Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules.

abstract：:A patient with severe anemia, reticulocytopenia, and erythroid hyperplasia of the bone marrow developed fatal acute nonlymphocytic leukemia after 3 yr. A Philadelphia chromosome with the typical 9/22 translocation t(9q +;22q-) was identified by banding techniques in a small number of bone marrow cells throughout the p...

journal_title：Blood

authors： Roth DG,Richman CM,Rowley JD

更新日期：1980-08-01 00:00:00

abstract：:Follicular lymphoma (FL) grades 1 and 2 are regarded as a distinct disease entity, whereas data suggest that FL grade 3 might be an inhomogeneous tumor category. To define the biologic spectrum of FL, 89 follicular lymphomas were studied for their cytologic composition, antigen expression, mitotic and proliferation in...

journal_title：Blood

authors： Ott G,Katzenberger T,Lohr A,Kindelberger S,Rüdiger T,Wilhelm M,Kalla J,Rosenwald A,Müller JG,Ott MM,Müller-Hermelink HK

更新日期：2002-05-15 00:00:00

abstract：:Tissue-derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an important negative regulator of T-cell function. In this report, we demonstrate that A(2A)R stimulation not only inhibits the generation of adaptive effector T cells but also promotes the induction of adaptive regulatory T ce...

journal_title：Blood

authors： Zarek PE,Huang CT,Lutz ER,Kowalski J,Horton MR,Linden J,Drake CG,Powell JD

更新日期：2008-01-01 00:00:00

abstract：:Oncogenic EZH2 is overexpressed and extensively involved in the pathophysiology of different cancers including extranodal natural killer/T-cell lymphoma (NKTL). However, the mechanisms regarding EZH2 upregulation is poorly understood, and it still remains untargetable in NKTL. In this study, we examine EZH2 protein tu...

journal_title：Blood

authors： Li B,Yan J,Phyu T,Fan S,Chung TH,Mustafa N,Lin B,Wang L,Eichhorn PJA,Goh BC,Ng SB,Kappei D,Chng WJ

更新日期：2019-12-05 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation system, synthesized in endothelial cells, which has recently been shown to play an important role in the regulation of activated coagulation factors at the endothelial cell surface. In the present study we investigated t...

journal_title：Blood

authors： Hansen JB,Olsen R,Webster P

更新日期：1997-11-01 00:00:00

abstract：:The cell-surface receptor c-kit and its cognate ligand stem-cell factor (SCF) or steel factor (SLF) are important for the maintenance of hematopoiesis both in vitro and in vivo. Transforming growth factor-beta (TGF-beta) has been shown to be a potent inhibitor of SLF-mediated synergistic growth of murine Lin-Sca-1+ pr...

journal_title：Blood

authors： Dubois CM,Ruscetti FW,Stankova J,Keller JR

更新日期：1994-06-01 00:00:00

abstract：:Interleukin-3 (IL-3) is a hematopoietic growth factor that regulates the differentiation of multilineage and committed progenitor cells and the functions of some mature blood cells. The expression of human IL-3 appears to be restricted to stimulated T lymphocytes. We have investigated the kinetics and mechanisms invol...

journal_title：Blood

authors： Ryan GR,Milton SE,Lopez AF,Bardy PG,Vadas MA,Shannon MF

更新日期：1991-03-15 00:00:00

abstract：:In patients with chronic lymphocytic leukemia (CLL), lenalidomide can promote humoral immune responses but also induces a distinct disease-specific toxicity of tumor flare and cytokine release. These CLL-specific events result from increased expression of costimulatory molecules on B cells. Here we demonstrate that le...

journal_title：Blood

authors： Herman SE,Lapalombella R,Gordon AL,Ramanunni A,Blum KA,Jones J,Zhang X,Lannutti BJ,Puri KD,Muthusamy N,Byrd JC,Johnson AJ

更新日期：2011-04-21 00:00:00

abstract：:Evidence supporting the efficacy of in utero hematopoietic cell transplantation (IUHCT) in a valid large animal model is needed prior to clinical application. The objective of this study was to establish clinically relevant levels of hematopoietic chimerism in a canine model of maternal-to-fetal IUHCT. We first assess...

journal_title：Blood

authors： Vrecenak JD,Pearson EG,Santore MT,Todorow CA,Li H,Radu A,Bhatti T,Peranteau WH,Johnson MP,Flake AW

更新日期：2014-09-18 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has a specific genetic rearrangement between the retinoic acid receptor (RAR)-alpha gene and the pml nuclear protein gene. All-trans retinoic acid (ATRA) induces granulocytic differentiation of APL-derived cells and is used to treat APL patients. However, ATRA interacts with normal c...

journal_title：Blood

authors： Makishima M,Umesono K,Shudo K,Naoe T,Kishi K,Honma Y

更新日期：1998-06-15 00:00:00

abstract：:Microparticles (MPs) are submicron extracellular vesicles exposing phosphatidylserine (PS), detected at high concentration in the circulation of sickle cell anemia (SS) patients. Several groups studied the biological effects of MPs generated ex vivo. Here, we analyzed for the first time the impact of circulating MPs o...

journal_title：Blood

authors： Garnier Y,Ferdinand S,Garnier M,Cita KC,Hierso R,Claes A,Connes P,Hardy-Dessources MD,Lapouméroulie C,Lemonne N,Etienne-Julan M,El Nemer W,Romana M

更新日期：2020-07-09 00:00:00

abstract：:In this issue of Blood, Navarrete et al report that upfront immunization of follicular B-cell lymphoma patients with bacterially produced Fab fragments induces immune responses; however, the influence on patient outcome is not yet known. ...

journal_title：Blood

authors： Bogen B

更新日期：2011-02-03 00:00:00

abstract：:Previous studies have suggested that, in patients with AL amyloidosis treated with high-dose melphalan and autologous stem-cell transplantation (HDM/SCT), the greatest benefit is seen in those patients achieving a hematologic complete response (CR). We analyzed a series of 421 consecutive patients treated with HDM/SCT...

journal_title：Blood

authors： Cibeira MT,Sanchorawala V,Seldin DC,Quillen K,Berk JL,Dember LM,Segal A,Ruberg F,Meier-Ewert H,Andrea NT,Sloan JM,Finn KT,Doros G,Blade J,Skinner M

更新日期：2011-10-20 00:00:00

abstract：:Although allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for patients with Fanconi anemia (FA), published series mostly refer to single-center experience with limited numbers of patients. We analyzed results in 795 patients with FA who underwent first HSCT between May 1972...

journal_title：Blood

authors： Peffault de Latour R,Porcher R,Dalle JH,Aljurf M,Korthof ET,Svahn J,Willemze R,Barrenetxea C,Mialou V,Soulier J,Ayas M,Oneto R,Bacigalupo A,Marsh JC,Peters C,Socie G,Dufour C,FA Committee of the Severe Aplastic Anemia W

更新日期：2013-12-19 00:00:00

abstract：:As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. In the present study, we report that NSC606985, a rarely studied camptothecin analog, induces apoptosis in acute myeloid leukemia (AML) cells NB4 and U937 and inhib...

journal_title：Blood

authors： Song MG,Gao SM,Du KM,Xu M,Yu Y,Zhou YH,Wang Q,Chen Z,Zhu YS,Chen GQ

更新日期：2005-05-01 00:00:00

abstract：:Allogeneic stem cell transplantation with umbilical cord blood (UCB) cells is limited by the cell dose a single unit provides recipients. Ex vivo expansion is one strategy to increase the number of cells available for transplantation. Aastrom Biosciences developed an automated continuous perfusion culture device for e...

journal_title：Blood

authors： Jaroscak J,Goltry K,Smith A,Waters-Pick B,Martin PL,Driscoll TA,Howrey R,Chao N,Douville J,Burhop S,Fu P,Kurtzberg J

更新日期：2003-06-15 00:00:00

abstract：:A 2-yr-old black girl presented with a thalassemic clinical picture and was found to have nearly 100% fetal hemoglobin in her red cells. Pedigree analysis indicated that she was a heterozygote for the hereditary persistence of fetal hemoglobin gene and for a beta O-thalassemia gene. A brother, who also had nearly 100%...

journal_title：Blood

authors： Beutler E,Turner E,Kuhl W

更新日期：1981-06-01 00:00:00

abstract：:In France, more than 80% of children with Burkitt's lymphoma or Burkitt's leukemia (ALL3) are now cured with the LMB (B-cell non-Hodgkin's lymphoma and B-ALL) protocols of the Société Française d'Oncologie Pédiatrique, but so far, poor results have been obtained in the few adult studies available. We have analyzed the...

journal_title：Blood

authors： Soussain C,Patte C,Ostronoff M,Delmer A,Rigal-Huguet F,Cambier N,Leprisé PY,François S,Cony-Makhoul P,Harousseau JL

更新日期：1995-02-01 00:00:00

abstract：:Blood cells of an adult vertebrate are continuously generated by hematopoietic stem cells (HSCs) that originate during embryonic life within the aorta-gonad-mesonephros region. There is now compelling in vivo evidence that HSCs are generated from aortic endothelial cells and that this process is critically regulated b...

journal_title：Blood

authors： Lam EY,Hall CJ,Crosier PS,Crosier KE,Flores MV

更新日期：2010-08-12 00:00:00

abstract：:The costimulatory effects of CD27 on T lymphocyte effector function and memory formation has been confined to evaluations in mouse models, in vitro human cell culture systems, and clinical observations. Here, we tested whether CD27 costimulation actively enhances human T-cell function, expansion, and survival in vitro...

journal_title：Blood

authors： Song DG,Ye Q,Poussin M,Harms GM,Figini M,Powell DJ Jr

更新日期：2012-01-19 00:00:00

abstract：:The subcellular localization of the platelet membrane receptors glycoproteins (GP) Ib and IIb/IIIa [corrected] has been studied within resting platelets by a combination of biochemical and cytochemical techniques. While both GPIb and GPIIb/IIIa are localized within the plasma membrane and surface-connected canalicular...

journal_title：Blood

authors： Cramer EM,Lu H,Caen JP,Soria C,Berndt MC,Tenza D

更新日期：1991-02-15 00:00:00

abstract：:The VLA-4 integrin (CD49d/CD29), initially discovered on lymphoid cells, is actually known to be highly expressed on T cells, B cells, monocytes, and derived cell lines. Unlike other VLA integrins, mainly involved in cell-matrix adhesive interactions, VLA-4 has also been implicated in several cellular interactions. Ba...

journal_title：Blood

authors： Zhang ZH,Vekemans S,Aly MS,Jaspers M,Marynen P,Cassiman JJ

更新日期：1991-11-01 00:00:00

abstract：:Loss or mutation of the TP53 tumor suppressor gene is not commonly observed in acute myeloid leukemia (AML), suggesting that there is an alternate route for cell transformation. We investigated the hypothesis that previously observed Bcl-2 family member overexpression suppresses wild-type p53 activity in AML. We demon...

journal_title：Blood

authors： Irish JM,Anensen N,Hovland R,Skavland J,Børresen-Dale AL,Bruserud O,Nolan GP,Gjertsen BT

更新日期：2007-03-15 00:00:00

abstract：:We have used (cryo) electron tomography to provide a 3-dimensional (3D) map of the intracellular membrane organization of human platelets at high spatial resolution. Our study shows that the open canalicular system and dense tubular system are highly intertwined and form close associations in specialized membrane regi...

journal_title：Blood

authors： van Nispen tot Pannerden H,de Haas F,Geerts W,Posthuma G,van Dijk S,Heijnen HF

更新日期：2010-08-19 00:00:00

abstract：:The translocation between chromosomes 8 and 21, t(8;21) (q22;q22), is the most frequent abnormality in acute myeloid leukemia (AML) with French-American-British type M2 (FAB-M2) morphology. The breakpoints in this translocation have been characterized at the molecular level, and the genes involved are AML1 on chromoso...

journal_title：Blood

authors： Nucifora G,Larson RA,Rowley JD

更新日期：1993-08-01 00:00:00

abstract：:The monoclonal antibodies Tab and AP3 are directed, respectively, against GPIIb and GPIIIa, the subunits of the platelet fibrinogen receptor. When added together to platelets, these antibodies prevent adenosine diphosphate (ADP)-induced platelet aggregation, despite normal fibrinogen binding (Newman et al, Blood 69:66...

journal_title：Blood

authors： Isenberg WM,Bainton DF,Newman PJ

更新日期：1990-10-15 00:00:00

abstract：:The Ca(2+)-activated K+ channels of human red blood cells (RBCs) (Gardos channels, hIK1, hSK4) can mediate rapid cell dehydration, of particular relevance to the pathophysiology of sickle cell disease. Previous investigations gave widely discrepant estimates of the number of Gardos channels per RBC, from as few as 1 t...

journal_title：Blood

authors： Lew VL,Tiffert T,Etzion Z,Perdomo D,Daw N,Macdonald L,Bookchin RM

更新日期：2005-01-01 00:00:00

abstract：:NF-kappaB is a transcription factor that controls the expression of a number of genes important for mediating immune and inflammatory responses. In this study, we examined whether bortezomib and PS-1145, each of which inhibits NF-kappaB, could protect mice from lethal graft-versus-host disease (GVHD), which is charact...

journal_title：Blood

authors： Vodanovic-Jankovic S,Hari P,Jacobs P,Komorowski R,Drobyski WR

更新日期：2006-01-15 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) lymphocytes manifest anomalous motility and cap formation. Since these processes involve cytoskeletal proteins, vimentin from intermediate filaments of normal and CLL lymphocytes was investigated using hetero- and monoclonal antisera. The antisera reacted predominantly with a 60-kD p...

journal_title：Blood

authors： Stark RS,Liebes LF,Shelanski ML,Silber R

更新日期：1984-02-01 00:00:00

abstract：:We compared 48-hour urinary iron excretion after a twice-daily subcutaneous bolus injection of deferoxamine and after 12 hours of subcutaneous continuous infusion of the drug in 27 patients with iron overload (mean age, 55.7 years). In most patients, the iron overload was due to multiple transfusions administered duri...

journal_title：Blood

authors： Franchini M,Gandini G,de Gironcoli M,Vassanelli A,Borgna-Pignatti C,Aprili G

更新日期：2000-05-01 00:00:00