International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia.

abstract：:Several strategies can be used to manage fetal or neonatal alloimmune thrombocytopenia (FNAIT) in subsequent pregnancies. Serial fetal blood sampling (FBS) and intrauterine platelet transfusions (IUPT), as well as weekly maternal IV immunoglobulin infusion (IVIG), with or without additional corticosteroid therapy, are...

journal_title：Blood

authors： Winkelhorst D,Murphy MF,Greinacher A,Shehata N,Bakchoul T,Massey E,Baker J,Lieberman L,Tanael S,Hume H,Arnold DM,Baidya S,Bertrand G,Bussel J,Kjaer M,Kaplan C,Kjeldsen-Kragh J,Oepkes D,Ryan G

更新日期：2017-03-16 00:00:00

abstract：:Hepatitis C virus (HCV) infection is not uncommon in cancer patients. Over the past 5 years, treatment of chronic HCV infection in patients with hematologic malignancies has evolved rapidly as safe and effective direct-acting antivirals (DAAs) have become the standard-of-care treatment. Today, chronic HCV infection sh...

journal_title：Blood

authors： Torres HA,McDonald GB

更新日期：2016-09-15 00:00:00

abstract：:Selinexor is the first oral selective inhibitor of nuclear export compound tested for cancer treatment. Selinexor has demonstrated a safety therapy profile with broad antitumor activity against solid and hematological malignancies in phases 2 and 3 clinical trials (#NCT03071276, #NCT02343042, #NCT02227251, #NCT0311056...

journal_title：Blood

authors： Machlus KR,Wu SK,Vijey P,Soussou TS,Liu ZJ,Shacham E,Unger TJ,Kashyap T,Klebanov B,Sola-Visner M,Crochiere M,Italiano JE Jr,Landesman Y

更新日期：2017-08-31 00:00:00

abstract：:Vascular endothelial growth factor-A is widely used in clinical trials for the treatment of cardiac ischemia. VEGF-A was recently suggested to act in a proinflammatory manner, which could aggravate adjacent atherogenesis in VEGF-A-based therapy. To assess potential bystander effects, VEGF-A was focally overexpressed i...

journal_title：Blood

authors： Lucerna M,Zernecke A,de Nooijer R,de Jager SC,Bot I,van der Lans C,Kholova I,Liehn EA,van Berkel TJ,Yla-Herttuala S,Weber C,Biessen EA

更新日期：2007-01-01 00:00:00

abstract：:An abnormal von Willebrand factor (vWF) gene restriction pattern has been found in a patient with von Willebrand disease. Because this gene alteration is not present in his parents or in 50 normal and 25 affected subjects, and the restriction fragment length polymorphism haplotypes are inherited normally in the patien...

journal_title：Blood

authors： Bernardi F,Marchetti G,Guerra S,Casonato A,Gemmati D,Patracchini P,Ballerini G,Conconi F

更新日期：1990-02-01 00:00:00

abstract：:We report the international experience in outcomes after related and unrelated hematopoietic transplantation for infantile osteopetrosis in 193 patients. Thirty-four percent of transplants used grafts from HLA-matched siblings, 13% from HLA-mismatched relatives, 12% from HLA-matched, and 41% from HLA-mismatched unrela...

journal_title：Blood

authors： Orchard PJ,Fasth AL,Le Rademacher J,He W,Boelens JJ,Horwitz EM,Al-Seraihy A,Ayas M,Bonfim CM,Boulad F,Lund T,Buchbinder DK,Kapoor N,O'Brien TA,Perez MA,Veys PA,Eapen M

更新日期：2015-07-09 00:00:00

abstract：:Immunoglobulin E (IgE) bound to multivalent antigen (Ag) elicits mast cell degranulation but not survival; on the contrary, IgE in the absence of Ag (IgE(-Ag)) induces survival only but not degranulation. Although these distinct responses are mediated through the same receptor, FcepsilonRI, the molecular mechanism gen...

journal_title：Blood

authors： Yamasaki S,Ishikawa E,Kohno M,Saito T

更新日期：2004-04-15 00:00:00

abstract：:Successful allogeneic hematopoietic stem cell transplantation (HSCT) requires reconstitution of normal T-cell immunity. Recipient thymic activity, biologic features of the allograft, and preparative regimens all contribute to immune reconstitution. We evaluated circulating T-cell phenotypes and T-cell receptor rearran...

journal_title：Blood

authors： Lewin SR,Heller G,Zhang L,Rodrigues E,Skulsky E,van den Brink MR,Small TN,Kernan NA,O'Reilly RJ,Ho DD,Young JW

更新日期：2002-09-15 00:00:00

abstract：:We tested baseline positron emission tomography (PET)/computed tomography (CT) as a measure of total tumor burden to better identify high-risk patients with early-stage Hodgkin lymphoma (HL). Patients with stage I-II HL enrolled in the standard arm (combined modality treatment) of the H10 trial (NCT00433433) with avai...

journal_title：Blood

authors： Cottereau AS,Versari A,Loft A,Casasnovas O,Bellei M,Ricci R,Bardet S,Castagnoli A,Brice P,Raemaekers J,Deau B,Fortpied C,Raveloarivahy T,Van Zele E,Chartier L,Vander Borght T,Federico M,Hutchings M,Ricardi U,Andre M

更新日期：2018-03-29 00:00:00

abstract：:We previously reported the inhibitory action of interleukin-6 (IL-6) on B lymphopoiesis with SHIP(-/-) mice and showed that IL-6 biases lineage commitment toward myeloid cell fates in vitro and in vivo. Because elevated IL-6 is a feature of chronic inflammatory diseases, we applied an animal model of systemic lupus er...

journal_title：Blood

authors： Maeda K,Malykhin A,Teague-Weber BN,Sun XH,Farris AD,Coggeshall KM

更新日期：2009-05-07 00:00:00

abstract：:Transfusions purportedly induce dysfunction of cell-mediated immunity in sickle cell anemia (SCA). We studied hematologic and lymphocytic indices in 173 human immunodeficiency virus (HIV)-negative subjects with SCA and 131 black controls. Children aged 1 to 7 years with SCA had leukocyte counts and percentages of gran...

journal_title：Blood

authors： Wong WY,Powars DR,Operskalski EA,Hassett J,Parker JW,Sarnaik S,Pegelow CH,Hilgartner MW,Johnson CS,Zhou Y

更新日期：1995-04-15 00:00:00

abstract：:Low-grade follicular non-Hodgkin's lymphomas are characterized by the presence of a t(14;18) chromosomal translocation that results in deregulation of the B-cell lymphoma (Bcl-2) gene. Studies in cell lines and transgenic animal models have suggested that this results in the suppression of apoptotic cell death in germ...

journal_title：Blood

authors： Johnson PW,Watt SM,Betts DR,Davies D,Jordan S,Norton AJ,Lister TA

更新日期：1993-09-15 00:00:00

abstract：:Purified recombinant human heavy-chain (acidic) ferritin (rHF) was assessed in vivo in mice for effects on the proliferation (percentage of cells in S-phase) and absolute numbers of granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM) progenitor cells in the femur and spleen and on the nuc...

journal_title：Blood

authors： Broxmeyer HE,Williams DE,Geissler K,Hangoc G,Cooper S,Bicknell DC,Levi S,Arosio P

更新日期：1989-01-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT). When GVHD is controlled by T-cell-depleted grafts or immunosuppressants, BM transplant recipients often suffer from an increased rate of leukemic relapse and impaired reconstitution of immunity. Using a mouse BMT ...

journal_title：Blood

authors： Imado T,Iwasaki T,Kataoka Y,Kuroiwa T,Hara H,Fujimoto J,Sano H

更新日期：2004-09-01 00:00:00

abstract：:Multiple myeloma is characterized by increased osteoclast activity that results in bone destruction and lytic lesions. With the prolonged overall patient survival achieved by new treatment modalities, additional drugs are required to inhibit bone destruction. We focused on a novel and more potent structural analog of ...

journal_title：Blood

authors： Feng R,Anderson G,Xiao G,Elliott G,Leoni L,Mapara MY,Roodman GD,Lentzsch S

更新日期：2007-03-01 00:00:00

abstract：:The CD11a/CD18 (leukocyte function-associated antigen 1 [LFA-1]) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses. The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid cells depends on a functional RUNX1/AML-1-binding site (AML-110) ...

journal_title：Blood

authors： Puig-Kröger A,Sanchez-Elsner T,Ruiz N,Andreu EJ,Prosper F,Jensen UB,Gil J,Erickson P,Drabkin H,Groner Y,Corbi AL

更新日期：2003-11-01 00:00:00

abstract：:The rapid transformation of human blood platelets from inert discoid cells to spheroechinocytes that is induced by adenosine diphosphate (ADP) has been followed by right-angle light scattering intensity measurements using a laser light source and a sensitive photomultiplier. Two steps have been observed, and their rat...

journal_title：Blood

authors： Hantgan RR

更新日期：1984-10-01 00:00:00

abstract：:An inverse relationship between BCL-2 expression and cell cycle transition has been suggested by recent studies in murine models. To investigate the clinical relevance of these laboratory studies, a group of 116 paraffin-embedded non-Hodgkin's lymphoma (NHL) biopsy specimens (Working Formulation Groups D-H, and J) fro...

journal_title：Blood

authors： Winter JN,Andersen J,Reed JC,Krajewski S,Variakojis D,Bauer KD,Fisher RI,Gordon LI,Oken MM,Jiang S,Jeffries D,Domer P

更新日期：1998-02-15 00:00:00

abstract：:In a study of the relationship between thrombocytopenia and increased vascular fragility, changes in the endothelium of capillaries and postcapillary venules of the tongue were examined by electron microscopy. Adult male albino rabbits (4 kg) were maintained thrombocytopenic (platelets less than 20,000/cu mm) up to 24...

journal_title：Blood

authors： Kitchens CS,Weiss L

更新日期：1975-10-01 00:00:00

abstract：:Transplantation of ex vivo expanded human umbilical cord blood cells (hCB) only partially enhances the hematopoietic recovery after myelosuppressive therapy. Incubation of hCB with optimal combinations of cytokines and niche cells, such as endothelial cells (ECs), could augment the efficiency of hCB expansion. We have...

journal_title：Blood

authors： Butler JM,Gars EJ,James DJ,Nolan DJ,Scandura JM,Rafii S

更新日期：2012-08-09 00:00:00

abstract：:p15(INK4b) gene is an inhibitor of cyclin-dependent kinase (CDK) 4 and CDK6 whose expression is induced by transforming growth factor (TGF)beta. Recent reports suggest frequent methylation of the p15(INK4b) gene promoter in leukemias, and it has been proposed that this methylation could be necessary for leukemic cells...

journal_title：Blood

authors： Quesnel B,Guillerm G,Vereecque R,Wattel E,Preudhomme C,Bauters F,Vanrumbeke M,Fenaux P

更新日期：1998-04-15 00:00:00

abstract：:We have established four hybridoma cells that produce monoclonal antibodies (MoAbs) R2, R4, R6, and R12 directed toward recombinant human erythropoietin (rHuEPO). MoAbs R2, R4, and R6 bound to EPO with high affinities (kd = approximately 2, 4, and 1 nmol/L, respectively) but MoAb R12 had a low affinity (240 nmol/L). T...

journal_title：Blood

authors： Goto M,Murakami A,Akai K,Kawanishi G,Ueda M,Chiba H,Sasaki R

更新日期：1989-09-01 00:00:00

abstract：:This article reports a Glanzmann thrombasthenia (GT) patient, N.M., with a point mutation in the third cysteine-rich repeat of beta3-integrin or platelet glycoprotein (GP) IIIa, leading to the expression of a constitutively activated fibrinogen receptor. The diagnosis of GT was based on a severely reduced platelet-agg...

journal_title：Blood

authors： Ruiz C,Liu CY,Sun QH,Sigaud-Fiks M,Fressinaud E,Muller JY,Nurden P,Nurden AT,Newman PJ,Valentin N

更新日期：2001-10-15 00:00:00

abstract：:Adoptive T-cell therapy in cancer or chronic viral infections is often impeded by the development of functional impairment of the transferred cells. To overcome this therapeutic limitation we combined adoptive transfer of naive, virus-specific CD8+ T cells with immunostimulative CpG oligodeoxynucleotides (ODNs) in mic...

journal_title：Blood

authors： Kraft AR,Krux F,Schimmer S,Ohlen C,Greenberg PD,Dittmer U

更新日期：2007-04-01 00:00:00

abstract：:Follicular lymphoma (FL) is a low-grade B-cell non-Hodgkin's lymphoma (NHL) that frequently transforms into diffuse aggressive NHL. The majority of FLs display a t(14; 18) translocation that places the bcl-2 gene into juxtaposition with the lg heavy-chain (H) gene locus. Morphologically transformed malignant FL cells ...

journal_title：Blood

authors： Matolcsy A,Casali P,Warnke RA,Knowles DM

更新日期：1996-11-15 00:00:00

abstract：:Cell-cell contact-dependent mechanisms that modulate proliferation and/or differentiation in the context of hematopoiesis include mechanisms characteristic of the interactions between members of the Notch family of signal transduction molecules and their ligands. Whereas Notch family members and their ligands clearly ...

journal_title：Blood

authors： Zhou L,Li LW,Yan Q,Petryniak B,Man Y,Su C,Shim J,Chervin S,Lowe JB

更新日期：2008-07-15 00:00:00

abstract：:The regulatory Tat protein of human immunodeficiency virus type-1 (HIV-1) exerts a pleyotropic activity on the survival and proliferation of different cell types in culture. In this report, we investigated the effect of either endogenous or exogenous Tat on Bcl-2 proto-oncogene expression and cell survival in Jurkat T...

journal_title：Blood

authors： Zauli G,Gibellini D,Caputo A,Bassini A,Negrini M,Monne M,Mazzoni M,Capitani S

更新日期：1995-11-15 00:00:00

abstract：:Immunizing bone marrow donors prior to bone marrow transplant (BMT) has the potential for adoptively transferring specific immunity against opportunistic pathogens. Studies have shown that long-term antibody production occurs in the bone marrow and that specific humoral immunity may be transferred from donor to recipi...

journal_title：Blood

authors： Slifka MK,Whitmire JK,Ahmed R

更新日期：1997-09-01 00:00:00

abstract：:Antiphospholipid antibodies including anticardiolipin antibodies, lupus anticoagulants, and anti-beta(2) glycoprotein-1-specific antibodies may identify patients at elevated risk of first or recurrent venous or arterial thromboembolism. Traditionally, published case series supplemented by anecdotal experience have for...

journal_title：Blood

authors： Garcia DA,Khamashta MA,Crowther MA

更新日期：2007-11-01 00:00:00

abstract：:It has now been 3 years since the von Willebrand factor (VWF)-cleaving protease implicated in thrombocytopenic purpura (TTP) pathogenesis was identified as ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13). More than 50 ADAMTS13 mutations resulting in familial TTP have been reported...

journal_title：Blood

authors： Levy GG,Motto DG,Ginsburg D

更新日期：2005-07-01 00:00:00