Abstract:
:In a series of 153 children with T-cell malignancies enrolled in 2 consecutive European Organization for Research and Treatment of Cancer (EORTC) trials, we assessed the HOX11L2 expression and/or the presence of a t(5;14)(q35;q32). Additionally, in 138 of these patients, HOX11 expression and SIL-TAL rearrangement were also assessed. These alterations were mutually exclusive, and their frequency was 23% (n = 35), 7% (n = 10), and 12% (n = 17), respectively. HOX11L2/t(5;14) positivity was more frequent in acute lymphoblastic leukemia (ALL) with cortical T immunophenotype and in children aged between 6 and 9 years. In contrast with previously reported data, patients positive and negative for HOX11L2/t(5;14) were comparable with regard to clinical outcome as well as to the response to a 7-day prephase treatment or to residual disease at completion of induction therapy. The 3-year event-free survival (EFS) rate (+/- SE percentage) for patients positive and negative for HOX11L2/t(5;14) was 75.5% (+/- 8.1%) and 68.3% (+/- 5.0%), respectively; the hazard ratio was 0.84 (95% confidence interval, 0.40-1.80). Patients with HOX11-high expression and those with SIL-TAL fusion had low levels of residual disease at the end of induction and a favorable prognosis: the 3-year EFS rate was 83.3% (+/- 8.5%) and 75.3% (+/- 12.6%), respectively. The results obtained in HOX11L2/t(5;14) patients in this study do not confirm the unfavorable prognosis reported in previous studies.
journal_name
Bloodjournal_title
Bloodauthors
Cavé H,Suciu S,Preudhomme C,Poppe B,Robert A,Uyttebroeck A,Malet M,Boutard P,Benoit Y,Mauvieux L,Lutz P,Méchinaud F,Grardel N,Mazingue F,Dupont M,Margueritte G,Pages MP,Bertrand Y,Plouvier E,Brunie G,Bastard C,Pdoi
10.1182/blood-2003-05-1495subject
Has Abstractpub_date
2004-01-15 00:00:00pages
442-50issue
2eissn
0006-4971issn
1528-0020pii
2003-05-1495journal_volume
103pub_type
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