Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies.

abstract：:We have demonstrated that high molecular weight kininogen (HK) binds specifically on endothelial cells to domain 2/3 of the urokinase receptor (uPAR). Inhibition by vitronectin suggests that kallikrein-cleaved HK (HKa) is antiadhesive. Plasma kallikrein bound to HK cleaves prourokinase to urokinase, initiating cell-as...

journal_title：Blood

authors： Colman RW,Jameson BA,Lin Y,Johnson D,Mousa SA

更新日期：2000-01-15 00:00:00

abstract：:Pediatric-type follicular lymphoma (PTFL) is a variant of follicular lymphoma (FL) with distinctive clinicopathological features. Patients are predominantly young males presenting with localized lymphadenopathy; the tumor shows high-grade cytology and lacks both BCL2 expression and t(14;18) translocation. The genetic ...

journal_title：Blood

authors： Schmidt J,Gong S,Marafioti T,Mankel B,Gonzalez-Farre B,Balagué O,Mozos A,Cabeçadas J,van der Walt J,Hoehn D,Rosenwald A,Ott G,Dojcinov S,Egan C,Nadeu F,Ramis-Zaldívar JE,Clot G,Bárcena C,Pérez-Alonso V,Endris V,Pe

更新日期：2016-08-25 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder described as a clinical triad of thrombocytopenia, eczema, and immunodeficiency. The gene responsible for WAS encodes a 502-amino acid proline-rich protein (WASp) that is likely to play a role in the cytoskeleton reorganization and/or in signal trans...

journal_title：Blood

authors： Parolini O,Berardelli S,Riedl E,Bello-Fernandez C,Strobl H,Majdic O,Knapp W

更新日期：1997-07-01 00:00:00

abstract：:The developmental relationship between the blood and endothelial cell (EC) lineages remains unclear. In the extra-embryonic blood islands of birds and mammals, ECs and blood cells are closely intermixed, and blood island precursor cells in the primitive streak express many of the same molecular markers, leading to the...

journal_title：Blood

authors： Myers CT,Krieg PA

更新日期：2013-12-05 00:00:00

abstract：:Immune function has been restored in 9 of 10 children with X-linked severe combined immunodeficiency by gamma c gene transfer in CD34+ cells. The distribution of both T-cell receptor (TCR) V beta family usage and TCR V beta complementarity-determining region 3 (CDR3) length revealed a broadly diversified T-cell repert...

journal_title：Blood

authors： Schmidt M,Hacein-Bey-Abina S,Wissler M,Carlier F,Lim A,Prinz C,Glimm H,Andre-Schmutz I,Hue C,Garrigue A,Le Deist F,Lagresle C,Fischer A,Cavazzana-Calvo M,von Kalle C

更新日期：2005-04-01 00:00:00

abstract：:High concentrations of bovine factor VIII cause clumping of platelets into a few very large aggregates. This response is termed superaggregation. It is distinct from factor-VIII-induced agglutination but is also independent of both extracellular calcium ions and platelet energy metabolism. Neither agglutinating lectin...

journal_title：Blood

authors： Kirby EP,Mills DC,Holmsen H,Russo M

更新日期：1982-12-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF)/differentiation-inhibiting activity (DIA)/human interleukin for DA cells (HILDA) is a cytokine with biologic activities involving a variety of different types of target cells. Here we have tested LIF/DIA for possible effects on the growth and differentiation of normal human hematopoiet...

journal_title：Blood

authors： Leary AG,Wong GG,Clark SC,Smith AG,Ogawa M

更新日期：1990-05-15 00:00:00

abstract：:Infusions of large numbers (> 10(8)/kg) of donor leukocytes can induce remissions in patients with chronic myeloid leukemia (CML) who relapse after marrow transplantation. We wanted to determine if substantially lower numbers of donor leukocytes could induce remissions and, if so, whether this would reduce the 90% inc...

journal_title：Blood

authors： Mackinnon S,Papadopoulos EB,Carabasi MH,Reich L,Collins NH,Boulad F,Castro-Malaspina H,Childs BH,Gillio AP,Kernan NA

更新日期：1995-08-15 00:00:00

abstract：:Mutations in human prothrombin that generate a stable form of meizothrombin or meizothrombin(desF1) cause dysprothrombinemia in both the homozygous and heterozygous state, suggesting that meizothrombin has dominant anticoagulant effects in vivo. The enzymatic characterization of recombinant mouse meizothrombin, meizot...

journal_title：Blood

authors： Shim K,Zhu H,Westfield LA,Sadler JE

更新日期：2004-07-15 00:00:00

abstract：:Nijmegen breakage syndrome 1 (NBS1) is a component of the MRE11 complex, which is a sensor of DNA double-strand breaks and plays a crucial role in the DNA damage response. Because activated macrophages produce large amounts of reactive oxygen species (ROS) that can cause DNA lesions, we examined the role of NBS1 in ma...

journal_title：Blood

authors： Pereira-Lopes S,Tur J,Calatayud-Subias JA,Lloberas J,Stracker TH,Celada A

更新日期：2015-11-26 00:00:00

abstract：:Patients after allogeneic stem-cell transplantation (alloSCT) have an increased risk for invasive aspergillosis (IA). Here, recipients of an allograft with IA (n=81) or without IA (n=58) were screened for 84 single nucleotide polymorphisms in 18 immune relevant genes. We found 3 markers in chemokine (C-X-C motif) liga...

journal_title：Blood

authors： Mezger M,Steffens M,Beyer M,Manger C,Eberle J,Toliat MR,Wienker TF,Ljungman P,Hebart H,Dornbusch HJ,Einsele H,Loeffler J

更新日期：2008-01-15 00:00:00

abstract：:The molecular basis of different outcomes in pediatric acute lymphoblastic leukemia (ALL) remains poorly understood. We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionizing radiation (IR)-induced DNA double-strand breaks in 74 pediatric patients with ALL. We found an apopto...

journal_title：Blood

authors： Marston E,Weston V,Jesson J,Maina E,McConville C,Agathanggelou A,Skowronska A,Mapp K,Sameith K,Powell JE,Lawson S,Kearns P,Falciani F,Taylor M,Stankovic T

更新日期：2009-01-01 00:00:00

abstract：:There is growing evidence that lymphocyte trafficking contributes to the clinical course of chronic lymphocytic leukemia (CLL), but to date, only static in vitro cultures have been used to study these phenomena. To address this lack of data, we have developed a dynamic in vitro model in which CLL cells experience shea...

journal_title：Blood

authors： Walsby E,Buggins A,Devereux S,Jones C,Pratt G,Brennan P,Fegan C,Pepper C

更新日期：2014-06-05 00:00:00

abstract：:In this phase 2 multicenter trial, we evaluated the efficacy of the combination of bortezomib, dexamethasone, and rituximab (BDR) in 59 previously untreated symptomatic patients with Waldenström macroglobulinemia (WM), most of which were of advanced age and with adverse prognostic factors. BDR consisted of a single 21...

journal_title：Blood

authors： Gavriatopoulou M,García-Sanz R,Kastritis E,Morel P,Kyrtsonis MC,Michalis E,Kartasis Z,Leleu X,Palladini G,Tedeschi A,Gika D,Merlini G,Sonneveld P,Dimopoulos MA

更新日期：2017-01-26 00:00:00

abstract：:Electrolyte disturbances in leukemia can be the result of the disease process or drug therapy. One group of electrolyte abnormalities is related to the stage of the leukemic process. Included in this group are newly diagnosed patients who may show elevated serum potassium, phosphorus, and magnesium--a result of their ...

journal_title：Blood

authors： O'Regan S,Carson S,Chesney RW,Drummond KN

更新日期：1977-03-01 00:00:00

abstract：:The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis. Previously we demonstrated that HSC quiescence and function are aberrant in mice lacking Irgm1. To investigate the molecular basis for these defects, we conducted microarray expression profil...

journal_title：Blood

authors： King KY,Baldridge MT,Weksberg DC,Chambers SM,Lukov GL,Wu S,Boles NC,Jung SY,Qin J,Liu D,Songyang Z,Eissa NT,Taylor GA,Goodell MA

更新日期：2011-08-11 00:00:00

abstract：:We report five patients who had greater than 30% peripheral blasts and less than 30% marrow blasts. By the current standards these cases would be classified as myelodysplastic syndrome. Four of five patients progressed to acute leukemia within approximately 1 1/2 months of developing greater than 30% peripheral blasts...

journal_title：Blood

authors： Cason JD,Trujillo JM,Estey EH,Huh YO,Freireich EJ,Stass SA

更新日期：1989-10-01 00:00:00

abstract：:Stem cell factor (SCF) is expressed as an integral membrane growth factor that may be differentially processed to produce predominantly soluble (S) (SCF(248)) or membrane-associated (MA) (SCF(220)) protein. A critical role for membrane presentation of SCF in the hematopoietic microenvironment (HM) has been suggested f...

journal_title：Blood

authors： Kapur R,Cooper R,Xiao X,Weiss MJ,Donovan P,Williams DA

更新日期：1999-09-15 00:00:00

abstract：:Late committed progenitor cells of erythropoiesis, CFU-E (colony-forming unit--erythroid), were isolated from mouse spleens to near homogeneity by a three-step enrichment procedure. The procedure included a four-day pretreatment of bled mice with the antibiotic thiamphenicol, a recovery period of 3 1/2 days, followed ...

journal_title：Blood

authors： Nijhof W,Wierenga PK,Staal GE,Jansen G

更新日期：1984-09-01 00:00:00

abstract：:In a prospective trial in 284 children with B-lineage acute lymphoblastic leukemia (ALL), we assessed the clinical utility of real-time quantitative polymerase chain reaction analysis of antigen receptor gene rearrangements for detection of minimal residual disease (MRD) to identify children at high risk of relapse. A...

journal_title：Blood

authors： Zhou J,Goldwasser MA,Li A,Dahlberg SE,Neuberg D,Wang H,Dalton V,McBride KD,Sallan SE,Silverman LB,Gribben JG,Dana-Farber Cancer Institute ALL Consortium.

更新日期：2007-09-01 00:00:00

abstract：:Mammalian beta-globin loci are composed of multiple orthologous genes whose expression is erythroid specific and developmentally regulated. The expression of these genes both from the endogenous locus and from transgenes is strongly influenced by a linked 15-kilobase region of clustered DNaseI hypersensitive sites (HS...

journal_title：Blood

authors： Bender MA,Mehaffey MG,Telling A,Hug B,Ley TJ,Groudine M,Fiering S

更新日期：2000-06-01 00:00:00

abstract：:This prospective multicenter study examined whether simultaneous administration of granulocyte colony-stimulating factor (G-CSF; Filgrastim) and induction chemotherapy for adult acute lymphoblastic leukemia (ALL) could prevent treatment-related neutropenia, infections, and resulting treatment delays. Seventy-six patie...

journal_title：Blood

authors： Ottmann OG,Hoelzer D,Gracien E,Ganser A,Kelly K,Reutzel R,Lipp T,Busch FW,Schwonzen M,Heil G

更新日期：1995-07-15 00:00:00

abstract：:Platelets stored as concentrates (PC) for 72 h at 22 degrees C develop a functional defect. Alterations in adenine nucleotides of platelets have been shown to affect platelet function. Adenine nucleotide content of platelets was measured before and after storage and a decrease of 27.1 /+- 1.7% (mean /+- SE) in ATP and...

journal_title：Blood

authors： Rao AK,Niewiarowski S,Murphy S

更新日期：1981-02-01 00:00:00

abstract：:The erythroid Krüppel-like factor (EKLF) is a key regulatory protein in globin gene expression. This zinc finger transcription factor is required for expression of the adult beta globin gene, and it has been suggested that it plays an important role in the developmental switch from fetal gamma to adult beta globin gen...

journal_title：Blood

authors： Anderson KP,Crable SC,Lingrel JB

更新日期：2000-03-01 00:00:00

abstract：:Defective function of dendritic cells (DC) in cancer has been recently described and may represent one of the mechanisms of tumor evasion from immune system control. We have previously shown in vitro that vascular endothelial growth factor (VEGF), produced by almost all tumors, is one of the tumor-derived factors resp...

journal_title：Blood

authors： Gabrilovich D,Ishida T,Oyama T,Ran S,Kravtsov V,Nadaf S,Carbone DP

更新日期：1998-12-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is an incurable adult disease of unknown etiology. Understanding the biology of CLL cells, particularly cell maturation and growth in vivo, has been impeded by lack of a reproducible adoptive transfer model. We report a simple, reproducible system in which primary CLL cells prolifera...

journal_title：Blood

authors： Bagnara D,Kaufman MS,Calissano C,Marsilio S,Patten PE,Simone R,Chum P,Yan XJ,Allen SL,Kolitz JE,Baskar S,Rader C,Mellstedt H,Rabbani H,Lee A,Gregersen PK,Rai KR,Chiorazzi N

更新日期：2011-05-19 00:00:00

abstract：:We analyzed the expression of myelomonocytic-associated antigens on lymphocytes from B cell chronic lymphocytic leukemia (B-CLL) patients. Blood mononuclear cells were depleted of monocytes by one-step Percoll density gradient centrifugation and tested for antigen expression by fluorescent microscopy and flow cytometr...

journal_title：Blood

authors： Morabito F,Prasthofer EF,Dunlap NE,Grossi CE,Tilden AB

更新日期：1987-12-01 00:00:00

abstract：:In most cases, the lack of Rh in Rh(null) red cells is associated with RHAG gene mutations. We explored the role of RhAG in the surface expression of Rh. Nonerythroid HEK293 cells, which lack Rh and RhAG, or erythroid K562 cells, which endogenously express RhAG but not Rh, were transfected with RhD and/or RhAG cDNAs u...

journal_title：Blood

authors： Mouro-Chanteloup I,D'Ambrosio AM,Gane P,Le Van Kim C,Raynal V,Dhermy D,Cartron JP,Colin Y

更新日期：2002-08-01 00:00:00

abstract：:The effect of both congenital and acquired factor VII deficiency on the cuticle bleeding time (CBT) was evaluated in dogs. The CBT has been previously documented to be a sensitive indicator of factor VIII:C deficiency in hemophilic dogs. Serial CBT determinations were made on normal dogs treated with high-dose warfari...

journal_title：Blood

authors： Giles AR,Tinlin S,Brosseau L,Hoogendoorn H

更新日期：1985-05-01 00:00:00

abstract：:The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcgamma receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders me...

journal_title：Blood

authors： Ephrem A,Chamat S,Miquel C,Fisson S,Mouthon L,Caligiuri G,Delignat S,Elluru S,Bayry J,Lacroix-Desmazes S,Cohen JL,Salomon BL,Kazatchkine MD,Kaveri SV,Misra N

更新日期：2008-01-15 00:00:00