Abstract:
:Several transgenic murine models for sickle cell anemia have been developed that closely reproduce the biochemical and physiological disorders in the human disease. A comprehensive characterization is described of hematologic parameters of mature red blood cells, reticulocytes, and red cell precursors in the bone marrow and spleen of a murine sickle cell model in which erythroid cells expressed exclusively human alpha, gamma, and betaS globin. Red cell survival was dramatically decreased in these anemic animals, partially compensated by considerable enhancement in erythropoietic activity. As in humans, these murine sickle cells contain a subpopulation of phosphatidylserine-exposing cells that may play a role in their premature removal. Continuous in vivo generation of this phosphatidylserine-exposing subset may have a significant impact on the pathophysiology of sickle cell disease.
journal_name
Bloodjournal_title
Bloodauthors
de Jong K,Emerson RK,Butler J,Bastacky J,Mohandas N,Kuypers FAdoi
10.1182/blood.v98.5.1577subject
Has Abstractpub_date
2001-09-01 00:00:00pages
1577-84issue
5eissn
0006-4971issn
1528-0020journal_volume
98pub_type
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