The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction.

abstract：:The regulatory Tat protein of human immunodeficiency virus type-1 (HIV-1) exerts a pleyotropic activity on the survival and proliferation of different cell types in culture. In this report, we investigated the effect of either endogenous or exogenous Tat on Bcl-2 proto-oncogene expression and cell survival in Jurkat T...

journal_title：Blood

authors： Zauli G,Gibellini D,Caputo A,Bassini A,Negrini M,Monne M,Mazzoni M,Capitani S

更新日期：1995-11-15 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is currently unexplained. We created and analyzed 3 separate iPSC clones from f...

journal_title：Blood

authors： Mills JA,Wang K,Paluru P,Ying L,Lu L,Galvão AM,Xu D,Yao Y,Sullivan SK,Sullivan LM,Mac H,Omari A,Jean JC,Shen S,Gower A,Spira A,Mostoslavsky G,Kotton DN,French DL,Weiss MJ,Gadue P

更新日期：2013-09-19 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

journal_title：Blood

authors： Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

更新日期：2005-06-15 00:00:00

abstract：:The transcription factor c-Maf is extensively involved in the pathophysiology of multiple myeloma (MM), a fatal malignancy of plasma cells. In the present study, affinity chromatography and mass spectrometry were used to identify c-Maf ubiquitination-associated proteins, from which the E3 ligase HERC4 was found to int...

journal_title：Blood

authors： Zhang Z,Tong J,Tang X,Juan J,Cao B,Hurren R,Chen G,Taylor P,Xu X,Shi CX,Du J,Hou J,Wang G,Wu D,Stewart AK,Schimmer AD,Moran MF,Mao X

更新日期：2016-03-31 00:00:00

abstract：:We recently identified aberrant cytoplasmic expression of nucleophosmin (NPM) as the immunohistochemical marker of a large subgroup of acute myeloid leukemia (AML) (about one-third of adult AML) that is characterized by normal karyotype and mutations occurring at the exon-12 of the NPM gene. In this paper, we have elu...

journal_title：Blood

authors： Falini B,Bolli N,Shan J,Martelli MP,Liso A,Pucciarini A,Bigerna B,Pasqualucci L,Mannucci R,Rosati R,Gorello P,Diverio D,Roti G,Tiacci E,Cazzaniga G,Biondi A,Schnittger S,Haferlach T,Hiddemann W,Martelli MF,Gu W,

更新日期：2006-06-01 00:00:00

abstract：:The calcium ionophore A23187 promotes histamine synthesis in murine bone marrow cells by increasing the expression of mRNA encoding histidine decarboxylase (HDC), the histamine-forming enzyme. The cells responsible for this biological activity copurify with hematopoietic progenitors in terms of density, light scatter ...

journal_title：Blood

authors： Dy M,Arnould A,Lemoine FM,Machavoine F,Ziltener H,Schneider E

更新日期：1996-04-15 00:00:00

abstract：:Coated vesicles bearing the transferrin-transferrin receptor complex were isolated from rabbit reticulocytes by freeze-thaw cell lysis, followed by differential centrifugation with pelleting of vesicles at 100,000 g. Electronmicroscopy demonstrated the vesicles to have the characteristic morphology of coated vesicles,...

journal_title：Blood

authors： Choe HR,Moseley ST,Glass J,Nunez MT

更新日期：1987-10-01 00:00:00

abstract：:Intracellular protein transport in endothelial cells is selectively inhibited by homocysteine, a thiol amino acid associated with both thrombosis and atherosclerosis. In a previous study, homocysteine decreased cell surface expression of the surface transmembrane glycoprotein thrombomodulin without decreasing secretio...

journal_title：Blood

authors： Lentz SR,Sadler JE

更新日期：1993-02-01 00:00:00

abstract：:The effect of FLT3/FLK2 ligand (FL) on the growth of primitive hematopoietic cells was investigated using ThyloSca1+ stem cells. FL was observed to interact with a variety of factors to initiate colony formation by stem cells. When stem cells were stimulated in liquid culture with FL plus interleukin (IL)-3, IL-6, gra...

journal_title：Blood

authors： Hudak S,Hunte B,Culpepper J,Menon S,Hannum C,Thompson-Snipes L,Rennick D

更新日期：1995-05-15 00:00:00

abstract：:Recently, we reported a novel system whereby human pericytes are recruited to endothelial cell (EC)-lined tubes in 3-dimensional (3D) extracellular matrices to stimulate vascular maturation including basement membrane matrix assembly. Through the use of this serum-free, defined system, we demonstrate that pericyte mot...

journal_title：Blood

authors： Stratman AN,Schwindt AE,Malotte KM,Davis GE

更新日期：2010-11-25 00:00:00

abstract：:The mechanisms by which transforming growth factor beta (TGF-beta) exerts a negative effect on cell-cycle entry in primary human hematopoietic stem/progenitor cells were examined at the molecular and cellular levels. After treatment of primary human CD34+ progenitors with TGF-beta there was a decrease in the levels of...

journal_title：Blood

authors： Dao MA,Hwa J,Nolta JA

更新日期：2002-01-15 00:00:00

abstract：:HIV-1-associated thrombocytopenia (HIV-1-ITP) is a common complication of HIV-1 infection, frequently caused by increased peripheral platelet destruction mediated by antiplatelet antibodies (Abs) and/or platelet-bound immune complexes. Little is known about the specificity of the antiplatelet Abs at a molecular level....

journal_title：Blood

authors： Koefoed K,Ditzel HJ

更新日期：2004-12-15 00:00:00

abstract：:Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA a...

journal_title：Blood

authors： Sekyere EO,Dunn LL,Suryo Rahmanto Y,Richardson DR

更新日期：2006-04-01 00:00:00

abstract：:We compared urokinase-type plasminogen activator (u-PA) in fluid phase and u-PA bound with its receptor on human blood monocytes with respect to proteolytic activity and susceptibility to inactivation by the plasminogen activator inhibitors PAI-1 and PAI-2. Receptor-bound u-PA is catalytically twice as efficient as fl...

journal_title：Blood

authors： Kirchheimer JC,Remold HG

更新日期：1989-09-01 00:00:00

abstract：:Colony forming cells (CFC) with high proliferative potential have been detected in nutrient agar cultures of human bone marrow cells containing recombinant human interleukin-3 (IL-3) and granulocyte macrophage colony stimulating factor (GM-CSF). These CFC were detected by the formation of large colonies with diameters...

journal_title：Blood

authors： McNiece IK,Stewart FM,Deacon DM,Temeles DS,Zsebo KM,Clark SC,Quesenberry PJ

更新日期：1989-08-01 00:00:00

abstract：:The effect of both congenital and acquired factor VII deficiency on the cuticle bleeding time (CBT) was evaluated in dogs. The CBT has been previously documented to be a sensitive indicator of factor VIII:C deficiency in hemophilic dogs. Serial CBT determinations were made on normal dogs treated with high-dose warfari...

journal_title：Blood

authors： Giles AR,Tinlin S,Brosseau L,Hoogendoorn H

更新日期：1985-05-01 00:00:00

abstract：:The regenerative capacity of hematopoietic stem cells (HSCs) is limited by the accumulation of DNA damage. Conditional mutagenesis of the histone 3 lysine 4 (H3K4) methyltransferase, Setd1a, revealed that it is required for the expression of DNA damage recognition and repair pathways in HSCs. Specific deletion of Setd...

journal_title：Blood

authors： Arndt K,Kranz A,Fohgrub J,Jolly A,Bledau AS,Di Virgilio M,Lesche M,Dahl A,Höfer T,Stewart AF,Waskow C

更新日期：2018-03-22 00:00:00

abstract：:Donor-matched transplantation of hematopoietic stem cells (HSCs) is widely used to treat hematologic malignancies but is associated with high mortality. The expansion of HSC numbers and their mobilization into the bloodstream could significantly improve therapy. We report here that adult mice conditionally deficient f...

journal_title：Blood

authors： Khandanpour C,Sharif-Askari E,Vassen L,Gaudreau MC,Zhu J,Paul WE,Okayama T,Kosan C,Möröy T

更新日期：2010-12-09 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is an incurable adult disease of unknown etiology. Understanding the biology of CLL cells, particularly cell maturation and growth in vivo, has been impeded by lack of a reproducible adoptive transfer model. We report a simple, reproducible system in which primary CLL cells prolifera...

journal_title：Blood

authors： Bagnara D,Kaufman MS,Calissano C,Marsilio S,Patten PE,Simone R,Chum P,Yan XJ,Allen SL,Kolitz JE,Baskar S,Rader C,Mellstedt H,Rabbani H,Lee A,Gregersen PK,Rai KR,Chiorazzi N

更新日期：2011-05-19 00:00:00

abstract：:Proapoptotic Bax and Bak are the key B-cell lymphoma-2 family members mediating apoptosis through the intrinsic pathway. Cells doubly deficient for Bax and Bak are profoundly resistant to apoptotic stimuli originating from multiple stimuli. Here we describe mice in which Bax and Bak have been deleted specifically in T...

journal_title：Blood

authors： Biswas S,Shi Q,Matise L,Cleveland S,Dave U,Zinkel S

更新日期：2010-12-09 00:00:00

abstract：:Neutrophils from healthy elderly donors generate significantly less diacylglycerol (DAG) and inositol triphosphate (IP3) than neutrophils from young donors, following stimulation by the chemotactic peptide, formyl-methionyl-leucylphenylalanine (FMLP). The defect in signal transduction occurred at a point proximal to t...

journal_title：Blood

authors： Lipschitz DA,Udupa KB,Indelicato SR,Das M

更新日期：1991-09-01 00:00:00

abstract：:An abnormal von Willebrand factor (vWF) gene restriction pattern has been found in a patient with von Willebrand disease. Because this gene alteration is not present in his parents or in 50 normal and 25 affected subjects, and the restriction fragment length polymorphism haplotypes are inherited normally in the patien...

journal_title：Blood

authors： Bernardi F,Marchetti G,Guerra S,Casonato A,Gemmati D,Patracchini P,Ballerini G,Conconi F

更新日期：1990-02-01 00:00:00

abstract：:Somatic mutation in immunoglobulin variable (V) region genes occurs largely in the germinal center and, after neoplastic transformation, imprints V genes of B-cell tumors with the mutational history of the cell of origin. Recently, it has been found that chronic lymphocytic leukemia (CLL) consists of 2 subsets, each w...

journal_title：Blood

authors： Sahota SS,Davis Z,Hamblin TJ,Stevenson FK

更新日期：2000-06-01 00:00:00

abstract：:Factor V Leiden (FVL) is associated with venous thrombosis; however, an association between FVL and arterial thrombosis remains controversial. We investigated FVL as a risk factor for myocardial infarction (MI), ischemic stroke (IS), or non-MI ischemic heart disease (non-MI-IHD). The design was 3 case-control studies ...

journal_title：Blood

authors： Juul K,Tybjaerg-Hansen A,Steffensen R,Kofoed S,Jensen G,Nordestgaard BG

更新日期：2002-07-01 00:00:00

abstract：:Prophylactic treatment in severe hemophilia is very effective but is limited by cost issues. The implementation of 2 different prophylactic regimens in The Netherlands and Sweden since the 1970s may be considered a natural experiment. We compared the costs and outcomes of Dutch intermediate- and Swedish high-dose prop...

journal_title：Blood

authors： Fischer K,Steen Carlsson K,Petrini P,Holmström M,Ljung R,van den Berg HM,Berntorp E

更新日期：2013-08-15 00:00:00

abstract：:The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, a bicistronic retroviral vector encoding GATA-2 and the green fluorescent protein (GFP) was used to maintain the high levels of...

journal_title：Blood

authors： Persons DA,Allay JA,Allay ER,Ashmun RA,Orlic D,Jane SM,Cunningham JM,Nienhuis AW

更新日期：1999-01-15 00:00:00

abstract：:Toll-like receptor 4 (TLR4) initiates both myeloid differentiation factor 88 (MyD88)-dependent and Toll/interleukin (IL)-1R domain-containing adapter, inducing interferon (IFN)-beta-dependent signaling, leading to production of proinflammatory mediators and type I interferon (IFN) to eliminate pathogens. However, unco...

journal_title：Blood

authors： Wang Y,Chen T,Han C,He D,Liu H,An H,Cai Z,Cao X

更新日期：2007-08-01 00:00:00

abstract：:Distinct human dendritic cell (DC) subsets differentially control immunity. Thus, insights into their in vivo functions are important to understand the launching and modulation of immune responses. We show that nonobese diabetic/LtSz-scid/scid (NOD/SCID) mice engrafted with human CD34+ hematopoietic progenitors develo...

journal_title：Blood

authors： Palucka AK,Gatlin J,Blanck JP,Melkus MW,Clayton S,Ueno H,Kraus ET,Cravens P,Bennett L,Padgett-Thomas A,Marches F,Islas-Ohlmayer M,Garcia JV,Banchereau J

更新日期：2003-11-01 00:00:00

abstract：:Advances in fluorescence-activated cell sorter technology have brought about multicolor analysis of cell phenotypes. To clarify the phenotypes of human hematopoietic stem cells (HSCs), we initially prepared novel antibodies against CD34 and labeled one of them (4A1) with allophycocyanin (APC). With this, we analyzed t...

journal_title：Blood

authors： Gunji Y,Nakamura M,Hagiwara T,Hayakawa K,Matsushita H,Osawa H,Nagayoshi K,Nakauchi H,Yanagisawa M,Miura Y

更新日期：1992-07-15 00:00:00

abstract：:Immune thrombocytopenias are usually associated with normal or increased numbers of megakaryocytes in the marrow. Therefore, the mechanism(s) responsible for the destruction of circulating platelets may not affect megakaryocytes in the same way. One of the possibilities which could account for the differential effect ...

journal_title：Blood

authors： Stahl CP,Zucker-Franklin D,McDonald TP

更新日期：1986-02-01 00:00:00