当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Specific involvement of caspases in the differentiation of monocytes into macrophages.

Specific involvement of caspases in the differentiation of monocytes into macrophages.

Abstract：

:Caspases are cysteine proteases involved in apoptosis and cytokine maturation. In erythroblasts, keratinocytes, and lens epithelial cells undergoing differentiation, enucleation has been regarded as a caspase-mediated incomplete apoptotic process. Here, we show that several caspases are activated in human peripheral blood monocytes whose differentiation into macrophages is induced by macrophage colony-stimulating factor (M-CSF). This activation is not associated with cell death and cannot be detected in monocytes undergoing dendritic cell differentiation in the presence of interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF). The mechanisms and consequences of caspase activation were further studied in U937 human monocytic cells undergoing phorbol ester-induced differentiation into macrophages. Differentiation-associated caspase activation involves the release of cytochrome c from the mitochondria and leads to the cleavage of the protein acinus while the poly(ADP-ribose)polymerase remains uncleaved. Inhibition of caspases by either exposure to the broad-spectrum inhibitor benzyloxycarbonyl-Val-Ala-(DL)-Asp-fluoromethylketone (z-VAD-fmk) or expression of the p35 baculovirus inhibitory protein or overexpression of Bcl-2 inhibits the differentiation process. In addition, z-VAD-fmk amplifies the differentiation-associated production of radical oxygen species in both phorbol ester-differentiated U937 cells and M-CSF-treated monocytes, shifting the differentiation process to nonapoptotic cell death. Altogether, these results indicate that caspase activation specifically contributes to the differentiation of monocytes into macrophages, in the absence of cell death.

journal_name

Blood

journal_title

Blood

authors

Sordet O,Rébé C,Plenchette S,Zermati Y,Hermine O,Vainchenker W,Garrido C,Solary E,Dubrez-Daloz L

doi

10.1182/blood-2002-06-1778

subject

Has Abstract

pub_date

2002-12-15 00:00:00

pages

4446-53

issue

13

eissn

0006-4971

issn

1528-0020

pii

2002-06-1778

journal_volume

100

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy.

    abstract：:Autologous T cells engineered to express a CD19-specific chimeric antigen receptor (CAR) have produced impressive minimal residual disease-negative (MRD-negative) complete remission (CR) rates in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the factors associated with durable...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2018-11-883710

    authors： Hay KA,Gauthier J,Hirayama AV,Voutsinas JM,Wu Q,Li D,Gooley TA,Cherian S,Chen X,Pender BS,Hawkins RM,Vakil A,Steinmetz RN,Schoch G,Chapuis AG,Till BG,Kiem HP,Ramos JD,Shadman M,Cassaday RD,Acharya UH,Riddell SR

    更新日期：2019-04-11 00:00:00

  • Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease.

    abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

    更新日期：1997-02-15 00:00:00

  • Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells.

    abstract：:Merkel cell polyomavirus (MCPyV) is detected in approximately 80% of Merkel cell carcinomas (MCC). Yet, clonal integration and truncating mutations of the large T antigen (LTAg) of MCPyV are restricted to MCC. We tested the presence and mutations of MCPyV in highly purified leukemic cells of 70 chronic lymphocytic leu...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-02-269829

    authors： Pantulu ND,Pallasch CP,Kurz AK,Kassem A,Frenzel L,Sodenkamp S,Kvasnicka HM,Wendtner CM,Zur Hausen A

    更新日期：2010-12-09 00:00:00

  • Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters.

    abstract：:The vitelline artery is a temporary structure that undergoes extensive remodeling during midgestation to eventually become the superior mesenteric artery (also called the cranial mesenteric artery, in the mouse). Here we show that, during this remodeling process, large clusters of hematopoietic progenitors emerge via ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-04-279497

    authors： Zovein AC,Turlo KA,Ponec RM,Lynch MR,Chen KC,Hofmann JJ,Cox TC,Gasson JC,Iruela-Arispe ML

    更新日期：2010-11-04 00:00:00

  • Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium.

    abstract：:The chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell expressed and secreted) are secreted by activated platelets and influence multiple cell types and biologic processes. For instance, PF4 inhibits progenitor cell proliferation and angiogenesis, while platelet-derived RANTES is invo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-06-2475

    authors： von Hundelshausen P,Koenen RR,Sack M,Mause SF,Adriaens W,Proudfoot AE,Hackeng TM,Weber C

    更新日期：2005-02-01 00:00:00

  • Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.

    abstract：:The cell-surface expression and the functional status of the CD95/Fas antigen on primitive hematopoietic progenitors (PHPs) freshly isolated from human fetal liver (FL) were studied. PHPs were phenotypically defined as CD34++ CD38 -/+ cells. The most immature subfractions of PHPs, CD34++CD38- and CD34+2CD38+ FL cells,...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bárcena A,Park SW,Banapour B,Muench MO,Mechetner E

    更新日期：1996-09-15 00:00:00

  • Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene.

    abstract：:To screen for point mutations causing protein S deficiency, we used a sequence of techniques specifically for the study of the protein S active gene, PS alpha. This strategy comprises amplification of exons and intron/exon junctions by means of the polymerase chain reaction (PCR) and electrophoresis of the amplified f...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Gandrille S,Borgel D,Eschwege-Gufflet V,Aillaud M,Dreyfus M,Matheron C,Gaussem P,Abgrall JF,Jude B,Sie P

    更新日期：1995-01-01 00:00:00

  • GATA factor mutations in hematologic disease.

    abstract：:GATA family proteins play essential roles in development of many cell types, including hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3, are essential for normal hematopoiesis, and their mutations are responsible for a variety of blood disorders. Acquired and inherited GATA1 ...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2016-09-687889

    authors： Crispino JD,Horwitz MS

    更新日期：2017-04-13 00:00:00

  • A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation.

    abstract：:Idiopathic pneumonia syndrome (IPS) is a major complication after allogeneic bone marrow transplantation (allo-BMT) and involves the infiltration of donor leukocytes and the secretion of inflammatory cytokines. We hypothesized that leukocyte recruitment during IPS is dependent in part upon interactions between chemoki...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-08-2708

    authors： Hildebrandt GC,Duffner UA,Olkiewicz KM,Corrion LA,Willmarth NE,Williams DL,Clouthier SG,Hogaboam CM,Reddy PR,Moore BB,Kuziel WA,Liu C,Yanik G,Cooke KR

    更新日期：2004-03-15 00:00:00

  • HHEX promotes myeloid transformation in cooperation with mutant ASXL1.

    abstract：:Additional sex combs-like 1 (ASXL1), an epigenetic modulator, is frequently mutated in myeloid neoplasms. Recent analyses of mutant ASXL1 conditional knockin (ASXL1-MT-KI) mice suggested that ASXL1-MT alone is insufficient for myeloid transformation. In our previous study, we used retrovirus-mediated insertional mutag...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019004613

    authors： Takeda R,Asada S,Park SJ,Yokoyama A,Becker HJ,Kanai A,Visconte V,Hershberger C,Hayashi Y,Yonezawa T,Tamura M,Fukushima T,Tanaka Y,Fukuyama T,Matsumoto A,Yamasaki S,Nakai K,Yamazaki S,Inaba T,Shibata T,Inoue D,Ho

    更新日期：2020-10-01 00:00:00

  • Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation.

    abstract：:Norovirus (NV) infections are a frequent cause of gastroenteritis (GE), but data on this disease in immunocompromised patients are limited. We analyzed an NV outbreak, which affected immunosuppressed patients in the context of chemotherapy or HSCT. On recognition, 7 days after admission of the index patient, preventiv...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-12-325886

    authors： Schwartz S,Vergoulidou M,Schreier E,Loddenkemper C,Reinwald M,Schmidt-Hieber M,Flegel WA,Thiel E,Schneider T

    更新日期：2011-06-02 00:00:00

  • Isolation and characterization of an acute promyelocytic leukemia cell line selectively resistant to the novel antileukemic and apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid.

    abstract：:6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) is a novel compound that represents the prototype of a new class of synthetic retinoids with apoptogenic properties in acute promyelocytic leukemia (APL) and other types of leukemia. In this article, using SCID mice xenografted with APL-derived NB4 ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ponzanelli I,Giannì M,Giavazzi R,Garofalo A,Nicoletti I,Reichert U,Erba E,Rambaldi A,Terao M,Garattini E

    更新日期：2000-04-15 00:00:00

  • Schistosoma mansoni excretory circulating cathodic antigen shares Lewis-x epitopes with a human granulocyte surface antigen and evokes host antibodies mediating complement-dependent lysis of granulocytes.

    abstract：:Parasitic worms of the genus Schistosoma excrete relatively large amounts of immunogenic glycoproteins (circulating cathodic antigen [CCA]) that contain polysaccharide side chains with the trisaccharide Lewis-x (L(ex)) as a repeating unit. These carbohydrates evoke high titers of specific IgM antibodies that cross-rea...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： van Dam GJ,Claas FH,Yazdanbakhsh M,Kruize YC,van Keulen AC,Ferreira ST,Rotmans JP,Deelder AM

    更新日期：1996-12-01 00:00:00

  • Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.

    abstract：:MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote sel...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2009-06-225573

    authors： Argiropoulos B,Yung E,Xiang P,Lo CY,Kuchenbauer F,Palmqvist L,Reindl C,Heuser M,Sekulovic S,Rosten P,Muranyi A,Goh SL,Featherstone M,Humphries RK

    更新日期：2010-05-20 00:00:00

  • Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.

    abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) is associated with KS, primary effusion lymphoma (PEL), and multicentric Castleman disease. Reactivation of KSHV in latently infected cells and subsequent plasma viremia occur before the development of KS. Intracellular signaling pathways involved in KSHV reactivation were ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v97.8.2374

    authors： Zoeteweij JP,Moses AV,Rinderknecht AS,Davis DA,Overwijk WW,Yarchoan R,Orenstein JM,Blauvelt A

    更新日期：2001-04-15 00:00:00

  • Measurement of basal levels of factor VIIa in hemophilia A and B patients.

    abstract：:Previous results, presented in abstract form, indicate that replacement of thromboplastin with a mixture of phospholipid and truncated soluble tissue factor apoprotein results in a coagulation assay that can directly measure plasma factor VIIa levels without interference from zymogen factor VII (Atherosclerosis Thromb...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Wildgoose P,Nemerson Y,Hansen LL,Nielsen FE,Glazer S,Hedner U

    更新日期：1992-07-01 00:00:00

  • The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment.

    abstract：:Leukocyte recruitment to inflammation sites depends on interactions between integrins and extracellular matrix (ECM). In this report we show that mice lacking the ECM protein mindin exhibit severely impaired recruitment of neutrophils and macrophages in 4 different inflammation models. Furthermore, neutrophils directl...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-04-1658

    authors： Jia W,Li H,He YW

    更新日期：2005-12-01 00:00:00

  • Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.

    abstract：:Plasminogen activation rates are enhanced by cell surface binding. We previously demonstrated that exogenous plasminogen binds to phosphatidylserine-exposing and spread platelets. Platelets contain plasminogen in their α-granules, but secretion of plasminogen from platelets has not been studied. Recently, a novel tran...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2020007263

    authors： Whyte CS,Morrow GB,Baik N,Booth NA,Jalal MM,Parmer RJ,Miles LA,Mutch NJ

    更新日期：2021-01-14 00:00:00

  • Biomarkers for prediction of venous thromboembolism in cancer.

    abstract：:Cancer patients are at increased risk of deep vein thrombosis and pulmonary embolism. The incidence among different groups of cancer patients varies considerably depending on clinical factors, the most important being tumor entity and stage. Biomarkers have been specifically investigated for their capacity of predicti...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2013-04-460147

    authors： Pabinger I,Thaler J,Ay C

    更新日期：2013-09-19 00:00:00

  • The Senegal DNA haplotype is associated with the amelioration of anemia in African-American sickle cell anemia patients.

    abstract：:We have previously determined that in African sickle cell anemia (SS) patients three different beta-like globin gene cluster haplotypes are associated with different percent G gamma (one of the two types of non-alpha chains comprising hemoglobin F [HbF]), mean percent HbF, and percent dense cells. We report now that i...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Nagel RL,Erlingsson S,Fabry ME,Croizat H,Susuka SM,Lachman H,Sutton M,Driscoll C,Bouhassira E,Billett HH

    更新日期：1991-03-15 00:00:00

  • Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling.

    abstract：:In haploidentical transplantation, the mismatched haplotype of the donor can originate from either of the parents. We refer to such mismatched haplotypes as noninherited maternal antigens (NIMA haplotype) or noninherited paternal antigens (NIPA haplotype). To determine whether exposure to maternal HLA antigens benefit...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.5.1572

    authors： van Rood JJ,Loberiza FR Jr,Zhang MJ,Oudshoorn M,Claas F,Cairo MS,Champlin RE,Gale RP,Ringdén O,Hows JM,Horowitz MH

    更新日期：2002-03-01 00:00:00

  • Regulation of human heme oxygenase-1 gene expression under thermal stress.

    abstract：:Heme oxygenase-1 is an essential enzyme in heme catabolism, and its human gene promoter contains a putative heat shock element (HHO-HSE). This study was designed to analyze the regulation of human heme oxygenase-1 gene expression under thermal stress. The amounts of heme oxygenase-1 protein were not increased by heat ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Okinaga S,Takahashi K,Takeda K,Yoshizawa M,Fujita H,Sasaki H,Shibahara S

    更新日期：1996-06-15 00:00:00

  • Adenovirus-mediated intralesional interferon-gamma gene transfer induces tumor regressions in cutaneous lymphomas.

    abstract：:Primary cutaneous lymphomas have been successfully treated with interferons (IFNs), counterbalancing the T-helper 2 (Th2)-skewing state. We undertook a phase 1, open-label, dose-escalating trial of repeated intratumoral administration of TG1042 in patients with advanced primary cutaneous T-cell lymphomas (CTCLs) and m...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2004-01-0360

    authors： Dummer R,Hassel JC,Fellenberg F,Eichmüller S,Maier T,Slos P,Acres B,Bleuzen P,Bataille V,Squiban P,Burg G,Urosevic M

    更新日期：2004-09-15 00:00:00

  • Activating STAT6 mutations in follicular lymphoma.

    abstract：:Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performed whole-exome sequencing of 23 highly purified FL cases and 1 transfo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-06-582650

    authors： Yildiz M,Li H,Bernard D,Amin NA,Ouillette P,Jones S,Saiya-Cork K,Parkin B,Jacobi K,Shedden K,Wang S,Chang AE,Kaminski MS,Malek SN

    更新日期：2015-01-22 00:00:00

  • Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation.

    abstract：:Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; man...

    journal_title：Blood

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Brodsky RA,Sensenbrenner LL,Jones RJ

    更新日期：1996-01-15 00:00:00

  • Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28.

    abstract：:Productive T-cell immunity requires both the activation and the migration of specific T cells to the antigenic tissue. The costimulatory molecule CD28 plays an essential role in the initiation of T-cell-mediated immunity. We investigated the possibility that CD28 may also regulate migration of primed T cells to target...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-10-050724

    authors： Mirenda V,Jarmin SJ,David R,Dyson J,Scott D,Gu Y,Lechler RI,Okkenhaug K,Marelli-Berg FM

    更新日期：2007-04-01 00:00:00

  • Differential expression of cytokines in human blood monocyte subpopulations.

    abstract：:Cytokine expression was analyzed in CD14++ regular monocytes and in the novel subset of CD14+/CD16+ small monocytes. Biologic activity for tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 in the supernatant of elutriator-enriched, cell sorter-purified small monocytes was about 10-fold lower compared with re...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ziegler-Heitbrock HW,Ströbel M,Kieper D,Fingerle G,Schlunck T,Petersmann I,Ellwart J,Blumenstein M,Haas JG

    更新日期：1992-01-15 00:00:00

  • Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011.

    abstract：:The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the Nat...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-07-580498

    authors： Collins PW,Palmer BP,Chalmers EA,Hart DP,Liesner R,Rangarajan S,Talks K,Williams M,Hay CR,UK Haemophilia Centre Doctors’ Organization.

    更新日期：2014-11-27 00:00:00

  • BCL-2 expression correlates with lower proliferative activity in the intermediate- and high-grade non-Hodgkin's lymphomas: an Eastern Cooperative Oncology Group and Southwest Oncology Group cooperative laboratory study.

    abstract：:An inverse relationship between BCL-2 expression and cell cycle transition has been suggested by recent studies in murine models. To investigate the clinical relevance of these laboratory studies, a group of 116 paraffin-embedded non-Hodgkin's lymphoma (NHL) biopsy specimens (Working Formulation Groups D-H, and J) fro...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：

    authors： Winter JN,Andersen J,Reed JC,Krajewski S,Variakojis D,Bauer KD,Fisher RI,Gordon LI,Oken MM,Jiang S,Jeffries D,Domer P

    更新日期：1998-02-15 00:00:00

  • The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells.

    abstract：:The role of hematopoietic growth factors in lineage commitment and differentiation is unclear. We present evidence that heterologous expression of an erythroid specific receptor allows granulocytic differentiation of a myeloid cell line. We have previously characterized a truncation mutant of the erythropoietin recept...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Harris KW,Hu XJ,Schultz S,Arcasoy MO,Forget BG,Clare N

    更新日期：1998-08-15 00:00:00