Endothelin-1 induces production of the neutrophil chemotactic factor interleukin-8 by human brain-derived endothelial cells.

abstract：:Three families with polycythemia inherited through apparently different modes are described. Secondary causes of polycythemia were ruled out. Erythropoietin (EPO) levels were normal or low, even after phlebotomy. In vitro erythroid colony growth in standard assay cultures containing EPO was normal; however, in the abs...

journal_title：Blood

authors： Emanuel PD,Eaves CJ,Broudy VC,Papayannopoulou T,Moore MR,D'Andrea AD,Prchal JF,Eaves AC,Prchal JT

更新日期：1992-06-01 00:00:00

abstract：:Many researchers have speculated that the clinical progression from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) is driven by defects in dendritic cell (DC) function. However, evidence supporting this assumption is controversial, and no mechanism for the putative DC dysfunction ha...

journal_title：Blood

authors： Leone P,Berardi S,Frassanito MA,Ria R,De Re V,Cicco S,Battaglia S,Ditonno P,Dammacco F,Vacca A,Racanelli V

更新日期：2015-09-17 00:00:00

abstract：:If bone marrow transplantation is to become widely applicable in the treatment of patients with leukemia and aplastic anemia, the necessity to have a perfectly histocompatible donor must be overcome. In an effort to define the roles of HL-A type and mixed lymphocyte culture (MLC) reactivity in the determination of suc...

journal_title：Blood

authors： Feig SA,Opelz G,Winter HS,Falk PM,Neerhout RC,Sparkes R,Gale RP

更新日期：1976-09-01 00:00:00

abstract：:In this issue of Blood, Kurtz et al report the potential clinical utility of immunoglobulin high-throughput sequencing as a tool for disease monitoring and surveillance in aggressive B-cell lymphoma. ...

journal_title：Blood

authors： Sweetenham JW

更新日期：2015-06-11 00:00:00

abstract：:We prepared a heterohybrid cell line that secretes a human IgM monoclonal autoantibody that recognizes an antigen found on thrombin-activated or stored platelets. The surface expression of the epitope recognized by this autoantibody, 5E5, increases with time as platelets age in vitro, suggesting that it may represent ...

journal_title：Blood

authors： Nugent DJ,Kunicki TJ,Berglund C,Bernstein ID

更新日期：1987-07-01 00:00:00

abstract：:We report two patients with a distinctive biphenotypic hematologic disorder characterized by lymphoblastic lymphoma (LBL), eosinophilia, and myeloid malignancy and/or hyperplasia associated with a t(8;13)(p11;q11) chromosomal translocation in both bone marrow and lymph node specimens. Both patients presented with lymp...

journal_title：Blood

authors： Inhorn RC,Aster JC,Roach SA,Slapak CA,Soiffer R,Tantravahi R,Stone RM

更新日期：1995-04-01 00:00:00

abstract：:The rapid recovery of hematopoiesis after allogeneic blood stem cell transplantation has been attributed to the quality and quantity of hematopoietic progenitors in the blood stem cell grafts from filgrastim-stimulated donors. To determine whether further stimulation with filgrastim after transplantation would affect ...

journal_title：Blood

authors： Przepiorka D,Smith TL,Folloder J,Anderlini P,Chan KW,Körbling M,Lichtiger B,Norfleet F,Champlin R

更新日期：2001-06-01 00:00:00

abstract：:Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for patients with a BPD is often unavailable. Many specialized tests are usually required to reach a put...

journal_title：Blood

authors： Simeoni I,Stephens JC,Hu F,Deevi SV,Megy K,Bariana TK,Lentaigne C,Schulman S,Sivapalaratnam S,Vries MJ,Westbury SK,Greene D,Papadia S,Alessi MC,Attwood AP,Ballmaier M,Baynam G,Bermejo E,Bertoli M,Bray PF,Bury L,

更新日期：2016-06-09 00:00:00

abstract：:P-selectin expression has been shown in Helicobacter pylori-infected persons, an infection that has been clinically associated with platelet-related diseases, such as idiopathic thrombocytopenic purpura. However, the role of P-selectin expression during H pylori infection remains unclear. In this study, we hypothesize...

journal_title：Blood

authors： Yeh JJ,Tsai S,Wu DC,Wu JY,Liu TC,Chen A

更新日期：2010-05-27 00:00:00

abstract：:The peripheral blood of acute myeloblastic leukemia (AML) patients often contains large numbers of two distinct cell populations, both capable of forming colonies in culture under similar conditions. The first population consists of the precursors of blast cells and has specificity for AML; the second population consi...

journal_title：Blood

authors： Minden MD,Buick RN,McCulloch EA

更新日期：1979-07-01 00:00:00

abstract：:Imatinib has revolutionized drug therapy of chronic myeloid leukemia (CML). Preclinical studies were promising but the results of clinical trials by far exceeded expectations. Responses in chronic phase are unprecedented, with rates of complete cytogenetic response (CCR) of more than 40% in patients after failure of i...

journal_title：Blood

authors： Deininger M,Buchdunger E,Druker BJ

更新日期：2005-04-01 00:00:00

abstract：:Many B-lineage-specific genes are down-regulated in Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL). We investigated the involvement of epigenetic modifications in gene silencing in cHL cell lines and in microdissected primary HRS cells. We assessed the expression and methylation status of C...

journal_title：Blood

authors： Ushmorov A,Leithäuser F,Sakk O,Weinhaüsel A,Popov SW,Möller P,Wirth T

更新日期：2006-03-15 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:Photochemical decontamination (PCD) of platelet concentrates, with adequate preservation of platelet function, has been shown using 8-methoxypsoralen (8-MOP) and long wavelength UV light (UVA). To further evaluate this technique, models for the inactivation of pathogenic human cell-associated viruses and integrated pr...

journal_title：Blood

authors： Lin L,Londe H,Hanson CV,Wiesehahn G,Isaacs S,Cimino G,Corash L

更新日期：1993-07-01 00:00:00

abstract：:The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-in...

journal_title：Blood

authors： Weller S,Braun MC,Tan BK,Rosenwald A,Cordier C,Conley ME,Plebani A,Kumararatne DS,Bonnet D,Tournilhac O,Tchernia G,Steiniger B,Staudt LM,Casanova JL,Reynaud CA,Weill JC

更新日期：2004-12-01 00:00:00

abstract：:Transplantation with 2-5 × 10(6) mobilized CD34(+)cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and a...

journal_title：Blood

authors： To LB,Levesque JP,Herbert KE

更新日期：2011-10-27 00:00:00

abstract：:An as yet single family with a bleeding history is shown to present the characteristic lack of membrane expression of procoagulant phospholipids observed in Scott syndrome. Low prothrombin consumption in the serum of the propositus, a 71-year-old woman, and two of her children was the sole abnormal hemostasis paramete...

journal_title：Blood

authors： Toti F,Satta N,Fressinaud E,Meyer D,Freyssinet JM

更新日期：1996-02-15 00:00:00

abstract：:Endothelial cells synthesize a heterodimeric adhesion molecule, the vitronectin receptor (VnR), which is similar to the platelet glycoprotein (GP)IIb/IIIa complex. The subunits of the endothelial VnR (VnR alpha and GPIIIa) have been studied for their ability to express alloantigens associated with platelet GPIIb and I...

journal_title：Blood

authors： Giltay JC,Leeksma OC,von dem Borne AE,van Mourik JA

更新日期：1988-07-01 00:00:00

abstract：:For this study, 118 children with standard-risk acute lymphoblastic leukemia (ALL) were given randomized assignments to receive native or pegylated Escherichia coli asparaginase as part of induction and 2 delayed intensification phases. Patients treated with pegaspargase had more rapid clearance of lymphoblasts from d...

journal_title：Blood

authors： Avramis VI,Sencer S,Periclou AP,Sather H,Bostrom BC,Cohen LJ,Ettinger AG,Ettinger LJ,Franklin J,Gaynon PS,Hilden JM,Lange B,Majlessipour F,Mathew P,Needle M,Neglia J,Reaman G,Holcenberg JS,Stork L

更新日期：2002-03-15 00:00:00

abstract：:Secretion of platelet granules is necessary for normal hemostasis. Platelet secretion requires soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complex formation between different members of the syntaxin, SNAP-25, and vesicle-associated membrane protein (VAMP) gene families. Using m...

journal_title：Blood

authors： Polgár J,Chung SH,Reed GL

更新日期：2002-08-01 00:00:00

abstract：:High molecular weight (HMW) kininogen, the cofactor for activation of the contact system of plasma proteolysis, transports and optimally positions prekallikrein and factor XI on a negatively charged surface, allowing those zymogens to be activated by surface-bound factor XIIa. HMW kininogen circulates in plasma as a p...

journal_title：Blood

authors： Chang JJ,Scott CF,Colman RW

更新日期：1986-03-01 00:00:00

abstract：:We previously showed that incorporating target sequences for the hematopoietic-specific microRNA miR-142 into an antigen-encoding transgene prevents antigen expression in antigen-presenting cells (APCs). To determine whether this approach induces immunologic tolerance, we treated mice with a miR-142-regulated lentivir...

journal_title：Blood

authors： Annoni A,Brown BD,Cantore A,Sergi LS,Naldini L,Roncarolo MG

更新日期：2009-12-10 00:00:00

abstract：:Granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) control the proliferation of human acute myeloid leukemia (AML) cells in vitro. Previously, we have shown that receptors for GM-CSF and IL-3 are often coexpressed on AML cells. Here we present experiments with purified AML blasts, norma...

journal_title：Blood

authors： Budel LM,Elbaz O,Hoogerbrugge H,Delwel R,Mahmoud LA,Löwenberg B,Touw IP

更新日期：1990-04-01 00:00:00

abstract：:Adenovirus-transduced CD34+ cells expressing membrane-bound tumor necrosis factor-related apoptosis-inducing ligand (CD34-TRAIL+ cells) exert potent antitumor activity. To further investigate the mechanism(s) of action of CD34-TRAIL+ cells, we analyzed their homing properties as well as antitumor and antivascular effe...

journal_title：Blood

authors： Lavazza C,Carlo-Stella C,Giacomini A,Cleris L,Righi M,Sia D,Di Nicola M,Magni M,Longoni P,Milanesi M,Francolini M,Gloghini A,Carbone A,Formelli F,Gianni AM

更新日期：2010-03-18 00:00:00

abstract：:Both total metabolic tumor volume (TMTV), computed on baseline positron emission tomography (PET), and end of induction (EOI) PET are imaging biomarkers showing promise for early risk stratification in patients with high-tumor-burden follicular lymphoma. A model was built incorporating these 2 factors in 159 patients ...

journal_title：Blood

authors： Cottereau AS,Versari A,Luminari S,Dupuis J,Chartier L,Casasnovas RO,Berriolo-Riedinger A,Menga M,Haioun C,Tilly H,Tarantino V,Federico M,Salles G,Trotman J,Meignan M

更新日期：2018-05-31 00:00:00

abstract：:This study examines the role of neutrophils (PMN) in the pathogenesis of endotoxin-induced microclot formation. It is intended to clarify whether granulocytes are involved in endotoxin-induced activation of intravascular coagulation (generation of soluble fibrin) and/or in endotoxin-induced precipitation of soluble fi...

journal_title：Blood

authors： Müller-Berghaus G,Eckhardt T

更新日期：1975-05-01 00:00:00

abstract：:During the early period following bone marrow transplantation before the immune system has reached full functional maturity, unprimed, nonspecific lytic systems may play a critical role as antiviral or antitumor effectors. The reconstitution of cells with this potential is of particular importance in recipients of bon...

journal_title：Blood

authors： Keever CA,Welte K,Small T,Levick J,Sullivan M,Hauch M,Evans RL,O'Reilly RJ

更新日期：1987-12-01 00:00:00

abstract：:Recently, we reported a novel system whereby human pericytes are recruited to endothelial cell (EC)-lined tubes in 3-dimensional (3D) extracellular matrices to stimulate vascular maturation including basement membrane matrix assembly. Through the use of this serum-free, defined system, we demonstrate that pericyte mot...

journal_title：Blood

authors： Stratman AN,Schwindt AE,Malotte KM,Davis GE

更新日期：2010-11-25 00:00:00

abstract：:We have examined the effects of administration of stem cell-factor (SCF) on the number and distribution of pluripotent hematopoietic stem cells (PHSC) in normal mice. Using the competitive repopulation assay we found that in vivo administration of SCF increases the absolute number of PHSC per mouse threefold. The incr...

journal_title：Blood

authors： Bodine DM,Seidel NE,Zsebo KM,Orlic D

更新日期：1993-07-15 00:00:00

abstract：:Recent studies in humans have highlighted the importance of a distinct cellular entity, the plasmacytoid dendritic cell (PDC). To identify genes for which expression is restricted to human PDCs, a cDNA subtraction technique was applied using cDNA from activated monocyte-derived DCs (MDDCs) as competitor. In the 650 se...

journal_title：Blood

authors： Rissoan MC,Duhen T,Bridon JM,Bendriss-Vermare N,Péronne C,de Saint Vis B,Brière F,Bates EE

更新日期：2002-11-01 00:00:00