Ectopic expression of rhombotin-2 causes selective expansion of CD4-CD8- lymphocytes in the thymus and T-cell tumors in transgenic mice.

abstract：:Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm with variable clinical course. To predict the clinical outcome, we previously developed a CMML-specific prognostic scoring system (CPSS) based on clinical parameters and cytogenetics. In this work, we tested the hypothesis that acc...

journal_title：Blood

authors： Elena C,Gallì A,Such E,Meggendorfer M,Germing U,Rizzo E,Cervera J,Molteni E,Fasan A,Schuler E,Ambaglio I,Lopez-Pavia M,Zibellini S,Kuendgen A,Travaglino E,Sancho-Tello R,Catricalà S,Vicente AI,Haferlach T,Haferlach

更新日期：2016-09-08 00:00:00

abstract：:It has recently been shown that the Naka antigen, which is absent in 3% to 11% of Japanese blood donors, is expressed on platelet glycoprotein IV (GPIV; CD36) (Tomiyama et al, BLOOD, 75:684, 1990). In the present studies, flow cytometry was used to distinguish differences in the reactivity of Naka+ and Naka- platelets...

journal_title：Blood

authors： Yamamoto N,Ikeda H,Tandon NN,Herman J,Tomiyama Y,Mitani T,Sekiguchi S,Lipsky R,Kralisz U,Jamieson GA

更新日期：1990-11-01 00:00:00

abstract：:In this study we investigated telomere restriction fragment (TRF) length in a panel of mature B-cell lymphoproliferative disorders (MBCLDs) and correlated this parameter with histology and histopathogenesis in relation to the germinal center (GC). We assessed 123 MBCLD samples containing 80% or more tumor cells. TRF l...

journal_title：Blood

authors： Ladetto M,Compagno M,Ricca I,Pagano M,Rocci A,Astolfi M,Drandi D,di Celle PF,Dell'Aquila M,Mantoan B,Vallet S,Pagliano G,De Marco F,Francese R,Santo L,Cuttica A,Marinone C,Boccadoro M,Tarella C

更新日期：2004-06-15 00:00:00

abstract：:The ability to determine the functional capacity of putative human hematopoietic stem cell (HSC) populations requires in vivo assays in which long-term multilineage differentiation can be assessed. We hypothesized that if human fetal bone was transplanted adjacent to a fetal thymus fragment in severe combined immunode...

journal_title：Blood

authors： Fraser CC,Kaneshima H,Hansteen G,Kilpatrick M,Hoffman R,Chen BP

更新日期：1995-09-01 00:00:00

abstract：:Thrombocytopenia developed in some individuals treated with a recombinant thrombopoietin (TPO), pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). Three of the subjects who developed severe thrombocytopenia were analyzed in detail to determine the cause of their thrombocytopenia. Ex...

journal_title：Blood

authors： Li J,Yang C,Xia Y,Bertino A,Glaspy J,Roberts M,Kuter DJ

更新日期：2001-12-01 00:00:00

abstract：:Cylindromatosis (CYLD) is a deubiquitinase that was initially identified as a tumor suppressor and has recently been implicated in diverse normal physiologic processes. In this study, we have investigated the involvement of CYLD in angiogenesis, the formation of new blood vessels from preexisting ones. We find that kn...

journal_title：Blood

authors： Gao J,Sun L,Huo L,Liu M,Li D,Zhou J

更新日期：2010-05-20 00:00:00

abstract：:The t(11;14)(q13;q32) translocation, which juxtaposes the BCL1 oncogene with the Ig heavy chain locus, has been associated with an uncommon subtype of non-Hodgkin's lymphoma (NHL) termed mantle cell lymphoma (MCL). To date, no molecular marker that serves as an indicator of tumor progression or clinical prognosis has ...

journal_title：Blood

authors： Louie DC,Offit K,Jaslow R,Parsa NZ,Murty VV,Schluger A,Chaganti RS

更新日期：1995-10-15 00:00:00

abstract：:In this study, we analyzed tyrosine phosphorylation of guanosine triphosphatase (GTPase) activating protein in human B cells stimulated through surface IgG, using Western blot and immunoprecipitation. Stimulation through surface IgG induced the tyrosine phosphorylation of GTPase-activating protein (GAP) and two associ...

journal_title：Blood

authors： Yagura H,Oyaizu N,Pahwa S

更新日期：1993-03-15 00:00:00

abstract：:Selective overexpression (50- to 100-fold) in adult erythroid cells of either G gamma or A gamma fetal globin gene is observed in hereditary conditions known as delta beta zero-thalassemia and hereditary persistence of fetal hemoglobin (HPFH). Recently, a C----T change at position -196 of an overexpressed A gamma glob...

journal_title：Blood

authors： Ottolenghi S,Giglioni B,Pulazzini A,Comi P,Camaschella C,Serra A,Guerrasio A,Saglio G

更新日期：1987-04-01 00:00:00

abstract：:The mechanism(s) underlying the release of stem/progenitor cells from bone marrow into the circulation is poorly understood. We hypothesized that matrix metalloproteinases (MMPs), especially gelatinases, which are believed to participate in the proteolysis of basement membranes and in the migration of leukocytes, may ...

journal_title：Blood

authors： Janowska-Wieczorek A,Marquez LA,Nabholtz JM,Cabuhat ML,Montaño J,Chang H,Rozmus J,Russell JA,Edwards DR,Turner AR

更新日期：1999-05-15 00:00:00

abstract：:Patients aged ≥60 years with treatment-naive Hodgkin lymphoma (HL) have few treatment options and inferior survival due to treatment-related toxicities and comorbidities. This phase 2, nonrandomized, open-label study evaluated brentuximab vedotin (BV) monotherapy (results previously reported), BV plus dacarbazine (DTI...

journal_title：Blood

authors： Friedberg JW,Forero-Torres A,Bordoni RE,Cline VJM,Patel Donnelly D,Flynn PJ,Olsen G,Chen R,Fong A,Wang Y,Yasenchak CA

更新日期：2017-12-28 00:00:00

abstract：:The pathologic hallmarks of thrombotic thrombocytopenic purpura (TTP) include endothelial cell proliferation and subendothelial hyalin deposits in the microvasculature leading to symptomatic thrombotic occlusions. Plasma or sera from three consecutive patients with TTP were subjected to multiple analyses to determine ...

journal_title：Blood

authors： Burns ER,Zucker-Franklin D

更新日期：1982-10-01 00:00:00

abstract：:Crystal formation by monoclonal immunoglobulins is a well-known but rare complication of B-cell neoplasia. We have designed an in vivo model of cryocrystalglobulinemia by grafting to mice hybridoma clones producing a pathogenic monoclonal immunogloblulin (Ig) G3kappa. One clone, 8A4, secreted a singular IgG3 that form...

journal_title：Blood

authors： Rengers JU,Touchard G,Decourt C,Deret S,Michel H,Cogné M

更新日期：2000-06-01 00:00:00

abstract：:Recently, the interleukin-2 receptor (IL-2R) was shown to be present on human neutrophils, and IL-2-neutrophil interactions are believed to be important in both tumor rejection and increased susceptibility to bacterial infections. Furthermore, neutrophils have been shown to synthesize host defense proteins, such as cy...

journal_title：Blood

authors： Girard D,Gosselin J,Heitz D,Paquin R,Beaulieu AD

更新日期：1995-08-01 00:00:00

abstract：:Clonal chromosomal abnormalities in Philadelphia chromosome-negative (CCA/Ph-) metaphases emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are treated with tyrosine kinase inhibitors (TKIs). We assessed the characteristics and prognostic impact of 598 patients with CP-CML treated on clinical tri...

journal_title：Blood

authors： Issa GC,Kantarjian HM,Gonzalez GN,Borthakur G,Tang G,Wierda W,Sasaki K,Short NJ,Ravandi F,Kadia T,Patel K,Luthra R,Ferrajoli A,Garcia-Manero G,Rios MB,Dellasala S,Jabbour E,Cortes JE

更新日期：2017-11-09 00:00:00

abstract：:This spotlight review focuses on the second-generation proteasome inhibitor carfilzomib, which was recently approved by the U.S. Food and Drug Administration for treatment of relapsed and refractory multiple myeloma patients who have received at least 2 prior therapies, including bortezomib and an immunomodulatory age...

journal_title：Blood

authors： Kortuem KM,Stewart AK

更新日期：2013-02-07 00:00:00

abstract：:The shape and parameters of platelet size distributions were studied in 50 normal persons and 97 patients in order to test the proposed thesis that platelet size heterogeneity results mainly from aging in the circulation. This thesis was contradicted (1) by size distributions of age-homogeneous, newly-born cell popula...

journal_title：Blood

authors： Paulus JM

更新日期：1975-09-01 00:00:00

abstract：:CXCL4 and CXCL4L1 are 2 closely related CXC chemokines that exhibit potent antiangiogenic activity. Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B. We further demo...

journal_title：Blood

authors： Dubrac A,Quemener C,Lacazette E,Lopez F,Zanibellato C,Wu WG,Bikfalvi A,Prats H

更新日期：2010-11-25 00:00:00

abstract：:C-C chemokine receptor type 7 (CCR7) is a chemokine receptor playing a pivotal role in the induction of human natural killer (NK)-cell migration to lymph nodes. We show that "licensed" peripheral blood killer immunoglobulin-like receptor-positive (KIR(+)) NK-cell populations, as well as KIR(+) NK-cell clones, de novo ...

journal_title：Blood

authors： Marcenaro E,Cantoni C,Pesce S,Prato C,Pende D,Agaugué S,Moretta L,Moretta A

更新日期：2009-11-05 00:00:00

abstract：:The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with aggressive non-Hodgkin lymphoma (NHL) for the past 20 years. Using raw clinical data from the National Comprehensive Cancer Network (NCCN) database collected during the rituximab era, we built an enhanced IPI with th...

journal_title：Blood

authors： Zhou Z,Sehn LH,Rademaker AW,Gordon LI,Lacasce AS,Crosby-Thompson A,Vanderplas A,Zelenetz AD,Abel GA,Rodriguez MA,Nademanee A,Kaminski MS,Czuczman MS,Millenson M,Niland J,Gascoyne RD,Connors JM,Friedberg JW,Winter JN

更新日期：2014-02-06 00:00:00

abstract：:Peripheral blood from patients with acute myeloblastic leukemia (AML) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (LCM) in the presence of phytohemagglutinin (PHA). Two types of colonies are recognized with high frequency: The first grows in the prese...

journal_title：Blood

authors： Minden MD,Till JE,McCulloch EA

更新日期：1978-09-01 00:00:00

abstract：:We analyzed the expression of myelomonocytic-associated antigens on lymphocytes from B cell chronic lymphocytic leukemia (B-CLL) patients. Blood mononuclear cells were depleted of monocytes by one-step Percoll density gradient centrifugation and tested for antigen expression by fluorescent microscopy and flow cytometr...

journal_title：Blood

authors： Morabito F,Prasthofer EF,Dunlap NE,Grossi CE,Tilden AB

更新日期：1987-12-01 00:00:00

abstract：:Although much is now known about the biological properties of the c-kit receptor and its ligand, stem cell factor (SCF), little is known of the structural basis for the binding and function of this hematopoietic cytokine. By analyzing the activities of chimeric interspecies and homologue muteins and epitope mapping of...

journal_title：Blood

authors： Matous JV,Langley K,Kaushansky K

更新日期：1996-07-15 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-1 (TIMP-1), the major physiological matrix metalloproteinase inhibitor and a potent antimetastatic factor, also stimulates the growth of erythroid progenitors (erythroid-potentiating activity). We analyzed the relationship between the growth factor activity and protease inhibitio...

journal_title：Blood

authors： Chesler L,Golde DW,Bersch N,Johnson MD

更新日期：1995-12-15 00:00:00

abstract：:CD40 is present on both normal and neoplastic B-lineage cells. CD40 stimulation of normal B cells has been shown to promote normal growth and differentiation, whereas aggressive histology B lymphomas are growth inhibited. The inhibition of neoplastic B-cell growth is believed to occur via activation-induced cell death...

journal_title：Blood

authors： Szocinski JL,Khaled AR,Hixon J,Halverson D,Funakoshi S,Fanslow WC,Boyd A,Taub DD,Durum SK,Siegall CB,Longo DL,Murphy WJ

更新日期：2002-07-01 00:00:00

abstract：:In this issue of Blood, Bhatia et al demonstrate the critical importance of an adherence to oral chemotherapy regimens in attaining cure for children with acute lymphoblastic leukemia (ALL) and identify race-specific determinants of adherence. ...

journal_title：Blood

authors： Winick N

更新日期：2014-10-09 00:00:00

abstract：:The contention that erythropoietin (Epo) affects platelet production was investigated in the rat with recombinant human Epo (rHuEpo). In normal rats, Epo caused a dose-dependent increase in both reticulocyte and platelet numbers, the reticulocyte response preceding that of platelets. Withdrawal of Epo resulted in reti...

journal_title：Blood

authors： Berridge MV,Fraser JK,Carter JM,Lin FK

更新日期：1988-09-01 00:00:00

abstract：:Drug-induced immune thrombocytopenia (DITP) is caused by drug-dependent antibodies (DDAbs) that are nonreactive in themselves but bind tightly to specific platelet membrane glycoproteins (GP) when soluble drug is present at pharmacologic concentrations. This reaction takes place without covalent linkage of drug to the...

journal_title：Blood

authors： Bougie DW,Birenbaum J,Rasmussen M,Poncz M,Aster RH

更新日期：2009-01-29 00:00:00

abstract：:We previously reported the characterization of human osteoclast-associated receptor (hOSCAR), a novel Fc receptor gamma-chain (FcRgamma)-associated receptor expressed by myeloid cells. Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell (DC) survival by an extracellular signal-regulated...

journal_title：Blood

authors： Merck E,de Saint-Vis B,Scuiller M,Gaillard C,Caux C,Trinchieri G,Bates EE

更新日期：2005-05-01 00:00:00

abstract：:Fanconi anemia (FA) is the most frequent inherited cause of bone marrow failure (BMF). Most FA patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the frequent emergence in their teens or young adulthood of...

journal_title：Blood

authors： Peffault de Latour R,Soulier J

更新日期：2016-06-16 00:00:00