Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status.

abstract：:Adoptive T-cell therapy using CD3/CD28 co-stimulation likely requires in vivo generation of antigen specificity. Because CD28 promotes TH1/TC1 (T1) or TH2/TC2 (T2) differentiation, costimulation may generate donor T1 or T2 cells capable of differentially mediating allogeneic graft-versus-tumor (GVT) effects and graft-...

journal_title：Blood

authors： Jung U,Foley JE,Erdmann AA,Eckhaus MA,Fowler DH

更新日期：2003-11-01 00:00:00

abstract：:Erythroid cell iron and transferrin uptake and release was studied in the anemia of the Belgrade laboratory rat (gene symbol, b), an autosomal recessive trait characterized by hypochromia and hyperferrinemia. When reticulocyte-rich red cells were incubated in vitro with doubly (59Fe, 125I) labeled transferrin, b/b cel...

journal_title：Blood

authors： Edwards JA,Sullivan AL,Hoke JE

更新日期：1980-04-01 00:00:00

abstract：:The syndrome of episodic angioedema and eosinophilia is characterized by cyclic edema, marked peripheral blood eosinophilia, and eosinophil degranulation in the dermis. Using a sensitive immunoenzymetric method, we measured serum interleukin (IL)-5 levels in four patients with this syndrome. We also determined the per...

journal_title：Blood

authors： Butterfield JH,Leiferman KM,Abrams J,Silver JE,Bower J,Gonchoroff N,Gleich GJ

更新日期：1992-02-01 00:00:00

abstract：:During acute falciparum malaria infection, red blood cells (RBC) containing abundant ring-infected erythrocyte surface antigen (Pf 155 or RESA), but no intracellular parasites, are present in the circulation. These RESA-positive parasite negative RBC are not seen in parasite cultures in vitro. This indicates that in a...

journal_title：Blood

authors： Angus BJ,Chotivanich K,Udomsangpetch R,White NJ

更新日期：1997-09-01 00:00:00

abstract：:Increased levels of endothelin-1 (Et-1), a potent vasoconstrictor, have been correlated with hypertension and neuronal damage in ischemic/reperfusion injury. The presence of polymorphonuclear cells (PMNs) in the brain has been shown to be directly responsible for this observed pathology. To address the question of whe...

journal_title：Blood

authors： Hofman FM,Chen P,Jeyaseelan R,Incardona F,Fisher M,Zidovetzki R

更新日期：1998-11-01 00:00:00

abstract：:We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8- [double-negative, DN], T-cell receptor [TCR] alpha beta+). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no differ...

journal_title：Blood

authors： Suzushima H,Asou N,Nishimura S,Nishikawa K,Wang JX,Okubo T,Naito M,Hattori T,Takatsuki K

更新日期：1993-02-15 00:00:00

abstract：:The chemokine receptors (CCRs) CCR4 and CCR10, and the cutaneous lymphocyte antigen (CLA), have each been proposed as critical mediators of skin-specific TH lymphocyte homing in mice and humans. CLA initiates skin homing by mediating E-selectin-dependent tethering and rolling within cutaneous venules, but the specific...

journal_title：Blood

authors： Soler D,Humphreys TL,Spinola SM,Campbell JJ

更新日期：2003-03-01 00:00:00

abstract：:Seventy-five patients with resistant acute leukemia or lymphoma received high-dose cyclophosphamide and etoposide to explore the activity of this combination in resistant hematologic malignancies, and to determine the maximum doses of these drugs that can be combined without bone marrow transplantation. Etoposide was ...

journal_title：Blood

authors： Brown RA,Herzig RH,Wolff SN,Frei-Lahr D,Pineiro L,Bolwell BJ,Lowder JN,Harden EA,Hande KR,Herzig GP

更新日期：1990-08-01 00:00:00

abstract：:Many B-lineage-specific genes are down-regulated in Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL). We investigated the involvement of epigenetic modifications in gene silencing in cHL cell lines and in microdissected primary HRS cells. We assessed the expression and methylation status of C...

journal_title：Blood

authors： Ushmorov A,Leithäuser F,Sakk O,Weinhaüsel A,Popov SW,Möller P,Wirth T

更新日期：2006-03-15 00:00:00

abstract：:Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from patients, are dependent on Bcr-Abl. In the tr...

journal_title：Blood

authors： Hamilton A,Helgason GV,Schemionek M,Zhang B,Myssina S,Allan EK,Nicolini FE,Müller-Tidow C,Bhatia R,Brunton VG,Koschmieder S,Holyoake TL

更新日期：2012-02-09 00:00:00

abstract：:Patients with PNH may be treated with a number of known agents. As in all patients with a chronic disease, a regimen tolerable over a long period of time must be selected. Knowledge and anticipation of complications and their proper treatment are essential parts in the treatment. When these principals are used, many p...

journal_title：Blood

authors： Rosse WF

更新日期：1982-07-01 00:00:00

abstract：:Recent studies have identified several populations of progenitor cells in the human thymus. The hematopoietic precursor activity of these populations has been determined. The most primitive human thymocytes express high levels of CD34 and lack CD1a. These cells acquire CD1a and differentiate into CD4(+)CD8(+) through ...

journal_title：Blood

authors： Blom B,Verschuren MC,Heemskerk MH,Bakker AQ,van Gastel-Mol EJ,Wolvers-Tettero IL,van Dongen JJ,Spits H

更新日期：1999-05-01 00:00:00

abstract：:The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcgamma receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders me...

journal_title：Blood

authors： Ephrem A,Chamat S,Miquel C,Fisson S,Mouthon L,Caligiuri G,Delignat S,Elluru S,Bayry J,Lacroix-Desmazes S,Cohen JL,Salomon BL,Kazatchkine MD,Kaveri SV,Misra N

更新日期：2008-01-15 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation. From 1987 through 1992, 195 patients in the Benelux with recent untreated CML were randomized between low-dose IFN-alpha2b (3 MIU, 5 days/wk) or hydroxyurea...

journal_title：Blood

authors：

更新日期：1998-04-15 00:00:00

abstract：:An autoantibody, developed by a patient with severe and recurrent arterial thrombosis, was characterized to be directed against the anion-binding exosite of thrombin, and inhibited all thrombin interactions requiring this secondary binding site without interfering with the catalytic site. The effect of the antibody wa...

journal_title：Blood

authors： Arnaud E,Lafay M,Gaussem P,Picard V,Jandrot-Perrus M,Aiach M,Rendu F

更新日期：1994-09-15 00:00:00

abstract：:Three cases of T-lymphoblastic lymphomas (T-LL) expressing the T cell antigen receptor gamma delta (TCR gamma delta) are reported. All of them were CD3+/beta F1-/TCR delta 1+. Moreover, neoplastic cells reacted with the delta TCS1 monoclonal antibody (MoAb) which binds to the non-disulfide-linked form of the TCR gamma...

journal_title：Blood

authors： Falini B,Flenghi L,Fagioli M,Martelli MF,Pileri S,Grignani F,Beltrami A,Novero D,Pelicci PG

更新日期：1989-11-15 00:00:00

abstract：:The risk of development of CNS leukemia was investigated in 153 adults with acute lymphocytic leukemia (ALL) who received systemic combination chemotherapy without CNS prophylaxis. Overall, 31 patients (20%) developed CNS leukemia after a median of 6 months of therapy; the estimated 1-year incidence of CNS leukemia wa...

journal_title：Blood

authors： Kantarjian HM,Walters RS,Smith TL,Keating MJ,Barlogie B,McCredie KB,Freireich EJ

更新日期：1988-11-01 00:00:00

abstract：:Caspases are cysteine proteases involved in apoptosis and cytokine maturation. In erythroblasts, keratinocytes, and lens epithelial cells undergoing differentiation, enucleation has been regarded as a caspase-mediated incomplete apoptotic process. Here, we show that several caspases are activated in human peripheral b...

journal_title：Blood

authors： Sordet O,Rébé C,Plenchette S,Zermati Y,Hermine O,Vainchenker W,Garrido C,Solary E,Dubrez-Daloz L

更新日期：2002-12-15 00:00:00

abstract：:Heme biosynthesis was examined in erythroid tissue of a 4-yr-old girl with severe sideroblastic anemia since infancy, as documented by the presence of intramitochondrial deposits of iron in erythroblasts. Free red cell protoporphyrin, urinary porphyrins, and activities of erythrocyte porphobilinogen synthase, uroporph...

journal_title：Blood

authors： Buchanan GR,Bottomley SS,Nitschke R

更新日期：1980-01-01 00:00:00

abstract：:Light chain deposition disease (LCDD) results from a propensity of some human monoclonal L chains to form tissue deposits. We designed an experimental model for in vivo expression of human kappa L chain sequences in mice and compared a somatically mutated LCDD chain with a closely related control kappa chain, both enc...

journal_title：Blood

authors： Khamlichi AA,Rocca A,Touchard G,Aucouturier P,Preud'homme JL,Cogné M

更新日期：1995-11-15 00:00:00

abstract：:Although NPM1 gene mutations leading to aberrant cytoplasmic expression of nucleophosmin (NPMc(+)) are the most frequent genetic lesions in acute myeloid leukemia, there is yet no experimental model demonstrating their oncogenicity in vivo. We report the generation and characterization of a transgenic mouse model expr...

journal_title：Blood

authors： Cheng K,Sportoletti P,Ito K,Clohessy JG,Teruya-Feldstein J,Kutok JL,Pandolfi PP

更新日期：2010-04-22 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is characterized by delayed senescence and slow accumulation of monoclonal, small lymphocytes. Basic fibroblast growth factor (bFGF) is a pleiotropic cytokine that plays a role in hematopoiesis and apoptosis. Elevated bFGF levels have been detected in urine from patients with a varie...

journal_title：Blood

authors： Menzel T,Rahman Z,Calleja E,White K,Wilson EL,Wieder R,Gabrilove J

更新日期：1996-02-01 00:00:00

abstract：:Natural killer T (NKT) cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self-antigens. The nature of NKT-cell autoreactive activation remains poorly understood. We show here that the mitogen-activated protein kinase (MAPK) pathway is operative during human NKT...

journal_title：Blood

authors： Wang X,Chen X,Rodenkirch L,Simonson W,Wernimont S,Ndonye RM,Veerapen N,Gibson D,Howell AR,Besra GS,Painter GF,Huttenlocher A,Gumperz JE

更新日期：2008-11-15 00:00:00

abstract：:The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the inte...

journal_title：Blood

authors： Swimm A,Giver CR,DeFilipp Z,Rangaraju S,Sharma A,Ulezko Antonova A,Sonowal R,Capaldo C,Powell D,Qayed M,Kalman D,Waller EK

更新日期：2018-12-06 00:00:00

abstract：:Phytohemagglutin-stimulated child and adult leukocytes equally supported CCR5-dependent (R5) and CXCR4-dependent (X4) HIV-1 replication. In contrast, when phytohemagglutin-stimulated leukocytes from either healthy or congenitally immunodeficient children were cultured on feeder cells, they well supported R5, but not X...

journal_title：Blood

authors： Mariani SA,Brigida I,Kajaste-Rudnitski A,Ghezzi S,Rocchi A,Plebani A,Vicenzi E,Aiuti A,Poli G

更新日期：2012-03-01 00:00:00

abstract：:Combined deficiency of ankyrin and spectrin represents the most common biochemical abnormality in hereditary spherocytosis (HS). To examine whether a decrease in ankyrin mRNA represents a frequent cause of this type of HS, we took advantage of the reported (AC)n microsatellite polymorphism in the 3' untranslated regio...

journal_title：Blood

authors： Jarolim P,Rubin HL,Brabec V,Palek J

更新日期：1995-06-01 00:00:00

abstract：:Inactivation of the retinoblastoma tumor-suppressor gene (RB-1) has been associated with tumorigenicity in various human malignancies. In chronic lymphoid leukemias of B-cell origin (B-CLL) an involvement of RB-1 has been suggested based on cytogenetic data. We examined RB-1 and its chromosomal locus 13q14 in 35 cases...

journal_title：Blood

authors： Stilgenbauer S,Döhner H,Bulgay-Mörschel M,Weitz S,Bentz M,Lichter P

更新日期：1993-04-15 00:00:00

abstract：:Chronic myeloid leukemia is effectively treated with imatinib, but reactivation of BCR-ABL frequently occurs through acquisition of kinase domain mutations. The additional approved ABL tyrosine kinase inhibitors (TKIs) nilotinib and dasatinib, along with investigational TKIs such as ponatinib (AP24534) and DCC-2036, s...

journal_title：Blood

authors： O'Hare T,Zabriskie MS,Eide CA,Agarwal A,Adrian LT,You H,Corbin AS,Yang F,Press RD,Rivera VM,Toplin J,Wong S,Deininger MW,Druker BJ

更新日期：2011-11-10 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a severe renal disease that is associated with defective complement regulation caused by multiple factors. We previously described the deficiency of factor H-related proteins CFHR1 and CFHR3 as predisposing factor for aHUS. Here we identify in an extended cohort of 147 aHUS...

journal_title：Blood

authors： Józsi M,Licht C,Strobel S,Zipfel SL,Richter H,Heinen S,Zipfel PF,Skerka C

更新日期：2008-02-01 00:00:00

abstract：:Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B...

journal_title：Blood

authors： Merkenschlager J,Eksmond U,Danelli L,Attig J,Young GR,Nowosad C,Tolar P,Kassiotis G

更新日期：2019-03-07 00:00:00