A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation.

abstract：:Rituximab is a chimeric monoclonal antibody directed at CD20 with significant activity in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). A variety of pathways of tumor cytotoxicity different from cytotoxic chemotherapy have been proposed for this therapeutic antibody including antibody-dependent ce...

journal_title：Blood

authors： Byrd JC,Kitada S,Flinn IW,Aron JL,Pearson M,Lucas D,Reed JC

更新日期：2002-02-01 00:00:00

abstract：:Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene therapy is severely limited by intrinsic HSC resistance to modification with lentiviral vectors (LVs), thus requiring high doses or repe...

journal_title：Blood

authors： Ozog S,Timberlake ND,Hermann K,Garijo O,Haworth KG,Shi G,Glinkerman CM,Schefter LE,D'Souza S,Simpson E,Sghia-Hughes G,Carillo RR,Boger DL,Kiem HP,Slukvin I,Ryu BY,Sorrentino BP,Adair JE,Snyder SA,Compton AA,Torbet

更新日期：2019-10-17 00:00:00

abstract：:Mutations that produce glucose-6-phosphate dehydrogenase (G6PD) deficiency have been identified in samples from patients with hemolytic disease in the United States, and in G6PD-deficient samples from Greece, the Canary Islands, the Czech and Slovak Republics, South China, and in samples from the Coriell Cell Reposito...

journal_title：Blood

authors： Xu W,Westwood B,Bartsocas CS,Malcorra-Azpiazu JJ,Indrák K,Beutler E

更新日期：1995-01-01 00:00:00

abstract：:Erythrocytes of neonates and adults were incubated with increasing concentrations of H2O2 in the presence of a catalase inhibitor and in the absence of glucose; the pattern of oxidation of vitamin E was analyzed in relationship to that of glutathione, hemoglobin, and polyunsaturated fatty acids (PUFA), and in relation...

journal_title：Blood

authors： Vanderpas J,Vertongen F

更新日期：1985-12-01 00:00:00

abstract：:Recently, we have demonstrated that human platelets carry preformed CD40 ligand (CD154) molecules, which rapidly appear on the platelet surface following stimulation by thrombin. Once on the surface, platelet CD154 induces an inflammatory reaction of CD40-bearing endothelial cells. This study shows that strong platele...

journal_title：Blood

authors： Henn V,Steinbach S,Büchner K,Presek P,Kroczek RA

更新日期：2001-08-15 00:00:00

abstract：:At present, one of the most sensitive assays for human erythropoietin (Ep) is a bioassay that measures the Ep-dependent proliferation of spleen cells from phenylhydrazine-treated mice after 24 hours in culture. We describe how this assay can be used as the basis of a very sensitive method for detecting mouse antibodie...

journal_title：Blood

authors： Wognum AW,Lansdorp PM,Eaves CJ,Krystal G

更新日期：1988-06-01 00:00:00

abstract：:A rapid sensitive spectrophotometric assay for the measurement of methylmalonic and propionic acids in urine is described. The assay is based upon the quantitation of propionic acid using acetyl coenzyme A synthetase isolated from baker's yeast. This enzyme is highly specific for acetate and propionate, and acetate in...

journal_title：Blood

authors： Frenkel EP,Kitchens RL

更新日期：1977-01-01 00:00:00

abstract：:Megakaryopoiesis is the hierarchical differentiation of hematopoietic stem cells into megakaryocytes. Differentiating megakaryocytes undergo maturation characterized by endomitosis and produce numerous platelets through proplatelet formation. C-type lectin-like receptor 2 (CLEC-2) is a podoplanin (PDPN) receptor mainl...

journal_title：Blood

authors： Tamura S,Suzuki-Inoue K,Tsukiji N,Shirai T,Sasaki T,Osada M,Satoh K,Ozaki Y

更新日期：2016-03-31 00:00:00

abstract：:The administration of interleukin-2 (IL-2) may induce complete remissions in acute myelogenous leukemia (AML) patients with a low proportion of residual bone marrow (BM) blasts. To confirm this preliminary observation, we treated 14 AML patients with advanced disease and with a residual BM blastosis that ranged betwee...

journal_title：Blood

authors： Meloni G,Foa R,Vignetti M,Guarini A,Fenu S,Tosti S,Tos AG,Mandelli F

更新日期：1994-10-01 00:00:00

abstract：:The effect of lipopolysaccharide (LPS) on endothelial cells is a key component of the inflammatory response seen in Gram-negative sepsis. LPS does not cause death of cultured human endothelial cells. However, when the expression of new proteins is inhibited by cycloheximide, microvascular endothelial cells in culture ...

journal_title：Blood

authors： Hu X,Yee E,Harlan JM,Wong F,Karsan A

更新日期：1998-10-15 00:00:00

abstract：:Severe elevation of red blood cell number is often associated with hypertension and thromboembolism resulting in severe cardiovascular complications. However, some individuals such as high altitude dwellers cope well with an increased hematocrit level. We analyzed adaptive mechanisms to excessive erythrocytosis in our...

journal_title：Blood

authors： Vogel J,Kiessling I,Heinicke K,Stallmach T,Ossent P,Vogel O,Aulmann M,Frietsch T,Schmid-Schönbein H,Kuschinsky W,Gassmann M

更新日期：2003-09-15 00:00:00

abstract：:In patients with chronic lymphocytic leukemia (CLL), lenalidomide can promote humoral immune responses but also induces a distinct disease-specific toxicity of tumor flare and cytokine release. These CLL-specific events result from increased expression of costimulatory molecules on B cells. Here we demonstrate that le...

journal_title：Blood

authors： Herman SE,Lapalombella R,Gordon AL,Ramanunni A,Blum KA,Jones J,Zhang X,Lannutti BJ,Puri KD,Muthusamy N,Byrd JC,Johnson AJ

更新日期：2011-04-21 00:00:00

abstract：:The effect of hydroxyurea in 35 patients with chronic granulocytic leukemia (CGL), who either had entered an accelerated phase of the disease or had experienced excessive myelosuppression following alkylating agents, was studied. By either intravenous or oral administration, the drug was successful in reducing periphe...

journal_title：Blood

authors： Schwartz JH,Cannellos GP

更新日期：1975-07-01 00:00:00

abstract：:The number of neutrophils in the blood is tightly regulated to ensure adequate protection against microbial pathogens while minimizing damage to host tissue. Neutrophil homeostasis in the blood is achieved through a balance of neutrophil production, release from the bone marrow, and clearance from the circulation. Acc...

journal_title：Blood

authors： Eash KJ,Means JM,White DW,Link DC

更新日期：2009-05-07 00:00:00

abstract：:DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display highly dysregulated DNA methylation profiles, characterized by global hypomethylation in conjunction with hypermethylation of promoter CpG is...

journal_title：Blood

authors： Lio CJ,Yuita H,Rao A

更新日期：2019-10-31 00:00:00

abstract：:The bone marrow plays a unique role within the immune system. We compared the phenotype and function of virus-specific CD8(+) T cells from matched samples of human peripheral blood and bone marrow. Analysis of virus-specific memory CD8(+) T cells showed widely divergent partition of antigen-specific populations betwee...

journal_title：Blood

authors： Palendira U,Chinn R,Raza W,Piper K,Pratt G,Machado L,Bell A,Khan N,Hislop AD,Steyn R,Rickinson AB,Buckley CD,Moss P

更新日期：2008-10-15 00:00:00

abstract：:Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cel...

journal_title：Blood

authors： Nilsson L,Edén P,Olsson E,Månsson R,Astrand-Grundström I,Strömbeck B,Theilgaard-Mönch K,Anderson K,Hast R,Hellström-Lindberg E,Samuelsson J,Bergh G,Nerlov C,Johansson B,Sigvardsson M,Borg A,Jacobsen SE

更新日期：2007-10-15 00:00:00

abstract：:Macrophages are motile leukocytes, targeted by HIV-1, thought to play a critical role in host dissemination of the virus. However, whether infection impacts their migration capacity remains unknown. We show that 2-dimensional migration and the 3-dimensional (3D) amoeboid migration mode of HIV-1-infected human monocyte...

journal_title：Blood

authors： Vérollet C,Souriant S,Bonnaud E,Jolicoeur P,Raynaud-Messina B,Kinnaer C,Fourquaux I,Imle A,Benichou S,Fackler OT,Poincloux R,Maridonneau-Parini I

更新日期：2015-03-05 00:00:00

abstract：:Aggregation of blood platelets contributes to the arrest of bleeding at sites of vascular injury, but it can occlude atherosclerotic arteries and precipitate diseases such as myocardial infarction. The bonds that link platelets under flow conditions were identified using confocal videomicroscopy in real time. Glycopro...

journal_title：Blood

authors： Ruggeri ZM,Dent JA,Saldívar E

更新日期：1999-07-01 00:00:00

abstract：:We report a novel t(7;9)(q11;p13) translocation in 2 patients with B-cell acute lymphoblastic leukemia (B-ALL). By fluorescent in situ hybridization and 3' rapid amplification of cDNA ends, we showed that the paired box domain of PAX5 was fused with the elastin (ELN) gene. After cloning the full-length cDNA of the chi...

journal_title：Blood

authors： Bousquet M,Broccardo C,Quelen C,Meggetto F,Kuhlein E,Delsol G,Dastugue N,Brousset P

更新日期：2007-04-15 00:00:00

abstract：:The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pe...

journal_title：Blood

authors： Paugh SW,Paugh BS,Rahmani M,Kapitonov D,Almenara JA,Kordula T,Milstien S,Adams JK,Zipkin RE,Grant S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:Alteration of lineage-specific transcriptional programs for hematopoiesis causes differentiation block and promotes leukemia development. Here, we show that AML1/ETO, the most common translocation fusion product in acute myeloid leukemia (AML), counteracts the activity of retinoic acid (RA), a transcriptional regulato...

journal_title：Blood

authors： Fazi F,Zardo G,Gelmetti V,Travaglini L,Ciolfi A,Di Croce L,Rosa A,Bozzoni I,Grignani F,Lo-Coco F,Pelicci PG,Nervi C

更新日期：2007-05-15 00:00:00

abstract：:Large granular lymphocytes (LGL) are defined as nonadherent mononuclear cells with cytoplasmic azurophilic granules, avid receptors for the Fc portion of IgG, and cytotoxic functions (NK or ADCC activities). In the present study, the granules of LGL isolated from human peripheral blood have been analyzed by enzyme cyt...

journal_title：Blood

authors： Grossi CE,Cadoni A,Zicca A,Leprini A,Ferrarini M

更新日期：1982-02-01 00:00:00

abstract：:We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 patients, a significa...

journal_title：Blood

authors： Gutman JA,Turtle CJ,Manley TJ,Heimfeld S,Bernstein ID,Riddell SR,Delaney C

更新日期：2010-01-28 00:00:00

abstract：:Hereditary glutathione reductase (GR) deficiency was found in only 2 cases when testing more than 15 000 blood samples. We have investigated the blood cells of 2 patients (1a and 1b) in a previously described family suffering from favism and cataract and of a novel patient (2) presenting with severe neonatal jaundice....

journal_title：Blood

authors： Kamerbeek NM,van Zwieten R,de Boer M,Morren G,Vuil H,Bannink N,Lincke C,Dolman KM,Becker K,Schirmer RH,Gromer S,Roos D

更新日期：2007-04-15 00:00:00

abstract：:Erythroid (red blood) cells are the first cell type to be specified in the postimplantation mammalian embryo and serve highly specialized, essential functions throughout gestation and postnatal life. The existence of 2 developmentally and morphologically distinct erythroid lineages, primitive (embryonic) and definitiv...

journal_title：Blood

authors： Baron MH,Isern J,Fraser ST

更新日期：2012-05-24 00:00:00

abstract：:CD44, a cell surface glycoprotein, is involved in lymphocyte trafficking from the blood to lymphatic tissues, and is of importance in dissemination of lymphoma. A variant form of CD44 that has additional amino acids in the common protein backbone (CD44v6) also seems to play a role in the metastatic dissemination of ma...

journal_title：Blood

authors： Ristamäki R,Joensuu H,Salmi M,Jalkanen S

更新日期：1994-07-01 00:00:00

abstract：:We have used two in vitro models to identify genes whose expression may serve as markers of lineage commitment during the development of hematopoietic stem cells. One system involves the development in vitro of blastocyst-derived embryonic stem cells into embryoid bodies. The second involves culturing of day 3.5 blast...

journal_title：Blood

authors： McClanahan T,Dalrymple S,Barkett M,Lee F

更新日期：1993-06-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) lymphocytes manifest anomalous motility and cap formation. Since these processes involve cytoskeletal proteins, vimentin from intermediate filaments of normal and CLL lymphocytes was investigated using hetero- and monoclonal antisera. The antisera reacted predominantly with a 60-kD p...

journal_title：Blood

authors： Stark RS,Liebes LF,Shelanski ML,Silber R

更新日期：1984-02-01 00:00:00

abstract：:Analysis of fresh human tumors have indicated that patients with B type lymphoproliferative diseases and the majority of patients with acute lymphoblastic leukemia (ALL) express elevated levels of p53 production. It is suggested that in these human malignancies, p53 may provide a novel tool for monitoring cancer activ...

journal_title：Blood

authors： Prokocimer M,Shaklai M,Bassat HB,Wolf D,Goldfinger N,Rotter V

更新日期：1986-07-01 00:00:00