors： Tomkowicz B,Lee C,Ravyn V,Cheung R,Ptasznik A,Collman RG

更新日期：2006-08-15 00:00:00

abstract：:We investigated the molecular genetic and biosynthetic basis of Bernard-Soulier syndrome in a severely affected white woman. Flow cytometric analysis showed a severe deficiency of glycoprotein (GP) Ib, GP IX, and GP V on the surface of her platelets. Similarly, GP Ib alpha was undetectable by immunoblot analysis of pl...

journal_title：Blood

authors： Afshar-Kharghan V,López JA

更新日期：1997-10-01 00:00:00

abstract：:Although the role of systemic activation of the nuclear factor kappaB (NF-kappaB) pathway in septic coagulation has been well documented, little is known about the contribution of endothelial-specific NF-kappaB signaling in this pathologic process. Here, we used transgenic mice that conditionally overexpress a mutant ...

journal_title：Blood

authors： Song D,Ye X,Xu H,Liu SF

更新日期：2009-09-17 00:00:00

abstract：:MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote sel...

journal_title：Blood

authors： Argiropoulos B,Yung E,Xiang P,Lo CY,Kuchenbauer F,Palmqvist L,Reindl C,Heuser M,Sekulovic S,Rosten P,Muranyi A,Goh SL,Featherstone M,Humphries RK

更新日期：2010-05-20 00:00:00

abstract：:Aurora-A kinase (Aur-A) is a member of the serine/threonine kinase family that regulates the cell division process, and has recently been implicated in tumorigenesis. In this study, we identified an antigenic 9-amino-acid epitope (Aur-A(207-215): YLILEYAPL) derived from Aur-A capable of generating leukemia-reactive cy...

journal_title：Blood

authors： Ochi T,Fujiwara H,Suemori K,Azuma T,Yakushijin Y,Hato T,Kuzushima K,Yasukawa M

更新日期：2009-01-01 00:00:00

abstract：:Phospholipase A(2) type IVA (IVAPLA(2)) is a cytosolic enzyme that on activation selectively releases arachidonic acid (AA) from cell membrane phospholipids. Both AA and lysophospholipid, products of the enzymic reaction, can function as signal transducers in cellular interactions. The enzyme is present in most cells,...

journal_title：Blood

authors： Macdonald DJ,Boyle RM,Glen AC,Horrobin DF

更新日期：2004-05-01 00:00:00