Abstract:
:We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1 (HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.
journal_name
Bloodjournal_title
Bloodauthors
Gibbons J,Cory JM,Hewlett IK,Epstein JS,Eyster MEsubject
Has Abstractpub_date
1990-11-15 00:00:00pages
1924-6issue
10eissn
0006-4971issn
1528-0020journal_volume
76pub_type
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