Abstract:
:A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive immune system. Levels of the marker are high on all progenitors with lymphopoietic potential, and progressive loss helps to establish relations between progenitors corresponding to myeloid and erythroid lineages. CD86 represents an important tool for subdividing HSCs in several circumstances, identifying those unlikely to generate a full spectrum of hematopoietic cells.
journal_name
Bloodjournal_title
Bloodauthors
Shimazu T,Iida R,Zhang Q,Welner RS,Medina KL,Alberola-Lla J,Kincade PWdoi
10.1182/blood-2011-10-388736subject
Has Abstractpub_date
2012-05-24 00:00:00pages
4889-97issue
21eissn
0006-4971issn
1528-0020pii
blood-2011-10-388736journal_volume
119pub_type
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