Mig, the monokine induced by interferon-gamma, promotes tumor necrosis in vivo.

abstract：:Hereditary hemochromatosis is caused by mutations in the hereditary hemochromatosis protein (HFE), transferrin-receptor 2 (TfR2), hemojuvelin, hepcidin, or ferroportin genes. Hepcidin is a key iron regulator, which is secreted by the liver, and decreases serum iron levels by causing the down-regulation of the iron tra...

journal_title：Blood

authors： Gao J,Chen J,De Domenico I,Koeller DM,Harding CO,Fleming RE,Koeberl DD,Enns CA

更新日期：2010-04-22 00:00:00

abstract：:Biopsies and cell lines of natural killer/T-cell lymphoma, nasal type (NKTCL) were subject to combined gene expression profiling and array-based comparative genomic hybridization analyses. Compared with peripheral T-cell lymphoma, not otherwise specified, NKTCL had greater transcript levels for NK-cell and cytotoxic m...

journal_title：Blood

authors： Huang Y,de Reyniès A,de Leval L,Ghazi B,Martin-Garcia N,Travert M,Bosq J,Brière J,Petit B,Thomas E,Coppo P,Marafioti T,Emile JF,Delfau-Larue MH,Schmitt C,Gaulard P

更新日期：2010-02-11 00:00:00

abstract：:Leukemic blasts from 774 children with newly diagnosed acute lymphocytic leukemia (ALL) have been phenotyped by microcytotoxicity testing with a panel of monoclonal antibodies and heteroantisera as part of a Pediatric Oncology Group classification study of acute leukemia. One hundred twenty-two cases, or 16% were desi...

journal_title：Blood

authors： Borowitz MJ,Dowell BL,Boyett JM,Falletta JM,Pullen DJ,Crist WM,Humphrey GB,Metzgar RS

更新日期：1985-04-01 00:00:00

abstract：:Epidemiologic studies have correlated elevated plasma fibrinogen (hyperfibrinogenemia) with risk of cardiovascular disease and arterial and venous thrombosis. However, it is unknown whether hyperfibrinogenemia is merely a biomarker of the proinflammatory disease state or is a causative mechanism in the etiology. We ra...

journal_title：Blood

authors： Machlus KR,Cardenas JC,Church FC,Wolberg AS

更新日期：2011-05-05 00:00:00

abstract：:CD43, a prevalent white blood cell molecule distinguished by its mucin-like surface region, has been proposed as a "functional barrier" that prevents or negatively regulates a variety of cell surface interactions. Implicit in this hypothesis is the expectation that CD43 will be altered or removed when white blood cell...

journal_title：Blood

authors： Remold-O'Donnell E,Parent D

更新日期：1995-01-15 00:00:00

abstract：:Classical 5q- syndrome is an acquired macrocytic anemia of the elderly. Similar to Diamond Blackfan anemia (DBA), an inherited red cell aplasia, the bone marrow is characterized by a paucity of erythroid precursors. RPS14 deletions in combination with other deletions in the region have been implicated as causative of ...

journal_title：Blood

authors： Vlachos A,Farrar JE,Atsidaftos E,Muir E,Narla A,Markello TC,Singh SA,Landowski M,Gazda HT,Blanc L,Liu JM,Ellis SR,Arceci RJ,Ebert BL,Bodine DM,Lipton JM

更新日期：2013-10-03 00:00:00

abstract：:Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected f...

journal_title：Blood

authors： Pui CH,Mullighan CG,Evans WE,Relling MV

更新日期：2012-08-09 00:00:00

abstract：:We have identified an intergenic transcriptional activity that is located between the human HOXA1 and HOXA2 genes, shows myeloid-specific expression, and is up-regulated during granulocytic differentiation. The novel gene, termed HOTAIRM1 (HOX antisense intergenic RNA myeloid 1), is transcribed antisense to the HOXA g...

journal_title：Blood

authors： Zhang X,Lian Z,Padden C,Gerstein MB,Rozowsky J,Snyder M,Gingeras TR,Kapranov P,Weissman SM,Newburger PE

更新日期：2009-03-12 00:00:00

abstract：:Chromosome 7 translocations, deletions, or monosomy are associated with myelodysplasia (MDS) and acute myeloid leukemia both in children and adults. These chromosomal anomalies represent one of the most common cytogenetic abnormalities associated with these diseases and usually herald a poor prognosis. In this study t...

journal_title：Blood

authors： Johnson EJ,Scherer SW,Osborne L,Tsui LC,Oscier D,Mould S,Cotter FE

更新日期：1996-05-01 00:00:00

abstract：:The introduction of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib has dramatically changed the management of chronic lymphocytic leukemia (CLL). Although responses have been durable in the majority of patients, relapses do occur, especially in the high-risk patient population. Most relapses occur as the result ...

journal_title：Blood

authors： Woyach JA

更新日期：2017-03-09 00:00:00

abstract：:Naive and memory CD8(+) T cells can undergo programmed activation and expansion in response to a short T-cell receptor stimulus, but the extent to which in vitro programming can qualitatively substitute for an in vivo antigen stimulation remains unknown. We show that self-/tumor-reactive effector memory CD8(+) T cells...

journal_title：Blood

authors： Klebanoff CA,Yu Z,Hwang LN,Palmer DC,Gattinoni L,Restifo NP

更新日期：2009-08-27 00:00:00

abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

journal_title：Blood

authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

更新日期：1997-02-15 00:00:00

abstract：:Time-lapse videotape recordings of polymorphonuclear leukocytes (PMNs) from clot preparations were used to quantify the locomotive behavior of individual PMNs from normal subjects. Tracings derived from the videotapes allow one to quantify multiple parameters of the locomotive behavior of PMNs--direction, distance, ra...

journal_title：Blood

authors： Howard TH

更新日期：1982-05-01 00:00:00

abstract：:We describe the membrane localization of a new platelet-specific alloantigen, designated Naka, that is involved in refractoriness to HLA-matched platelet transfusions. By indirect immunoprecipitation, anti-Naka antibody precipitated a single, radiolabeled platelet membrane protein with a molecular weight (mol wt) of 9...

journal_title：Blood

authors： Tomiyama Y,Take H,Ikeda H,Mitani T,Furubayashi T,Mizutani H,Yamamoto N,Tandon NN,Sekiguchi S,Jamieson GA

更新日期：1990-02-01 00:00:00

abstract：:The nonobese diabetic/severe combined immunodeficient (NOD/SCID) assay is the current model for assessment of human normal and leukemic stem cells. We explored why 51% of 59 acute myeloid leukemia (AML) patients were unable to initiate leukemia in NOD/SCID mice. Increasing the cell dose, using more permissive recipien...

journal_title：Blood

authors： Pearce DJ,Taussig D,Zibara K,Smith LL,Ridler CM,Preudhomme C,Young BD,Rohatiner AZ,Lister TA,Bonnet D

更新日期：2006-02-01 00:00:00

abstract：:The choice of either induction or postremission therapy for adults with acute myeloid leukemia is still largely based on the "one size fits all" principle. Moreover, pretreatment prognostic parameters, especially chromosome and gene abnormalities, may fail in predicting individual patient outcome. Measurement of minim...

journal_title：Blood

authors： Buccisano F,Maurillo L,Del Principe MI,Del Poeta G,Sconocchia G,Lo-Coco F,Arcese W,Amadori S,Venditti A

更新日期：2012-01-12 00:00:00

abstract：:Targeting mechanisms of neutrophil elastase (NE) and other luminal proteins stored in myeloperoxidase (MPO)-positive secretory lysosomes/primary granules of neutrophils are unknown. These granules contain an integral membrane protein, CD63, with an adaptor protein-3-dependent granule delivery system. Therefore, we hyp...

journal_title：Blood

authors： Källquist L,Hansson M,Persson AM,Janssen H,Calafat J,Tapper H,Olsson I

更新日期：2008-10-15 00:00:00

abstract：:ADAMTS13 metalloprotease cleaves von Willebrand factor (VWF), thereby inhibiting platelet aggregation and arterial thrombosis. An inability to cleave ultralarge VWF resulting from hereditary or acquired deficiency of plasma ADAMTS13 activity leads to a potentially fatal syndrome, thrombotic thrombocytopenic purpura (T...

journal_title：Blood

authors： Pickens B,Mao Y,Li D,Siegel DL,Poncz M,Cines DB,Zheng XL

更新日期：2015-05-21 00:00:00

abstract：:The activation of polymorphonuclear leukocytes (PMN) is an important step in the development of tissue damage associated with inflammatory and ischemic conditions. Catecholamines have been reported to inhibit PMN functions, but the high concentrations required cast doubt on their actual relevance as a defense mechanis...

journal_title：Blood

authors： Bazzoni G,Dejana E,Del Maschio A

更新日期：1991-05-01 00:00:00

abstract：:The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, a bicistronic retroviral vector encoding GATA-2 and the green fluorescent protein (GFP) was used to maintain the high levels of...

journal_title：Blood

authors： Persons DA,Allay JA,Allay ER,Ashmun RA,Orlic D,Jane SM,Cunningham JM,Nienhuis AW

更新日期：1999-01-15 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is typified by the t(15;17) translocation, which leads to the formation of the PML/RARA fusion gene and predicts a beneficial response to retinoids. However, approximately 10% of all APL cases lack the classic t(15;17). This group includes (1) cases with cryptic PML/RARA gene rearran...

journal_title：Blood

authors： Sainty D,Liso V,Cantù-Rajnoldi A,Head D,Mozziconacci MJ,Arnoulet C,Benattar L,Fenu S,Mancini M,Duchayne E,Mahon FX,Gutierrez N,Birg F,Biondi A,Grimwade D,Lafage-Pochitaloff M,Hagemeijer A,Flandrin G,Groupe Français d'

更新日期：2000-08-15 00:00:00

abstract：:Maintenance of myeloid cell homeostasis requires continuous turnover of phagocytes from the bloodstream, yet whether environmental signals influence phagocyte longevity in the absence of inflammation remains unknown. Here, we show that the gut microbiota regulates the steady-state cellular lifespan of neutrophils and ...

journal_title：Blood

authors： Hergott CB,Roche AM,Tamashiro E,Clarke TB,Bailey AG,Laughlin A,Bushman FD,Weiser JN

更新日期：2016-05-19 00:00:00

abstract：:Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm with variable clinical course. To predict the clinical outcome, we previously developed a CMML-specific prognostic scoring system (CPSS) based on clinical parameters and cytogenetics. In this work, we tested the hypothesis that acc...

journal_title：Blood

authors： Elena C,Gallì A,Such E,Meggendorfer M,Germing U,Rizzo E,Cervera J,Molteni E,Fasan A,Schuler E,Ambaglio I,Lopez-Pavia M,Zibellini S,Kuendgen A,Travaglino E,Sancho-Tello R,Catricalà S,Vicente AI,Haferlach T,Haferlach

更新日期：2016-09-08 00:00:00

abstract：:Clonal hematopoiesis (CH) in aplastic anemia (AA) has been closely linked to the evolution of late clonal disorders, including paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), which are common complications after successful immunosuppressive therapy (IST). With the ...

journal_title：Blood

authors： Ogawa S

更新日期：2016-07-21 00:00:00

abstract：:Many surface receptors and signaling molecules are thought to associate with unique membrane microdomains termed lipid rafts. We examined the involvement of lipid rafts in the activation of leukocyte function-associated antigen-1 (LFA-1). Depletion or sequestration of cholesterol with methyl-beta-cyclodextrin (MCD) or...

journal_title：Blood

authors： Marwali MR,Rey-Ladino J,Dreolini L,Shaw D,Takei F

更新日期：2003-07-01 00:00:00

abstract：:The incidence and role of p53 abnormalities have not been reported in splenic lymphoma with villous lymphocytes (SLVL), the leukemic counterpart of splenic marginal zone lymphoma. Because p53 abnormalities correlate with progressive and refractory disease in cancer and isochromosome 17q has been described in SLVL, a l...

journal_title：Blood

authors： Gruszka-Westwood AM,Hamoudi RA,Matutes E,Tuset E,Catovsky D

更新日期：2001-06-01 00:00:00

abstract：:Interactions between vascular endothelial cells and blood platelets have been investigated using a model microcirculation consisting of microcarrier beads colonized with human umbilical vein endothelial cells (HUVECs) and perfused with washed platelet suspensions. To simulate the effects of endothelial desquamation an...

journal_title：Blood

authors： Chesterman CN,Owe-Young R,Macpherson J,Krilis SA

更新日期：1986-06-01 00:00:00

abstract：:Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; man...

journal_title：Blood

authors： Brodsky RA,Sensenbrenner LL,Jones RJ

更新日期：1996-01-15 00:00:00

abstract：:In multiple myeloma (MM), both vascular endothelial (VEGF) and basic fibroblast growth factor (bFGF) promote tumor growth and survival. We have used the novel indolinone BIBF 1000 to study effects of simultaneous inhibition of VEGF, FGF and transforming growth factor-beta on MM cells and their interactions with bone m...

journal_title：Blood

authors： Bisping G,Kropff M,Wenning D,Dreyer B,Bessonov S,Hilberg F,Roth GJ,Munzert G,Stefanic M,Stelljes M,Scheffold C,Müller-Tidow C,Liebisch P,Lang N,Tchinda J,Serve HL,Mesters RM,Berdel WE,Kienast J

更新日期：2006-03-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cells are characterized by unlimited self-renewal and an impaired capacity to undergo terminal differentiation. The MUC1 oncoprotein is aberrantly expressed in AML cells; however, there has been no evidence for involvement of MUC1 in myeloid leukemogenesis. Cell-penetrating peptide inhibit...

journal_title：Blood

authors： Yin L,Wu Z,Avigan D,Rosenblatt J,Stone R,Kharbanda S,Kufe D

更新日期：2011-05-05 00:00:00