Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.

abstract：:B-cell precursors are present in the thymus, and the thymic microenvironment is the source of lymphopoietic factors that include interleukin-7 (IL-7). Despite the fact that intrathymic B-cell progenitors are bone marrow-derived cells, the data in this report demonstrate that these progenitors accumulate at an early pr...

journal_title：Blood

authors： Hashimoto Y,Montecino-Rodriguez E,Leathers H,Stephan RP,Dorshkind K

更新日期：2002-11-15 00:00:00

abstract：:In this issue of Blood, Bagnara et al describe the development of a reliable and convincing xenograft model of CLL that recapitulates aspects of the leukemic microenvironment and gives intriguing insights into disease biology. ...

journal_title：Blood

authors： Devereux S

更新日期：2011-05-19 00:00:00

abstract：:Maintaining a steady pool of self-renewing hematopoietic stem cells (HSCs) is critical for sustained production of multiple blood lineages. Many transcription factors and molecules involved in chromatin and epigenetic modifications have been found to be critical for HSC self-renewal and differentiation; however, their...

journal_title：Blood

authors： Yu S,Cui K,Jothi R,Zhao DM,Jing X,Zhao K,Xue HH

更新日期：2011-02-17 00:00:00

abstract：:Factor VIII procoagulant protein (VIII:C) purified from commercial factor VIII concentrate contained multiple polypeptides ranging in mol wt from 79,000 to 188,000, all of which were removed from solution by a monoclonal anti-VIII:C antibody specific for a thrombin-sensitive epitope. In a time-course digest of the pur...

journal_title：Blood

authors： Fulcher CA,Roberts JR,Zimmerman TS

更新日期：1983-04-01 00:00:00

abstract：:Bortezomib (PS-341), a selective inhibitor of proteasomes, induces apoptosis in multiple myeloma (MM) cells; however, prolonged drug exposure may result in cumulative toxicity and the development of chemoresistance. Here we show that combining PK-11195 (PK), an antagonist to mitochondrial peripheral benzodiazepine rec...

journal_title：Blood

authors： Chauhan D,Li G,Podar K,Hideshima T,Mitsiades C,Schlossman R,Munshi N,Richardson P,Cotter FE,Anderson KC

更新日期：2004-10-15 00:00:00

abstract：:Plasminogen activator inhibitor 1 (PAI-1) is the fast-acting inhibitor of both tissue-type and urokinase-type plasminogen activators (t-PA, u-PA) and is an essential regulatory protein of the fibrinolytic system. In the presence of either the protein vitronectin or the glycosaminoglycan heparin, PAI-1 is also an effic...

journal_title：Blood

authors： Keijer J,Linders M,Wegman JJ,Ehrlich HJ,Mertens K,Pannekoek H

更新日期：1991-09-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a major gram-negative bacterial component that stimulates innate immune response and also induces B-lymphocyte activation. Recent studies have revealed that common molecular patterns of microorganisms such as LPS are recognized by toll-like receptors (TLRs). B cells have 2 known TLRs that m...

journal_title：Blood

authors： Yazawa N,Fujimoto M,Sato S,Miyake K,Asano N,Nagai Y,Takeuchi O,Takeda K,Okochi H,Akira S,Tedder TF,Tamaki K

更新日期：2003-08-15 00:00:00

abstract：:[This corrects the article DOI: 10.1182/blood-2014-09-599423.]. ...

journal_title：Blood

authors：

更新日期：2016-03-24 00:00:00

abstract：:Phosphoinositide 3-kinase gamma (PI3Kgamma) in neutrophils plays a critical role in the directed migration of these cells into inflamed tissues. In this study, we demonstrate the importance of the endothelial component of PI3Kgamma activity relative to its leukocyte counterpart in supporting neutrophil interactions wi...

journal_title：Blood

authors： Puri KD,Doggett TA,Huang CY,Douangpanya J,Hayflick JS,Turner M,Penninger J,Diacovo TG

更新日期：2005-07-01 00:00:00

abstract：:Recombinant gibbon interleukin-3 (IL-3) is a multilineage hematopoietic colony-stimulating factor (CSF) that recently was cloned and found to be highly homologous with human IL-3. Gibbon IL-3, as well as human granulocyte-CSF (G-CSF) and human granulocyte-macrophage CSF (GM-CSF), stimulated normal human bone marrow ce...

journal_title：Blood

authors： Paquette RL,Zhou JY,Yang YC,Clark SC,Koeffler HP

更新日期：1988-06-01 00:00:00

abstract：:Genetic variation in the PEAR1 locus is linked to platelet reactivity and cardiovascular disease. The major G allele of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG-SNP), is associated with higher PEAR1 expression in platelets and endothelial cells than the minor A allele. ...

journal_title：Blood

authors： Izzi B,Pistoni M,Cludts K,Akkor P,Lambrechts D,Verfaillie C,Verhamme P,Freson K,Hoylaerts MF

更新日期：2016-08-18 00:00:00

abstract：:Increased levels of endothelin-1 (Et-1), a potent vasoconstrictor, have been correlated with hypertension and neuronal damage in ischemic/reperfusion injury. The presence of polymorphonuclear cells (PMNs) in the brain has been shown to be directly responsible for this observed pathology. To address the question of whe...

journal_title：Blood

authors： Hofman FM,Chen P,Jeyaseelan R,Incardona F,Fisher M,Zidovetzki R

更新日期：1998-11-01 00:00:00

abstract：:Mutations in the SH2D1A gene have been described in most patients with the clinical syndrome of X-linked lymphoproliferative disease (XLP). The diagnosis of XLP is still difficult given its clinical heterogeneity and the lack of a readily available rapid diagnostic laboratory test, particularly in patients without a f...

journal_title：Blood

authors： Tabata Y,Villanueva J,Lee SM,Zhang K,Kanegane H,Miyawaki T,Sumegi J,Filipovich AH

更新日期：2005-04-15 00:00:00

abstract：:Pharmacologic infusion of activated protein C (APC) improves survival in severe sepsis, and platelet factor 4 (PF4) accelerates APC generation in a primate thrombin-infusion model. We now tested whether endogenous platelet PF4 content affects APC generation. Mice completely deficient in PF4 (mPF4(-/-)) had impaired AP...

journal_title：Blood

authors： Kowalska MA,Mahmud SA,Lambert MP,Poncz M,Slungaard A

更新日期：2007-09-15 00:00:00

abstract：:In the majority of Philadelphia (Ph)-positive chronic myeloid leukemia (CML) patients, the c-abl gene is fused to the bcr gene, resulting in the transcription of an 8.5 kb chimeric bcr-abl mRNA, which is translated into a p210bcr-abl fusion protein. In about 50% of the Ph-positive acute lymphoid leukemias (ALL), the b...

journal_title：Blood

authors： Selleri L,von Lindern M,Hermans A,Meijer D,Torelli G,Grosveld G

更新日期：1990-03-01 00:00:00

abstract：:An estimated 22 350 patients had multiple myeloma diagnosed in 2013, representing 1.3% of all new cancers; 10 710 deaths are projected, representing 1.8% of cancer deaths. Approximately 0.7% of US men and women will have a myeloma diagnosis in their lifetime, and with advances in therapy, 77 600 US patients are living...

journal_title：Blood

authors： Gertz MA,Dingli D

更新日期：2014-08-07 00:00:00

abstract：:Bone disease is one of the most debilitating manifestations of multiple myeloma. A complex interdependence exists between myeloma bone disease and tumor growth, creating a vicious circle of extensive bone destruction and myeloma progression. Proteasome inhibitors have recently been shown to promote bone formation in v...

journal_title：Blood

authors： Terpos E,Sezer O,Croucher P,Dimopoulos MA

更新日期：2007-08-15 00:00:00

abstract：:Interaction of platelets with collagen under conditions of blood flow is a multi-step process with tethering via glycoprotein IbIXV (GPIbIXV) over von Willebrand factor, adhesion by direct interaction with the integrin GPIaIIa, and signaling via GPVI. GPVI can be specifically agonized by cross-linked collagen-related ...

journal_title：Blood

authors： Joutsi-Korhonen L,Smethurst PA,Rankin A,Gray E,IJsseldijk M,Onley CM,Watkins NA,Williamson LM,Goodall AH,de Groot PG,Farndale RW,Ouwehand WH

更新日期：2003-06-01 00:00:00

abstract：:Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for much of the biologic activity of HO-1, including anti-inflammatory, antiapo-ptotic, antiproliferative, and antioxidant effects. We have identified an additional cytoprote...

journal_title：Blood

authors： Kinderlerer AR,Pombo Gregoire I,Hamdulay SS,Ali F,Steinberg R,Silva G,Ali N,Wang B,Haskard DO,Soares MP,Mason JC

更新日期：2009-02-12 00:00:00

abstract：:Children with sickle cell anemia (SCA) carry a 200-fold increased risk for cerebral infarction. Stroke can be the result of small-vessel (SV) or large-vessel (LV) disease. However, it is unknown whether these subtypes result from the same pathophysiologic processes. Complete HLA genotyping was performed on 231 eligibl...

journal_title：Blood

authors： Hoppe C,Klitz W,Noble J,Vigil L,Vichinsky E,Styles L

更新日期：2003-04-01 00:00:00

abstract：:The most abundant intracellular proteins, heat shock proteins (HSPs), serve as molecular chaperones for regulatory and maturation pathways. Diverse families of HSPs have been shown to bind antigenic peptides and to play major roles in innate and adaptive immune responses through the common HSP receptor, CD91. HIV-1+ p...

journal_title：Blood

authors： Stebbing J,Gazzard B,Portsmouth S,Gotch F,Kim L,Bower M,Mandalia S,Binder R,Srivastava P,Patterson S

更新日期：2003-09-01 00:00:00

abstract：:We treated 109 patients with adult acute lymphoblastic leukemia (ALL) diagnosed by histochemical and immunologic techniques. Patients were excluded only for age greater than 50 years and Burkitt's leukemia. Treatment included a four-drug remission induction phase followed by alternating cycles of noncrossresistant che...

journal_title：Blood

authors： Linker CA,Levitt LJ,O'Donnell M,Forman SJ,Ries CA

更新日期：1991-12-01 00:00:00

abstract：:Sickle cell disease (SCD) is characterized by a single point mutation in the seventh codon of the β-globin gene. Site-specific correction of the sickle mutation in hematopoietic stem cells would allow for permanent production of normal red blood cells. Using zinc-finger nucleases (ZFNs) designed to flank the sickle mu...

journal_title：Blood

authors： Hoban MD,Cost GJ,Mendel MC,Romero Z,Kaufman ML,Joglekar AV,Ho M,Lumaquin D,Gray D,Lill GR,Cooper AR,Urbinati F,Senadheera S,Zhu A,Liu PQ,Paschon DE,Zhang L,Rebar EJ,Wilber A,Wang X,Gregory PD,Holmes MC,Reik A

更新日期：2015-04-23 00:00:00

abstract：:Glanzmann thrombasthenia (GT) is a rare bleeding disorder resulting from mutations in either glycoprotein (GP) IIb or GPIIIa genes. The disease is relatively frequent in highly inbred populations such as Iraqi Jews. The molecular basis of GT in 6 unrelated Iraqi-Jewish patients was previously identified as an 11-bp de...

journal_title：Blood

authors： Rosenberg N,Yatuv R,Orion Y,Zivelin A,Dardik R,Peretz H,Seligsohn U

更新日期：1997-05-15 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:The presence and physiologic role of cyclic GMP-dependent protein kinase (G-kinase) in human neutrophils was investigated by Western blot analysis and immunocytochemistry. Small quantities of G-kinase were found in the cytoskeletal-enriched fraction of neutrophil lysates as detected by Western blots using a polyclonal...

journal_title：Blood

authors： Pryzwansky KB,Wyatt TA,Nichols H,Lincoln TM

更新日期：1990-08-01 00:00:00

abstract：:We report here 7 new mutations in the ADAMTS13 gene responsible for Upshaw-Schulman syndrome (USS), a catastrophic phenotype of congenital thrombotic thrombocytopenic purpura, by analyzing 5 Japanese families. There were 3 mutations that occurred at exon-intron boundaries: 414+1G>A at intron 4, 686+1G>A at intron 6, a...

journal_title：Blood

authors： Matsumoto M,Kokame K,Soejima K,Miura M,Hayashi S,Fujii Y,Iwai A,Ito E,Tsuji Y,Takeda-Shitaka M,Iwadate M,Umeyama H,Yagi H,Ishizashi H,Banno F,Nakagaki T,Miyata T,Fujimura Y

更新日期：2004-02-15 00:00:00

abstract：:Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular hemostasis and local inflammation. Endothelial activation triggers rapid exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rolling (P-selectin) and pl...

journal_title：Blood

authors： Holthenrich A,Drexler HCA,Chehab T,Naß J,Gerke V

更新日期：2019-09-19 00:00:00

abstract：:CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation. To further characterize mechanisms by which cell-surface signaling might regulate CD10/NEP expression, we determined whether CD10/NEP wa...

journal_title：Blood

authors： Ganju RK,Shpektor RG,Brenner DG,Shipp MA

更新日期：1996-12-01 00:00:00

abstract：:Neutrophil dysfunction consequent to influenza A virus infection has been described in vivo and in vitro and may contribute to the serious bacterial sequelae which occur in influenza-infected hosts. On the premise that such dysfunction may represent a form of "deactivation," we sought to characterize neutrophil activa...

journal_title：Blood

authors： Hartshorn KL,Collamer M,White MR,Schwartz JH,Tauber AI

更新日期：1990-01-01 00:00:00