Clinical quantitation of immune signature in follicular lymphoma by RT-PCR-based gene expression profiling.

abstract：:Several lines of evidence indicate that macrophage inflammatory protein-1alpha (MIP-1alpha) modulates the proliferation of hematopoietic progenitor cells, depending on their maturational stages. To clarify the mechanisms for the modulation of hematopoiesis by this chemokine, we examined the expression of a receptor fo...

journal_title：Blood

authors： Su S,Mukaida N,Wang J,Zhang Y,Takami A,Nakao S,Matsushima K

更新日期：1997-07-15 00:00:00

abstract：:Immunological control may contribute to achievement of deep molecular response in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor (TKI) therapy and may promote treatment-free remission (TFR). We investigated effector and suppressor immune responses in CML patients at diagnosis (n = 21), on TKI (im...

journal_title：Blood

authors： Hughes A,Clarson J,Tang C,Vidovic L,White DL,Hughes TP,Yong AS

更新日期：2017-03-02 00:00:00

abstract：:Factor V Leiden (factor V Arg506Gln), the genetic defect underlying resistance to activated protein C, is the most common risk factor for venous thrombosis. The relationship between this genetic abnormality and arterial disease is still unresolved. To assess whether factor V Leiden increases the risk of myocardial inf...

journal_title：Blood

authors： Rosendaal FR,Siscovick DS,Schwartz SM,Beverly RK,Psaty BM,Longstreth WT Jr,Raghunathan TE,Koepsell TD,Reitsma PH

更新日期：1997-04-15 00:00:00

abstract：:Posttranscriptional modification of histones by methylation plays an important role in regulating Ag-driven T-cell responses. We have recently drawn correlations between allogeneic T-cell responses and the histone methyltransferase Ezh2, which catalyzes histone H3 lysine 27 trimethylation. The functional relevance of ...

journal_title：Blood

authors： He S,Xie F,Liu Y,Tong Q,Mochizuki K,Lapinski PE,Mani RS,Reddy P,Mochizuki I,Chinnaiyan AM,Mineishi S,King PD,Zhang Y

更新日期：2013-12-12 00:00:00

abstract：:Posttranscriptional mechanisms are now widely acknowledged to play a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation, and tumorigenesis. Although much attention has focused on microRNAs as regulators of mRNA stability/translation, recent data have highlighted the ro...

journal_title：Blood

authors： Baou M,Norton JD,Murphy JJ

更新日期：2011-11-24 00:00:00

abstract：:A nonanemic chronic lymphocytic leukemia patient with nearly 500,000 lymphocytes/microL underwent leukapheresis when she presented with CNS symptoms and retinal vascular engorgement. Respiratory distress developed during the cell separator run, which led us to ask whether the procedure could have changed the adhesive ...

journal_title：Blood

authors： Hammerschmidt DE,Jeanneret C,Husak M,Lobell M,Jacob HS

更新日期：1988-05-01 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:In this study human mononuclear phagocytes from the bone marrow (promonocytes and monocytes), peripheral blood monocytes, and tissue macrophages from the skin and the peritoneal cavity were studied with respect to their morphological, cytochemical, and functional characteristics, cell surface receptors, and 3H-thymidi...

journal_title：Blood

authors： van Furth R,Raeburn JA,van Zwet TL

更新日期：1979-08-01 00:00:00

abstract：:Arsenic trioxide (As₂O₃) is a highly effective treatment for patients with refractory/relapsed acute promyelocytic leukemia (APL), but resistance to As₂O₃ has recently been seen. In the present study, we report the findings that 2 of 15 patients with refractory/relapsed APL treated with As₂O₃ were clinically As₂O₃ res...

journal_title：Blood

authors： Goto E,Tomita A,Hayakawa F,Atsumi A,Kiyoi H,Naoe T

更新日期：2011-08-11 00:00:00

abstract：:Protein C is activated by thrombin with a value of k(cat)/K(m) = 0.11mM(-1)s(-1) that increases 1700-fold in the presence of the cofactor thrombomodulin. The molecular origin of this effect triggering an important feedback loop in the coagulation cascade remains elusive. Acidic residues in the activation domain of pro...

journal_title：Blood

authors： Pozzi N,Barranco-Medina S,Chen Z,Di Cera E

更新日期：2012-07-19 00:00:00

abstract：:Twenty-two molecular diagnostic laboratories from 14 countries participated in a consortium study to estimate the impact of Factor VIII gene inversions in severe hemophilia A. A total of 2,093 patients with severe hemophilia A were studied; of those, 740 (35%) had a type 1 (distal) factor VIII inversion, and 140 (7%) ...

journal_title：Blood

authors： Antonarakis SE,Rossiter JP,Young M,Horst J,de Moerloose P,Sommer SS,Ketterling RP,Kazazian HH Jr,Négrier C,Vinciguerra C,Gitschier J,Goossens M,Girodon E,Ghanem N,Plassa F,Lavergne JM,Vidaud M,Costa JM,Laurian Y,Lin

更新日期：1995-09-15 00:00:00

abstract：:Virally infected cells degrade intracellular viral proteins proteolytically and present the resulting peptides in association with major histocompatibility complex (MHC) class I molecules to CD8+ cytotoxic T lymphocytes (CTLs). These cells are normally prone to CTL-mediated elimination. However, several viruses have e...

journal_title：Blood

authors： Zeidler R,Eissner G,Meissner P,Uebel S,Tampé R,Lazis S,Hammerschmidt W

更新日期：1997-09-15 00:00:00

abstract：:RANTES (CCL5) is a chemokine implicated in many human diseases. We previously showed that the transcription factor Kruppel-like factor 13 (KLF13) controls the late (3-5 days after activation) expression of RANTES in T lymphocytes and that KLF13 itself is translationally regulated through the 5'-untranslated region of ...

journal_title：Blood

authors： Kim DS,Zhang W,Millman SE,Hwang BJ,Kwon SJ,Clayberger C,Pagano M,Krensky AM

更新日期：2012-08-23 00:00:00

abstract：:Fas (CD95/Apo-1) mutations were previously reported as the genetic defect responsible for human lymphoproliferative syndrome associated with autoimmune manifestations (also known as autoimmune lymphoproliferative syndrome or Canale-Smith syndrome). We have identified 14 new heterozygous Fas mutations. Analysis of pati...

journal_title：Blood

authors： Rieux-Laucat F,Blachère S,Danielan S,De Villartay JP,Oleastro M,Solary E,Bader-Meunier B,Arkwright P,Pondaré C,Bernaudin F,Chapel H,Nielsen S,Berrah M,Fischer A,Le Deist F

更新日期：1999-10-15 00:00:00

abstract：:Previous analyses of the roles of alpha4 integrins in hematopoiesis by other groups have led to conflicting evidence. alpha4 integrin mutant cells developing in [alpha4 integrin(-/-): wt] chimeric mice are not capable of completing lymphomyeloid differentiation, whereas conditional inactivation of alpha4 integrin in a...

journal_title：Blood

authors： Gribi R,Hook L,Ure J,Medvinsky A

更新日期：2006-07-15 00:00:00

abstract：:Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to contribute to the broad population variability observed for this trait. B...

journal_title：Blood

authors： Viel KR,Machiah DK,Warren DM,Khachidze M,Buil A,Fernstrom K,Souto JC,Peralta JM,Smith T,Blangero J,Porter S,Warren ST,Fontcuberta J,Soria JM,Flanders WD,Almasy L,Howard TE

更新日期：2007-05-01 00:00:00

abstract：:GATA family proteins play essential roles in development of many cell types, including hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3, are essential for normal hematopoiesis, and their mutations are responsible for a variety of blood disorders. Acquired and inherited GATA1 ...

journal_title：Blood

authors： Crispino JD,Horwitz MS

更新日期：2017-04-13 00:00:00

abstract：:C3H mice have higher average ploidy megakaryocytes than all other mouse strains tested, but the mode of inheritance of this anomaly is unknown. Therefore, to clarify the genetics of high ploidy megakaryocytes in C3H mice, we measured megakaryocyte DNA content from both male and female offspring from F1, as well as bac...

journal_title：Blood

authors： McDonald TP,Jackson CW

更新日期：1994-03-15 00:00:00

abstract：:Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors (TLRs), suggesting that bacterial/viral products may influence blood cell formation. We now show that common lymphoid progenitors (CLPs) from mice with active HSV-1 infection are biased to dendritic cell (DC) differentiation, ...

journal_title：Blood

authors： Welner RS,Pelayo R,Nagai Y,Garrett KP,Wuest TR,Carr DJ,Borghesi LA,Farrar MA,Kincade PW

更新日期：2008-11-01 00:00:00

abstract：:Gimap4, a member of the newly identified GTPase of the immunity-associated protein family (Gimap), is strongly induced by the pre-T-cell receptor in precursor T lymphocytes, transiently shut off in double-positive thymocytes, and reappears after TCR-mediated positive selection. Here, we show that Gimap4 remains expres...

journal_title：Blood

authors： Schnell S,Démollière C,van den Berk P,Jacobs H

更新日期：2006-07-15 00:00:00

abstract：:Allogeneic stem cell transplantation (SCT) is now a commonplace procedure. Clinicians who care for patients with hematologic malignancies and aplastic anemia are almost certain to follow up patients after SCT. This review is intended to help clinicians observe patients for probably the most important late complication...

journal_title：Blood

authors： Vogelsang GB

更新日期：2001-03-01 00:00:00

abstract：:The glutathione S-transferase (GST) genes are involved in the metabolism of environmental carcinogens and of some classes of chemotherapy drugs. GSTM1 and GSTT1 genotypes are polymorphic in humans, and the phenotypic absence of enzyme activity is caused by a homozygous inherited deletion of the gene. Previous, smaller...

journal_title：Blood

authors： Davies SM,Bhatia S,Ross JA,Kiffmeyer WR,Gaynon PS,Radloff GA,Robison LL,Perentesis JP

更新日期：2002-07-01 00:00:00

abstract：:The present studies were undertaken to determine whether factor VIII/von Willebrand factor (vWF) present in the vessel wall (in addition to that in plasma) may mediate the attachment of platelets to subendothelium. Subendothelium from everted rabbit aorta was exposed to human citrated blood flowing through an annular ...

journal_title：Blood

authors： Turitto VT,Weiss HJ,Zimmerman TS,Sussman II

更新日期：1985-04-01 00:00:00

abstract：:Mutations that produce glucose-6-phosphate dehydrogenase (G6PD) deficiency have been identified in samples from patients with hemolytic disease in the United States, and in G6PD-deficient samples from Greece, the Canary Islands, the Czech and Slovak Republics, South China, and in samples from the Coriell Cell Reposito...

journal_title：Blood

authors： Xu W,Westwood B,Bartsocas CS,Malcorra-Azpiazu JJ,Indrák K,Beutler E

更新日期：1995-01-01 00:00:00

abstract：:Commercial porcine factor VIII concentrate (Hyate:C) is effective in treatment of patients with hemophilia A who have circulating antibodies to factor VIII. The molecular forms of factor VIII in the concentrate were identified and evaluated in light of the known properties of porcine and human factor VIII. The factor ...

journal_title：Blood

authors： Lollar P,Parker CG,Tracy RP

更新日期：1988-01-01 00:00:00

abstract：:Clinical and cytogenetic findings in 10 patients with deletions of the long arm of chromosomes 5 (5q-) are reported. Five cases had refractory anemia, the preleukemic syndrome, or refractory anemia with an excess of blasts; in all but one, the 5q- was the single initial abnormality. Three patients had overt leukemia; ...

journal_title：Blood

authors： Swolin B,Weinfeld A,Ridell B,Waldenström J,Westin J

更新日期：1981-11-01 00:00:00

abstract：:Chronic infection with Schistosoma mansoni induces in humans and mice a Th2-dominant immune response in which eosinophils and IgE are conspicuously elevated. Human eosinophils express IgE receptors that participate in an IgE-dependent eosinophil-mediated ADCC reaction against Schistosomula larvae in vitro. To investig...

journal_title：Blood

authors： de Andres B,Rakasz E,Hagen M,McCormik ML,Mueller AL,Elliot D,Metwali A,Sandor M,Britigan BE,Weinstock JV,Lynch RG

更新日期：1997-05-15 00:00:00

abstract：:The TEL-JAK2 gene fusion, which has been identified in human leukemia, encodes a chimeric protein endowed with constitutive tyrosine kinase activity. TEL-JAK2 transgenic expression in the mouse lymphoid lineage results in fatal and rapid T-cell leukemia/lymphoma. In the present report we show that T-cell leukemic cell...

journal_title：Blood

authors： dos Santos NR,Rickman DS,de Reynies A,Cormier F,Williame M,Blanchard C,Stern MH,Ghysdael J

更新日期：2007-05-01 00:00:00

abstract：:Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[+]) ALCLs, 25 ALK-negative (ALK[-]) ALCLs, 9 angioimmunoblastic T-cell lymp...

journal_title：Blood

authors： Liu C,Iqbal J,Teruya-Feldstein J,Shen Y,Dabrowska MJ,Dybkaer K,Lim MS,Piva R,Barreca A,Pellegrino E,Spaccarotella E,Lachel CM,Kucuk C,Jiang CS,Hu X,Bhagavathi S,Greiner TC,Weisenburger DD,Aoun P,Perkins SL,McKeith

更新日期：2013-09-19 00:00:00

abstract：:X-linked lymphoproliferative disease (XLP1), described in the mid-1970s and molecularly defined in 1998, and XLP2, reported in 2006, are prematurely lethal genetic immunodeficiencies that share susceptibility to overwhelming inflammatory responses to certain infectious triggers. Signaling lymphocytic activation molecu...

journal_title：Blood

authors： Filipovich AH,Zhang K,Snow AL,Marsh RA

更新日期：2010-11-04 00:00:00