Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium.

abstract：:Combined deficiency of ankyrin and spectrin represents the most common biochemical abnormality in hereditary spherocytosis (HS). To examine whether a decrease in ankyrin mRNA represents a frequent cause of this type of HS, we took advantage of the reported (AC)n microsatellite polymorphism in the 3' untranslated regio...

journal_title：Blood

authors： Jarolim P,Rubin HL,Brabec V,Palek J

更新日期：1995-06-01 00:00:00

abstract：:Fibrin is essential for hemostasis; however, abnormal fibrin formation is hypothesized to increase thrombotic risk. We previously showed that in situ thrombin generation on a cell's surface modulates the 3-dimensional structure and stability of the fibrin network. Currently, we compared the abilities of extravascular ...

journal_title：Blood

authors： Campbell RA,Overmyer KA,Selzman CH,Sheridan BC,Wolberg AS

更新日期：2009-11-26 00:00:00

abstract：:Type 3 von Willebrand disease (VWD) is a severe hemorrhagic defect in humans. We now identify the homozygous mutation in the Chapel Hill strain of canine type 3 VWD that results in premature termination of von Willebrand factor (VWF) protein synthesis. We cultured endothelium from VWD and normal dogs to study intracel...

journal_title：Blood

authors： Haberichter SL,Merricks EP,Fahs SA,Christopherson PA,Nichols TC,Montgomery RR

更新日期：2005-01-01 00:00:00

abstract：:A microperfusion system containing a glass capillary, the inner surface of which is coated with a phospholipid bilayer containing tissue factor, was used to explore the requirement for factors VIIa and Xa in the complex formed with the lipoprotein-associated coagulation inhibitor (LACI). Various combinations of factor...

journal_title：Blood

authors： Gemmell CH,Broze GJ Jr,Turitto VT,Nemerson Y

更新日期：1990-12-01 00:00:00

abstract：:Current knowledge is inadequate to explain the different patterns of blast cell accumulation in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We compared the growth patterns of blast cell progenitors (CFU-L) in 23 patients with advanced MDS and 32 patients with de novo AML. Circulating blast progen...

journal_title：Blood

authors： Aul C,Gattermann N,Schneider W

更新日期：1992-08-01 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hep...

journal_title：Blood

authors： Pippard MJ,Johnson DK,Finch CA

更新日期：1981-10-01 00:00:00

abstract：:To address the mechanism by which the human globin genes are activated during erythropoiesis, we have used a tiled microarray to analyze the pattern of transcription factor binding and associated histone modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroid cells. This ...

journal_title：Blood

authors： De Gobbi M,Anguita E,Hughes J,Sloane-Stanley JA,Sharpe JA,Koch CM,Dunham I,Gibbons RJ,Wood WG,Higgs DR

更新日期：2007-12-15 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that are highly effective adjuvants for immunizing against pathogens and tumor antigens. The potential merit of genetic approaches to loading DCs with antigens is to express high and sustained levels of proteins that can be subsequently processed and pres...

journal_title：Blood

authors： Dyall J,Latouche JB,Schnell S,Sadelain M

更新日期：2001-01-01 00:00:00

abstract：:The ataxia telangiectasia mutated (ATM)-interacting protein ATMIN mediates noncanonical ATM signaling in response to oxidative and replicative stress conditions. Like ATM, ATMIN can function as a tumor suppressor in the hematopoietic system: deletion of Atmin under the control of CD19-Cre results in B-cell lymphomas i...

journal_title：Blood

authors： Anjos-Afonso F,Loizou JI,Bradburn A,Kanu N,Purewal S,Da Costa C,Bonnet D,Behrens A

更新日期：2016-10-20 00:00:00

abstract：:After invading human red blood cells (RBCs) the malaria parasite Plasmodium falciparum remodels the host cell by trafficking proteins to the RBC compartment. The virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) is responsible for cytoadherence of infected cells to host endothelial receptors. Thi...

journal_title：Blood

authors： Knuepfer E,Rug M,Klonis N,Tilley L,Cowman AF

更新日期：2005-05-15 00:00:00

abstract：:The FOXP1 forkhead transcription factor is targeted by recurrent chromosome translocations in several subtypes of B-cell non-Hodgkin lymphomas, where high-level FOXP1 protein expression has been linked to a poor prognosis. Western blotting studies of diffuse large B-cell lymphoma (DLBCL) cell lines unexpectedly identi...

journal_title：Blood

authors： Brown PJ,Ashe SL,Leich E,Burek C,Barrans S,Fenton JA,Jack AS,Pulford K,Rosenwald A,Banham AH

更新日期：2008-03-01 00:00:00

abstract：:CXC ligand 12 (CXCL12; also known as stromal cell-derived factor 1alpha/SDF-1alpha) chemoattracts hematopoietic stem and progenitor cells (HSCs/HPCs) and is thought to play a crucial role in the mobilization of HSCs/HPCs from the bone marrow. CD26 (dipeptidylpeptidase IV [DPPIV]) is a membrane-bound extracellular pept...

journal_title：Blood

authors： Christopherson KW 2nd,Cooper S,Broxmeyer HE

更新日期：2003-06-15 00:00:00

abstract：:Deletion of Runx1 in adult mice produces a myeloproliferative phenotype. We now find that Runx1 gene deletion increases marrow monocyte while reducing granulocyte progenitors and that exogenous RUNX1 rescues granulopoiesis. Deletion of Runx1 reduces Cebpa mRNA in lineage-negative marrow cells and in granulocyte-monocy...

journal_title：Blood

authors： Guo H,Ma O,Speck NA,Friedman AD

更新日期：2012-05-10 00:00:00

abstract：:Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroid cells not only co...

journal_title：Blood

authors： Zhang DL,Ghosh MC,Ollivierre H,Li Y,Rouault TA

更新日期：2018-11-08 00:00:00

abstract：:Activation of inflammatory and procoagulant mechanisms is thought to contribute significantly to the initiation of restenosis, a common complication after balloon angioplasty of obstructed arteries. During this process, expression of tissue factor (TF) represents one of the major physiologic triggers of coagulation th...

journal_title：Blood

authors： Kopp CW,Hölzenbein T,Steiner S,Marculescu R,Bergmeister H,Seidinger D,Mosberger I,Kaun C,Cejna M,Horvat R,Wojta J,Maurer G,Binder BR,Breuss JM,Ecker RC,de Martin R,Minar E

更新日期：2004-03-01 00:00:00

abstract：:Renal disease has not been considered a major late complication of bone marrow transplantation. Of 31 evaluable pediatric patients undergoing allogeneic or autologous bone marrow transplantation for neuroblastoma or acute lymphoblastic leukemia, 14 developed a hemolytic anemia, microscopic hematuria, and renal insuffi...

journal_title：Blood

authors： Guinan EC,Tarbell NJ,Niemeyer CM,Sallan SE,Weinstein HJ

更新日期：1988-08-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population that shares certain characteristics including an aberrant myeloid phenotype and the ability to suppress T cells. MDSCs have been predominantly studied in malignant diseases and findings suggest involvement in tumor-associated immune suppress...

journal_title：Blood

authors： Jitschin R,Braun M,Büttner M,Dettmer-Wilde K,Bricks J,Berger J,Eckart MJ,Krause SW,Oefner PJ,Le Blanc K,Mackensen A,Mougiakakos D

更新日期：2014-07-31 00:00:00

abstract：:The anti-CD33 antibody calicheamicinconjugate gemtuzumab ozogamicin (GO) was used to treat 16 patients with acute promyelocytic leukemia (APL) who had relapsed at the molecular level. Of these patients, 8 were experiencing a first, 5 a second, 2 a third, and 1 a fourth relapse. GO was administered at 6 mg/m2 for 2 dos...

journal_title：Blood

authors： Lo-Coco F,Cimino G,Breccia M,Noguera NI,Diverio D,Finolezzi E,Pogliani EM,Di Bona E,Micalizzi C,Kropp M,Venditti A,Tafuri A,Mandelli F

更新日期：2004-10-01 00:00:00

abstract：:Intensive leukapheresis has been used as the initial treatment of chronic granulocytic leukemia (CGL) in six patients. The number of leukaphereses ranged from 3 in 7 days to 13 in 39 days (mean, 8 in 22 days). The procedures were well tolerated, and in all patients there was improvement in hematologic values, in most ...

journal_title：Blood

authors： Lowenthal RM,Buskard NA,Goldman JM,Spiers AS,Bergier N,Graubner M,Galton DA

更新日期：1975-12-01 00:00:00

abstract：:It has been shown that in vivo and in vitro treatment with G-CSF induces the generation of low-density granulocytes (LDGs), which copurify with PBMCs and inhibit IFN-gamma production by human T cells. These results prompted us to postulate an immunomodulatory role for LDGs in acute graft-versus-host disease (aGVHD). H...

journal_title：Blood

authors： Vasconcelos ZF,Dos Santos BM,Farache J,Palmeira TS,Areal RB,Cunha JM,Barcinski MA,Bonomo A

更新日期：2006-03-01 00:00:00

abstract：:It is known that at 37 degrees C plasmin may have two opposite effects on platelets: at high concentrations (greater than 1.5 caseinolytic units [CU]/mL), plasmin activates platelets; at lower concentrations (0.1 to 1.0 CU/mL) it inhibits platelet activation induced by thrombin, collagen, or calcium ionophore A23187. ...

journal_title：Blood

authors： Lu H,Soria C,Cramer EM,Soria J,Maclouf J,Perrot JY,Li H,Commin PL,Schumann F,Regnier O

更新日期：1991-03-01 00:00:00

abstract：:An estimated 22 350 patients had multiple myeloma diagnosed in 2013, representing 1.3% of all new cancers; 10 710 deaths are projected, representing 1.8% of cancer deaths. Approximately 0.7% of US men and women will have a myeloma diagnosis in their lifetime, and with advances in therapy, 77 600 US patients are living...

journal_title：Blood

authors： Gertz MA,Dingli D

更新日期：2014-08-07 00:00:00

abstract：:During the inflammatory response, granulocytes and other leukocytes adhere to and emigrate from small venules. Before firm attachment, leukocytes are observed rolling slowly along the endothelium in venules of most tissues accessible to intravital microscopy. The molecular mechanism underlying this early type of leuko...

journal_title：Blood

authors： Ley K,Gaehtgens P,Fennie C,Singer MS,Lasky LA,Rosen SD

更新日期：1991-06-15 00:00:00

abstract：:CCAAT/enhancer binding proteins (C/EBPs) are a family of factors that regulate cell growth and differentiation. These factors, particularly C/EBPalpha and C/EBPepsilon, have important roles in normal myelopoiesis. In addition, loss of C/EBP activity appears to have a role in the pathogenesis of myeloid disorders inclu...

journal_title：Blood

authors： Truong BT,Lee YJ,Lodie TA,Park DJ,Perrotti D,Watanabe N,Koeffler HP,Nakajima H,Tenen DG,Kogan SC

更新日期：2003-02-01 00:00:00

abstract：:To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silencing. Ribosomal pro...

journal_title：Blood

authors： Zhu YX,Yin H,Bruins LA,Shi CX,Jedlowski P,Aziz M,Sereduk C,Kortuem KM,Schmidt JE,Champion M,Braggio E,Keith Stewart A

更新日期：2015-01-15 00:00:00

abstract：:Primary myelofibrosis (PMF) is the most serious myeloproliferative disorder, characterized by clonal myeloproliferation associated with cytokine-mediated bone marrow stromal reaction including fibrosis and osteosclerosis. Current drug therapy remains mainly palliative. Because the NF-kappaB pathway is implicated in th...

journal_title：Blood

authors： Wagner-Ballon O,Pisani DF,Gastinne T,Tulliez M,Chaligné R,Lacout C,Auradé F,Villeval JL,Gonin P,Vainchenker W,Giraudier S

更新日期：2007-07-01 00:00:00

abstract：:Several transgenic murine models for sickle cell anemia have been developed that closely reproduce the biochemical and physiological disorders in the human disease. A comprehensive characterization is described of hematologic parameters of mature red blood cells, reticulocytes, and red cell precursors in the bone marr...

journal_title：Blood

authors： de Jong K,Emerson RK,Butler J,Bastacky J,Mohandas N,Kuypers FA

更新日期：2001-09-01 00:00:00

abstract：:Inflammatory responses represent a hallmark of numerous pathologies including sepsis, bacterial infection, insulin resistance, and malign obesity. Here we describe an unexpected coactivator function for the nuclear receptor interacting protein 140 (RIP140) for nuclear factor kappaB (NFkappaB), a master transcriptional...

journal_title：Blood

authors： Zschiedrich I,Hardeland U,Krones-Herzig A,Berriel Diaz M,Vegiopoulos A,Müggenburg J,Sombroek D,Hofmann TG,Zawatzky R,Yu X,Gretz N,Christian M,White R,Parker MG,Herzig S

更新日期：2008-07-15 00:00:00

abstract：:Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B...

journal_title：Blood

authors： Merkenschlager J,Eksmond U,Danelli L,Attig J,Young GR,Nowosad C,Tolar P,Kassiotis G

更新日期：2019-03-07 00:00:00