Use of prothrombin complex concentrates in the treatment of a hemophilic patient with an inhibitor of factor VIII.

abstract：:Dendritic cells (DC) are highly efficient antigen-presenting cells (APC) that have an essential function in the development of immune responses against microbial pathogens and tumors. Although during the past few years our understanding of DC biology has remarkably increased, a precise characterization of the differen...

journal_title：Blood

authors： Anjuère F,Martín P,Ferrero I,Fraga ML,del Hoyo GM,Wright N,Ardavín C

更新日期：1999-01-15 00:00:00

abstract：:During the early period following bone marrow transplantation before the immune system has reached full functional maturity, unprimed, nonspecific lytic systems may play a critical role as antiviral or antitumor effectors. The reconstitution of cells with this potential is of particular importance in recipients of bon...

journal_title：Blood

authors： Keever CA,Welte K,Small T,Levick J,Sullivan M,Hauch M,Evans RL,O'Reilly RJ

更新日期：1987-12-01 00:00:00

abstract：:Severe deficiency of ADAMTS13, a plasma metalloprotease, leads to thrombotic thrombocytopenic purpura. ADAMTS13 contains 10 putative N-glycosylation sites in or near its metalloprotease sequence, spacer region, thrombospondin type 1 repeat no. 4 (TSR no. 4), and CUB domains. Tunicamycin treatment markedly decreased th...

journal_title：Blood

authors： Zhou W,Tsai HM

更新日期：2009-01-22 00:00:00

abstract：:The bcl-2 gene is translocated into the Ig loci in about 80% of human follicular lymphomas and in 10% of B-type chronic lymphocytic leukemias (B-CLL), resulting in a high level of expression. We have compared the expression of bcl-2 transcripts and protein in B-CLL cells in their normal equivalent CD5+ B cells and in ...

journal_title：Blood

authors： Schena M,Larsson LG,Gottardi D,Gaidano G,Carlsson M,Nilsson K,Caligaris-Cappio F

更新日期：1992-06-01 00:00:00

abstract：:Loss-of-function mutation in the heme oxygenase 1 (Hmox1) gene causes a rare and lethal disease in children, characterized by severe anemia and intravascular hemolysis, with damage to endothelia and kidneys. Previously, we found that macrophages engaged in recycling of red cells were depleted from the tissues of Hmox1...

journal_title：Blood

authors： Kovtunovych G,Ghosh MC,Ollivierre W,Weitzel RP,Eckhaus MA,Tisdale JF,Yachie A,Rouault TA

更新日期：2014-08-28 00:00:00

abstract：:The Philadelphia (Ph1) chromosome is present in greater than 90% of patients with chronic myelogenous leukemia (CML) and in 2% to 20% of those with acute leukemias, for which it is an important prognostic marker too. The chimeric BCR-ABL mRNAs resulting from the translocation encode either a 210-Kd or a 190-Kd protein...

journal_title：Blood

authors： Dhingra K,Talpaz M,Riggs MG,Eastman PS,Zipf T,Ku S,Kurzrock R

更新日期：1991-01-15 00:00:00

abstract：:Tryptases are serine proteases primarily expressed in mast cells. Normal blood basophils express only trace amounts of the enzyme. However, recent immunohistochemical studies have raised the possibility that neoplastic basophils express significant amounts of tryptase. In this study, tryptase expression was analyzed i...

journal_title：Blood

authors： Samorapoompichit P,Kiener HP,Schernthaner GH,Jordan JH,Agis H,Wimazal F,Baghestanian M,Rezaie-Majd A,Sperr WR,Lechner K,Valent P

更新日期：2001-10-15 00:00:00

abstract：:T-cell homing to secondary lymphoid tissues generally depends on chemokine-induced firm adhesion in high endothelial venules (HEVs) and is primarily mediated through the CC chemokine receptor 7 (CCR7) on lymphocytes. The CCR7 ligand designated CCL21 is considered the most important trigger because it appears constitut...

journal_title：Blood

authors： Carlsen HS,Haraldsen G,Brandtzaeg P,Baekkevold ES

更新日期：2005-07-15 00:00:00

abstract：:In a series of 153 children with T-cell malignancies enrolled in 2 consecutive European Organization for Research and Treatment of Cancer (EORTC) trials, we assessed the HOX11L2 expression and/or the presence of a t(5;14)(q35;q32). Additionally, in 138 of these patients, HOX11 expression and SIL-TAL rearrangement were...

journal_title：Blood

authors： Cavé H,Suciu S,Preudhomme C,Poppe B,Robert A,Uyttebroeck A,Malet M,Boutard P,Benoit Y,Mauvieux L,Lutz P,Méchinaud F,Grardel N,Mazingue F,Dupont M,Margueritte G,Pages MP,Bertrand Y,Plouvier E,Brunie G,Bastard C,P

更新日期：2004-01-15 00:00:00

abstract：:Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)-driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This ma...

journal_title：Blood

authors： Xu W,Roos A,Schlagwein N,Woltman AM,Daha MR,van Kooten C

更新日期：2006-06-15 00:00:00

abstract：:Functional studies on native human dendritic cells (DCs) are hampered by technical difficulties in preparing fresh DCs. Recently, with the help of the monoclonal antibody M-DC8, we succeeded in isolating a major subpopulation of human blood DCs by a one-step immunomagnetic separation procedure. These cells strongly ex...

journal_title：Blood

authors： Schmitz M,Zhao S,Schäkel K,Bornhäuser M,Ockert D,Rieber EP

更新日期：2002-08-15 00:00:00

abstract：:Essential thrombocythemia (ET) is characterized by abnormal megakaryopoiesis and enhanced thrombotic risk. Once-daily low-dose aspirin is the recommended antithrombotic regimen, but accelerated platelet generation may reduce the duration of platelet cyclooxygenase-1 (COX-1) inhibition. We performed a multicenter doubl...

journal_title：Blood

authors： Rocca B,Tosetto A,Betti S,Soldati D,Petrucci G,Rossi E,Timillero A,Cavalca V,Porro B,Iurlo A,Cattaneo D,Bucelli C,Dragani A,Di Ianni M,Ranalli P,Palandri F,Vianelli N,Beggiato E,Lanzarone G,Ruggeri M,Carli G,Ell

更新日期：2020-07-09 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplant (alloHSCT), underscoring the need to further elucidate its mechanisms and develop novel treatments. Based on recent observations that microRNA-155 (miR-155) is up-regulated during T-cell activation, we...

journal_title：Blood

authors： Ranganathan P,Heaphy CE,Costinean S,Stauffer N,Na C,Hamadani M,Santhanam R,Mao C,Taylor PA,Sandhu S,He G,Shana'ah A,Nuovo GJ,Lagana A,Cascione L,Obad S,Broom O,Kauppinen S,Byrd JC,Caligiuri M,Perrotti D,Hadley G

更新日期：2012-05-17 00:00:00

abstract：:The tal-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor required for primitive and definitive hematopoiesis. Additionally, ectopic activation of the tal-1 gene during T lymphopoiesis occurs in numerous cases of human T-cell acute lymphoblastic leukemia. With the use of transgenic mice, we show that...

journal_title：Blood

authors： Goardon N,Schuh A,Hajar I,Ma X,Jouault H,Dzierzak E,Roméo PH,Maouche-Chrétien L

更新日期：2002-07-15 00:00:00

abstract：:In sickle cell (SS) vaso-occlusion, the culminating event is blockage of blood vessels by sickled red blood cells (SS RBCs). As shown in animal models, SS RBC-induced vaso-occlusion is often partial, allowing for a residual flow, hence oxygen delivery to partially occluded vessels could reduce vaso-occlusion. The effi...

journal_title：Blood

authors： Kaul DK,Liu X,Nagel RL

更新日期：2001-11-15 00:00:00

abstract：:In most cases, the lack of Rh in Rh(null) red cells is associated with RHAG gene mutations. We explored the role of RhAG in the surface expression of Rh. Nonerythroid HEK293 cells, which lack Rh and RhAG, or erythroid K562 cells, which endogenously express RhAG but not Rh, were transfected with RhD and/or RhAG cDNAs u...

journal_title：Blood

authors： Mouro-Chanteloup I,D'Ambrosio AM,Gane P,Le Van Kim C,Raynal V,Dhermy D,Cartron JP,Colin Y

更新日期：2002-08-01 00:00:00

abstract：:We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1 (HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 pr...

journal_title：Blood

authors： Gibbons J,Cory JM,Hewlett IK,Epstein JS,Eyster ME

更新日期：1990-11-15 00:00:00

abstract：:To ascertain the genetic basis of a paroxysmal nocturnal hemoglobinuria (PNH) case without somatic mutations in PIGA, we performed deep next-generation sequencing on all exons of known genes of the glycosylphosphatidylinositol (GPI) anchor synthesis pathway. We identified a heterozygous germline splice site mutation i...

journal_title：Blood

authors： Krawitz PM,Höchsmann B,Murakami Y,Teubner B,Krüger U,Klopocki E,Neitzel H,Hoellein A,Schneider C,Parkhomchuk D,Hecht J,Robinson PN,Mundlos S,Kinoshita T,Schrezenmeier H

更新日期：2013-08-15 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that stimulates the proliferation, maturation, and functional activity of myeloid cells in peripheral blood and bone marrow. Expression of GM-CSF is tightly regulated and is limited to cells stimulated directly (T cells, macroph...

journal_title：Blood

authors： Fraser JK,Tran S,Nimer SD,Gasson JC

更新日期：1994-10-15 00:00:00

abstract：:Contraction of blood clots is necessary for hemostasis and wound healing and to restore flow past obstructive thrombi, but little is known about the structure of contracted clots or the role of erythrocytes in contraction. We found that contracted blood clots develop a remarkable structure, with a meshwork of fibrin a...

journal_title：Blood

authors： Cines DB,Lebedeva T,Nagaswami C,Hayes V,Massefski W,Litvinov RI,Rauova L,Lowery TJ,Weisel JW

更新日期：2014-03-06 00:00:00

abstract：:We describe in vitro studies and a therapeutic trial of retinoic acid (RA) in a patient with acute promyelocytic leukemia (APL) refractory to chemotherapy. Bone marrow promyelocytes from the patient, prior to RA, matured morphologically in liquid culture with RA (97% maturing myeloid cells compared with 26% in control...

journal_title：Blood

authors： Flynn PJ,Miller WJ,Weisdorf DJ,Arthur DC,Brunning R,Branda RF

更新日期：1983-12-01 00:00:00

abstract：:Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, muri...

journal_title：Blood

authors： Sgadari C,Farber JM,Angiolillo AL,Liao F,Teruya-Feldstein J,Burd PR,Yao L,Gupta G,Kanegane C,Tosato G

更新日期：1997-04-15 00:00:00

abstract：:Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of VCAN proteolysis re...

journal_title：Blood

authors： Hope C,Foulcer S,Jagodinsky J,Chen SX,Jensen JL,Patel S,Leith C,Maroulakou I,Callander N,Miyamoto S,Hematti P,Apte SS,Asimakopoulos F

更新日期：2016-08-04 00:00:00

abstract：:A number of studies have recently demonstrated that super-enhancers, which are large cluster of enhancers typically marked by a high level of acetylation of histone H3 lysine 27 and mediator bindings, are frequently associated with genes that control and define cell identity during normal development. Super-enhancers ...

journal_title：Blood

authors： Wong RWJ,Ngoc PCT,Leong WZ,Yam AWY,Zhang T,Asamitsu K,Iida S,Okamoto T,Ueda R,Gray NS,Ishida T,Sanda T

更新日期：2017-11-23 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency with microthrombocytopenia, eczema, recurrent infections, autoimmune disorders, and malignancies that are life-threatening in the majority of patients. In this long-term, retrospective, multicenter study, we analyzed events that occurred in 96 WAS pati...

journal_title：Blood

authors： Ozsahin H,Cavazzana-Calvo M,Notarangelo LD,Schulz A,Thrasher AJ,Mazzolari E,Slatter MA,Le Deist F,Blanche S,Veys P,Fasth A,Bredius R,Sedlacek P,Wulffraat N,Ortega J,Heilmann C,O'Meara A,Wachowiak J,Kalwak K,Matthes-

更新日期：2008-01-01 00:00:00

abstract：:Administration of hematopoietic growth factors is being used increasingly to obtain populations of blood progenitor/stem cells (PBPC) for clinical transplantation. Here we examined the effect of combining stem cell factor (SCF ) and granulocyte colony-stimulating factor (G-CSF ) versus G-CSF alone in a randomized clin...

journal_title：Blood

authors： Begley CG,Basser R,Mansfield R,Thomson B,Parker WR,Layton J,To B,Cebon J,Sheridan WP,Fox RM,Green MD

更新日期：1997-11-01 00:00:00

abstract：:Signaling through the Notch pathway plays an essential role in inducing T-lineage commitment and promoting the maturation of immature thymocytes. Using an in vitro culture system, we show that 2 different classes of Notch ligands, Jagged1 or Delta1, transmit distinct signals to T-cell progenitors. OP9 stromal cells ex...

journal_title：Blood

authors： Lehar SM,Dooley J,Farr AG,Bevan MJ

更新日期：2005-02-15 00:00:00

abstract：:The non-Hodgkin's lymphoma (NHL) subset commonly referred to as large cell lymphoma (LCL) has historically been characterized by it's marked cytological, immunological, and clinical heterogeneity. One potential defining feature of these lymphomas, the t(2;5)(p23;q35), occurs in 25% to 30% of anaplastic LCLs and is als...

journal_title：Blood

authors： Mathew P,Sanger WG,Weisenburger DD,Valentine M,Valentine V,Pickering D,Higgins C,Hess M,Cui X,Srivastava DK,Morris SW

更新日期：1997-03-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), members of the transforming growth factor (TGF)-beta superfamily, are a group of related proteins that are capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines. We show in this report a novel function of BMPs in hematopoietic cell...

journal_title：Blood

authors： Kawamura C,Kizaki M,Yamato K,Uchida H,Fukuchi Y,Hattori Y,Koseki T,Nishihara T,Ikeda Y

更新日期：2000-09-15 00:00:00

abstract：:The unique t(15;17) of acute promyelocytic leukemia (APL) fuses the PML gene with the retinoic acid receptor alpha (RAR alpha) gene. Although retinoic acid (RA) inhibits cell growth and induces differentiation in human APL cells, resistance to RA develops both in vitro and in patients. We have developed RA-resistant s...

journal_title：Blood

authors： Shao W,Benedetti L,Lamph WW,Nervi C,Miller WH Jr

更新日期：1997-06-15 00:00:00