Electrolyte and acid-base disturbances in the management of leukemia.

abstract：:Mantle cell lymphoma (MCL) is a clinicopathologic entity that is difficult to diagnose on histopathologic criteria. Approximately 50% to 70% of MCL contain a t(11;14)(q13;q32) translocation involving the cyclin D1 gene. Irrespective of this rearrangement, almost all MCL show overexpression of the cyclin D1 gene at the...

journal_title：Blood

authors： de Boer CJ,Schuuring E,Dreef E,Peters G,Bartek J,Kluin PM,van Krieken JH

更新日期：1995-10-01 00:00:00

abstract：:The selectins are lectin-like cell surface glycoproteins that have been implicated in playing a crucial role in the initiation of leukocyte adhesion to endothelial cells (ECs) during inflammation. Binding of selectins under conditions of flow mediates leukocyte rolling, which in vivo is almost exclusively observed in ...

journal_title：Blood

authors： Olofsson AM,Arfors KE,Ramezani L,Wolitzky BA,Butcher EC,von Andrian UH

更新日期：1994-10-15 00:00:00

abstract：:Idiopathic pneumonia syndrome (IPS) is a major complication after allogeneic bone marrow transplantation (allo-BMT) and involves the infiltration of donor leukocytes and the secretion of inflammatory cytokines. We hypothesized that leukocyte recruitment during IPS is dependent in part upon interactions between chemoki...

journal_title：Blood

authors： Hildebrandt GC,Duffner UA,Olkiewicz KM,Corrion LA,Willmarth NE,Williams DL,Clouthier SG,Hogaboam CM,Reddy PR,Moore BB,Kuziel WA,Liu C,Yanik G,Cooke KR

更新日期：2004-03-15 00:00:00

abstract：:Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalatio...

journal_title：Blood

authors： Dale DC,Firkin F,Bolyard AA,Kelley M,Makaryan V,Gorelick KJ,Ebrahim T,Garg V,Tang W,Jiang H,Skerlj R,Beaussant Cohen S

更新日期：2020-12-24 00:00:00

abstract：:Fetal hemoglobin (HbF) is a potent genetic modifier of the severity of beta-thalassemia and sickle cell anemia. We used an in vitro culture model of human erythropoiesis in which late-stage erythroblasts are derived directly from human CD34(+) hematopoietic cells to evaluate HbF production. This system recapitulates e...

journal_title：Blood

authors： Wilber A,Tschulena U,Hargrove PW,Kim YS,Persons DA,Barbas CF 3rd,Nienhuis AW

更新日期：2010-04-15 00:00:00

abstract：UNLABELLED:Several studies have demonstrated that hematopoietic cells originate from endotheliumin early development; however, the phenotypic progression of progenitor cells during human embryonic hemogenesis is not well described. Here, we define the developmental hierarchy among intermediate populations of hematopoie...

journal_title：Blood

authors： Rafii S,Kloss CC,Butler JM,Ginsberg M,Gars E,Lis R,Zhan Q,Josipovic P,Ding BS,Xiang J,Elemento O,Zaninovic N,Rosenwaks Z,Sadelain M,Rafii JA,James D

更新日期：2013-01-31 00:00:00

abstract：:The HOXA9 homeoprotein exerts dramatic effects in hematopoiesis. Enforced expression of HOXA9 enhances proliferation of primitive blood cells, expands hematopoietic stem cells (HSCs), and leads to myeloid leukemia. Conversely, loss of HOXA9 inhibits proliferation and impairs HSC function. The pathways by which HOXA9 a...

journal_title：Blood

authors： Hu YL,Passegué E,Fong S,Largman C,Lawrence HJ

更新日期：2007-06-01 00:00:00

abstract：:CD99 is a crucial regulator of the transmigration (diapedesis) of leukocytes through the blood vessel wall. Here, we report that CD99 acts at 2 different steps in the extravasation process. In agreement with previous antibody-blocking experiments, we found that CD99 gene inactivation caused neutrophil accumulation bet...

journal_title：Blood

authors： Goswami D,März S,Li YT,Artz A,Schäfer K,Seelige R,Pacheco-Blanco M,Jing D,Bixel MG,Araki M,Araki K,Yamamura KI,Vestweber D

更新日期：2017-03-30 00:00:00

abstract：:Erythropoietin-responsive stem cell (ERC) kinetics in anephric uremic rabbits were studied in vitro using the growth of erythroid colonies in a methyl cellulose system in cultures with and without the addition of erythropoietin (ESF). Approximately 68 hr after bilateral nephrectomy, an increase in BUN and decreases in...

journal_title：Blood

authors： Moriyama Y,Fisher JW

更新日期：1975-05-01 00:00:00

abstract：:Human cord blood (CB) offers an attractive source of cells for clinical transplants because of its rich content of cells with sustained repopulating ability in spite of an apparent deficiency of cells with rapid reconstituting ability. Nevertheless, the clonal dynamics of nonlimiting CB transplants remain poorly under...

journal_title：Blood

authors： Cheung AM,Nguyen LV,Carles A,Beer P,Miller PH,Knapp DJ,Dhillon K,Hirst M,Eaves CJ

更新日期：2013-10-31 00:00:00

abstract：:The signals that mediate T-cell infiltration during T-cell autoimmune diseases are poorly understood. The chemokine CCL21 (originally isolated by us and others as Exodus-2/6Ckine/SLC/TCA4) is highly potent and highly specific for stimulating T-cell migration. However, it is thought to be expressed only in secondary ly...

journal_title：Blood

authors： Christopherson KW 2nd,Hood AF,Travers JB,Ramsey H,Hromas RA

更新日期：2003-02-01 00:00:00

abstract：:We prospectively evaluated 169 patients with a number of screening studies performed between 71 to 121 days after allogeneic marrow transplantation to detect the development of chronic graft-versus-host disease (GVHD). Group 1 patients (n = 78) were asymptomatic and had normal physical examinations at the time of scre...

journal_title：Blood

authors： Loughran TP Jr,Sullivan K,Morton T,Beckham C,Schubert M,Witherspoon R,Sale G,Sanders J,Fisher L,Shulman H

更新日期：1990-07-01 00:00:00

abstract：:A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions an...

journal_title：Blood

authors： Boukerche H,Berthier-Vergnes O,Tabone E,Doré JF,Leung LL,McGregor JL

更新日期：1989-08-01 00:00:00

abstract：:We have shown previously that the cause of anemia in healthy elderly subjects can usually not be identified. In this study, hematopoiesis was examined in 18 healthy elderly subjects with unexplained anemia and in 15 young and 15 healthy elderly individuals without anemia. No reduction in circulating testosterone was n...

journal_title：Blood

authors： Lipschitz DA,Udupa KB,Milton KY,Thompson CO

更新日期：1984-03-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) is important in tissue repair and wound healing and its administration can abrogate chemical- and radiation-induced tissue damage in rodents. We investigated KGF as a therapeutic agent for the prevention of graft-versus-host disease (GVHD)-induced tissue damage, morbidity, and mortalit...

journal_title：Blood

authors： Panoskaltsis-Mortari A,Lacey DL,Vallera DA,Blazar BR

更新日期：1998-11-15 00:00:00

abstract：:Mycobacterium avium-intracellulare (MAI) is an opportunistic pathogen commonly found in acquired immunodeficiency syndrome patients, whose immune systems are severely compromised. However, normal responses to this bacterium are apparently sufficient to prevent disseminated infection because disease is rarely found unl...

journal_title：Blood

authors： Blanchard DK,Michelini-Norris MB,Pearson CA,Freitag CS,Djeu JY

更新日期：1991-05-15 00:00:00

abstract：:Absorption of iron was studied with a double-isotope technique that allowed differentiation between "mucosal uptake," "mucosal transfer," and ultimate "retention" of iron. A physiologic dose of ferrous sulfate was administered to 25 healthy young adults, 40 active aged persons, and 20 patients with uncomplicated iron ...

journal_title：Blood

authors： Marx JJ

更新日期：1979-02-01 00:00:00

abstract：:Allogeneic bone marrow transplantation is still limited by the morbidity and mortality caused by graft-versus-host disease (GVHD), resulting from host recognition by donor T lymphocytes. It is possible to drastically reduce the T-cell content of the graft. However, transplanted T cells can also have a beneficial effec...

journal_title：Blood

authors： Gallot G,Hallet MM,Gaschet J,Moreau JF,Vivien R,Bonneville M,Milpied N,Vié H

更新日期：1996-08-01 00:00:00

abstract：:The variability of laboratory findings in von Willebrand's disease (vWd) was evaluated by performing serial studies of bleeding time (BT), factor VIII coagulant activity (VIII:C), factor-VIII-related antigen (VIIIR:Ag) and ristocetin cofactor (VIIIR:Rcof) in 50 individuals from 25 families with this disorder. The type...

journal_title：Blood

authors： Abildgaard CF,Suzuki Z,Harrison J,Jefcoat K,Zimmerman TS

更新日期：1980-10-01 00:00:00

abstract：:Patients with polycythemia vera (PV) have a JAK2 (a cytosolic tyrosine kinase) mutation and an increased risk of vascular thrombosis related to red blood cell (RBC) mass and platelet activation. We investigated functional RBC abnormalities that could be involved in thrombosis. RBC adhesion to human umbilical vein endo...

journal_title：Blood

authors： Wautier MP,El Nemer W,Gane P,Rain JD,Cartron JP,Colin Y,Le Van Kim C,Wautier JL

更新日期：2007-08-01 00:00:00

abstract：:As tyrosine kinase inhibitors (TKIs) fail to induce long-term response in blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL), novel therapies targeting leukemia-dysregulated pathways are necessary. Exportin-1 (XPO1), also known as chromoso...

journal_title：Blood

authors： Walker CJ,Oaks JJ,Santhanam R,Neviani P,Harb JG,Ferenchak G,Ellis JJ,Landesman Y,Eisfeld AK,Gabrail NY,Smith CL,Caligiuri MA,Hokland P,Roy DC,Reid A,Milojkovic D,Goldman JM,Apperley J,Garzon R,Marcucci G,Shacham S

更新日期：2013-10-24 00:00:00

abstract：:All-trans retinoic acid (ATRA) is an essential component of the treatment of acute promyelocytic leukemia (APL), but the optimal timing and duration remain to be determined. Molecular characterization of this disease can refine the diagnosis and could be potentially useful in monitoring response to treatment. Patients...

journal_title：Blood

authors： Burnett AK,Grimwade D,Solomon E,Wheatley K,Goldstone AH

更新日期：1999-06-15 00:00:00

abstract：:Vascular tube morphogenesis requires the establishment of endothelial cell (EC) apical-basal polarity in three-dimensional (3D) extracellular matrices. To date, there is little understanding of how EC polarity is controlled during these highly dynamic and rapid morphogenic events. We show that the microtubule tip comp...

journal_title：Blood

authors： Kim DJ,Martinez-Lemus LA,Davis GE

更新日期：2013-04-25 00:00:00

abstract：:IgE and IgE receptors (FcεRI) are well-known inducers of allergy. We recently found in mice that active systemic anaphylaxis depends on IgG and IgG receptors (FcγRIIIA and FcγRIV) expressed by neutrophils, rather than on IgE and FcεRI expressed by mast cells and basophils. In humans, neutrophils, mast cells, basophils...

journal_title：Blood

authors： Jönsson F,Mancardi DA,Zhao W,Kita Y,Iannascoli B,Khun H,van Rooijen N,Shimizu T,Schwartz LB,Daëron M,Bruhns P

更新日期：2012-03-15 00:00:00

abstract：:It has previously been shown that human granulocyte-macrophage colony-stimulating factor (GM-CSF) can be fused to a truncated diphtheria toxin (DT) to produce a recombinant fusion toxin that kills GM-CSF receptor-bearing cells. We now report that DT388-GM-CSF induces apoptosis and inhibition of colony formation in sem...

journal_title：Blood

authors： Frankel AE,Hall PD,Burbage C,Vesely J,Willingham M,Bhalla K,Kreitman RJ

更新日期：1997-11-01 00:00:00

abstract：:CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of nonhematopoietic origin. CD38 is a transmembrane glycoprotein with ectoenzymatic activity, and also functions as a receptor and adhesion molecule. Altogether,...

journal_title：Blood

authors： van de Donk NWCJ,Richardson PG,Malavasi F

更新日期：2018-01-04 00:00:00

abstract：:We previously reported a benefit for all-trans retinoic acid (ATRA) in both induction and maintenance therapy in patients with acute promyelocytic leukemia (APL). To determine the durability of this benefit and identify important prognostic factors, long-term follow-up of the North American Intergroup APL trial is rep...

journal_title：Blood

authors： Tallman MS,Andersen JW,Schiffer CA,Appelbaum FR,Feusner JH,Woods WG,Ogden A,Weinstein H,Shepherd L,Willman C,Bloomfield CD,Rowe JM,Wiernik PH

更新日期：2002-12-15 00:00:00

abstract：:Scott syndrome, a bleeding disorder caused by defective phospholipid scrambling, has been associated with mutations in the TMEM16F gene. The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects. Whereas stimulation...

journal_title：Blood

authors： van Kruchten R,Mattheij NJ,Saunders C,Feijge MA,Swieringa F,Wolfs JL,Collins PW,Heemskerk JW,Bevers EM

更新日期：2013-03-07 00:00:00

abstract：:We report long-term results of treatment of myelodysplastic syndrome (MDS) with erythropoietin and granulocyte colony-stimulating factor (G-CSF). A total of 129 patients were followed up 45 months after last inclusion in the Nordic MDS Group studies. Erythroid response rate was 39% and median response duration 23 mont...

journal_title：Blood

authors： Jädersten M,Montgomery SM,Dybedal I,Porwit-MacDonald A,Hellström-Lindberg E

更新日期：2005-08-01 00:00:00

abstract：:Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to stem-loop structures known as iron-responsive elements (IREs). IREs are located in the 5'- or 3'-untranslated regions (UTRs) of specific mRNAs that encode proteins involved in iron homeostasis. The binding of IRPs to 5' IREs represses trans...

journal_title：Blood

authors： Phillips JD,Kinikini DV,Yu Y,Guo B,Leibold EA

更新日期：1996-04-01 00:00:00