Prediction of hepatitis C virus infectivity in seropositive Australian blood donors by supplemental immunoassays and detection of viral RNA.

abstract：:We document findings on c-kit (CD117) expression in 1,937 pediatric and adult de novo acute leukemia cases, diagnosed in five single European centers. All cases were well characterized as to the morphologic, cytochemical, and immunologic features, according to the European Group for the Immunological Classification of...

journal_title：Blood

authors： Bene MC,Bernier M,Casasnovas RO,Castoldi G,Knapp W,Lanza F,Ludwig WD,Matutes E,Orfao A,Sperling C,van't Veer MB

更新日期：1998-07-15 00:00:00

abstract：:Loxosceles is the most venomous spider in Brazil, and envenomation causes dermonecrosis and complement (C)-dependent intravascular hemolysis. The authors studied the mechanism of induction of C-induced hemolysis. Purified Loxosceles toxins rendered human erythrocytes susceptible to lysis by human C but did not have an...

journal_title：Blood

authors： Tambourgi DV,Morgan BP,de Andrade RM,Magnoli FC,van Den Berg CW

更新日期：2000-01-15 00:00:00

abstract：:Eosinophils are associated with type 2 immune responses to allergens and helminths. They release various proinflammatory mediators and toxic proteins on activation and are therefore considered proinflammatory effector cells. Eosinophilia is promoted by the cytokines interleukin (IL)-3, IL-5, and granulocyte macrophage...

journal_title：Blood

authors： Schwartz C,Willebrand R,Huber S,Rupec RA,Wu D,Locksley R,Voehringer D

更新日期：2015-06-18 00:00:00

abstract：:Using thiol deprivation, we have previously shown that the response of natural killer (NK) cells to interleukin-2 (IL-2) is subject to redox regulation downstream of IL-2 binding and internalization. We have now used the IL-2-dependent cell line, NK3.3 to study redox regulation of NK cells further, and found that NK3....

journal_title：Blood

authors： Yamauchi A,Bloom ET

更新日期：1997-06-01 00:00:00

abstract：:In lymphocytes, the second messenger cyclic adenosine monophosphate (cAMP) plays a well-established antiproliferative role through inhibition of G(1)/S transition and S-phase progression. We have previously demonstrated that, during S-phase arrest, cAMP inhibits the action of S phase-specific cytotoxic compounds, lead...

journal_title：Blood

authors： Naderi EH,Findley HW,Ruud E,Blomhoff HK,Naderi S

更新日期：2009-07-16 00:00:00

abstract：:Inhibitors of cyclin-dependent kinases (Cdks) have been reported to have activities in chronic lymphocytic leukemia cells by inhibiting Cdk7 and Cdk9, which control transcription. Here we studied the novel Cdk inhibitor SNS-032, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. We h...

journal_title：Blood

authors： Chen R,Wierda WG,Chubb S,Hawtin RE,Fox JA,Keating MJ,Gandhi V,Plunkett W

更新日期：2009-05-07 00:00:00

abstract：:Low linear energy transfer (LET) ionizing radiation (IR) is an important form of therapy for acute leukemias administered externally or as radioimmunotherapy. IR is also a potential source of DNA damage. High LET IR produces structurally different forms of DNA damage and has emerged as potential treatment of metastati...

journal_title：Blood

authors： Haro KJ,Scott AC,Scheinberg DA

更新日期：2012-09-06 00:00:00

abstract：:Despite multiple disparate prognostic risk analysis systems for evaluating clinical outcome for patients with myelodysplastic syndrome (MDS), imprecision persists with such analyses. To attempt to improve on these systems, an International MDS Risk Analysis Workshop combined cytogenetic, morphological, and clinical da...

journal_title：Blood

authors： Greenberg P,Cox C,LeBeau MM,Fenaux P,Morel P,Sanz G,Sanz M,Vallespi T,Hamblin T,Oscier D,Ohyashiki K,Toyama K,Aul C,Mufti G,Bennett J

更新日期：1997-03-15 00:00:00

abstract：:A single-stage disposable channel and seal that provides for leukocyte and granulocyte collection by continuous-flow cell separation (CFCS) has been designed by the IBM Corporation. This paper describes (1) the separation characteristics of whole blood as it responds to varying gravitational (G) forces and flow rates ...

journal_title：Blood

authors： Hester JP,Kellogg RM,Mulzet AP,Kruger VR,McCredie KB,Freireich EJ

更新日期：1979-07-01 00:00:00

abstract：:Recombinant human interleukin-6 (IL-6) has previously been shown to increase platelet counts in normal and sublethally irradiated mice, dogs, and primates. To assess its tolerance and efficacy in clinical use, we performed a randomized phase Ib study in patients with ovarian carcinoma. IL-6 was administered during an ...

journal_title：Blood

authors： D'Hondt V,Humblet Y,Guillaume T,Baatout S,Chatelain C,Berlière M,Longueville J,Feyens AM,de Greve J,Van Oosterom A

更新日期：1995-05-01 00:00:00

abstract：:CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable proportion of human neutrophils that mediates surface expression of the antineutrophil cytoplasmic antibody antigen proteinase 3. CD177 associates with β2 integrins and recognizes platelet endothelial cell adhesion molecule 1 (PECAM...

journal_title：Blood

authors： Bai M,Grieshaber-Bouyer R,Wang J,Schmider AB,Wilson ZS,Zeng L,Halyabar O,Godin MD,Nguyen HN,Levescot A,Cunin P,Lefort CT,Soberman RJ,Nigrovic PA

更新日期：2017-11-09 00:00:00

abstract：:Collagen binding to glycoprotein VI (GPVI) induces signals critical for platelet activation in thrombosis. Both ligand-induced GPVI signaling through its coassociated Fc-receptor gamma-chain (FcRgamma) immunoreceptor tyrosine-activation motif (ITAM) and the calmodulin inhibitor, W7, dissociate calmodulin from GPVI and...

journal_title：Blood

authors： Gardiner EE,Karunakaran D,Arthur JF,Mu FT,Powell MS,Baker RI,Hogarth PM,Kahn ML,Andrews RK,Berndt MC

更新日期：2008-01-01 00:00:00

abstract：:Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family. Proliferation of murine B lymphomas CH31, CH12.Lx, BKS-2, and WEHI-231 and the human B lymp...

journal_title：Blood

authors： Gururajan M,Chui R,Karuppannan AK,Ke J,Jennings CD,Bondada S

更新日期：2005-08-15 00:00:00

abstract：:Cytokine-induced expansion of hematopoietic stem and progenitor cells (HSPCs) is not fully understood. In the present study, we show that whereas steady-state hematopoiesis is normal in basic fibroblast growth factor (FGF-2)-knockout mice, parathyroid hormone stimulation and myeloablative treatments failed to induce n...

journal_title：Blood

authors： Itkin T,Ludin A,Gradus B,Gur-Cohen S,Kalinkovich A,Schajnovitz A,Ovadya Y,Kollet O,Canaani J,Shezen E,Coffin DJ,Enikolopov GN,Berg T,Piacibello W,Hornstein E,Lapidot T

更新日期：2012-08-30 00:00:00

abstract：:Leukocyte adhesion deficiency II (LAD II), also known as congenital disorder of glycosylation IIc (CDG-IIc), is a human disease in which a defective GDP-fucose transporter (SLC35C1) causes developmental defects and an immunodeficiency that is based on the lack of fucosylated selectin ligands. Since the study of in viv...

journal_title：Blood

authors： Yakubenia S,Frommhold D,Schölch D,Hellbusch CC,Körner C,Petri B,Jones C,Ipe U,Bixel MG,Krempien R,Sperandio M,Wild MK

更新日期：2008-08-15 00:00:00

abstract：:Microscopic intracellular detection of Epstein-Barr virus (EBV) messenger RNA in Reed-Sternberg cells of Hodgkin's disease (HD) was possible by in situ hybridization, in tissue sections prepared by a method termed modified acetone methyl benzoate xylene (ModAMeX). The ModAMeX method was initially developed for simulta...

journal_title：Blood

authors： Brousset P,Chittal S,Schlaifer D,Icart J,Payen C,Rigal-Huguet F,Voigt JJ,Delsol G

更新日期：1991-04-15 00:00:00

abstract：:Naive T cells continuously recirculate between secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances of an encounter between a T cell and its cognate antigen. This recirculation depends on signals from chemokine receptors, integrins, and the sphingosine-1-phosphate recepto...

journal_title：Blood

authors： Faroudi M,Hons M,Zachacz A,Dumont C,Lyck R,Stein JV,Tybulewicz VL

更新日期：2010-12-16 00:00:00

abstract：:The bone marrow plays a unique role within the immune system. We compared the phenotype and function of virus-specific CD8(+) T cells from matched samples of human peripheral blood and bone marrow. Analysis of virus-specific memory CD8(+) T cells showed widely divergent partition of antigen-specific populations betwee...

journal_title：Blood

authors： Palendira U,Chinn R,Raza W,Piper K,Pratt G,Machado L,Bell A,Khan N,Hislop AD,Steyn R,Rickinson AB,Buckley CD,Moss P

更新日期：2008-10-15 00:00:00

abstract：:In attempting to identify antigens that are differentially expressed on tumor cells following transformation from follicular small cleaved cell lymphoma (FSC) to immunoblastic lymphoma (IL), we identified a unique epitope of the transferrin receptor (TfR). The epitope is available for binding in aggressive lymphomas b...

journal_title：Blood

authors： Esserman L,Takahashi S,Rojas V,Warnke R,Levy R

更新日期：1989-12-01 00:00:00

abstract：:The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice leads to embryonic lethality before embryonic day 10 (E10.0). EPCR is detected in the giant trophoblast cells at the feto-maternal boundary from E7.5 and weakly...

journal_title：Blood

authors： Li W,Zheng X,Gu JM,Ferrell GL,Brady M,Esmon NL,Esmon CT

更新日期：2005-10-15 00:00:00

abstract：:Rituximab is a chimeric monoclonal antibody directed at CD20 with significant activity in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). A variety of pathways of tumor cytotoxicity different from cytotoxic chemotherapy have been proposed for this therapeutic antibody including antibody-dependent ce...

journal_title：Blood

authors： Byrd JC,Kitada S,Flinn IW,Aron JL,Pearson M,Lucas D,Reed JC

更新日期：2002-02-01 00:00:00

abstract：:A functional thrombin receptor (TR) structurally related to other members of the seven-transmembrane receptor family has been isolated from diverse cellular types intimately involved in the regulation of the thrombotic response. This receptor recapitulates many of the previously identified sequelae of thrombin-mediate...

journal_title：Blood

authors： Bahou WF,Nierman WC,Durkin AS,Potter CL,Demetrick DJ

更新日期：1993-09-01 00:00:00

abstract：:Dendritic cells (DCs) process and present bacterial and endogenous lipid antigens in complex with CD1 molecules to T cells and invariant natural killer T (NKT) cells. However, different types of DCs, such as blood myeloid DCs and skin Langerhans cells, exhibit distinct patterns of CD1a, CD1b, CD1c, and CD1d expression...

journal_title：Blood

authors： Smed-Sörensen A,Moll M,Cheng TY,Loré K,Norlin AC,Perbeck L,Moody DB,Spetz AL,Sandberg JK

更新日期：2008-05-15 00:00:00

abstract：:MRP8 and MRP14 are two S100-like calcium-binding proteins of unknown function, associated with numbers of human inflammatory disorders. Both molecules have been described as L1 complex, cystic fibrosis antigen, or p8 and p14. We report here the cloning of mouse MRP8 and MRP14 and their pattern of expression during hem...

journal_title：Blood

authors： Lagasse E,Weissman IL

更新日期：1992-04-15 00:00:00

abstract：:Human mast cells in adult tissues have been thought to have limited, if any, proliferative potential. The current study examined mast cells obtained from adult skin and cultured in serum-free medium with recombinant human stem cell factor. During the first 4 weeks of culture, the percentages of mast cells increased fr...

journal_title：Blood

authors： Kambe N,Kambe M,Kochan JP,Schwartz LB

更新日期：2001-04-01 00:00:00

abstract：:Transformation to aggressive lymphoma is a critical event in the clinical course of follicular lymphoma (FL) patients. Yet, it is a challenge to reliably predict transformation at the time of diagnosis. Understanding the risk of transformation would be useful for guiding and monitoring patients, as well as for evaluat...

journal_title：Blood

authors： Kridel R,Sehn LH,Gascoyne RD

更新日期：2017-07-20 00:00:00

abstract：:Severe deficiency of ADAMTS13, a plasma metalloprotease, leads to thrombotic thrombocytopenic purpura. ADAMTS13 contains 10 putative N-glycosylation sites in or near its metalloprotease sequence, spacer region, thrombospondin type 1 repeat no. 4 (TSR no. 4), and CUB domains. Tunicamycin treatment markedly decreased th...

journal_title：Blood

authors： Zhou W,Tsai HM

更新日期：2009-01-22 00:00:00

abstract：:The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS) syndrome is a rare multisystemic disorder associated with osteosclerotic myeloma and multicentric Castleman's disease (MCD). Human herpesvirus type 8 (HHV-8) DNA sequences have been detected in lymph nodes of about 40% of human immunodef...

journal_title：Blood

authors： Bélec L,Mohamed AS,Authier FJ,Hallouin MC,Soe AM,Cotigny S,Gaulard P,Gherardi RK

更新日期：1999-06-01 00:00:00

abstract：:To elucidate the role of thrombocytosis, alone or in combination with standard (age, previous cardiovascular events) and novel (leukocytosis, JAK2(V617F) mutational status) risk factors, in the cardiovascular events of essential thrombocythemia (ET), we analyzed a cohort of 1063 patients. We found that a platelet coun...

journal_title：Blood

authors： Carobbio A,Finazzi G,Antonioli E,Guglielmelli P,Vannucchi AM,Delaini F,Guerini V,Ruggeri M,Rodeghiero F,Rambaldi A,Barbui T

更新日期：2008-10-15 00:00:00

abstract：:Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such vaccines in children have been limited. We demonstrate that CD40-activated...

journal_title：Blood

authors： Coughlin CM,Vance BA,Grupp SA,Vonderheide RH

更新日期：2004-03-15 00:00:00