Rapid prenatal diagnosis of beta thalassemia using DNA amplification and nonradioactive probes.

abstract：:Among the most striking morphological features of acute nonlymphoblastic leukemias (ANLL) is the occurrence of eosinophilic cytoplasmic inclusions known as Auer rods on Auer bodies. We examined immature myeloid cells from the peripheral blood of 9 human fetuses of 16-19 wk gestation for the presence of such structures...

journal_title：Blood

authors： Newburger PE,Novak TJ,McCaffrey RP

更新日期：1983-03-01 00:00:00

abstract：:We prospectively evaluated 169 patients with a number of screening studies performed between 71 to 121 days after allogeneic marrow transplantation to detect the development of chronic graft-versus-host disease (GVHD). Group 1 patients (n = 78) were asymptomatic and had normal physical examinations at the time of scre...

journal_title：Blood

authors： Loughran TP Jr,Sullivan K,Morton T,Beckham C,Schubert M,Witherspoon R,Sale G,Sanders J,Fisher L,Shulman H

更新日期：1990-07-01 00:00:00

abstract：:To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silencing. Ribosomal pro...

journal_title：Blood

authors： Zhu YX,Yin H,Bruins LA,Shi CX,Jedlowski P,Aziz M,Sereduk C,Kortuem KM,Schmidt JE,Champion M,Braggio E,Keith Stewart A

更新日期：2015-01-15 00:00:00

abstract：:Anemia is a common clinical problem, and there is much interest in its role in promoting left ventricular hypertrophy through increasing cardiac workload. Normally, red blood cell production is adjusted through the regulation of erythropoietin (Epo) production by the kidney. One important cause of anemia is relative d...

journal_title：Blood

authors： Binley K,Askham Z,Iqball S,Spearman H,Martin L,de Alwis M,Thrasher AJ,Ali RR,Maxwell PH,Kingsman S,Naylor S

更新日期：2002-10-01 00:00:00

abstract：:The c-myb proto-oncogene has been implicated in leukemogenesis, but possible mechanisms remain ill defined. To gain further insight to this process, we used transcript profiling in K562 cells expressing a dominant-negative Myb (MERT) protein. A total of 105 potential Myb gene targets were identified. Neuromedin U (NmU...

journal_title：Blood

authors： Shetzline SE,Rallapalli R,Dowd KJ,Zou S,Nakata Y,Swider CR,Kalota A,Choi JK,Gewirtz AM

更新日期：2004-09-15 00:00:00

abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

journal_title：Blood

authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

更新日期：2007-05-15 00:00:00

abstract：:R115777 is a potent farnesyltransferase (FTase) inhibitor with substantial antitumor activity in preclinical models. We conducted a phase 1 study (3 + 3 design) of R115777 in patients with myelodysplastic syndrome (MDS). R115777 was administered twice daily (3-weeks-on/1-week-off schedule for 8 weeks) (starting dosage...

journal_title：Blood

authors： Kurzrock R,Kantarjian HM,Cortes JE,Singhania N,Thomas DA,Wilson EF,Wright JJ,Freireich EJ,Talpaz M,Sebti SM

更新日期：2003-12-15 00:00:00

abstract：:Human umbilical vein endothelial cells were analyzed for the presence of prothrombin, factor VII, protein C, and protein S in culture supernatants and cell extracts using specific radioimmunoassays. Only protein S was detected. Conditioned medium from 24-hour cultures and cell lysates contained 21.7 ng/mL and 88.8 ng/...

journal_title：Blood

authors： Fair DS,Marlar RA,Levin EG

更新日期：1986-04-01 00:00:00

abstract：:Seventy-one patients with acute myeloid leukemia (AML), most of them (63/71) considered ineligible for conventional allogeneic hematopoietic stem cell transplantation (HSCT), were enrolled into a phase 2 study on reduced-intensity myeloablative conditioning with fractionated 8-Gy total body irradiation (TBI) and fluda...

journal_title：Blood

authors： Stelljes M,Bornhauser M,Kroger M,Beyer J,Sauerland MC,Heinecke A,Berning B,Scheffold C,Silling G,Buchner T,Neubauer A,Fauser AA,Ehninger G,Berdel WE,Kienast J,Cooperative German Transplant Study Group.

更新日期：2005-11-01 00:00:00

abstract：:Using a polyclonal antiserum against canine CD34, we previously found that CD34 is expressed on canine bone marrow progenitor cells in a manner analogous to that found in humans. To further characterize CD34+ cells and to facilitate preclinical canine stem cell transplant studies, monoclonal antibodies (MoAbs) were ra...

journal_title：Blood

authors： McSweeney PA,Rouleau KA,Wallace PM,Bruno B,Andrews RG,Krizanac-Bengez L,Sandmaier BM,Storb R,Wayner E,Nash RA

更新日期：1998-03-15 00:00:00

abstract：:NF-IL6 was originally identified as a DNA binding protein regulating interleukin-1 (IL-1)-stimulated IL-6 expression. Direct cloning of NF-IL6 showed its homology with C/EBP, a hepatocyte- and adipocyte-specific transcription factor. This study showed that the expression of NF-IL6 messenger RNA (mRNA) increased marked...

journal_title：Blood

authors： Natsuka S,Akira S,Nishio Y,Hashimoto S,Sugita T,Isshiki H,Kishimoto T

更新日期：1992-01-15 00:00:00

abstract：:Here we report that a new nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse line harboring a complete null mutation of the common cytokine receptor gamma chain (NOD/SCID/interleukin 2 receptor [IL2r] gamma(null)) efficiently supports development of functional human hemato-lymphopoiesis. Purified human...

journal_title：Blood

authors： Ishikawa F,Yasukawa M,Lyons B,Yoshida S,Miyamoto T,Yoshimoto G,Watanabe T,Akashi K,Shultz LD,Harada M

更新日期：2005-09-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) is able to detect the increase of adipocytes in the hematopoietic bone marrow that occurs as a consequence of radiotherapy and is indicative of the loss of myeloid tissue. By monitoring this process, it is also possible to determine the recovery of the bone marrow. The amount of viable...

journal_title：Blood

authors： Casamassima F,Ruggiero C,Caramella D,Tinacci E,Villari N,Ruggiero M

更新日期：1989-05-01 00:00:00

abstract：:ADAMTS13 proteolytically regulates the platelet-tethering function of von Willebrand factor (VWF). ADAMTS13 function is dependent upon multiple exosites that specifically bind the unraveled VWF A2 domain and enable proteolysis. We carried out a comprehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich)...

journal_title：Blood

authors： de Groot R,Lane DA,Crawley JT

更新日期：2015-03-19 00:00:00

abstract：:Fifty-four patients with severe aplastic anemia were treated with horse anti-human thymocyte globulin (ATG) and androgens. Thirty of these patients also received an infusion of HLA-haploidentical marrow cells. Only those patients having evidence of hematologic recovery within 3 mo after ATG therapy were considered res...

journal_title：Blood

authors： Doney K,Dahlberg SJ,Monroe D,Storb R,Buckner CD,Thomas ED

更新日期：1984-02-01 00:00:00

abstract：:Activated ras genes are often associated with human myeloid leukemias with a monocytic differentiated phenotype. To investigate the role of the activated ras gene in leukemogenesis, a myeloid nontumorigenic cell line (FDC-P1) was infected with a selectable retroviral vector carrying the v-Ha-ras gene (H1neo). Infected...

journal_title：Blood

authors： Hibi S,Löhler J,Friel J,Stocking C,Ostertag W

更新日期：1993-04-01 00:00:00

abstract：:Families with 3 different syndromes characterized by autosomal dominant inheritance of low platelet count and giant platelets were studied. Fechtner syndrome is an autosomal-dominant variant of Alport syndrome manifested by nephritis, sensorineural hearing loss, and cataract formation in addition to macrothrombocytope...

journal_title：Blood

authors： Toren A,Rozenfeld-Granot G,Rocca B,Epstein CJ,Amariglio N,Laghi F,Landolfi R,Brok-Simoni F,Carlsson LE,Rechavi G,Greinacher A

更新日期：2000-11-15 00:00:00

abstract：:The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological end points of hemorrhage or thrombosis with vessel occlusion. However, fibrin(ogen) and proteases controlling its deposition and clearance, including (pro)thro...

journal_title：Blood

authors： Luyendyk JP,Schoenecker JG,Flick MJ

更新日期：2019-02-07 00:00:00

abstract：:Keratinocyte growth factor (KGF) is important in tissue repair and wound healing and its administration can abrogate chemical- and radiation-induced tissue damage in rodents. We investigated KGF as a therapeutic agent for the prevention of graft-versus-host disease (GVHD)-induced tissue damage, morbidity, and mortalit...

journal_title：Blood

authors： Panoskaltsis-Mortari A,Lacey DL,Vallera DA,Blazar BR

更新日期：1998-11-15 00:00:00

abstract：:Sickle red blood cells (RBC) become dehydrated as a consequence of potassium loss. This process depends at least partly on deoxygenation and may be influenced by the presence of oxygenation/deoxygenation cycles and the frequency of cycling. In this study, sickle RBC were subjected to approximately 180 oxygenation/deox...

journal_title：Blood

authors： McGoron AJ,Joiner CH,Palascak MB,Claussen WJ,Franco RS

更新日期：2000-03-15 00:00:00

abstract：:Notch signaling pathway regulates many different events of embryonic and adult development; among them, Notch plays an essential role in the onset of hematopoietic stem cells and influences multiple maturation steps of developing lymphoid and myeloid cells. Deregulation of Notch signaling determines several human diso...

journal_title：Blood

authors： Nwabo Kamdje AH,Krampera M

更新日期：2011-12-15 00:00:00

abstract：:We conducted a multicenter trial of treatment with all-trans retinoic acid (ATRA) for newly diagnosed acute promyelocytic leukemia (APL) in the AML-92 study and compared it with our previous study with standard intensive chemotherapy, the AML-89 study, in the view of complete remission (CR) rate, incidence of early de...

journal_title：Blood

authors： Kanamaru A,Takemoto Y,Tanimoto M,Murakami H,Asou N,Kobayashi T,Kuriyama K,Ohmoto E,Sakamaki H,Tsubaki K

更新日期：1995-03-01 00:00:00

abstract：:The 5-lipoxygenase (5-LO) pathway in human CD34(+) hematopoietic progenitor cells, which were induced to differentiate into dendritic cells (DCs) by cytokines in vitro and in DCs of lymphoid tissues in situ, was examined. Extracts prepared from HPCs contained low levels of 5-LO or 5-LO-activating protein. Granulocyte-...

journal_title：Blood

authors： Spanbroek R,Hildner M,Steinhilber D,Fusenig N,Yoneda K,Rådmark O,Samuelsson B,Habenicht AJ

更新日期：2000-12-01 00:00:00

abstract：:Beside its classical role in the coagulation cascade, coagulation factor X (FX) is involved in several major biological processes including inflammation and enhancement of virus-induced immune responses. We recently reported that the long circulatory half-life of FX is linked to its interaction with liver-resident mac...

journal_title：Blood

authors： Muczynski V,Bazaa A,Loubière C,Harel A,Cherel G,Denis CV,Lenting PJ,Christophe OD

更新日期：2016-02-11 00:00:00

abstract：:Erythroblastic synartesis is a rare form of acquired dyserythropoiesis, first described by Breton-Gorius et al in 1973. This syndrome is characterized by the presence of septate-like membrane junctions and "glove finger" invaginations between erythroblasts, which are very tightly linked together. This phenomenon, resp...

journal_title：Blood

authors： Cramer EM,Garcia I,Massé JM,Zini JM,Lambin P,Oksenhendler E,Souni F,Smith M,Flandrin G,Breton-Gorius J,Tobelem G,Casadevall N

更新日期：1999-12-01 00:00:00

abstract：:Uncontrolled activation of the complement system against endothelial and blood cells is central to the pathogenesis of atypical hemolytic uremic syndrome (aHUS). aHUS patients frequently carry mutations in the inhibitory complement regulator factor H (FH). Mutations cluster in domains 19 and 20 (FH19-20), which are cr...

journal_title：Blood

authors： Hyvärinen S,Meri S,Jokiranta TS

更新日期：2016-06-02 00:00:00

abstract：:During ontogeny, the transcription factor RUNX1 governs the emergence of definitive hematopoietic cells from specialized endothelial cells called hemogenic endothelium (HE). The ultimate consequence of this endothelial-to-hematopoietic transition is the concomitant activation of the hematopoietic program and downregul...

journal_title：Blood

authors： Lie-A-Ling M,Marinopoulou E,Li Y,Patel R,Stefanska M,Bonifer C,Miller C,Kouskoff V,Lacaud G

更新日期：2014-09-11 00:00:00

abstract：:Annexin V has phospholipid-binding capacity and plays a potent antithrombotic role. Recently, a C to T transition has been described in the Kozak region of this gene, affecting the nucleotide preceding the initiation ATG codon. We have developed a simple method to detect this genetic change, showing by analysis of 580...

journal_title：Blood

authors： González-Conejero R,Corral J,Roldán V,Martínez C,Marín F,Rivera J,Iniesta JA,Lozano ML,Marco P,Vicente V

更新日期：2002-09-15 00:00:00

abstract：:Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor. We hypothesized that having a higher mtDNA copy number in peripheral white blood ce...

journal_title：Blood

authors： Lan Q,Lim U,Liu CS,Weinstein SJ,Chanock S,Bonner MR,Virtamo J,Albanes D,Rothman N

更新日期：2008-11-15 00:00:00

abstract：:Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma). Although there is some knowledge about molecular mechanisms that induce IFN-gamma in NK cells, considerably less is known about the mechanisms that reduce its expression. Here, w...

journal_title：Blood

authors： Becknell B,Hughes TL,Freud AG,Blaser BW,Yu J,Trotta R,Mao HC,Caligiuri de Jesús ML,Alghothani M,Benson DM Jr,Lehman A,Jarjoura D,Perrotti D,Bates MD,Caligiuri MA

更新日期：2007-03-15 00:00:00