Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review.

abstract：:The number of cells transplanted and their capacity to induce graft-versus-host reactivity (GvHR) are two factors that are suspected to influence the engraftment of allogeneic bone marrow. We have investigated their impact on graft rejection rates in busulfan-treated LEW rats. In a series of experiments, we varied (1)...

journal_title：Blood

authors： Uharek L,Gassmann W,Glass B,Steinmann J,Loeffler H,Mueller-Ruchholtz W

更新日期：1992-03-15 00:00:00

abstract：:The regulation of plasmin generation on cell surfaces is of critical importance in the control of vascular homeostasis. Cell-derived microparticles participate in the dissemination of biological activities. However, their capacity to promote plasmin generation has not been documented. In this study, we show that endot...

journal_title：Blood

authors： Lacroix R,Sabatier F,Mialhe A,Basire A,Pannell R,Borghi H,Robert S,Lamy E,Plawinski L,Camoin-Jau L,Gurewich V,Angles-Cano E,Dignat-George F

更新日期：2007-10-01 00:00:00

abstract：:We investigated the intracellular site of pro-von Willebrand factor (pro-vWF) cleavage and multimerization, as well as the fate of the propolypeptide (von Willebrand antigen II) after cleavage. Analysis of subcellular fractions of endothelial cells metabolically labeled with sulfate showed that both cleavage and coval...

journal_title：Blood

authors： Vischer UM,Wagner DD

更新日期：1994-06-15 00:00:00

abstract：:Twenty-two molecular diagnostic laboratories from 14 countries participated in a consortium study to estimate the impact of Factor VIII gene inversions in severe hemophilia A. A total of 2,093 patients with severe hemophilia A were studied; of those, 740 (35%) had a type 1 (distal) factor VIII inversion, and 140 (7%) ...

journal_title：Blood

authors： Antonarakis SE,Rossiter JP,Young M,Horst J,de Moerloose P,Sommer SS,Ketterling RP,Kazazian HH Jr,Négrier C,Vinciguerra C,Gitschier J,Goossens M,Girodon E,Ghanem N,Plassa F,Lavergne JM,Vidaud M,Costa JM,Laurian Y,Lin

更新日期：1995-09-15 00:00:00

abstract：:Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in ∼12% of patients with acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2-hydroxyglutarate resulting in DNA and histone hypermethylation, which leads to blocked cellular differentiation. Enasidenib (AG-221/CC-90007) is a firs...

journal_title：Blood

authors： Stein EM,DiNardo CD,Pollyea DA,Fathi AT,Roboz GJ,Altman JK,Stone RM,DeAngelo DJ,Levine RL,Flinn IW,Kantarjian HM,Collins R,Patel MR,Frankel AE,Stein A,Sekeres MA,Swords RT,Medeiros BC,Willekens C,Vyas P,Tosolini A

更新日期：2017-08-10 00:00:00

abstract：:The clinical hallmark of paroxysmal nocturnal hemoglobinuria (PNH) is chronic intravascular hemolysis that is a consequence of unregulated activation of the alternative pathway of complement (APC). Intravascular hemolysis can be inhibited in patients by treatment with eculizumab, a monoclonal antibody that binds compl...

journal_title：Blood

authors： Lindorfer MA,Pawluczkowycz AW,Peek EM,Hickman K,Taylor RP,Parker CJ

更新日期：2010-03-18 00:00:00

abstract：:Iron overload is common in patients undergoing allogeneic hematopoietic cell transplantation (HCT), but the mechanisms leading to overload are unknown. Here, we determined iron levels and the expression of iron regulatory proteins in the liver and gut of nonobese diabetic-severe combined immunodeficient (NOD/SCID) mic...

journal_title：Blood

authors： Bair S,Spaulding E,Parkkinen J,Shulman HM,Lesnikov V,Beauchamp M,Canonne-Hergaux F,Kowdley KV,Deeg HJ

更新日期：2009-02-19 00:00:00

abstract：:The Children's Cancer Group (CCG) and the Pediatric Oncology Group (POG) joined to form the Children's Oncology Group (COG) in 2000. This merger allowed analysis of clinical, biologic, and early response data predictive of event-free survival (EFS) in acute lymphoblastic leukemia (ALL) to develop a new classification ...

journal_title：Blood

authors： Schultz KR,Pullen DJ,Sather HN,Shuster JJ,Devidas M,Borowitz MJ,Carroll AJ,Heerema NA,Rubnitz JE,Loh ML,Raetz EA,Winick NJ,Hunger SP,Carroll WL,Gaynon PS,Camitta BM

更新日期：2007-02-01 00:00:00

abstract：:NF-IL6 was originally identified as a DNA binding protein regulating interleukin-1 (IL-1)-stimulated IL-6 expression. Direct cloning of NF-IL6 showed its homology with C/EBP, a hepatocyte- and adipocyte-specific transcription factor. This study showed that the expression of NF-IL6 messenger RNA (mRNA) increased marked...

journal_title：Blood

authors： Natsuka S,Akira S,Nishio Y,Hashimoto S,Sugita T,Isshiki H,Kishimoto T

更新日期：1992-01-15 00:00:00

abstract：:A mutant strain of Escherichia coli (E. coli ML-35) was used to follow the kinetics of phagocytosis, perforation of the bacterial cell envelope, and inactivation of bacterial proteins by human neutrophils. This particular E. coli mutant strain has no lactose permease, but constitutively forms the cytoplasmic enzyme be...

journal_title：Blood

authors： Hamers MN,Bot AA,Weening RS,Sips HJ,Roos D

更新日期：1984-09-01 00:00:00

abstract：:In a double-blind study, we compared the postoperative (post-op) blood loss in 161 children undergoing open heart surgery with cardiopulmonary bypass whose immediate post-op transfusion requirements were met with either very fresh whole blood (VFWB), 24- to 48-hour-old whole blood or reconstituted whole blood (packed ...

journal_title：Blood

authors： Manno CS,Hedberg KW,Kim HC,Bunin GR,Nicolson S,Jobes D,Schwartz E,Norwood WI

更新日期：1991-03-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

journal_title：Blood

authors： Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

更新日期：2005-06-15 00:00:00

abstract：:Previous studies showed that Fanconi anemia (FA) murine stem cells have defective reconstitution after bone marrow (BM) transplantation. The mechanism underlying this defect is not known. Here, we report defective homing of FA patient BM progenitors transplanted into mouse models. Using cells from patients carrying mu...

journal_title：Blood

authors： Zhang X,Shang X,Guo F,Murphy K,Kirby M,Kelly P,Reeves L,Smith FO,Williams DA,Zheng Y,Pang Q

更新日期：2008-09-01 00:00:00

abstract：:Hematopoietic bone marrow stem cells generate differentiated blood cells and, when transplanted, may contribute to other organs, such as the brain, heart, and liver. An understanding of in vivo clonal behavior of stem cells will have important implications for cellular and gene therapy. For the first time, we have dir...

journal_title：Blood

authors： Schmidt M,Zickler P,Hoffmann G,Haas S,Wissler M,Muessig A,Tisdale JF,Kuramoto K,Andrews RG,Wu T,Kiem HP,Dunbar CE,von Kalle C

更新日期：2002-10-15 00:00:00

abstract：:During the inflammatory response, granulocytes and other leukocytes adhere to and emigrate from small venules. Before firm attachment, leukocytes are observed rolling slowly along the endothelium in venules of most tissues accessible to intravital microscopy. The molecular mechanism underlying this early type of leuko...

journal_title：Blood

authors： Ley K,Gaehtgens P,Fennie C,Singer MS,Lasky LA,Rosen SD

更新日期：1991-06-15 00:00:00

abstract：:Transforming mutations in NRAS and KRAS are thought to play a causative role in the development of numerous cancers, including myeloid malignancies. Although mutations at amino acids 12, 13, or 61 account for the majority of oncogenic Ras variants, we hypothesized that less frequent mutations at alternate residues may...

journal_title：Blood

authors： Tyner JW,Erickson H,Deininger MW,Willis SG,Eide CA,Levine RL,Heinrich MC,Gattermann N,Gilliland DG,Druker BJ,Loriaux MM

更新日期：2009-02-19 00:00:00

abstract：:The monoclonal antibodies Tab and AP3 are directed, respectively, against GPIIb and GPIIIa, the subunits of the platelet fibrinogen receptor. When added together to platelets, these antibodies prevent adenosine diphosphate (ADP)-induced platelet aggregation, despite normal fibrinogen binding (Newman et al, Blood 69:66...

journal_title：Blood

authors： Isenberg WM,Bainton DF,Newman PJ

更新日期：1990-10-15 00:00:00

abstract：:The receptor for hyaluronic acid-mediated motility (RHAMM) is an antigen eliciting both humoral and cellular immune responses in patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and multiple myeloma (MM). We initiated a phase 1 clinical trial vaccinating 10 patients with R3 (ILSLELMKL), a hi...

journal_title：Blood

authors： Schmitt M,Schmitt A,Rojewski MT,Chen J,Giannopoulos K,Fei F,Yu Y,Götz M,Heyduk M,Ritter G,Speiser DE,Gnjatic S,Guillaume P,Ringhoffer M,Schlenk RF,Liebisch P,Bunjes D,Shiku H,Dohner H,Greiner J

更新日期：2008-02-01 00:00:00

abstract：:Protein tyrosine phosphorylation plays a crucial role in signaling from the receptor for erythropoietin (Epo), although the Epo receptor (EpoR) lacks the tyrosine kinase domain. We have previously shown that the Jak2 tyrosine kinase couples with the EpoR to transduce a growth signal. In the present study, we demonstra...

journal_title：Blood

authors： Chin H,Arai A,Wakao H,Kamiyama R,Miyasaka N,Miura O

更新日期：1998-05-15 00:00:00

abstract：:ADP-induced TXA2 generation requires the costimulation of P2Y1, P2Y12, and the GPIIb/IIIa receptors. Signaling events downstream of the P2Y receptors that contribute to ADP-induced TXA2 generation have not been clearly delineated. In this study, we have investigated the role of G-protein-gated inwardly rectifying pota...

journal_title：Blood

authors： Shankar H,Kahner BN,Prabhakar J,Lakhani P,Kim S,Kunapuli SP

更新日期：2006-11-01 00:00:00

abstract：:The effects of selectively depleting CD8+ cells from donor bone marrow were assessed in 36 patients receiving transplantation from an HLA-identical sibling as treatment for leukemia. Donor bone marrow underwent ex vivo treatment using anti-Leu-2 monoclonal antibody and complement. Patients received cyclosporine post-t...

journal_title：Blood

authors： Champlin R,Ho W,Gajewski J,Feig S,Burnison M,Holley G,Greenberg P,Lee K,Schmid I,Giorgi J

更新日期：1990-07-15 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a severe immunodeficiency and platelet deficiency disease arising from mutation(s) in the WASP gene, which in normal cells encodes an intracellular protein able to interact with other proteins relevant to the control of cytoskeleton organization. Immunodeficiency is mainly due to ...

journal_title：Blood

authors： Gallego MD,Santamaría M,Peña J,Molina IJ

更新日期：1997-10-15 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is classically described to result from a dysregulation of the complement alternative pathway, leading to glomerular endothelial cell (EC) damage and thrombosis. However, recent findings in families with aHUS of mutations in the DGKE gene, which is not an integral component of...

journal_title：Blood

authors： Bruneau S,Néel M,Roumenina LT,Frimat M,Laurent L,Frémeaux-Bacchi V,Fakhouri F

更新日期：2015-02-05 00:00:00

abstract：:We evaluated the impact of recipient and cord blood unit (CBU) genetic polymorphisms related to immune response on outcomes after unrelated cord blood transplantations (CBTs). Pretransplant DNA samples from 696 CBUs with malignant diseases were genotyped for NLRP1, NLRP2, NLRP3, TIRAP/Mal, IL10, REL, TNFRSF1B, and CTL...

journal_title：Blood

authors： Cunha R,Zago MA,Querol S,Volt F,Ruggeri A,Sanz G,Pouthier F,Kogler G,Vicario JL,Bergamaschi P,Saccardi R,Lamas CH,Díaz-de-Heredia C,Michel G,Bittencourt H,Tavella M,Panepucci RA,Fernandes F,Pavan J,Gluckman E,Roch

更新日期：2017-01-26 00:00:00

abstract：:Fifty-one children with acute lymphoblastic leukemia (ALL) in second or subsequent remission after a first remission of at least 24 months underwent purged, autologous bone marrow transplantation (ABMT). Bone marrow was harvested in remission and purged in vitro with monoclonal antibodies specific for leukemia-associa...

journal_title：Blood

authors： Billett AL,Kornmehl E,Tarbell NJ,Weinstein HJ,Gelber RD,Ritz J,Sallan SE

更新日期：1993-03-15 00:00:00

abstract：:Posttranscriptional mechanisms are now widely acknowledged to play a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation, and tumorigenesis. Although much attention has focused on microRNAs as regulators of mRNA stability/translation, recent data have highlighted the ro...

journal_title：Blood

authors： Baou M,Norton JD,Murphy JJ

更新日期：2011-11-24 00:00:00

abstract：:The functional activities of the tumor suppressor promyelocytic leukemia protein (PML) are mostly associated with its nuclear location. In the present study, we discovered an unexpected role of PML in NLRP3 inflammasome activation. In PML-deficient macrophages, the production of IL-1β was strongly impaired. The expres...

journal_title：Blood

authors： Lo YH,Huang YW,Wu YH,Tsai CS,Lin YC,Mo ST,Kuo WC,Chuang YT,Jiang ST,Shih HM,Lai MZ

更新日期：2013-04-18 00:00:00

abstract：:Clonal chromosomal abnormalities in Philadelphia chromosome-negative (CCA/Ph-) metaphases emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are treated with tyrosine kinase inhibitors (TKIs). We assessed the characteristics and prognostic impact of 598 patients with CP-CML treated on clinical tri...

journal_title：Blood

authors： Issa GC,Kantarjian HM,Gonzalez GN,Borthakur G,Tang G,Wierda W,Sasaki K,Short NJ,Ravandi F,Kadia T,Patel K,Luthra R,Ferrajoli A,Garcia-Manero G,Rios MB,Dellasala S,Jabbour E,Cortes JE

更新日期：2017-11-09 00:00:00

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00

abstract：:Rh(o)(D) immune globulin intravenous (anti-D IGIV) was licensed by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP). Anti-D IGIV induces extravascular hemolysis, an expected adverse reaction that is consistent with the presumed mechanism of...

journal_title：Blood

authors： Gaines AR

更新日期：2000-04-15 00:00:00