Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia.

abstract：:High-pressure liquid chromatography analysis of polyamines in bone narrow from leukemic and nonleukemic subjects demonstrated increased concentrations of putrescine, spermidine, and spermine associated with increased cellularity. The most striking abnormality was the marked elevation of putrescine. Bone marrow polyami...

journal_title：Blood

authors： Rennert O,Miale T,Shukla J,Lawson D,Frias J

更新日期：1976-04-01 00:00:00

abstract：:Umbilical cord blood (UCB) is used for HSCT. It is known that UCB can comprise Ag-specific T cells. Here we question whether solely transmaternal cell flow may immunize UCB. Twenty-three female UCB samples were collected from healthy mothers and analyzed for minor histocompatibility Ag HY-specific responses. Forty-two...

journal_title：Blood

authors： Dierselhuis MP,Blokland EC,Pool J,Schrama E,Scherjon SA,Goulmy E

更新日期：2012-07-19 00:00:00

abstract：:The most common chromosomal abnormality of infant acute lymphoblastic leukemia (ALL) is the t(4;11)(q21;q23) that gives rise to the MLL/AF4 fusion gene. Leukemic blasts expressing MLL/AF4 are arrested at an early progenitor stage with lymphoid or monocytoid characteristics. A novel B-lineage ALL cell line termed B-lin...

journal_title：Blood

authors： Bertrand FE,Vogtenhuber C,Shah N,LeBien TW

更新日期：2001-12-01 00:00:00

abstract：:Erythroid progenitors (BFU-E) from adult human peripheral blood generate erythroid bursts in semisolid culture supplemented with at least two growth factors, ie, erythropoietin (Ep) and interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF). We have analyzed the hematopoietin(s) requirement ...

journal_title：Blood

authors： Valtieri M,Gabbianelli M,Pelosi E,Bassano E,Petti S,Russo G,Testa U,Peschle C

更新日期：1989-07-01 00:00:00

abstract：:Truncation of asparaginase treatment due to asparaginase related toxicities or silent inactivation (SI) is common and may increase relapse risk in acute lymphoblastic leukemia (ALL). We investigated relapse risk following suboptimal asparaginase exposure among 1401 children aged 1-17 years, diagnosed with ALL between ...

journal_title：Blood

authors： Gottschalk Højfeldt S,Grell K,Abrahamsson J,Lund B,Vettenranta K,Jonsson OG,Frandsen TL,Wolthers BO,Marquart HVH,Vaitkeviciene G,Lepik K,Heyman M,Schmiegelow K,Albertsen BK

更新日期：2020-11-04 00:00:00

abstract：:Zosuquidar, which modulates P-glycoprotein (P-gp) with minimal delay of anthracycline clearance, may reverse P-gp-mediated resistance in acute myeloid leukemia without increased toxicity. A total of 449 adults older than 60 years with acute myeloid leukemia or high-risk myelodysplastic syndrome enrolled in a randomize...

journal_title：Blood

authors： Cripe LD,Uno H,Paietta EM,Litzow MR,Ketterling RP,Bennett JM,Rowe JM,Lazarus HM,Luger S,Tallman MS

更新日期：2010-11-18 00:00:00

abstract：:Microarray gene expression profiling studies have demonstrated immune response gene signatures that appear predictive of outcome in follicular lymphoma (FL). However, measurement of these marker genes in routine practice remains difficult. We have therefore investigated the immune response in FL using real-time polyme...

journal_title：Blood

authors： Byers RJ,Sakhinia E,Joseph P,Glennie C,Hoyland JA,Menasce LP,Radford JA,Illidge T

更新日期：2008-05-01 00:00:00

abstract：:In the 2005-01 trial, we have demonstrated that bortezomib-dexamethasone as induction therapy before autologous stem cell transplantation was superior to vincristine-adriamycin-dexamethasone. We conducted a post-hoc analysis to assess the prognostic impact of initial characteristics as well as response to therapy in p...

journal_title：Blood

authors： Moreau P,Attal M,Pégourié B,Planche L,Hulin C,Facon T,Stoppa AM,Fuzibet JG,Grosbois B,Doyen C,Ketterer N,Sebban C,Kolb B,Chaleteix C,Dib M,Voillat L,Fontan J,Garderet L,Jaubert J,Mathiot C,Esseltine D,Avet-Loise

更新日期：2011-03-17 00:00:00

abstract：:Posttranscriptional modification of histones by methylation plays an important role in regulating Ag-driven T-cell responses. We have recently drawn correlations between allogeneic T-cell responses and the histone methyltransferase Ezh2, which catalyzes histone H3 lysine 27 trimethylation. The functional relevance of ...

journal_title：Blood

authors： He S,Xie F,Liu Y,Tong Q,Mochizuki K,Lapinski PE,Mani RS,Reddy P,Mochizuki I,Chinnaiyan AM,Mineishi S,King PD,Zhang Y

更新日期：2013-12-12 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea, is an antioxidant with chemopreventive and chemotherapeutic actions. Based on its ability to modulate growth factor-mediated cell proliferation, we evaluated its efficacy in multiple myeloma (MM). EGCG induced both dose- and time-dependent growt...

journal_title：Blood

authors： Shammas MA,Neri P,Koley H,Batchu RB,Bertheau RC,Munshi V,Prabhala R,Fulciniti M,Tai YT,Treon SP,Goyal RK,Anderson KC,Munshi NC

更新日期：2006-10-15 00:00:00

abstract：:AML1-ETO (AE) is a fusion product of t(8;21) observed in 40% French-American-British M2 type of acute myeloid leukemia (AML). Clinical data suggest that Ras mutation is a frequent cooperating event in t(8;21) AML. Whether constitutively active Ras promotes leukemogenesis on the t(8;21) background has not been demonstr...

journal_title：Blood

authors： Chou FS,Wunderlich M,Griesinger A,Mulloy JC

更新日期：2011-02-17 00:00:00

abstract：:The production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue mac...

journal_title：Blood

authors： Dale DC,Boxer L,Liles WC

更新日期：2008-08-15 00:00:00

abstract：:Oxygen deprivation (hypoxia) is a consistent component of ischemia that induces an inflammatory and prothrombotic response in the endothelium. In this report, it is demonstrated that exposure of endothelial cells to hypoxia (1% O(2)) increases messenger RNA and protein levels of transforming growth factor-beta2 (TGF-b...

journal_title：Blood

authors： Akman HO,Zhang H,Siddiqui MA,Solomon W,Smith EL,Batuman OA

更新日期：2001-12-01 00:00:00

abstract：:Staining with CD14 and CD16 monoclonal antibodies will identify two monocyte subpopulations in human blood: a major population of regular monocytes, which strongly expresses the CD14 antigen (CD14++), and a minor population with weak expression of CD14 and expression of the CD16 antigen (CD14+/CD16+ cells). As shown h...

journal_title：Blood

authors： Fingerle G,Pforte A,Passlick B,Blumenstein M,Ströbel M,Ziegler-Heitbrock HW

更新日期：1993-11-15 00:00:00

abstract：:Polymorphonuclear neutrophils (PMN) contain multiple distinct secretory compartments that are sequentially mobilized during cell activation. Complement receptor type 1 (CR1) is a marker for a readily mobilizable secretory vesicle compartment, which can undergo exocytic fusion with the plasma membrane independently of ...

journal_title：Blood

authors： Jost C,Klickstein L,Wetzler E,Kumar A,Berger M

更新日期：1998-07-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with remarkable preclinical and clinical antitumor activity in multiple myeloma (MM) patients. The initial rationale for its use in MM was inhibition of nuclear factor (NF)-kappaB activity by blocking proteasomal degradation of inhibitor of kappaBalpha (IkappaBalpha). Bortezomib in...

journal_title：Blood

authors： Hideshima T,Ikeda H,Chauhan D,Okawa Y,Raje N,Podar K,Mitsiades C,Munshi NC,Richardson PG,Carrasco RD,Anderson KC

更新日期：2009-07-30 00:00:00

abstract：:The microsomal fraction of M1 cells (an established cell line of myeloid leukemia) was capable of catalyzing acylation of sn-glycerol 3-phosphate by long-chain fatty acyl-CoA thioesters. The principal lipid product formed was identified as phosphatidic acid. Palmityl-CoA, stearyl-CoA, and oleyl-CoA were more effective...

journal_title：Blood

authors： Okuma M,Ichikawa Y,Yamashita S,Kitajima K,Numa S

更新日期：1976-03-01 00:00:00

abstract：:The clinical and prognostic relevance of many recently identified driver gene mutations in adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or hotspot areas of 68 recurrently mutated genes in a cohort of 664 patients aged 18 to 86 years treated on 2 phase 3 trials of the German AML...

journal_title：Blood

authors： Metzeler KH,Herold T,Rothenberg-Thurley M,Amler S,Sauerland MC,Görlich D,Schneider S,Konstandin NP,Dufour A,Bräundl K,Ksienzyk B,Zellmeier E,Hartmann L,Greif PA,Fiegl M,Subklewe M,Bohlander SK,Krug U,Faldum A,Berdel

更新日期：2016-08-04 00:00:00

abstract：:Mice homozygous for an autosomal recessive scid (severe combined immune deficiency) mutation on chromosome 16 exhibit a defect that specifically impairs lymphoid differentiation but not myelopoiesis. Consequently such mice are deficient in both humoral and cell-mediated immune functions. Despite their defect, scid mic...

journal_title：Blood

authors： Fulop GM,Phillips RA

更新日期：1989-10-01 00:00:00

abstract：:We have generated a large, unique database that includes morphologic, clinical, cytogenetic, and follow-up data from 2124 patients with myelodysplastic syndromes (MDSs) at 4 institutions in Austria and 4 in Germany. Cytogenetic analyses were successfully performed in 2072 (97.6%) patients, revealing clonal abnormaliti...

journal_title：Blood

authors： Haase D,Germing U,Schanz J,Pfeilstöcker M,Nösslinger T,Hildebrandt B,Kundgen A,Lübbert M,Kunzmann R,Giagounidis AA,Aul C,Trümper L,Krieger O,Stauder R,Müller TH,Wimazal F,Valent P,Fonatsch C,Steidl C

更新日期：2007-12-15 00:00:00

abstract：:Previous in vitro findings suggest a critical role for the polymorphonuclear leukocyte (PMN) membrane glycoprotein complex CD18 in PMN adherence and chemotaxis. We examined the effect of the murine monoclonal antibody (MoAb) 60.3, recognizing CD18, on induced PMN accumulation in vivo. Rabbits were pretreated with MoAb...

journal_title：Blood

authors： Arfors KE,Lundberg C,Lindbom L,Lundberg K,Beatty PG,Harlan JM

更新日期：1987-01-01 00:00:00

abstract：:Heme biosynthesis was examined in erythroid tissue of a 4-yr-old girl with severe sideroblastic anemia since infancy, as documented by the presence of intramitochondrial deposits of iron in erythroblasts. Free red cell protoporphyrin, urinary porphyrins, and activities of erythrocyte porphobilinogen synthase, uroporph...

journal_title：Blood

authors： Buchanan GR,Bottomley SS,Nitschke R

更新日期：1980-01-01 00:00:00

abstract：:The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/p...

journal_title：Blood

authors： Dos Santos C,McDonald T,Ho YW,Liu H,Lin A,Forman SJ,Kuo YH,Bhatia R

更新日期：2013-09-12 00:00:00

abstract：:The inclusion of exon 16 in the mature protein 4.1R messenger RNA (mRNA) is a critical event in red blood cell membrane biogenesis. It occurs during late erythroid development and results in inclusion of the 10-kd domain needed for stabilization of the spectrin/actin lattice. In this study, an experimental model was e...

journal_title：Blood

authors： Deguillien M,Huang SC,Morinière M,Dreumont N,Benz EJ Jr,Baklouti F

更新日期：2001-12-15 00:00:00

abstract：:Interleukin-1 beta (IL-1 beta) converting enzyme (ICE) is a cysteine protease that specifically cleaves precursor IL-1 beta to its biologically active form. Recent studies have also implicated ICE in the induction of apoptosis in vertebrate cells. Because IL-1 plays a major role in acute myelogenous leukemia (AML) bla...

journal_title：Blood

authors： Estrov Z,Black RA,Sleath PR,Harris D,Van Q,LaPushin R,Estey EH,Talpaz M

更新日期：1995-12-15 00:00:00

abstract：:We recently demonstrated that immunoglobulin E (IgE), in the absence of cross-linking agents, activates signaling pathways in healthy murine bone marrow-derived mast cells (BMMCs) and that this activation enhances BMMC survival, at least in part, via secretion of autocrine-acting cytokines. We report herein that IgE a...

journal_title：Blood

authors： Lam V,Kalesnikoff J,Lee CW,Hernandez-Hansen V,Wilson BS,Oliver JM,Krystal G

更新日期：2003-08-15 00:00:00

abstract：:Overexpression of transcription factors runt-related transcription factor 1 (RUNX1) and nuclear factor, erythroid-derived 2 (NF-E2) was reported in granulocytes of patients with polycythemia vera and other myeloproliferative neoplasms (MPNs). Further, a transgenic mouse overexpressing the NF-E2 transgene was reported ...

journal_title：Blood

authors： Kapralova K,Lanikova L,Lorenzo F,Song J,Horvathova M,Divoky V,Prchal JT

更新日期：2014-01-16 00:00:00

abstract：:Mammalian 15-lipoxygenases, which have been implicated in the differentiation of hematopoietic cells are commonly regarded as cytosolic enzymes. Studying the interaction of the purified rabbit reticulocyte 15-lipoxygenase with various types of biomembranes, we found that the enzyme binds to biomembranes when calcium i...

journal_title：Blood

authors： Brinckmann R,Schnurr K,Heydeck D,Rosenbach T,Kolde G,Kühn H

更新日期：1998-01-01 00:00:00

abstract：:The course and treatment of a life-threatening hemorrhagic episode in a patient with hemophilia A whose plasma contained a high concentration of an inhibitor of factor VIII activity is presented. The inhibitor of factor VIII was localized to the most anodal fractions of immunoglobulin G on electrophoresis, and was thu...

journal_title：Blood

authors： Sonoda T,Solomon A,Krauss S,Cruz P,Jones FS,Levin J

更新日期：1976-06-01 00:00:00

abstract：:Arsenic trioxide (As2O3) induces clinical remission in acute promyelocytic leukemia (APL) with minimal toxicity and apoptosis in APL-derived NB4 cells at low (1 to 2 micromol/L) concentration. We examined the basis for NB4 cell sensitivity to As2O3 to identify experimental conditions that would render other malignant ...

journal_title：Blood

authors： Dai J,Weinberg RS,Waxman S,Jing Y

更新日期：1999-01-01 00:00:00