Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia.

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome featuring diverse symptoms including progressive bone marrow failure and early occurrence of acute myeloid leukemia. Nine genetic subtypes have been described for FA (A, B, C, D1, D2, E, F, G, and L), all of which have been connected to distinct disease genes, exc...

journal_title：Blood

authors： Levitus M,Rooimans MA,Steltenpool J,Cool NF,Oostra AB,Mathew CG,Hoatlin ME,Waisfisz Q,Arwert F,de Winter JP,Joenje H

更新日期：2004-04-01 00:00:00

abstract：:Adhesive interactions between circulating sickle red blood cells (RBCs), leukocytes, and endothelial cells are major pathophysiologic events in sickle cell disease (SCD). To develop new therapeutics that efficiently inhibit adhesive interactions, we generated an anti-P-selectin aptamer and examined its effects on cell...

journal_title：Blood

authors： Gutsaeva DR,Parkerson JB,Yerigenahally SD,Kurz JC,Schaub RG,Ikuta T,Head CA

更新日期：2011-01-13 00:00:00

abstract：:Gene delivery via the hematopoietic stem cell (HSC) offers an attractive means to introduce antiviral genes into both T cells and macrophages for acquired immunodeficiency syndrome (AIDS) gene therapy. An amphotropic retroviral vector encoding a bicistronic gene coexpressing RevM10 and the murine CD8alpha' chain (lyt2...

journal_title：Blood

authors： Su L,Lee R,Bonyhadi M,Matsuzaki H,Forestell S,Escaich S,Böhnlein E,Kaneshima H

更新日期：1997-04-01 00:00:00

abstract：:Increased levels of endothelin-1 (Et-1), a potent vasoconstrictor, have been correlated with hypertension and neuronal damage in ischemic/reperfusion injury. The presence of polymorphonuclear cells (PMNs) in the brain has been shown to be directly responsible for this observed pathology. To address the question of whe...

journal_title：Blood

authors： Hofman FM,Chen P,Jeyaseelan R,Incardona F,Fisher M,Zidovetzki R

更新日期：1998-11-01 00:00:00

abstract：:To determine whether the sensitivity of the human long-term culture-initiating cell (LTC-IC) assay could be increased, we have evaluated a spectrum of different fibroblast cell lines for their abilities to influence the number of cells detectable as LTC-IC, to influence LTC-IC maintenance, and/or to influence LTC-IC d...

journal_title：Blood

authors： Hogge DE,Lansdorp PM,Reid D,Gerhard B,Eaves CJ

更新日期：1996-11-15 00:00:00

abstract：:Enzymes of the glycolytic pathway as well as some ancillary enzymes were studied in normal red cells parasitized with Plasmodium falciparum in culture at varying parasitemias as well as in isolated parasites. The levels of all enzymes except diphosphoglycerate mutase, glucose-6-phosphate dehydrogenase, and adenylate k...

journal_title：Blood

authors： Roth EF Jr,Calvin MC,Max-Audit I,Rosa J,Rosa R

更新日期：1988-12-01 00:00:00

abstract：:The relationship between class switch recombination (CSR) and somatic hypermutation has been unclear. By using human CD27(-) naive B cells, we investigated the somatic hypermutation and producibility of immunoglobulins (Igs) that occur after CSR. Although neither adult CD27(-) nor cord blood B cells, which showed the ...

journal_title：Blood

authors： Nagumo H,Agematsu K,Kobayashi N,Shinozaki K,Hokibara S,Nagase H,Takamoto M,Yasui K,Sugane K,Komiyama A

更新日期：2002-01-15 00:00:00

abstract：:Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers. All 50 household contac...

journal_title：Blood

authors： Lawrence DN,Jason JM,Bouhasin JD,McDougal JS,Knutsen AP,Evatt BL,Joist JH

更新日期：1985-09-01 00:00:00

abstract：:Although the role of systemic activation of the nuclear factor kappaB (NF-kappaB) pathway in septic coagulation has been well documented, little is known about the contribution of endothelial-specific NF-kappaB signaling in this pathologic process. Here, we used transgenic mice that conditionally overexpress a mutant ...

journal_title：Blood

authors： Song D,Ye X,Xu H,Liu SF

更新日期：2009-09-17 00:00:00

abstract：:Eosinophil accumulation has been associated with the pathogenesis of numerous allergic inflammatory disorders. Despite the great interest in this response, many aspects of eosinophil accumulation remain unknown. This is particularly true with respect to tissue-specific mechanisms that may regulate the accumulation of ...

journal_title：Blood

authors： Larbi KY,Allen AR,Tam FW,Haskard DO,Lobb RR,Silva PM,Nourshargh S

更新日期：2000-11-15 00:00:00

abstract：:BCL3 encodes a protein with close homology to IkappaB proteins and interacts with p50 NF-kappaB homodimers. However, the regulation and transcriptional activity of BCL3 remain ill-defined. We observed here that interleukin-9 (IL-9) and IL-4, but not IL-2 or IL-3, transcriptionally upregulated BCL3 expression in T cell...

journal_title：Blood

authors： Richard M,Louahed J,Demoulin JB,Renauld JC

更新日期：1999-06-15 00:00:00

abstract：:Although CD4(+)CD25(+) T cells (T regulatory cells [Tregs]) and natural killer T cells (NKT cells) each protect against graft-versus-host disease (GVHD), interactions between these 2 regulatory cell populations after allogeneic bone marrow transplantation (BMT) have not been studied. We show that host NKT cells can in...

journal_title：Blood

authors： Pillai AB,George TI,Dutt S,Strober S

更新日期：2009-04-30 00:00:00

abstract：:The Leukemia and Lymphoma Molecular Profiling Project recently published results from DNA microarray analyses of 240 diffuse large B-cell lymphomas (DLBCLs). Four gene expression "signatures" were identified as correlated with patient outcome, including the major histocompatibility complex (MHC) class II genes (eg, HL...

journal_title：Blood

authors： Rimsza LM,Roberts RA,Miller TP,Unger JM,LeBlanc M,Braziel RM,Weisenberger DD,Chan WC,Muller-Hermelink HK,Jaffe ES,Gascoyne RD,Campo E,Fuchs DA,Spier CM,Fisher RI,Delabie J,Rosenwald A,Staudt LM,Grogan TM

更新日期：2004-06-01 00:00:00

abstract：:AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD. AC133 antigen is selectively expressed on CD34(bright) hematopoietic stem and progenitor cells (progenitors) derived from human fetal liver and b...

journal_title：Blood

authors： Yin AH,Miraglia S,Zanjani ED,Almeida-Porada G,Ogawa M,Leary AG,Olweus J,Kearney J,Buck DW

更新日期：1997-12-15 00:00:00

abstract：:Conflicting data have been reported on the risk for venous thrombosis in subjects with low free protein S levels. We performed a post-hoc analysis in a single-center retrospective thrombophilic family cohort, to define the optimal free protein S level that can identify subjects at risk for venous thrombosis. Relatives...

journal_title：Blood

authors： Lijfering WM,Mulder R,ten Kate MK,Veeger NJ,Mulder AB,van der Meer J

更新日期：2009-02-05 00:00:00

abstract：:Signaling through the Notch pathway plays an essential role in inducing T-lineage commitment and promoting the maturation of immature thymocytes. Using an in vitro culture system, we show that 2 different classes of Notch ligands, Jagged1 or Delta1, transmit distinct signals to T-cell progenitors. OP9 stromal cells ex...

journal_title：Blood

authors： Lehar SM,Dooley J,Farr AG,Bevan MJ

更新日期：2005-02-15 00:00:00

abstract：:We have analyzed the phenotype, cytokine profile, and mitotic history (telomere length) of monoclonal T-cell expansions in 5 CD3(+) T-cell large granular lymphocyte (TLGL) leukemia patients by fluorescence activated cell sorting (FACS) and single-cell polymerase chain reaction (PCR). We confirm that the common phenoty...

journal_title：Blood

authors： Bigouret V,Hoffmann T,Arlettaz L,Villard J,Colonna M,Ticheli A,Gratwohl A,Samii K,Chapuis B,Rufer N,Roosnek E

更新日期：2003-04-15 00:00:00

abstract：:We confirmed that murine hematopoietic stem cells express the c-kit molecule but not lymphohematopoietic lineage markers. These lineage marker-negative c-kit-positive (Lin- c-kit+) cells were further divided according to the uptake of rhodamine-123 (Rh-123). Approximately 1,000 Lin- c-kit+ rhodamine-123dull cells, whi...

journal_title：Blood

authors： Okada S,Nagayoshi K,Nakauchi H,Nishikawa S,Miura Y,Suda T

更新日期：1993-04-01 00:00:00

abstract：:Wilms' tumor 1 (WT1) is constantly expressed in leukemic cells of acute leukemia and myelodysplastic syndrome (MDS). A T-cell receptor (TCR) that specifically reacts with WT1 peptide in the context of HLA-A*24:02 has been identified. We conducted a first-in-human trial of TCR-gene transduced T-cell (TCR-T-cell) transf...

journal_title：Blood

authors： Tawara I,Kageyama S,Miyahara Y,Fujiwara H,Nishida T,Akatsuka Y,Ikeda H,Tanimoto K,Terakura S,Murata M,Inaguma Y,Masuya M,Inoue N,Kidokoro T,Okamoto S,Tomura D,Chono H,Nukaya I,Mineno J,Naoe T,Emi N,Yasukawa M,

更新日期：2017-11-02 00:00:00

abstract：:The JAK2 V617F mutation is present in the majority of patients with a myeloproliferative neoplasm (MPN) and is sufficient to recapitulate an MPN in murine models. However, the consequences of JAK2 mutations for myeloid differentiation are poorly understood. After systematic analyses of a large cohort of JAK2-mutated M...

journal_title：Blood

authors： Anand S,Stedham F,Beer P,Gudgin E,Ortmann CA,Bench A,Erber W,Green AR,Huntly BJ

更新日期：2011-07-07 00:00:00

abstract：:Pattern recognition receptors (PRRs) play an essential role in a macrophage's response to mycobacterial infections. However, how these receptors work in concert to promote this macrophage response remains unclear. In this study, we used bone marrow-derived macrophages isolated from mannose receptor (MR), complement re...

journal_title：Blood

authors： Yadav M,Schorey JS

更新日期：2006-11-01 00:00:00

abstract：:Deletions at the 3' end of the human beta-globin locus are associated with the hereditary persistence of fetal hemoglobin (HPFH) in adults, potentially through the juxtaposition of enhancer elements in the vicinity of the fetal gamma-globin genes. We have tested how sequences at the HPFH-2, HPFH-3, and HPFH-6 breakpoi...

journal_title：Blood

authors： Katsantoni EZ,Langeveld A,Wai AW,Drabek D,Grosveld F,Anagnou NP,Strouboulis J

更新日期：2003-11-01 00:00:00

abstract：:We describe two assays to detect the action of colony-inhibiting cells. In the first assay, we used a simple density separation technique to remove dense neutrophils (PMN) from suspensions of blood and of bone marrow cells prior to culture in semisolid agar. Conditions were arranged to ensure that control suspensions ...

journal_title：Blood

authors： Broxmeyer HE,Baker FL,Galbraith PR

更新日期：1976-03-01 00:00:00

abstract：:BCR-ABL antisense oligodeoxynucleotides (ODN) have provided evidence of antileukemia effect when tested in vitro against Philadelphia-positive (Ph-pos) cells and in vivo when injected into leukemic mice. On the basis of the results obtained in vitro at diagnosis, eight patients with chronic myelogenous leukemia (CML) ...

journal_title：Blood

authors： de Fabritiis P,Petti MC,Montefusco E,De Propris MS,Sala R,Bellucci R,Mancini M,Lisci A,Bonetto F,Geiser T,Calabretta B,Mandelli F

更新日期：1998-05-01 00:00:00

abstract：:Platelets contain and release several matrix metalloproteinases (MMPs). Among these, active MMP-2 enhances platelet aggregation by favoring the activation of phosphatidylinositol 3- kinase (PI3K) and contributes to arterial thrombosis. The platelet surface target of MMP-2 and the mechanism through which it primes plat...

journal_title：Blood

authors： Sebastiano M,Momi S,Falcinelli E,Bury L,Hoylaerts MF,Gresele P

更新日期：2017-02-16 00:00:00

abstract：:The International Prognostic Scoring System (IPSS) has been widely used to predict the prognosis of patients with myelodysplastic syndrome (MDS). However, IPSS does not always provide a sufficiently precise evaluation of patients to allow the appropriate choice of clinical interventions. Here, we analyzed the expressi...

journal_title：Blood

authors： Mihara K,Chowdhury M,Nakaju N,Hidani S,Ihara A,Hyodo H,Yasunaga S,Takihara Y,Kimura A

更新日期：2006-01-01 00:00:00

abstract：:Targeted irradiation of the bone marrow with radiolabeled monoclonal antibodies (radioimmunotherapy) represents a novel therapeutic approach with both myeloablative and antileukemic potential. In an open-label, single-center pilot study, 30 pediatric and adolescent patients undergoing hematopoietic cell transplantatio...

journal_title：Blood

authors： Schulz AS,Glatting G,Hoenig M,Schuetz C,Gatz SA,Grewendorf S,Sparber-Sauer M,Muche R,Blumstein N,Kropshofer G,Suttorp M,Bunjes D,Debatin KM,Reske SN,Friedrich W

更新日期：2011-04-28 00:00:00

abstract：:Interferon (IFN)-alpha inhibits DNA synthesis stimulated by low molecular weight B-cell growth factor (BCGF) in hairy cells in vitro, suggesting that the therapeutic efficacy of IFN-alpha in hairy cell leukemia (HCL) involves growth inhibition of malignant B cells. Evidence that the 16-Kd cell surface protein Leu-13 m...

journal_title：Blood

authors： Evans SS,Lee DB,Han T,Tomasi TB,Evans RL

更新日期：1990-12-15 00:00:00

abstract：:Endothelial cell-mediated coagulation and leukocyte adhesion are processes that might be connected by the generation of thrombin. To examine the interaction of procoagulant and proadhesive activity, cultures of endothelial cells were stimulated with tumor necrosis factor-alpha, which resulted in the surface expression...

journal_title：Blood

authors： Kirchhofer D,Sakariassen KS,Clozel M,Tschopp TB,Hadváry P,Nemerson Y,Baumgartner HR

更新日期：1993-04-15 00:00:00

abstract：:The plasmid pUC18 contains a lacZ alpha-complementation gene that codes for a small peptide that can complement the delta M15 mutation of the Escherichia coli lacZ (beta-galactosidase) gene, converting bacteria carrying that mutated gene from the lacZ- to the lacZ+ phenotype. This plasmid was used in experiments desig...

journal_title：Blood

authors： De Togni P,Fox HB,Morrissey S,Tansey LR,Levy SB,Babior BM

更新日期：1988-02-01 00:00:00