SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells.

abstract：:Dendritic cells (DC) are the main stimulators of primary T-cell responses and, thus, probably play a role in the immune reactions after stem cell transplantation. Very little is known about DC in cord blood (CB) and about their potential involvement in the low incidence and severity of acute graft-versus-host disease ...

journal_title：Blood

authors： Sorg RV,Kögler G,Wernet P

更新日期：1999-04-01 00:00:00

abstract：:The efficacy and safety of zanolimumab in patients with refractory cutaneous T-cell lymphoma (CTCL) have been assessed in two phase 2, multicenter, prospective, open-label, uncontrolled clinical studies. Patients with treatment refractory CD4(+) CTCL (mycosis fungoides [MF], n = 38; Sézary syndrome [SS], n = 9) receiv...

journal_title：Blood

authors： Kim YH,Duvic M,Obitz E,Gniadecki R,Iversen L,Osterborg A,Whittaker S,Illidge TM,Schwarz T,Kaufmann R,Cooper K,Knudsen KM,Lisby S,Baadsgaard O,Knox SJ

更新日期：2007-06-01 00:00:00

abstract：:P-selectin, an endothelial leukocyte adhesion receptor, is rapidly translocated to the cell surface upon release from storage granules called Weibel-Palade bodies and is also transcriptionally upregulated upon cytokine stimulation of endothelial cells (ECs). These two pathways of surface expression are coincident with...

journal_title：Blood

authors： Barkalow FJ,Goodman MJ,Gerritsen ME,Mayadas TN

更新日期：1996-12-15 00:00:00

abstract：:The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hep...

journal_title：Blood

authors： Pippard MJ,Johnson DK,Finch CA

更新日期：1981-10-01 00:00:00

abstract：:We assessed frequency and predictive factors for major cardiovascular (CV) events in 707 patients with primary myelofibrosis (PMF) followed in 4 European institutions. A total of 236 deaths (33%) were recorded for an overall mortality of 7.7% patient-years (pt-yr). Fatal and nonfatal thromboses were registered in 51 (...

journal_title：Blood

authors： Barbui T,Carobbio A,Cervantes F,Vannucchi AM,Guglielmelli P,Antonioli E,Alvarez-Larrán A,Rambaldi A,Finazzi G,Barosi G

更新日期：2010-01-28 00:00:00

abstract：:Custom-made monoclonal anti-idiotype antibodies (anti-Id MoAbs) have been tested as a treatment modality in 34 non-Hodgkin's lymphoma (NHL) patients. Partial or complete tumor remissions have been induced with this treatment in 68% of these patients. One mechanism by which anti-idiotype antibodies may have induced the...

journal_title：Blood

authors： Vuist WM,Levy R,Maloney DG

更新日期：1994-02-15 00:00:00

abstract：:Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers. All 50 household contac...

journal_title：Blood

authors： Lawrence DN,Jason JM,Bouhasin JD,McDougal JS,Knutsen AP,Evatt BL,Joist JH

更新日期：1985-09-01 00:00:00

abstract：:GVHD is still one of the major complications after allogeneic stem cell transplantation. Whereas murine data have clearly shown the beneficial effects of regulatory T cells (Tregs) on the prevention of GVHD, data from the human system are rare. Here, we present a comparative dynamic analysis of CD4(+)CD25(hi)CD127(lo/...

journal_title：Blood

authors： Ukena SN,Velaga S,Geffers R,Grosse J,Baron U,Buchholz S,Stadler M,Bruder D,Ganser A,Franzke A

更新日期：2011-09-29 00:00:00

abstract：:Pattern recognition receptors (PRRs) play an essential role in a macrophage's response to mycobacterial infections. However, how these receptors work in concert to promote this macrophage response remains unclear. In this study, we used bone marrow-derived macrophages isolated from mannose receptor (MR), complement re...

journal_title：Blood

authors： Yadav M,Schorey JS

更新日期：2006-11-01 00:00:00

abstract：:Retrovirus-mediated gene transfer into long-lived human pluripotent hematopoietic stem cells (HSCs) is a widely sought but elusive goal. A major problem is the quiescent nature of most HSCs, with the perceived requirement for ex vivo prestimulation in cytokines to induce stem cell cycling and allow stable gene integra...

journal_title：Blood

authors： Rebel VI,Tanaka M,Lee JS,Hartnett S,Pulsipher M,Nathan DG,Mulligan RC,Sieff CA

更新日期：1999-04-01 00:00:00

abstract：:The expression of tumor-associated antigens (TAAs) might play a critical role in the control of minimal residual disease (MRD) in acute myeloid leukemia (AML), and therefore might be associated with clinical outcome in AML. In a DNA microarray analysis of 116 AML samples, we found a significant correlation between hig...

journal_title：Blood

authors： Greiner J,Schmitt M,Li L,Giannopoulos K,Bosch K,Schmitt A,Dohner K,Schlenk RF,Pollack JR,Dohner H,Bullinger L

更新日期：2006-12-15 00:00:00

abstract：:This study assessed the incidence of cytomegalovirus (CMV) infection after transplantation of cord blood (CB) from unrelated donors and evaluated strategies for screening CB donors. Posttransplantation CMV infection, reported in 23% of 1221 CB recipients, was associated with patient pretransplantation CMV serology (P ...

journal_title：Blood

authors： Albano MS,Taylor P,Pass RF,Scaradavou A,Ciubotariu R,Carrier C,Dobrila L,Rubinstein P,Stevens CE

更新日期：2006-12-15 00:00:00

abstract：:Salivary gland mucosa-associated lymphoid tissue (MALT) type lymphomas are typically indolent B-cell neoplasms that are often associated with Sjogren's syndrome. To better define the cell of origin and evaluate whether antigen receptor stimulation may be playing a role in tumor growth, the Ig heavy and light chain var...

journal_title：Blood

authors： Bahler DW,Miklos JA,Swerdlow SH

更新日期：1997-05-01 00:00:00

abstract：:Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by Toll-like receptor...

journal_title：Blood

authors： Taylor PA,Ehrhardt MJ,Lees CJ,Panoskaltsis-Mortari A,Krieg AM,Sharpe AH,Murphy WJ,Serody JS,Hemmi H,Akira S,Levy RB,Blazar BR

更新日期：2008-10-15 00:00:00

abstract：:Stem cell homing into the bone microenvironment is the first step in the initiation of marrow-derived blood cells. It is reported that human severe combined immunodeficient (SCID) repopulating cells home and accumulate rapidly, within a few hours, in the bone marrow and spleen of immunodeficient mice previously condit...

journal_title：Blood

authors： Kollet O,Spiegel A,Peled A,Petit I,Byk T,Hershkoviz R,Guetta E,Barkai G,Nagler A,Lapidot T

更新日期：2001-05-15 00:00:00

abstract：:The most frequently recurring translocations in mucosa-associated lymphoid tissue (MALT) B-cell non-Hodgkin lymphoma, t(11;18)(q21;q21) and t(14;18)(q32; q21), lead to formation of an API2-MALT1 fusion or IgH-mediated MALT1 overexpression. Various approaches have implicated these proteins in nuclear factor kappaB (NF-...

journal_title：Blood

authors： Ho L,Davis RE,Conne B,Chappuis R,Berczy M,Mhawech P,Staudt LM,Schwaller J

更新日期：2005-04-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection is characterized by the massive infiltration of secondary lymphoid organs with activated CD8(+) T lymphocytes. While converging data indicated that these cells were HIV-specific cytotoxic T lymphocytes (CTLs) responsible for HIV spread limitation, direct evidence was lackin...

journal_title：Blood

authors： Hosmalin A,Samri A,Dumaurier MJ,Dudoit Y,Oksenhendler E,Karmochkine M,Autran B,Wain-Hobson S,Cheynier R

更新日期：2001-05-01 00:00:00

abstract：:Activation of human normal serum with tetanus/antitetanus immune complexes (TAT-IC) resulted in increased binding of 125I-labeled interleukin-1 beta (IL-1 beta) to serum factors, as opposed to untreated serum. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) followed by autoradiography showed label...

journal_title：Blood

authors： Borth W,Urbanski A,Prohaska R,Susanj M,Luger TA

更新日期：1990-06-15 00:00:00

abstract：:The original activated partial thromboplastin time-based assay for activated protein C (APC)-resistant factor Va (FVa) requires carefully prepared fresh plasma and cannot be used in patients receiving warfarin or in patients with antiphospholipid antibodies. A new test is described here that circumvents these limitati...

journal_title：Blood

authors： Le DT,Griffin JH,Greengard JS,Mujumdar V,Rapaport SI

更新日期：1995-04-01 00:00:00

abstract：:We have applied a proteomics approach to analyze signaling cascades in human platelets stimulated by thrombin receptor activating peptide (TRAP). By analyzing basal and TRAP-activated platelets using 2-dimensional gel electrophoresis (2-DE), we detected 62 differentially regulated protein features. From these, 41 coul...

journal_title：Blood

authors： García A,Prabhakar S,Hughan S,Anderson TW,Brock CJ,Pearce AC,Dwek RA,Watson SP,Hebestreit HF,Zitzmann N

更新日期：2004-03-15 00:00:00

abstract：:P-selectin glycoprotein ligand-1 (PSGL-1) serves as the leukocyte ligand for P-selectin, and many of the structural features of its ectodomain required for interactions with P-selectin have been uncovered. In contrast, the function of the highly conserved PSGL-1 cytoplasmic domain has not been explored. Stable transfe...

journal_title：Blood

authors： Snapp KR,Heitzig CE,Kansas GS

更新日期：2002-06-15 00:00:00

abstract：:Shiga-like toxin-1 (SLT-1) is a bacterial toxin that kills cells by inhibiting protein synthesis. SLT-1 is composed of one cytotoxic A-subunit and five B-subunits that bind to CD77, a cell-surface glycolipid. In the human hematopoietic system, CD77 expression is restricted to a subset of activated B cells and derived ...

journal_title：Blood

authors： LaCasse EC,Saleh MT,Patterson B,Minden MD,Gariépy J

更新日期：1996-09-01 00:00:00

abstract：UNLABELLED:Polymorphonuclear neutrophil granulocytes (neutrophils) are tightly controlled by an incompletely understood homeostatic feedback loop adjusting the marrow's supply to peripheral needs. Although it has long been known that marrow cellularity is inversely correlated with G-CSF levels, the mechanism linking pe...

journal_title：Blood

authors： Bugl S,Wirths S,Radsak MP,Schild H,Stein P,André MC,Müller MR,Malenke E,Wiesner T,Märklin M,Frick JS,Handgretinger R,Rammensee HG,Kanz L,Kopp HG

更新日期：2013-01-31 00:00:00

abstract：:The initiation of primary hemostasis is mediated by interaction of the platelet glycoprotein Ib (GPIb) surface receptor and its arterial subendothelial von Willebrand factor (vWF) ligand. The intracellular signaling immediately following GPIb receptor occupancy connecting the adhesive event to platelet activation and ...

journal_title：Blood

authors： Calverley DC,Kavanagh TJ,Roth GJ

更新日期：1998-02-15 00:00:00

abstract：:Seven of 21 patients with sickle cell anemia developed neurologic complications 5 to 243 days (median, 33 days) after allogeneic marrow transplantation. Among these 7 patients, indications for transplantation included either a past history of stroke (4 patients) or recurrent severe vaso-occlusive events (3 patients). ...

journal_title：Blood

authors： Walters MC,Sullivan KM,Bernaudin F,Souillet G,Vannier JP,Johnson FL,Lenarsky C,Powars D,Bunin N,Ohene-Frempong K

更新日期：1995-02-15 00:00:00

abstract：:In the absence of conclusive assays capable of determining the functionality of ex vivo expanded human hematopoietic progenitor cells, we combined cell tracking with the membrane dye PKH2, immunostaining for CD34, and limiting dilution analysis to estimate the frequency of long-term hematopoietic culture-initiating ce...

journal_title：Blood

authors： Traycoff CM,Kosak ST,Grigsby S,Srour EF

更新日期：1995-04-15 00:00:00

abstract：:Multiple mechanisms operate to ensure T-cell tolerance toward self-antigens. Three main processes have been described: clonal deletion, anergy, and deviation to CD4(+) regulatory T cells (Tregs) that suppress autoreactive T cells that have escaped the first 2 mechanisms. Although it is accepted that dendritic cells (D...

journal_title：Blood

authors： Morlacchi S,Soldani C,Viola A,Sarukhan A

更新日期：2011-07-28 00:00:00

abstract：:Although mycosis fungoides (MF) is typically an indolent disease, patients with advanced-stage disease (stages IIB-IVB), including Sézary syndrome (SS), often have a poor outcome. A 31-year, retrospective analysis of our cutaneous lymphoma database, of 297 patients with MF and SS, was undertaken to study long-term out...

journal_title：Blood

authors： Arulogun SO,Prince HM,Ng J,Lade S,Ryan GF,Blewitt O,McCormack C

更新日期：2008-10-15 00:00:00

abstract：:Vascular calcification is a marker of increased cardiovascular risk. Vitamin K-dependent matrix Gla protein (MGP) is important in inhibiting calcification. Because MGP activation is vitamin K dependent, we performed a cross-sectional study investigating the relationship between the use of vitamin K antagonists and ext...

journal_title：Blood

authors： Rennenberg RJ,van Varik BJ,Schurgers LJ,Hamulyak K,Ten Cate H,Leiner T,Vermeer C,de Leeuw PW,Kroon AA

更新日期：2010-06-17 00:00:00

abstract：:To study the role of the stress-induced "readthrough" acetylcholinesterase splice variant, AChE-R, in thrombopoiesis, we used transgenic mice overexpressing human AChE-R (TgR). Increased AChE hydrolytic activity in the peripheral blood of TgR mice was associated with increased thrombopoietin levels and platelet counts...

journal_title：Blood

authors： Pick M,Perry C,Lapidot T,Guimaraes-Sternberg C,Naparstek E,Deutsch V,Soreq H

更新日期：2006-04-15 00:00:00