Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999.

abstract：:AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD. AC133 antigen is selectively expressed on CD34(bright) hematopoietic stem and progenitor cells (progenitors) derived from human fetal liver and b...

journal_title：Blood

authors： Yin AH,Miraglia S,Zanjani ED,Almeida-Porada G,Ogawa M,Leary AG,Olweus J,Kearney J,Buck DW

更新日期：1997-12-15 00:00:00

abstract：:The proto-oncogene c-fos was transiently upregulated in primitive hematopoietic stem (Lin-Sca-1(+)) cells stimulated with stem cell factor, interleukin-3 (IL-3), and IL-6. To investigate a role of the c-fos in hematopoietic stem cells, we used bone marrow (BM) cells from transgenic mice carrying the c-fos gene under t...

journal_title：Blood

authors： Okada S,Fukuda T,Inada K,Tokuhisa T

更新日期：1999-02-01 00:00:00

abstract：:Perfluorocarbons have shown promise as clinical blood substitutes. Although early experience in Japan with one such product--Fluosol-DA--has been uncomplicated, we observed an adverse pulmonary reaction in the first American patient to receive it and know of similar reactions in two other Americans so treated. Postula...

journal_title：Blood

authors： Vercellotti GM,Hammerschmidt DE,Craddock PR,Jacob HS

更新日期：1982-06-01 00:00:00

abstract：:Ticagrelor is a direct-acting reversibly binding P2Y12 antagonist and is widely used as an antiplatelet therapy for the prevention of cardiovascular events in acute coronary syndrome patients. However, antiplatelet therapy can be associated with an increased risk of bleeding. Here, we present data on the identificatio...

journal_title：Blood

authors： Buchanan A,Newton P,Pehrsson S,Inghardt T,Antonsson T,Svensson P,Sjögren T,Öster L,Janefeldt A,Sandinge AS,Keyes F,Austin M,Spooner J,Gennemark P,Penney M,Howells G,Vaughan T,Nylander S

更新日期：2015-05-28 00:00:00

abstract：:We compared urokinase-type plasminogen activator (u-PA) in fluid phase and u-PA bound with its receptor on human blood monocytes with respect to proteolytic activity and susceptibility to inactivation by the plasminogen activator inhibitors PAI-1 and PAI-2. Receptor-bound u-PA is catalytically twice as efficient as fl...

journal_title：Blood

authors： Kirchheimer JC,Remold HG

更新日期：1989-09-01 00:00:00

abstract：:Interleukin-12 (IL-12) is a cytokine that plays a central role in the control of cell-mediated immunity. We have previously shown that transforming growth factor-beta1 (TGF-beta) inhibitory effects on human primary allogeneic cytotoxicity and proliferative responses interfere with IL-12 pathway. The present study was ...

journal_title：Blood

authors： Pardoux C,Ma X,Gobert S,Pellegrini S,Mayeux P,Gay F,Trinchieri G,Chouaib S

更新日期：1999-03-01 00:00:00

abstract：:The diagnosis of heparin-induced thrombocytopenia (HIT) requires detection of antibodies to the heparin/platelet factor 4 (PF4) complexes via enzyme-linked immunosorbent assay. Addition of excess heparin to the sample decreases the optical density by 50% or more and confirms the presence of these antibodies. One hundr...

journal_title：Blood

authors： Whitlatch NL,Kong DF,Metjian AD,Arepally GM,Ortel TL

更新日期：2010-09-09 00:00:00

abstract：:Umbilical cord blood (UCB) is an attractive cell source for hematopoietic cell transplantation (HCT). Here we examine whether the combination of homeobox B4 (HOXB4) and Delta-1 ligand (DL) synergize when used together. Monkey and human UCB CD34(+) cells were transduced with a HOXB4-expressing gammaretroviral vector an...

journal_title：Blood

authors： Watts KL,Delaney C,Humphries RK,Bernstein ID,Kiem HP

更新日期：2010-12-23 00:00:00

abstract：:Human transferrin receptor-2 (TFR-2) is a protein highly homologous to TFR-1/CD71 and is endowed with the ability to bind transferrin (TF) with low affinity. High levels of TFR-2 mRNA were found in the liver and in erythroid precursors. Mutations affecting the TFR-2 gene led to hemochromatosis type 3, a form of inheri...

journal_title：Blood

authors： Deaglio S,Capobianco A,Calì A,Bellora F,Alberti F,Righi L,Sapino A,Camaschella C,Malavasi F

更新日期：2002-11-15 00:00:00

abstract：:Thioredoxin (Trx) is a ubiquitous protein disulfide oxidoreductase with antioxidant, cytokine, and chemotactic properties. Previously, we showed that Trx, in synergy with interleukin 1 (IL-1), IL-2, IL-4, tumor necrosis factor alpha (TNF-alpha), and CD40-ligation induced S-phase entry and mitosis in normal B cells and...

journal_title：Blood

authors： Nilsson J,Söderberg O,Nilsson K,Rosén A

更新日期：2000-02-15 00:00:00

abstract：:Therapy for childhood acute lymphoblastic leukemia (ALL) is associated with 5-year survival rates of ∼90% even after largely eliminating cranial radiation. This meta-analysis assesses the long-term neurocognitive functioning after chemotherapy-only regimens among survivors of childhood ALL. We conducted a systematic r...

journal_title：Blood

authors： Iyer NS,Balsamo LM,Bracken MB,Kadan-Lottick NS

更新日期：2015-07-16 00:00:00

abstract：:Cervical internal carotid artery (cICA) occlusion is a recognized cause of acute ischemic stroke (AIS) in sickle cell disease (SCD), but the associated clinical and radiologic features are not well described. We reviewed data on cervical magnetic resonance angiography (cMRA) performed prospectively in 67 patients (55 ...

journal_title：Blood

authors： Telfer PT,Evanson J,Butler P,Hemmaway C,Abdulla C,Gadong N,Whitmarsh S,Kaya B,Kirkham FJ

更新日期：2011-12-01 00:00:00

abstract：:Eighteen patients with relapse of chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation (BMT) were treated with recombinant human alpha 2a interferon (IFN). Relapse was defined as greater than 90% metaphases containing the Philadelphia chromosome (Ph) and hematologic abnormalities consistent ...

journal_title：Blood

authors： Higano CS,Raskind WH,Singer JW

更新日期：1992-09-15 00:00:00

abstract：:The ability to transfer new genetic material into human hematopoietic cells provides the foundation for characterizing the organization and developmental program of human hematopoietic stem cells. It also provides a valuable model in which to test gene transfer and long-term expression in human hematopoietic cells as ...

journal_title：Blood

authors： Dick JE,Kamel-Reid S,Murdoch B,Doedens M

更新日期：1991-08-01 00:00:00

abstract：:Expression of the von Willebrand factor (vWF) gene is restricted to the endothelial and megakaryocyte lineages. Within the endothelium, expression of vWF varies between different vascular beds. We have previously shown that the human vWF promoter spanning a region between -2182 (relative to the start site of transcrip...

journal_title：Blood

authors： Guan J,Guillot PV,Aird WC

更新日期：1999-11-15 00:00:00

abstract：:Interleukin-15 (IL-15) induces proliferation and promotes cell survival of human T and B lymphocytes, natural killer cells, and neutrophils. Here we report the constitutive expression of a functional IL-15 receptor (IL-15R) in 6 of 6 myeloma cell lines and in CD38(high)/CD45(low )plasma cells belonging to 14 of 14 pat...

journal_title：Blood

authors： Tinhofer I,Marschitz I,Henn T,Egle A,Greil R

更新日期：2000-01-15 00:00:00

abstract：:Lumiliximab is a chimeric macaque-human monoclonal antibody to CD23, a protein expressed on virtually all chronic lymphocytic leukemia (CLL) cells. We examined the ability of lumiliximab to mediate apoptosis, antibody-dependent cellular cytotoxicity, and complement-dependent cytotoxicity against primary CLL cells and ...

journal_title：Blood

authors： Pathan NI,Chu P,Hariharan K,Cheney C,Molina A,Byrd J

更新日期：2008-02-01 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplant reflects a complex immune response resulting in chronic damage to multiple tissues. Previous studies indicated that donor B cells and the antibodies they produce play an important role in the development of cGVHD. To understa...

journal_title：Blood

authors： Wang KS,Kim HT,Nikiforow S,Heubeck AT,Ho VT,Koreth J,Alyea EP,Armand P,Blazar BR,Soiffer RJ,Antin JH,Cutler CS,Ritz J

更新日期：2017-12-28 00:00:00

abstract：:Sepsis and septic shock remain an important medical problem, emphasizing the need to identify novel therapeutic opportunities. Hypovolemic hypotension, coagulation dysfunction, disturbed microcirculation, and multiorgan failure resulting from vascular leakage are often observed in these severe conditions. In the prese...

journal_title：Blood

authors： Oehmcke S,Shannon O,von Köckritz-Blickwede M,Mörgelin M,Linder A,Olin AI,Björck L,Herwald H

更新日期：2009-07-09 00:00:00

abstract：:Twenty-eight patients with multiple myeloma responding to prior melphalan-prednisone combinations, but without additional chemotherapy, were followed until relapse. Patients receiving no further treatment had a median survival time similar to that of those receiving indefinite courses of melphalan-prednisone or carmus...

journal_title：Blood

authors： Alexanian R,Gehan E,Haut A,Saiki J,Weick J

更新日期：1978-06-01 00:00:00

abstract：:We demonstrate a methodology for tracing the clonal history of hematopoietic stem and progenitor cells (HSPCs) behavior in live tissues in 4 dimensions (4D). This integrates genetic combinatorial marking using lentiviral vectors encoding various fluorescent proteins (FPs) with advanced imaging methods. Five FPs: Cerul...

journal_title：Blood

authors： Malide D,Métais JY,Dunbar CE

更新日期：2012-12-20 00:00:00

abstract：:The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely impairs the development and function of B cells but not T cells. Here w...

journal_title：Blood

authors： Deane JA,Kharas MG,Oak JS,Stiles LN,Luo J,Moore TI,Ji H,Rommel C,Cantley LC,Lane TE,Fruman DA

更新日期：2007-04-01 00:00:00

abstract：:An inactivating polymorphism at position 609 in the NAD(P)H:quinone oxidoreductase 1 gene (NQO1 C609T) is associated with an increased risk of adult leukemia. A small British study suggested that NQO1 C609T was associated with an increased risk of infant leukemias with MLL translocations, especially infant acute lymph...

journal_title：Blood

authors： Smith MT,Wang Y,Skibola CF,Slater DJ,Lo Nigro L,Nowell PC,Lange BJ,Felix CA

更新日期：2002-12-15 00:00:00

abstract：:Aberrant expression of Aurora kinases and inactivation of wild-type p53 by Mdm2 overexpression are frequent molecular events in acute myelogenous leukemia (AML), and preclinical data for inhibition of Aurora kinases or Mdm2 are promising. However, it remains largely unknown whether the viability of cells exposed to Au...

journal_title：Blood

authors： Kojima K,Konopleva M,Tsao T,Nakakuma H,Andreeff M

更新日期：2008-10-01 00:00:00

abstract：:The authors have identified a 12-residue carboxyl-terminal extension of Lys-Ser-Pro-Met-Arg-Arg-Phe-Leu-Leu-Phe-Cys-Met in a dysfibrinogen derived from a woman heterozygotic for this abnormality and associated with severe bleeding. This extension is due to a T-to-A mutation that creates AAG encoding Lys at the stop (T...

journal_title：Blood

authors： Sugo T,Nakamikawa C,Yoshida N,Niwa K,Sameshima M,Mimuro J,Weisel JW,Nagita A,Matsuda M

更新日期：2000-12-01 00:00:00

abstract：:Platelets are pivotal to the process of arterial thrombosis resulting in ischemic stroke. Occlusive thrombosis is initiated by the interaction of von Willebrand factor (vWf) and platelet glycoprotein (GP) Ibalpha. Three polymorphisms have been described in GP Ibalpha (Kozak T/C polymorphism, variable number of tandem ...

journal_title：Blood

authors： Baker RI,Eikelboom J,Lofthouse E,Staples N,Afshar-Kharghan V,López JA,Shen Y,Berndt MC,Hankey G

更新日期：2001-07-01 00:00:00

abstract：:Adhesive interactions between circulating sickle red blood cells (RBCs), leukocytes, and endothelial cells are major pathophysiologic events in sickle cell disease (SCD). To develop new therapeutics that efficiently inhibit adhesive interactions, we generated an anti-P-selectin aptamer and examined its effects on cell...

journal_title：Blood

authors： Gutsaeva DR,Parkerson JB,Yerigenahally SD,Kurz JC,Schaub RG,Ikuta T,Head CA

更新日期：2011-01-13 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi sarcoma (KS) and multicentric Castleman disease (MCD), a life-threatening, virally induced B-cell lymphoproliferative disorder. HHV-8 is a B-lymphotropic γ-herpesvirus closely related to the Epstein-Barr virus (EBV). Invariant natural killer T (iNKT) cells a...

journal_title：Blood

authors： Sbihi Z,Dossier A,Boutboul D,Galicier L,Parizot C,Emarre A,Hoareau B,Dupin N,Marcelin AG,Oudin A,Fieschi C,Agbalika F,Autran B,Oksenhendler E,Carcelain G

更新日期：2017-02-16 00:00:00

abstract：:Protein S is a cofactor for tissue factor pathway inhibitor (TFPI), accelerating the inhibition of activated factor X (FXa). TFPI Kunitz domain 3 residue Glu226 is essential for enhancement of TFPI by protein S. To investigate the complementary functional interaction site on protein S, we screened 44 protein S point, ...

journal_title：Blood

authors： Reglińska-Matveyev N,Andersson HM,Rezende SM,Dahlbäck B,Crawley JT,Lane DA,Ahnström J

更新日期：2014-06-19 00:00:00

abstract：:Interactions between vascular endothelial cells and blood platelets have been investigated using a model microcirculation consisting of microcarrier beads colonized with human umbilical vein endothelial cells (HUVECs) and perfused with washed platelet suspensions. To simulate the effects of endothelial desquamation an...

journal_title：Blood

authors： Chesterman CN,Owe-Young R,Macpherson J,Krilis SA

更新日期：1986-06-01 00:00:00