2-Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T-cell lymphoma.

abstract：:In this issue of Blood, Donadieu et al present what may be the most encouraging data to date on a group of patients with Langerhans cell histiocytosis (LCH), which historically has poor disease-free survival and poor overall survival. ...

journal_title：Blood

authors： Stine KC

更新日期：2015-09-17 00:00:00

abstract：:Omenn syndrome (OS) is an inherited disorder characterized by an absence of circulating B cells and an infiltration of the skin and the intestine by activated oligoclonal T lymphocytes, indicating that a profound defect in the lymphoid developmental program could be accountable for this condition. Inherited mutations ...

journal_title：Blood

authors： Corneo B,Moshous D,Güngör T,Wulffraat N,Philippet P,Le Deist FL,Fischer A,de Villartay JP

更新日期：2001-05-01 00:00:00

abstract：:Altered expression of the Fas-Fas ligand apoptotic pathway leads to lymphoproliferative and autoimmune diseases. In lpr/lpr mice and children with autoimmune lymphoproliferative syndrome, defective apoptosis is due to Fas mutations. Large granular lymphocyte (LGL) leukemia is a clonal lymphoproliferative disorder asso...

journal_title：Blood

authors： Liu JH,Wei S,Lamy T,Li Y,Epling-Burnette PK,Djeu JY,Loughran TP Jr

更新日期：2002-08-15 00:00:00

abstract：:Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs). We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarc...

journal_title：Blood

authors： Massa M,Rosti V,Ferrario M,Campanelli R,Ramajoli I,Rosso R,De Ferrari GM,Ferlini M,Goffredo L,Bertoletti A,Klersy C,Pecci A,Moratti R,Tavazzi L

更新日期：2005-01-01 00:00:00

abstract：:Eleven of twenty-four patients with severe aplastic anemia given marrow grafts from HLA-identical siblings between October 1970 and March 1973 are alive with normal marrow function and continued evidence of engraftment 3-5 yr later. Ten have been leading normal lives with no immunosuppressive or other drug therapy sin...

journal_title：Blood

authors： Storb R,Thomas ED,Buckner CD,Clift RA,Fefer A,Fernando LP,Giblett ER,Johnson FL,Neiman PE

更新日期：1976-10-01 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which th...

journal_title：Blood

authors： Sachs UJ,Hattar K,Weissmann N,Bohle RM,Weiss T,Sibelius U,Bux J

更新日期：2006-02-01 00:00:00

abstract：:The costimulatory effects of CD27 on T lymphocyte effector function and memory formation has been confined to evaluations in mouse models, in vitro human cell culture systems, and clinical observations. Here, we tested whether CD27 costimulation actively enhances human T-cell function, expansion, and survival in vitro...

journal_title：Blood

authors： Song DG,Ye Q,Poussin M,Harms GM,Figini M,Powell DJ Jr

更新日期：2012-01-19 00:00:00

abstract：:The platelet release reaction plays a critical role in thrombosis and contributes to the events that follow hemostasis. Previous studies have shown that platelet secretion is mediated by Soluble NSF Attachment Protein Receptor (SNARE) proteins from granule and plasma membranes. The SNAREs form transmembrane complexes ...

journal_title：Blood

authors： Ye S,Karim ZA,Al Hawas R,Pessin JE,Filipovich AH,Whiteheart SW

更新日期：2012-09-20 00:00:00

abstract：:Autologous T cells targeting Epstein-Barr virus (EBV) latent membrane proteins (LMPs) have shown safety and efficacy in the treatment of patients with type 2 latency EBV-associated lymphomas for whom standard therapies have failed, including high-dose chemotherapy followed by autologous stem-cell rescue. However, the ...

journal_title：Blood

authors： McLaughlin LP,Rouce R,Gottschalk S,Torrano V,Carrum G,Wu MF,Hoq F,Grilley B,Marcogliese AM,Hanley PJ,Gee AP,Brenner MK,Rooney CM,Heslop HE,Bollard CM

更新日期：2018-11-29 00:00:00

abstract：:The ultrastructure of the lymphocytes from three children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53%, 41%, and 13%) in three SCID patients when compared to age-matched controls. The size of these incl...

journal_title：Blood

authors： Payne CM,Jones JF,Sieber OF Jr,Fulginiti VA

更新日期：1977-07-01 00:00:00

abstract：:Patients referred to tertiary care centers occasionally may have their diagnostic procedures repeated and have a final diagnosis that differs from that of the referring center. The aim of this study was to evaluate discordance rates and their clinical implications in the diagnosis of patients with myelodysplastic synd...

journal_title：Blood

authors： Naqvi K,Jabbour E,Bueso-Ramos C,Pierce S,Borthakur G,Estrov Z,Ravandi F,Faderl S,Kantarjian H,Garcia-Manero G

更新日期：2011-10-27 00:00:00

abstract：:Infection with human T-cell leukemia virus type II (HTLV-II) has been associated with rare chronic T-cell malignancies and has recently been demonstrated in a significant proportion of American intravenous drug abusers (IVDA). Identification of an HTLV-II-infected cohort of IVDA has allowed analysis of the HTLV-II car...

journal_title：Blood

authors： Rosenblatt JD,Plaeger-Marshall S,Giorgi JV,Swanson P,Chen IS,Chin E,Wang HJ,Canavaggio M,Hausner MA,Black AC

更新日期：1990-07-15 00:00:00

abstract：:In 21 patients with lymphoproliferative disease of granular lymphocytes (LDGL), we investigated the expression and the function of molecules belonging to TNF-receptor and TNF-ligand superfamilies (CD30/CD30L; CD40/CD40L; CD27/CD70; Fas [CD95]/FasL[CD95L]). Fourteen patients were characterized by a proliferation of gra...

journal_title：Blood

authors： Zambello R,Trentin L,Facco M,Siviero M,Galvan S,Piazza F,Perin A,Agostini C,Semenzato G

更新日期：2000-07-15 00:00:00

abstract：:Twenty-six patients with progressive Hodgkin's disease after conventional chemotherapy received intensive chemoradiotherapy and autologous bone marrow transplantation (ABMT); 19 also received additional involved-field radiotherapy. Twenty-one patients [81%, 95% confidence intervals (CI) 61% to 94%] attained complete (...

journal_title：Blood

authors： Phillips GL,Wolff SN,Herzig RH,Lazarus HM,Fay JW,Lin HS,Shina DC,Glasgow GP,Griffith RC,Lamb CW

更新日期：1989-06-01 00:00:00

abstract：:Fifty-eight acute promyelocytic leukemia (APL) patients (11 newly diagnosed and 47 relapsed) were studied for arsenic trioxide (As2O3) treatment. Clinical complete remission (CR) was obtained in 8 of 11 (72.7%) newly diagnosed cases. However, As2O3 treatment resulted in hepatic toxicity in 7 cases including 2 deaths, ...

journal_title：Blood

authors： Niu C,Yan H,Yu T,Sun HP,Liu JX,Li XS,Wu W,Zhang FQ,Chen Y,Zhou L,Li JM,Zeng XY,Yang RR,Yuan MM,Ren MY,Gu FY,Cao Q,Gu BW,Su XY,Chen GQ,Xiong SM,Zhang TD,Waxman S,Wang ZY,Chen Z,Hu J,Shen ZX,Chen SJ

更新日期：1999-11-15 00:00:00

abstract：:The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of defective immune cells through an unknown mechanism. A likely candid...

journal_title：Blood

authors： Annunziata CM,Safiran YJ,Irving SG,Kasid UN,Cossman J

更新日期：2000-10-15 00:00:00

abstract：:We have generated a large, unique database that includes morphologic, clinical, cytogenetic, and follow-up data from 2124 patients with myelodysplastic syndromes (MDSs) at 4 institutions in Austria and 4 in Germany. Cytogenetic analyses were successfully performed in 2072 (97.6%) patients, revealing clonal abnormaliti...

journal_title：Blood

authors： Haase D,Germing U,Schanz J,Pfeilstöcker M,Nösslinger T,Hildebrandt B,Kundgen A,Lübbert M,Kunzmann R,Giagounidis AA,Aul C,Trümper L,Krieger O,Stauder R,Müller TH,Wimazal F,Valent P,Fonatsch C,Steidl C

更新日期：2007-12-15 00:00:00

abstract：:beta and gamma T cell receptor (TCR) gene configuration was studied in 12 patients with large granular lymphocyte T cell leukemia (LGL-leukemia). Both genes were found rearranged in ten cases. In the remaining two patients TCR beta was found in germline configuration. In one of them rearrangement of T cell-rearranging...

journal_title：Blood

authors： Foroni L,Matutes E,Foldi J,Morilla R,Rabbitts T,Luzzatto L,Catovsky D

更新日期：1988-02-01 00:00:00

abstract：:CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-...

journal_title：Blood

authors： Wei S,Kryczek I,Zou W

更新日期：2006-07-15 00:00:00

abstract：:In this issue of Blood, Pagel et al carefully deliniate some fascinating phenotype/genotype correlations in a larger cohort than in their earlier reports of familial hemophagocytic lymphohistiocytosis (HLH). ...

journal_title：Blood

authors： McClain KL

更新日期：2012-06-21 00:00:00

abstract：:The human immunodeficiency virus (HIV) causes impairment of the immune system in part by targeting CD4(+) T cells for infection and dysfunction. HIV envelope (Env) present on free virions and infected cells causes dysfunction of uninfected bystander CD4(+) T cells via interaction with both CD4 and coreceptors. Env is ...

journal_title：Blood

authors： Fernando K,Hu H,Ni H,Hoxie JA,Weissman D

更新日期：2007-03-15 00:00:00

abstract：:The developmental relationship between the blood and endothelial cell (EC) lineages remains unclear. In the extra-embryonic blood islands of birds and mammals, ECs and blood cells are closely intermixed, and blood island precursor cells in the primitive streak express many of the same molecular markers, leading to the...

journal_title：Blood

authors： Myers CT,Krieg PA

更新日期：2013-12-05 00:00:00

abstract：:The cytokine interleukin-10 (IL-10) has been implicated in the pathogenesis of a number of disease states, including Epstein-Barr virus and human immunodeficiency virus (HIV-1) infections. In the acquired immunodeficiency syndrome (AIDS), it has been suggested that IL-10 may have a deleterious effect by suppressing ce...

journal_title：Blood

authors： Saville MW,Taga K,Foli A,Broder S,Tosato G,Yarchoan R

更新日期：1994-06-15 00:00:00

abstract：:In an effort to develop a clinically useful approach to overcoming P-glycoprotein-mediated multidrug resistance (MDR1), we evaluated combined chemosensitization with verapamil and quinine in a multidrug-resistant (MDR) human myeloma cell line model. In clonogenic assay, verapamil was used at concentrations from 0.1 to...

journal_title：Blood

authors： Lehnert M,Dalton WS,Roe D,Emerson S,Salmon SE

更新日期：1991-01-15 00:00:00

abstract：:HTLV-II has been found in some cases of the rare T-cell form of hairy-cell leukemia (HCL) and in a leukopenic chronic T-cell leukemia mimicking HCL. We asked whether the virus is implicated in the more frequent B-cell form of HCL. DNA extracted from the mononuclear cells derived from spleen (eight cases) or peripheral...

journal_title：Blood

authors： Lion T,Razvi N,Golomb HM,Brownstein RH

更新日期：1988-10-01 00:00:00

abstract：:Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of inducing differentiation or proliferation in nonhematopoietic c...

journal_title：Blood

authors： Melemed AS,Ryder JW,Vik TA

更新日期：1997-11-01 00:00:00

abstract：:Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA a...

journal_title：Blood

authors： Sekyere EO,Dunn LL,Suryo Rahmanto Y,Richardson DR

更新日期：2006-04-01 00:00:00

abstract：:One hundred twenty-five cases of Hodgkin's disease from the United States (79), Mexico City (31), and Costa Rica (15) were analyzed for the presence of Epstein-Barr virus (EBV) by in situ hybridization to EBER1 transcripts. EBV was more frequently detected in the Reed-Sternberg (RS) cells of mixed cellularity Hodgkin'...

journal_title：Blood

authors： Gulley ML,Eagan PA,Quintanilla-Martinez L,Picado AL,Smir BN,Childs C,Dunn CD,Craig FE,Williams JW Jr,Banks PM

更新日期：1994-03-15 00:00:00

abstract：:We made a disease-specific comparison of unrelated cord blood (CB) recipients and human leukocyte antigen allele-matched unrelated bone marrow (BM) recipients among 484 patients with acute myeloid leukemia (AML; 173 CB and 311 BM) and 336 patients with acute lymphoblastic leukemia (ALL; 114 CB and 222 BM) who received...

journal_title：Blood

authors： Atsuta Y,Suzuki R,Nagamura-Inoue T,Taniguchi S,Takahashi S,Kai S,Sakamaki H,Kouzai Y,Kasai M,Fukuda T,Azuma H,Takanashi M,Okamoto S,Tsuchida M,Kawa K,Morishima Y,Kodera Y,Kato S,Japan Cord Blood Bank Network.

更新日期：2009-02-19 00:00:00

abstract：:The BCL1 lymphoma in Balb/c mice can be successfully treated with bispecific (anti-CD3 x anti-idiotype) antibodies (BSABs). In these experiments, animals were injected intraperitoneally (IP) with 5 x 10(3) tumor cells (day 0) and treated with one single intravenous (IV) injection of 5 micrograms BSAB (day 9). Because ...

journal_title：Blood

authors： Demanet C,Brissinck J,De Jonge J,Thielemans K

更新日期：1996-05-15 00:00:00