A clinical, hematologic, and immunologic analysis of 21 HTLV-II-infected intravenous drug users.

abstract：:Sequencing the complete factor IX gene of 2 sisters with hemophilia B with different phenotypes and no family history of hemorrhagic diathesis revealed a common 5' splice site mutation in intron 3 (T6704C) in both and an additional missense mutation (I344T) in one. The presence of dysfunctional antigen in the latter s...

journal_title：Blood

authors： Costa JM,Vidaud D,Laurendeau I,Vidaud M,Fressinaud E,Moisan JP,David A,Meyer D,Lavergne JM

更新日期：2000-08-15 00:00:00

abstract：:The blockade of platelet integrin glycoprotein (GP) IIb/IIIa is a promising new antiplatelet strategy. The binding of ligands or of the ligand-mimetic peptide RGD causes a conformational change of GP IIb/IIIa from the nonactivated to the activated state. Because several blocking agents/inhibitors are ligand-mimetics, ...

journal_title：Blood

authors： Peter K,Schwarz M,Ylänne J,Kohler B,Moser M,Nordt T,Salbach P,Kübler W,Bode C

更新日期：1998-11-01 00:00:00

abstract：:Using a recently described serum-free culture system of purified human CD34+ progenitor cells, we show here a critical cooperation of flt3 ligand (FL) with transforming growth factor-beta1 (TGF-beta1) in the induction of in vitro dendritic cell/Langerhans cell (DC/LC) development. The addition of FL to serum-free cult...

journal_title：Blood

authors： Strobl H,Bello-Fernandez C,Riedl E,Pickl WF,Majdic O,Lyman SD,Knapp W

更新日期：1997-08-15 00:00:00

abstract：:To evaluate the importance of the thymus for the reconstitution of immunity in recipients of a T-cell-depleted bone marrow, we measured the appearance of CD4(+)CD45RA(+)RO(-) naive T cells (thymic rebound), restoration of the diversity of the T-cell-receptor (TCR) repertoire and the response to vaccinations with tetan...

journal_title：Blood

authors： Roux E,Dumont-Girard F,Starobinski M,Siegrist CA,Helg C,Chapuis B,Roosnek E

更新日期：2000-09-15 00:00:00

abstract：:Dendritic cells (DC) are highly efficient antigen-presenting cells (APC) that have an essential function in the development of immune responses against microbial pathogens and tumors. Although during the past few years our understanding of DC biology has remarkably increased, a precise characterization of the differen...

journal_title：Blood

authors： Anjuère F,Martín P,Ferrero I,Fraga ML,del Hoyo GM,Wright N,Ardavín C

更新日期：1999-01-15 00:00:00

abstract：:The unique t(15;17) of acute promyelocytic leukemia (APL) fuses the PML gene with the retinoic acid receptor alpha (RAR alpha) gene. Although retinoic acid (RA) inhibits cell growth and induces differentiation in human APL cells, resistance to RA develops both in vitro and in patients. We have developed RA-resistant s...

journal_title：Blood

authors： Shao W,Benedetti L,Lamph WW,Nervi C,Miller WH Jr

更新日期：1997-06-15 00:00:00

abstract：:Purified T lymphocytes (E rosetting cells) isolated from the involved lymphoid organs (lymph nodes and spleen) of five patients with Hodgkin's disease (HD) were cloned under culture conditions (phytohemagglutinin plus interleukin-2) that allow clonal expansion of most T lymphocytes. A total number of 104 CD4+ T cell c...

journal_title：Blood

authors： Maggi E,Parronchi P,Macchia D,Bellesi G,Romagnani S

更新日期：1988-05-01 00:00:00

abstract：:Hemophiliac patients with chronic hepatitis C might be exposed to and become infected with multiple hepatitis C virus (HCV) strains by means of frequent use of blood products, even if they are infected with a single subtype of HCV. To test this hypothesis, we analyzed the genetic diversity of hypervariable region 1 (H...

journal_title：Blood

authors： Toyoda H,Fukuda Y,Koyama Y,Nakano I,Kinoshita M,Hadama T,Takamatsu J,Hayakawa T

更新日期：1996-08-15 00:00:00

abstract：:Cell cycle checkpoints ensure orderly progression of events during cell division. A microtubule damage (MTD)-induced checkpoint has been described in G(1) phase of the cell cycle (G(1)MTC) for which little is known. The present study shows that the G(1)MTC is intact in activated T lymphocytes from mice with the p21(wa...

journal_title：Blood

authors： Mantel CR,Braun SE,Lee Y,Kim YJ,Broxmeyer HE

更新日期：2001-03-01 00:00:00

abstract：:Five novel monoclonal antibodies (mAbs; p0p 1-5) were used to characterize the structural and functional properties and the in vivo expression of the murine GPIb-IX complex (von Willebrand factor receptor). The molecular weights of the subunits are similar to the human homologs: GPIbalpha (150 kd), GPIbbeta (25 kd), a...

journal_title：Blood

authors： Bergmeier W,Rackebrandt K,Schröder W,Zirngibl H,Nieswandt B

更新日期：2000-02-01 00:00:00

abstract：:Fibrinogen was isolated from the plasma of a 25-year-old female with a history of mild bleeding and several recent moderate to severe hemorrhagic episodes. Coagulability with thrombin approached 100% and varied directly with the time of incubation with the enzyme. High-performance liquid chromatography analysis of thr...

journal_title：Blood

authors： Siebenlist KR,Prchal JT,Mosesson MW

更新日期：1988-03-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but responses are usually partial and short-li...

journal_title：Blood

authors： Gupta M,Hendrickson AE,Yun SS,Han JJ,Schneider PA,Koh BD,Stenson MJ,Wellik LE,Shing JC,Peterson KL,Flatten KS,Hess AD,Smith BD,Karp JE,Barr S,Witzig TE,Kaufmann SH

更新日期：2012-01-12 00:00:00

abstract：:We have re-evaluated the previously reported ability of TLCK-thrombin (N alpha-tosyl-L-lysine chloromethyl ketone-treated alpha-thrombin) and PPACK-thrombin (D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-treated alpha-thrombin) to inhibit alpha-thrombin-induced platelet activation (Harmon JT, Jamieson GA: J B...

journal_title：Blood

authors： Greco NJ,Tenner TE Jr,Tandon NN,Jamieson GA

更新日期：1990-05-15 00:00:00

abstract：:Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI (GPVI)/FcRgamma-chain complex is a central collagen receptor and inhibitors of GPVI produce a major defect in arterial thrombogenesis. In this study we have examined art...

journal_title：Blood

authors： Mangin P,Yap CL,Nonne C,Sturgeon SA,Goncalves I,Yuan Y,Schoenwaelder SM,Wright CE,Lanza F,Jackson SP

更新日期：2006-06-01 00:00:00

abstract：:The intercellular crosstalk between hematological malignancies and the tumor microenvironment is mediated by cell-to-cell interactions and soluble factors. One component of the secretome that is gaining increasing attention is the extracellular vesicles and, in particular, the exosomes. Apart from the role as vectors ...

journal_title：Blood

authors： Vardaki I,Sanchez C,Fonseca P,Olsson M,Chioureas D,Rassidakis G,Ullén A,Zhivotovsky B,Björkholm M,Panaretakis T

更新日期：2016-12-08 00:00:00

abstract：:The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, the available data fully justify critical reassessment of CML management. The panel therefore reviewed treatment of CML sinc...

journal_title：Blood

authors： Baccarani M,Saglio G,Goldman J,Hochhaus A,Simonsson B,Appelbaum F,Apperley J,Cervantes F,Cortes J,Deininger M,Gratwohl A,Guilhot F,Horowitz M,Hughes T,Kantarjian H,Larson R,Niederwieser D,Silver R,Hehlmann R,Europea

更新日期：2006-09-15 00:00:00

abstract：:The large multimeric glyocoprotein von Willebrand factor (VWF) is a crucial component of both primary and secondary hemostasis. It is stored in secretory granules of vascular endothelial cells, the Weibel-Palade bodies (WPBs), and is released following stimulation by agonists that raise intracellular Ca(2+) or cyclic ...

journal_title：Blood

authors： Brandherm I,Disse J,Zeuschner D,Gerke V

更新日期：2013-08-08 00:00:00

abstract：:Microarray gene expression profiling studies have demonstrated immune response gene signatures that appear predictive of outcome in follicular lymphoma (FL). However, measurement of these marker genes in routine practice remains difficult. We have therefore investigated the immune response in FL using real-time polyme...

journal_title：Blood

authors： Byers RJ,Sakhinia E,Joseph P,Glennie C,Hoyland JA,Menasce LP,Radford JA,Illidge T

更新日期：2008-05-01 00:00:00

abstract：:The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions. We demonstrate that SMI-4a, a novel benzylidene-thiazolidine-2, 4-dione small molecule ...

journal_title：Blood

authors： Lin YW,Beharry ZM,Hill EG,Song JH,Wang W,Xia Z,Zhang Z,Aplan PD,Aster JC,Smith CD,Kraft AS

更新日期：2010-01-28 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry. It was recently demonstrated that HIV-1 glycoprotein 120 (gp120) elevated calcium and activated several ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo...

journal_title：Blood

authors： Del Corno M,Liu QH,Schols D,de Clercq E,Gessani S,Freedman BD,Collman RG

更新日期：2001-11-15 00:00:00

abstract：:Krüppel-like factor 5 (Klf5) encodes a zinc-finger transcription factor and has been reported to be a direct target of C/EBPα, a master transcription factor critical for formation of granulocyte-macrophage progenitors (GMP) and leukemic GMP. Using an in vivo hematopoietic-specific gene ablation model, we demonstrate t...

journal_title：Blood

authors： Shahrin NH,Diakiw S,Dent LA,Brown AL,D'Andrea RJ

更新日期：2016-07-07 00:00:00

abstract：:Fifty-one children with acute lymphoblastic leukemia (ALL) in second or subsequent remission after a first remission of at least 24 months underwent purged, autologous bone marrow transplantation (ABMT). Bone marrow was harvested in remission and purged in vitro with monoclonal antibodies specific for leukemia-associa...

journal_title：Blood

authors： Billett AL,Kornmehl E,Tarbell NJ,Weinstein HJ,Gelber RD,Ritz J,Sallan SE

更新日期：1993-03-15 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV), a DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia. MCPyV sequences have also been detected in various normal tissues in tumor-affected patients. Immunologic studies have detected MCPyV antibodies in as many as 80% of healthy...

journal_title：Blood

authors： Pancaldi C,Corazzari V,Maniero S,Mazzoni E,Comar M,Martini F,Tognon M

更新日期：2011-06-30 00:00:00

abstract：:The murine Ly6-E gene is transcriptionally induced by interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma in a variety of distinct cell types. The mechanism of IFN inducibility in B-cell lines was investigated by deletion analysis of the promoter and by identifying DNA binding proteins in mobility shift assays. A reg...

journal_title：Blood

authors： Khodadoust MM,Khan KD,Park EH,Bothwell AL

更新日期：1998-10-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) patients exhibit a variable clinical course. To investigate the association between clinicobiologic features and responsiveness of CLL cells to anti-IgM stimulation, we evaluated gene expression changes and modifications in cell-cycle distribution, proliferation, and apoptosis of IgV...

journal_title：Blood

authors： Guarini A,Chiaretti S,Tavolaro S,Maggio R,Peragine N,Citarella F,Ricciardi MR,Santangelo S,Marinelli M,De Propris MS,Messina M,Mauro FR,Del Giudice I,Foà R

更新日期：2008-08-01 00:00:00

abstract：:An abnormality of platelet aggregation has been detected in six family members with mild bleeding tendencies. In citrated platelet-rich plasma, primary aggregation induced by ADP or epinephrine and agglutination in response to ristocetin were present but second wave aggregation and aggregation in response to collagen ...

journal_title：Blood

authors： Ingerman CM,Smith JB,Shapiro S,Sedar A,Silver MJ

更新日期：1978-08-01 00:00:00

abstract：:We have investigated the structure of the Ig heavy (IGH) chain locus in 309 cases of acute leukemia. Seventy-one cases of B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were analyzed: in six cases deletion of joining (JH) segments in the presence of cytogenetically normal chromosome 14 was observed. Similar...

journal_title：Blood

authors： Dyer MJ,Heward JM,Zani VJ,Buccheri V,Catovsky D

更新日期：1993-08-01 00:00:00

abstract：:In order to determine if mutant hemoglobins can be identified by relatively simple methods, a Working Group of the ICSH Expert Panel on Abnormal Hemoglobins and Thalassemia analyzed 17 hemolysates containing 14 different mutant hemoglobins by four electrophoretic methods: (1) cellulose acetate in alkaline buffers, (2)...

journal_title：Blood

authors：

更新日期：1978-11-01 00:00:00

abstract：:Signaling mediated by various Notch receptors and their ligands regulates diverse biological processes, including lymphoid cell fate decisions. Notch1 is required during T-cell development, while Notch2 and the Notch ligand Delta-like1 control marginal zone B (MZB) cell development. We previously determined that Maste...

journal_title：Blood

authors： Wu L,Maillard I,Nakamura M,Pear WS,Griffin JD

更新日期：2007-11-15 00:00:00

abstract：:In primary human T cells, anergy induction results in enhanced p59Fyn activity. Because Fyn is the kinase primarily responsible for the phosphorylation of PAG (the phosphoprotein associated with glycosphingolipid-enriched microdomains), which negatively regulates Src-kinase activity by recruiting Csk (the C-terminal S...

journal_title：Blood

authors： Smida M,Posevitz-Fejfar A,Horejsi V,Schraven B,Lindquist JA

更新日期：2007-07-15 00:00:00