Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells.

abstract：:The main interface of the 2 subunits of platelet integrin alphaIIbbeta3 comprises the beta-propeller domain of alphaIIb and the betaA domain of beta3. In the center of the beta-propeller, several aromatic residues interact by cation-pi and hydrophobic bonds with Arg261 of betaA. In this study, we substituted alphaIIb-...

journal_title：Blood

authors： Hauschner H,Landau M,Seligsohn U,Rosenberg N

更新日期：2010-06-03 00:00:00

abstract：:We have used two in vitro models to identify genes whose expression may serve as markers of lineage commitment during the development of hematopoietic stem cells. One system involves the development in vitro of blastocyst-derived embryonic stem cells into embryoid bodies. The second involves culturing of day 3.5 blast...

journal_title：Blood

authors： McClanahan T,Dalrymple S,Barkett M,Lee F

更新日期：1993-06-01 00:00:00

abstract：:Current guidelines advocate to limit red blood cell (RBC) transfusion during surgery, but the feasibility and safety of such a strategy remain unclear, as the majority of evidence is based on postoperatively stable patients. We assessed the effects of a protocol aiming to restrict RBC transfusion throughout hospitaliz...

journal_title：Blood

authors： Møller A,Nielsen HB,Wetterslev J,Pedersen OB,Hellemann D,Winkel P,Marcussen KV,Ramsing BGU,Mortensen A,Jakobsen JC,Shahidi S

更新日期：2019-06-20 00:00:00

abstract：:Interleukin-2 (IL-2) induces differential secretion of lymphokines by IL-2 receptor (IL-2R)-positive and IL-2R-negative T cells. We studied T cell IL-2R-specific modulation of adult bone marrow erythropoiesis by recombinant IL-2 (rIL-2). I3-2R were induced by CD3 T cell surface determinant-triggering and analyzed by c...

journal_title：Blood

authors： Burdach SE,Levitt LJ

更新日期：1987-05-01 00:00:00

abstract：:Platelets play a crucial role in the physiology of primary hemostasis and pathophysiologic processes such as arterial thrombosis. Accumulating evidence suggests a role of reactive oxygen species (ROSs) in platelet activation. Here we show that platelets activated with different agonists produced intracellular ROSs, wh...

journal_title：Blood

authors： Begonja AJ,Gambaryan S,Geiger J,Aktas B,Pozgajova M,Nieswandt B,Walter U

更新日期：2005-10-15 00:00:00

abstract：:Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected f...

journal_title：Blood

authors： Pui CH,Mullighan CG,Evans WE,Relling MV

更新日期：2012-08-09 00:00:00

abstract：:Approximately 30% to 40% of patients with acute leukemia receiving repeated pooled random-donor platelet transfusions develop anti-HLA alloantibodies. Over time, however, serum anti-HLA concentrations decrease in approximately 50% of these patients, despite continued exposure to platelet and/or red blood cell transfus...

journal_title：Blood

authors： Atlas E,Freedman J,Blanchette V,Kazatchkine MD,Semple JW

更新日期：1993-01-15 00:00:00

abstract：:Identification of a novel therapy for prevention of sudden death by ischemic cardiac infarction is an area of intensive investigation. We here report that the mortality due to an experimental acute myocardial infarction (AMI) was markedly increased in mice deficient in alpha2-antiplasmin (alpha2-AP(-/-) mice) but not ...

journal_title：Blood

authors： Matsuno H,Kozawa O,Yoshimi N,Akamatsu S,Hara A,Mori H,Okada K,Ueshima S,Matsuo O,Uematsu T

更新日期：2002-10-01 00:00:00

abstract：:The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological end points of hemorrhage or thrombosis with vessel occlusion. However, fibrin(ogen) and proteases controlling its deposition and clearance, including (pro)thro...

journal_title：Blood

authors： Luyendyk JP,Schoenecker JG,Flick MJ

更新日期：2019-02-07 00:00:00

abstract：:Memory stem T cells (TSCM) have been proposed as key determinants of immunologic memory. However, their exact contribution to a mounting immune response, as well as the mechanisms and timing of their in vivo generation, are poorly understood. We longitudinally tracked TSCM dynamics in patients undergoing haploidentica...

journal_title：Blood

authors： Cieri N,Oliveira G,Greco R,Forcato M,Taccioli C,Cianciotti B,Valtolina V,Noviello M,Vago L,Bondanza A,Lunghi F,Marktel S,Bellio L,Bordignon C,Bicciato S,Peccatori J,Ciceri F,Bonini C

更新日期：2015-04-30 00:00:00

abstract：:In patients with hematologic malignancies, Di Bartolomeo et al report encouraging outcomes after transplantation of granulocyte-colony stimulating factor (G-CSF)– primed unmanipulated bone marrow from human leukocyte antigen (HLA)– haplotype mismatched (haploidentical) related donors, suggesting that this procedure ma...

journal_title：Blood

authors： Velardi A

更新日期：2013-01-31 00:00:00

abstract：:Interphase cytogenetics by means of in situ hybridization with the chromosome 12-specific biotinylated alpha satellite DNA probe pSP 12-1 was used for the study of trisomy 12, the most common chromosomal abnormality in chronic lymphocytic leukemia. In situ hybridization was performed on methanol/acetic acid fixed cell...

journal_title：Blood

authors： Losada AP,Wessman M,Tiainen M,Hopman AH,Willard HF,Solé F,Caballín MR,Woessner S,Knuutila S

更新日期：1991-08-01 00:00:00

abstract：:Epithin/PRSS14, a type II transmembrane serine protease, is involved in normal epithelial development and tumor progression. Here we report, as an interacting substrate of epithin, a receptor tyrosine kinase Tie2 that is well known for important roles in the vessel stability. Epithin interacts with and degrades the Ti...

journal_title：Blood

authors： Kim C,Lee HS,Lee D,Lee SD,Cho EG,Yang SJ,Kim SB,Park D,Kim MG

更新日期：2011-01-27 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an internatio...

journal_title：Blood

authors： Condoluci A,Terzi di Bergamo L,Langerbeins P,Hoechstetter MA,Herling CD,De Paoli L,Delgado J,Rabe KG,Gentile M,Doubek M,Mauro FR,Chiodin G,Mattsson M,Bahlo J,Cutrona G,Kotaskova J,Deambrogi C,Smedby KE,Spina V,Brusc

更新日期：2020-05-21 00:00:00

abstract：:The effects of the deoxygenation rate on the formation of irreversibly sickled cells (ISCs) were investigated by using metabolically replete sickle cells (SS cells). We found that the formation of ISCs required Ca2+ and that the amount formed depended on the rate of deoxygenation. When less dense SS discocytes were de...

journal_title：Blood

authors： Horiuchi K,Ballas SK,Asakura T

更新日期：1988-01-01 00:00:00

abstract：:Phosphoinositide 3-kinase gamma (PI3Kgamma) in neutrophils plays a critical role in the directed migration of these cells into inflamed tissues. In this study, we demonstrate the importance of the endothelial component of PI3Kgamma activity relative to its leukocyte counterpart in supporting neutrophil interactions wi...

journal_title：Blood

authors： Puri KD,Doggett TA,Huang CY,Douangpanya J,Hayflick JS,Turner M,Penninger J,Diacovo TG

更新日期：2005-07-01 00:00:00

abstract：:Platelets contain and release several matrix metalloproteinases (MMPs). Among these, active MMP-2 enhances platelet aggregation by favoring the activation of phosphatidylinositol 3- kinase (PI3K) and contributes to arterial thrombosis. The platelet surface target of MMP-2 and the mechanism through which it primes plat...

journal_title：Blood

authors： Sebastiano M,Momi S,Falcinelli E,Bury L,Hoylaerts MF,Gresele P

更新日期：2017-02-16 00:00:00

abstract：:Prior studies have reported high response rates with recombinant interferon-α (rIFN-α) therapy in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To further define the role of rIFN-α, we investigated the outcomes of pegylated-rIFN-α2a (PEG) therapy in ET and PV patients previously treated with...

journal_title：Blood

authors： Yacoub A,Mascarenhas J,Kosiorek H,Prchal JT,Berenzon D,Baer MR,Ritchie E,Silver RT,Kessler C,Winton E,Finazzi MC,Rambaldi A,Vannucchi AM,Leibowitz D,Rondelli D,Arcasoy MO,Catchatourian R,Vadakara J,Rosti V,Hexner E

更新日期：2019-10-31 00:00:00

abstract：:ADAMTS13 proteolytically regulates the platelet-tethering function of von Willebrand factor (VWF). ADAMTS13 function is dependent upon multiple exosites that specifically bind the unraveled VWF A2 domain and enable proteolysis. We carried out a comprehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich)...

journal_title：Blood

authors： de Groot R,Lane DA,Crawley JT

更新日期：2015-03-19 00:00:00

abstract：:T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associated translocation (MALT1) gene. In 2 patients with MALT lymphoma of th...

journal_title：Blood

authors： Streubel B,Lamprecht A,Dierlamm J,Cerroni L,Stolte M,Ott G,Raderer M,Chott A

更新日期：2003-03-15 00:00:00

abstract：:Subsets of natural killer (NK) cells are characterized by the expression of inhibitory and/or stimulatory receptors specific for major histocompatibility complex (MHC) class I determinants. In mice, these include the Ly49 family of molecules. One mechanism by which tumor cells may evade NK cell killing is by expressin...

journal_title：Blood

authors： Koh CY,Blazar BR,George T,Welniak LA,Capitini CM,Raziuddin A,Murphy WJ,Bennett M

更新日期：2001-05-15 00:00:00

abstract：:In an effort to develop a clinically useful approach to overcoming P-glycoprotein-mediated multidrug resistance (MDR1), we evaluated combined chemosensitization with verapamil and quinine in a multidrug-resistant (MDR) human myeloma cell line model. In clonogenic assay, verapamil was used at concentrations from 0.1 to...

journal_title：Blood

authors： Lehnert M,Dalton WS,Roe D,Emerson S,Salmon SE

更新日期：1991-01-15 00:00:00

abstract：:CD8+ Foxp3+ T cells (Tregs) are a potent regulatory population whose functional and ontological similarities to CD4+ Fox3+ T cells have not been well delineated. Using an experimental model of graft-versus-host disease (GVHD), we observed that CD8+ Tregs were significantly less potent than CD4+ Tregs for the suppressi...

journal_title：Blood

authors： Agle K,Vincent BG,Piper C,Belle L,Zhou V,Shlomchik W,Serody JS,Drobyski WR

更新日期：2018-07-26 00:00:00

abstract：:Hairy cell leukemia variant (HCLv) presents with high disease burden, lack of typical antigens like CD25, and poor response to standard treatments like cladribine. Occasionally, patients with classic HCL respond poorly. Clinical and molecular features of HCL and HCLv has not been compared. Rearrangements expressing im...

journal_title：Blood

authors： Arons E,Suntum T,Stetler-Stevenson M,Kreitman RJ

更新日期：2009-11-19 00:00:00

abstract：:Donor lymphocyte infusion (DLI) can restore durable molecular remission in a high percentage of patients with chronic myeloid leukemia (CML) who have relapses after allogeneic stem cell transplantation, but for patients who do not respond survival is poor. Imatinib mesylate (STI571) is a specific inhibitor of BCR-ABL ...

journal_title：Blood

authors： Olavarria E,Craddock C,Dazzi F,Marin D,Marktel S,Apperley JF,Goldman JM

更新日期：2002-05-15 00:00:00

abstract：:2B4 belongs to the CD2 subset of the IgG family of receptors. Members in this family have been shown to function as coreceptors via homophilic or heterophilic interactions. Both 2B4 and CD2 bind to CD48, another member of this family. Because all 3 molecules are expressed on natural killer (NK) cells, it raises a poss...

journal_title：Blood

authors： Lee KM,Forman JP,McNerney ME,Stepp S,Kuppireddi S,Guzior D,Latchman YE,Sayegh MH,Yagita H,Park CK,Oh SB,Wülfing C,Schatzle J,Mathew PA,Sharpe AH,Kumar V

更新日期：2006-04-15 00:00:00

abstract：:We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) stimulate the differentiation of human monocytes into two phenotypically distinct types of macrophages. However, in vivo, not only CSF but also many other cytokines are produced under va...

journal_title：Blood

authors： Akagawa KS,Takasuka N,Nozaki Y,Komuro I,Azuma M,Ueda M,Naito M,Takahashi K

更新日期：1996-11-15 00:00:00

abstract：:In this issue of Blood, Kurtz et al report the potential clinical utility of immunoglobulin high-throughput sequencing as a tool for disease monitoring and surveillance in aggressive B-cell lymphoma. ...

journal_title：Blood

authors： Sweetenham JW

更新日期：2015-06-11 00:00:00

abstract：:Optimal conditions necessary for the cytochemical demonstration of megakaryocyte (Mk) and platelet acid phosphatase (AP) were determined. Methanol, a constituent of fixatives commonly used in AP cytochemistry, was found to inhibit MkAP, and the degree of inhibition varied with Mk maturity. Immature Mk contained predom...

journal_title：Blood

authors： Markovic OS,Shulman NR

更新日期：1977-11-01 00:00:00

abstract：:Twenty-two molecular diagnostic laboratories from 14 countries participated in a consortium study to estimate the impact of Factor VIII gene inversions in severe hemophilia A. A total of 2,093 patients with severe hemophilia A were studied; of those, 740 (35%) had a type 1 (distal) factor VIII inversion, and 140 (7%) ...

journal_title：Blood

authors： Antonarakis SE,Rossiter JP,Young M,Horst J,de Moerloose P,Sommer SS,Ketterling RP,Kazazian HH Jr,Négrier C,Vinciguerra C,Gitschier J,Goossens M,Girodon E,Ghanem N,Plassa F,Lavergne JM,Vidaud M,Costa JM,Laurian Y,Lin

更新日期：1995-09-15 00:00:00